BR0314979A - ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóide - Google Patents
ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóideInfo
- Publication number
- BR0314979A BR0314979A BR0314979-0A BR0314979A BR0314979A BR 0314979 A BR0314979 A BR 0314979A BR 0314979 A BR0314979 A BR 0314979A BR 0314979 A BR0314979 A BR 0314979A
- Authority
- BR
- Brazil
- Prior art keywords
- making
- host cell
- polypeptide
- methods
- vector
- Prior art date
Links
- 101710093888 Pentalenene synthase Proteins 0.000 title abstract 5
- 101710115850 Sesquiterpene synthase Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title 2
- 108090000765 processed proteins & peptides Proteins 0.000 title 2
- 150000003505 terpenes Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- VPDZRSSKICPUEY-GQRSATBHSA-N (+)-Bicyclogermacrene Natural products CC1(C)[C@@H]/2[C@H]1CC/C(/C)=C\CC/C(/C)=C\2 VPDZRSSKICPUEY-GQRSATBHSA-N 0.000 abstract 1
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 abstract 1
- FUCYIEXQVQJBKY-ZFWWWQNUSA-N (+)-δ-Cadinene Chemical compound C1CC(C)=C[C@H]2[C@H](C(C)C)CCC(C)=C21 FUCYIEXQVQJBKY-ZFWWWQNUSA-N 0.000 abstract 1
- KONGRWVLXLWGDV-BYGOPZEFSA-N (-)-cubebol Chemical compound CC(C)[C@@H]([C@H]12)CC[C@@H](C)[C@]32[C@@H]1[C@@](C)(O)CC3 KONGRWVLXLWGDV-BYGOPZEFSA-N 0.000 abstract 1
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 abstract 1
- VWFJDQUYCIWHTN-YFVJMOTDSA-N 2-trans,6-trans-farnesyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-YFVJMOTDSA-N 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- VWFJDQUYCIWHTN-UHFFFAOYSA-N Farnesyl pyrophosphate Natural products CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- QMAYBMKBYCGXDH-UHFFFAOYSA-N alpha-amorphene Natural products C1CC(C)=CC2C(C(C)C)CC=C(C)C21 QMAYBMKBYCGXDH-UHFFFAOYSA-N 0.000 abstract 1
- VPDZRSSKICPUEY-JEPMYXAXSA-N bicyclogermacrene Chemical compound C1CC(/C)=C/CC\C(C)=C\[C@@H]2C(C)(C)[C@H]12 VPDZRSSKICPUEY-JEPMYXAXSA-N 0.000 abstract 1
- RXARZHLXLNWPFG-UHFFFAOYSA-N bicyclogermacrene Natural products CC1=C2C3C(CCC2=CCC1)C3(C)C RXARZHLXLNWPFG-UHFFFAOYSA-N 0.000 abstract 1
- KONGRWVLXLWGDV-UHFFFAOYSA-N cubebol Natural products C12C(C(C)C)CCC(C)C32C1C(C)(O)CC3 KONGRWVLXLWGDV-UHFFFAOYSA-N 0.000 abstract 1
- YOCDGWMCBBMMGJ-UHFFFAOYSA-N delta-cadinene Natural products C1C=C(C)CC2C(C(C)C)CCC(=C)C21 YOCDGWMCBBMMGJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- USDOQCCMRDNVAH-UHFFFAOYSA-N sigma-cadinene Natural products C1C=C(C)CC2C(C(C)C)CC=C(C)C21 USDOQCCMRDNVAH-UHFFFAOYSA-N 0.000 abstract 1
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41576502P | 2002-10-04 | 2002-10-04 | |
| IB0205070 | 2002-12-02 | ||
| PCT/IB2003/005072 WO2004031376A2 (en) | 2002-10-04 | 2003-10-02 | Sesquiterpene synthases and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0314979A true BR0314979A (pt) | 2005-08-02 |
Family
ID=34590004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0314979-0A BR0314979A (pt) | 2002-10-04 | 2003-10-02 | ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóide |
Country Status (8)
| Country | Link |
|---|---|
| EP (3) | EP2365070B1 (https=) |
| JP (1) | JP4571862B2 (https=) |
| CN (3) | CN1703507B (https=) |
| AU (1) | AU2003278478A1 (https=) |
| BR (1) | BR0314979A (https=) |
| IL (1) | IL167832A (https=) |
| RU (1) | RU2005113300A (https=) |
| WO (1) | WO2004031376A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8106260B2 (en) | 1996-04-12 | 2012-01-31 | The Board Of Trustees Of The University Of Kentucky | Chimeric isoprenoid synthases and uses thereof |
| US7442785B2 (en) | 2003-07-24 | 2008-10-28 | The University Of Kentucky Research Foundation | Sesquiterpene synthase gene and protein |
| CA2537505A1 (en) * | 2003-09-02 | 2005-03-10 | Yoram Eyal | Citrus sesquiterpene synthase, methods of production and uses thereof |
| WO2006111924A2 (en) | 2005-04-19 | 2006-10-26 | University Of Kentucky Research Foundation | Transformed plants accumulating terpenes |
| JP5430929B2 (ja) | 2005-06-17 | 2014-03-05 | フイルメニツヒ ソシエテ アノニム | 新規セスキテルペン合成酵素ならびにその使用方法 |
| JP5135215B2 (ja) | 2005-07-01 | 2013-02-06 | ユニバーシティー オブ ケンタッキー リサーチ ファンデーション | モノテルペン及び／又はセスキテルペンを蓄積する形質転換植物 |
| WO2008100251A1 (en) * | 2007-02-13 | 2008-08-21 | Ls9, Inc. | Modified microorganism uses therefor |
| CN101384719B (zh) * | 2006-02-14 | 2012-10-03 | 弗门尼舍有限公司 | 用于生成萜的方法和用于该方法的mep转化后的微生物 |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| PL2252691T3 (pl) | 2008-03-06 | 2013-08-30 | Firmenich & Cie | Sposób otrzymywania alfa-santalenu |
| WO2010019696A2 (en) | 2008-08-12 | 2010-02-18 | Allylix, Inc. | Method for production of isoprenoids |
| ES2535722T3 (es) * | 2008-12-05 | 2015-05-14 | Keygene N.V. | Farneseno sintasa |
| CN111808892A (zh) | 2009-04-27 | 2020-10-23 | 基因组股份公司 | 脂肪酸酯的产生 |
| EP2449107B1 (en) | 2009-06-29 | 2015-04-08 | The University Of Western Australia | Terpene synthases from santalum |
| PT2493318T (pt) | 2009-10-28 | 2016-12-23 | Fundo De Defesa Da Citricultura - Fundecitrus | Composições repelentes e abordagens genéticas para controlo de huanglongbing |
| PL2569427T3 (pl) * | 2010-05-10 | 2018-02-28 | Firmenich Sa | Sposób wytwarzania alkoholu paczulowego i 7-epi-alfa-selinenu |
| CN103282492A (zh) | 2010-10-29 | 2013-09-04 | 奥利里克斯股份有限公司 | 修饰的瓦伦烯合酶多肽、编码核酸分子及其用途 |
| EP2537926A1 (en) * | 2011-06-21 | 2012-12-26 | Isobionics B.V. | Valencene synthase |
| EP2768955A1 (en) * | 2011-10-19 | 2014-08-27 | Keygene N.V. | Methods and compositions for producing drimenol |
| US9550815B2 (en) | 2012-01-23 | 2017-01-24 | University Of British Columbia | ABC terpenoid transporters and methods of using the same |
| CN103243083B (zh) * | 2012-02-06 | 2015-06-03 | 中国科学院上海生命科学研究院 | 一种新的倍半萜合成酶及其用途 |
| US10000749B2 (en) | 2013-03-14 | 2018-06-19 | Evolva, Inc. | Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof |
| ES2540791B1 (es) * | 2013-12-13 | 2016-05-09 | Consejo Superior De Investigaciones Científicas (Csic) | Nuevas sesquiterpeno sintasas aisladas de la piel de naranja. |
| SG11201701278RA (en) * | 2014-08-21 | 2017-03-30 | Manus Biosynthesis Inc | Methods for production of oxygenated terpenes |
| WO2017077125A1 (en) * | 2015-11-05 | 2017-05-11 | Firmenich S.A | Drimenol synthases iii |
| CN105524908B (zh) * | 2016-02-04 | 2018-12-28 | 中国农业科学院植物保护研究所 | 一种与(E)-β-石竹烯和(E)-a-律草烯合成相关的蛋白及其应用 |
| CN110093329B (zh) * | 2018-01-30 | 2023-07-04 | 深圳艾格鑫科技有限公司 | 萜类合酶及其应用 |
| CN108977426B (zh) * | 2018-06-29 | 2020-08-14 | 中国林业科学研究院热带林业研究所 | 一种油楠倍半萜合成酶及其编码基因和应用 |
| CN109852600B (zh) * | 2018-12-25 | 2021-12-31 | 天津大学 | 一种小萼苔倍半萜合成酶MTb及其基因序列 |
| CN109666668B (zh) * | 2019-01-24 | 2022-04-15 | 天津大学 | 一种小萼苔倍半萜合成酶MTa及其基因序列 |
| CN109837266B (zh) * | 2019-01-24 | 2021-12-31 | 天津大学 | 一种小萼苔倍半萜合成酶MTc及其基因序列 |
| CN109929828A (zh) * | 2019-01-30 | 2019-06-25 | 天津大学 | 一种苦皮藤倍半萜合成酶CaTPS1及其基因序列 |
| CN111004763B (zh) * | 2019-12-26 | 2022-06-03 | 中国科学院青岛生物能源与过程研究所 | 一种生产β-石竹烯的工程菌及其构建方法与应用 |
| CN115404228B (zh) * | 2021-05-28 | 2024-03-08 | 中国中医科学院中药研究所 | 山沉香倍半萜合酶蛋白tps1及其编码基因和应用 |
| CN116004490A (zh) * | 2022-07-12 | 2023-04-25 | 华东理工大学 | 一种生物合成右旋-双环吉玛烯的重组大肠杆菌、构建方法及应用 |
| CN116555238B (zh) * | 2023-06-09 | 2023-10-20 | 中国中医科学院中药研究所 | SoSTPS1在作为倍半萜合酶中的应用 |
| CN117126835B (zh) * | 2023-08-11 | 2025-04-25 | 武汉合生科技有限公司 | 瓦伦烯合成酶及其应用 |
| CN119899828B (zh) * | 2025-01-17 | 2026-01-30 | 中国药科大学 | 利用SsDMS突变体高效生产新颖drimane型倍半萜化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| ES2272209T3 (es) * | 1999-03-31 | 2007-05-01 | Firmenich Sa | Utilizacion de cubebol como ingrediente aromatizante. |
-
2003
- 2003-10-02 EP EP10177152.5A patent/EP2365070B1/en not_active Expired - Lifetime
- 2003-10-02 CN CN2003801009412A patent/CN1703507B/zh not_active Expired - Fee Related
- 2003-10-02 CN CN2010102392305A patent/CN101914559B/zh not_active Expired - Fee Related
- 2003-10-02 AU AU2003278478A patent/AU2003278478A1/en not_active Abandoned
- 2003-10-02 EP EP03769780A patent/EP1554379B1/en not_active Expired - Lifetime
- 2003-10-02 WO PCT/IB2003/005072 patent/WO2004031376A2/en not_active Ceased
- 2003-10-02 CN CN2010102391730A patent/CN101914558B/zh not_active Expired - Fee Related
- 2003-10-02 EP EP16182020.4A patent/EP3109319A1/en not_active Withdrawn
- 2003-10-02 RU RU2005113300/13A patent/RU2005113300A/ru not_active Application Discontinuation
- 2003-10-02 JP JP2004541126A patent/JP4571862B2/ja not_active Expired - Fee Related
- 2003-10-02 BR BR0314979-0A patent/BR0314979A/pt active IP Right Grant
-
2005
- 2005-04-03 IL IL167832A patent/IL167832A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3109319A1 (en) | 2016-12-28 |
| EP2365070B1 (en) | 2016-09-14 |
| EP2365070A1 (en) | 2011-09-14 |
| AU2003278478A1 (en) | 2004-04-23 |
| IL167832A (en) | 2010-11-30 |
| CN101914559B (zh) | 2012-04-04 |
| EP1554379A2 (en) | 2005-07-20 |
| WO2004031376A2 (en) | 2004-04-15 |
| CN1703507A (zh) | 2005-11-30 |
| CN101914559A (zh) | 2010-12-15 |
| CN1703507B (zh) | 2010-09-29 |
| CN101914558B (zh) | 2013-05-29 |
| RU2005113300A (ru) | 2005-10-27 |
| JP4571862B2 (ja) | 2010-10-27 |
| JP2006500942A (ja) | 2006-01-12 |
| EP1554379B1 (en) | 2012-02-22 |
| AU2003278478A8 (en) | 2004-04-23 |
| WO2004031376A3 (en) | 2005-05-26 |
| CN101914558A (zh) | 2010-12-15 |
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| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B12B | Appeal: appeal against refusal | ||
| B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/10/2019, OBSERVADAS AS CONDICOES LEGAIS. |