BR0314979A - ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóide - Google Patents
ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóideInfo
- Publication number
- BR0314979A BR0314979A BR0314979-0A BR0314979A BR0314979A BR 0314979 A BR0314979 A BR 0314979A BR 0314979 A BR0314979 A BR 0314979A BR 0314979 A BR0314979 A BR 0314979A
- Authority
- BR
- Brazil
- Prior art keywords
- making
- host cell
- polypeptide
- methods
- vector
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"áCIDO NUCLEICO ISOLADO, POLIPEPTìDEO, VETOR, CéLULA HOSPEDEIRA, ORGANISMO NãO HUMANO, E, MéTODOS DE FABRICAR UMA CéLULA HOSPEDEIRA RECOMBINANTE, DE PRODUZIR UM POLIPEPTìDEO, DE FABRICAR PELO MENOS UMA SESQUITERPENO SINTASE, E DE FABRICAR PELO MENOS UM TERPENóIDE". A invenção diz respeito a sesquiterpeno sintases e aos métodos de sua produção e uso. Em uma forma de realização, a invenção fornece ácidos nucleicos que compreendem uma seq³ência de nucleotídeo como aqui descrito que codifica pelo menos uma sesquiterpeno sintase. Em uma outra forma de realização, a invenção também fornece sesquiterpeno sintases e métodos de fabricar e usar estas enzimas. Por exemplo, as sesquiterpeno sintases da invenção podem ser usadas para converter farnesil-pirofosfato aos vários sesquiterpenos oxigenados e alifáticos incluindo valenceno, biciclogermacreno, cubebol e delta-cadineno.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41576502P | 2002-10-04 | 2002-10-04 | |
| IB0205070 | 2002-12-02 | ||
| PCT/IB2003/005072 WO2004031376A2 (en) | 2002-10-04 | 2003-10-02 | Sesquiterpene synthases and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0314979A true BR0314979A (pt) | 2005-08-02 |
Family
ID=34590004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0314979-0A BR0314979A (pt) | 2002-10-04 | 2003-10-02 | ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóide |
Country Status (8)
| Country | Link |
|---|---|
| EP (3) | EP3109319A1 (pt) |
| JP (1) | JP4571862B2 (pt) |
| CN (3) | CN1703507B (pt) |
| AU (1) | AU2003278478A1 (pt) |
| BR (1) | BR0314979A (pt) |
| IL (1) | IL167832A (pt) |
| RU (1) | RU2005113300A (pt) |
| WO (1) | WO2004031376A2 (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8106260B2 (en) | 1996-04-12 | 2012-01-31 | The Board Of Trustees Of The University Of Kentucky | Chimeric isoprenoid synthases and uses thereof |
| US7442785B2 (en) | 2003-07-24 | 2008-10-28 | The University Of Kentucky Research Foundation | Sesquiterpene synthase gene and protein |
| WO2005021705A2 (en) * | 2003-09-02 | 2005-03-10 | State Of Israel, Ministry Of Agriculture, Agricultural Research Organization | Citrus sesquiterpene synthase, methods of production and uses thereof |
| CN101163795B (zh) | 2005-04-19 | 2014-04-23 | 肯塔基大学研究机构 | 积聚萜的转化的植物 |
| WO2006134523A2 (en) | 2005-06-17 | 2006-12-21 | Firmenich Sa | Novel sesquiterpene synthases and methods of their use |
| US20080201796A1 (en) | 2005-07-01 | 2008-08-21 | University Of Kentucky Research Foundation | Transformed plants accumulating mono-and/or sesquiterpenes |
| WO2008100251A1 (en) * | 2007-02-13 | 2008-08-21 | Ls9, Inc. | Modified microorganism uses therefor |
| EP1987147B1 (en) | 2006-02-14 | 2010-07-28 | Firmenich S.A. | Method for producing terpenes and mep-transformed microorganisms therefore |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| ES2410906T3 (es) | 2008-03-06 | 2013-07-03 | Firmenich S.A. | Procedimiento de producción de alfa-santaleno |
| EP2326707B1 (en) | 2008-08-12 | 2016-11-23 | Evolva, Inc. | Method for production of isoprenoids |
| WO2010126891A1 (en) | 2009-04-27 | 2010-11-04 | Ls9, Inc. | Production of fatty acid esters |
| CA2766810C (en) | 2009-06-29 | 2017-10-10 | The University Of Western Australia | Terpene synthases from santalum |
| ES2608480T4 (es) | 2009-10-28 | 2017-10-05 | Fundo De Defesa Da Citricultura - Fundecitrus | Composiciones repelentes y enfoques genéticos para controlar el Huanglongbing |
| EP3312276B1 (en) * | 2010-05-10 | 2020-02-19 | Firmenich SA | Method for producing sesquiterpenes |
| JP2013544084A (ja) | 2010-10-29 | 2013-12-12 | アリリクス・インコーポレイテッド | 改変されたバレンセンシンターゼポリペプチド、コーディング核酸分子およびその使用 |
| EP2537926A1 (en) * | 2011-06-21 | 2012-12-26 | Isobionics B.V. | Valencene synthase |
| IN2014MN00854A (pt) | 2011-10-19 | 2015-04-17 | Keygene Nv | |
| US9550815B2 (en) | 2012-01-23 | 2017-01-24 | University Of British Columbia | ABC terpenoid transporters and methods of using the same |
| CN103243083B (zh) * | 2012-02-06 | 2015-06-03 | 中国科学院上海生命科学研究院 | 一种新的倍半萜合成酶及其用途 |
| EP3085778B1 (en) | 2013-03-14 | 2021-07-07 | Evolva, Inc. | Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof |
| ES2540791B1 (es) * | 2013-12-13 | 2016-05-09 | Consejo Superior De Investigaciones Científicas (Csic) | Nuevas sesquiterpeno sintasas aisladas de la piel de naranja. |
| US10934564B2 (en) * | 2014-08-21 | 2021-03-02 | Manus Bio Inc. | Methods for production of oxygenated terpenes |
| MX2018005218A (es) * | 2015-11-05 | 2018-08-01 | Firmenich & Cie | Drimenol sintasas iii. |
| CN105524908B (zh) * | 2016-02-04 | 2018-12-28 | 中国农业科学院植物保护研究所 | 一种与(E)-β-石竹烯和(E)-a-律草烯合成相关的蛋白及其应用 |
| CN110093329B (zh) * | 2018-01-30 | 2023-07-04 | 深圳艾格鑫科技有限公司 | 萜类合酶及其应用 |
| CN108977426B (zh) * | 2018-06-29 | 2020-08-14 | 中国林业科学研究院热带林业研究所 | 一种油楠倍半萜合成酶及其编码基因和应用 |
| CN109852600B (zh) * | 2018-12-25 | 2021-12-31 | 天津大学 | 一种小萼苔倍半萜合成酶MTb及其基因序列 |
| CN109666668B (zh) * | 2019-01-24 | 2022-04-15 | 天津大学 | 一种小萼苔倍半萜合成酶MTa及其基因序列 |
| CN109837266B (zh) * | 2019-01-24 | 2021-12-31 | 天津大学 | 一种小萼苔倍半萜合成酶MTc及其基因序列 |
| CN109929828A (zh) * | 2019-01-30 | 2019-06-25 | 天津大学 | 一种苦皮藤倍半萜合成酶CaTPS1及其基因序列 |
| CN111004763B (zh) * | 2019-12-26 | 2022-06-03 | 中国科学院青岛生物能源与过程研究所 | 一种生产β-石竹烯的工程菌及其构建方法与应用 |
| CN115404228B (zh) * | 2021-05-28 | 2024-03-08 | 中国中医科学院中药研究所 | 山沉香倍半萜合酶蛋白tps1及其编码基因和应用 |
| CN116555238B (zh) * | 2023-06-09 | 2023-10-20 | 中国中医科学院中药研究所 | SoSTPS1在作为倍半萜合酶中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| EP1541039B1 (en) * | 1999-03-31 | 2008-01-02 | Firmenich Sa | Flavour composition comprising cubebol and a further refreshing agent |
-
2003
- 2003-10-02 WO PCT/IB2003/005072 patent/WO2004031376A2/en active Application Filing
- 2003-10-02 EP EP16182020.4A patent/EP3109319A1/en not_active Withdrawn
- 2003-10-02 EP EP10177152.5A patent/EP2365070B1/en not_active Expired - Lifetime
- 2003-10-02 RU RU2005113300/13A patent/RU2005113300A/ru not_active Application Discontinuation
- 2003-10-02 BR BR0314979-0A patent/BR0314979A/pt active IP Right Grant
- 2003-10-02 JP JP2004541126A patent/JP4571862B2/ja not_active Expired - Fee Related
- 2003-10-02 EP EP03769780A patent/EP1554379B1/en not_active Expired - Lifetime
- 2003-10-02 CN CN2003801009412A patent/CN1703507B/zh not_active Expired - Fee Related
- 2003-10-02 CN CN2010102392305A patent/CN101914559B/zh not_active Expired - Fee Related
- 2003-10-02 AU AU2003278478A patent/AU2003278478A1/en not_active Abandoned
- 2003-10-02 CN CN2010102391730A patent/CN101914558B/zh not_active Expired - Fee Related
-
2005
- 2005-04-03 IL IL167832A patent/IL167832A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101914559A (zh) | 2010-12-15 |
| EP1554379A2 (en) | 2005-07-20 |
| EP1554379B1 (en) | 2012-02-22 |
| IL167832A (en) | 2010-11-30 |
| AU2003278478A8 (en) | 2004-04-23 |
| WO2004031376A2 (en) | 2004-04-15 |
| EP3109319A1 (en) | 2016-12-28 |
| EP2365070A1 (en) | 2011-09-14 |
| RU2005113300A (ru) | 2005-10-27 |
| JP2006500942A (ja) | 2006-01-12 |
| EP2365070B1 (en) | 2016-09-14 |
| WO2004031376A3 (en) | 2005-05-26 |
| CN101914559B (zh) | 2012-04-04 |
| CN101914558B (zh) | 2013-05-29 |
| CN101914558A (zh) | 2010-12-15 |
| CN1703507B (zh) | 2010-09-29 |
| JP4571862B2 (ja) | 2010-10-27 |
| CN1703507A (zh) | 2005-11-30 |
| AU2003278478A1 (en) | 2004-04-23 |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
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