RU2005113300A - Сесквитерпенсинтазы и способы их применения - Google Patents
Сесквитерпенсинтазы и способы их применения Download PDFInfo
- Publication number
- RU2005113300A RU2005113300A RU2005113300/13A RU2005113300A RU2005113300A RU 2005113300 A RU2005113300 A RU 2005113300A RU 2005113300/13 A RU2005113300/13 A RU 2005113300/13A RU 2005113300 A RU2005113300 A RU 2005113300A RU 2005113300 A RU2005113300 A RU 2005113300A
- Authority
- RU
- Russia
- Prior art keywords
- seq
- nucleic acid
- polypeptide
- nucleotide sequence
- cells
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 47
- 108020004707 nucleic acids Proteins 0.000 claims 46
- 102000039446 nucleic acids Human genes 0.000 claims 46
- 229920001184 polypeptide Polymers 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 23
- 238000000034 method Methods 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 20
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 150000003505 terpenes Chemical class 0.000 claims 6
- 241000196324 Embryophyta Species 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 244000005700 microbiome Species 0.000 claims 4
- 210000004102 animal cell Anatomy 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229930004725 sesquiterpene Natural products 0.000 claims 3
- 150000004354 sesquiterpene derivatives Chemical class 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 210000005253 yeast cell Anatomy 0.000 claims 3
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 claims 2
- KONGRWVLXLWGDV-BYGOPZEFSA-N (-)-cubebol Chemical compound CC(C)[C@@H]([C@H]12)CC[C@@H](C)[C@]32[C@@H]1[C@@](C)(O)CC3 KONGRWVLXLWGDV-BYGOPZEFSA-N 0.000 claims 2
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 claims 2
- 241000207199 Citrus Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 125000002015 acyclic group Chemical group 0.000 claims 2
- XUEHVOLRMXNRKQ-KHMAMNHCSA-N alpha-cubebene Chemical compound CC(C)[C@@H]([C@H]12)CC[C@@H](C)[C@]32[C@@H]1C(C)=CC3 XUEHVOLRMXNRKQ-KHMAMNHCSA-N 0.000 claims 2
- 235000020971 citrus fruits Nutrition 0.000 claims 2
- KONGRWVLXLWGDV-UHFFFAOYSA-N cubebol Natural products C12C(C(C)C)CCC(C)C32C1C(C)(O)CC3 KONGRWVLXLWGDV-UHFFFAOYSA-N 0.000 claims 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 2
- 235000011180 diphosphates Nutrition 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 235000007586 terpenes Nutrition 0.000 claims 2
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 claims 2
- GAIBLDCXCZKKJE-QRYCCKSOSA-N (-)-Germacrene D Natural products C(C)(C)[C@H]1/C=C/C(=C)CC/C=C(/C)\CC1 GAIBLDCXCZKKJE-QRYCCKSOSA-N 0.000 claims 1
- VWFJDQUYCIWHTN-YFVJMOTDSA-N 2-trans,6-trans-farnesyl diphosphate Chemical group CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-YFVJMOTDSA-N 0.000 claims 1
- 240000000560 Citrus x paradisi Species 0.000 claims 1
- VWFJDQUYCIWHTN-UHFFFAOYSA-N Farnesyl pyrophosphate Natural products CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-UHFFFAOYSA-N 0.000 claims 1
- GAIBLDCXCZKKJE-YZJXYJLZSA-N Germacren D Chemical compound CC(C)C/1CC\C(C)=C\CCC(=C)\C=C\1 GAIBLDCXCZKKJE-YZJXYJLZSA-N 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 238000004520 electroporation Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- OJIGFVZZEVQUNV-UHFFFAOYSA-N germacrene D Natural products CC(C)C1CCC=C(/C)CCC(=C)C=C1 OJIGFVZZEVQUNV-UHFFFAOYSA-N 0.000 claims 1
- GAIBLDCXCZKKJE-UHFFFAOYSA-N isogermacrene D Natural products CC(C)C1CCC(C)=CCCC(=C)C=C1 GAIBLDCXCZKKJE-UHFFFAOYSA-N 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41576502P | 2002-10-04 | 2002-10-04 | |
| US60/415,765 | 2002-10-04 | ||
| IB0205070 | 2002-12-02 | ||
| IBPCT/IB02/05070 | 2002-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005113300A true RU2005113300A (ru) | 2005-10-27 |
Family
ID=34590004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005113300/13A RU2005113300A (ru) | 2002-10-04 | 2003-10-02 | Сесквитерпенсинтазы и способы их применения |
Country Status (8)
| Country | Link |
|---|---|
| EP (3) | EP2365070B1 (https=) |
| JP (1) | JP4571862B2 (https=) |
| CN (3) | CN1703507B (https=) |
| AU (1) | AU2003278478A1 (https=) |
| BR (1) | BR0314979A (https=) |
| IL (1) | IL167832A (https=) |
| RU (1) | RU2005113300A (https=) |
| WO (1) | WO2004031376A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2546877C2 (ru) * | 2008-12-05 | 2015-04-10 | Кинджин Н.В. | Фарнезен-синтаза |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8106260B2 (en) | 1996-04-12 | 2012-01-31 | The Board Of Trustees Of The University Of Kentucky | Chimeric isoprenoid synthases and uses thereof |
| US7442785B2 (en) | 2003-07-24 | 2008-10-28 | The University Of Kentucky Research Foundation | Sesquiterpene synthase gene and protein |
| CA2537505A1 (en) * | 2003-09-02 | 2005-03-10 | Yoram Eyal | Citrus sesquiterpene synthase, methods of production and uses thereof |
| WO2006111924A2 (en) | 2005-04-19 | 2006-10-26 | University Of Kentucky Research Foundation | Transformed plants accumulating terpenes |
| JP5430929B2 (ja) | 2005-06-17 | 2014-03-05 | フイルメニツヒ ソシエテ アノニム | 新規セスキテルペン合成酵素ならびにその使用方法 |
| JP5135215B2 (ja) | 2005-07-01 | 2013-02-06 | ユニバーシティー オブ ケンタッキー リサーチ ファンデーション | モノテルペン及び／又はセスキテルペンを蓄積する形質転換植物 |
| WO2008100251A1 (en) * | 2007-02-13 | 2008-08-21 | Ls9, Inc. | Modified microorganism uses therefor |
| CN101384719B (zh) * | 2006-02-14 | 2012-10-03 | 弗门尼舍有限公司 | 用于生成萜的方法和用于该方法的mep转化后的微生物 |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| PL2252691T3 (pl) | 2008-03-06 | 2013-08-30 | Firmenich & Cie | Sposób otrzymywania alfa-santalenu |
| WO2010019696A2 (en) | 2008-08-12 | 2010-02-18 | Allylix, Inc. | Method for production of isoprenoids |
| CN111808892A (zh) | 2009-04-27 | 2020-10-23 | 基因组股份公司 | 脂肪酸酯的产生 |
| EP2449107B1 (en) | 2009-06-29 | 2015-04-08 | The University Of Western Australia | Terpene synthases from santalum |
| PT2493318T (pt) | 2009-10-28 | 2016-12-23 | Fundo De Defesa Da Citricultura - Fundecitrus | Composições repelentes e abordagens genéticas para controlo de huanglongbing |
| PL2569427T3 (pl) * | 2010-05-10 | 2018-02-28 | Firmenich Sa | Sposób wytwarzania alkoholu paczulowego i 7-epi-alfa-selinenu |
| CN103282492A (zh) | 2010-10-29 | 2013-09-04 | 奥利里克斯股份有限公司 | 修饰的瓦伦烯合酶多肽、编码核酸分子及其用途 |
| EP2537926A1 (en) * | 2011-06-21 | 2012-12-26 | Isobionics B.V. | Valencene synthase |
| EP2768955A1 (en) * | 2011-10-19 | 2014-08-27 | Keygene N.V. | Methods and compositions for producing drimenol |
| US9550815B2 (en) | 2012-01-23 | 2017-01-24 | University Of British Columbia | ABC terpenoid transporters and methods of using the same |
| CN103243083B (zh) * | 2012-02-06 | 2015-06-03 | 中国科学院上海生命科学研究院 | 一种新的倍半萜合成酶及其用途 |
| US10000749B2 (en) | 2013-03-14 | 2018-06-19 | Evolva, Inc. | Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof |
| ES2540791B1 (es) * | 2013-12-13 | 2016-05-09 | Consejo Superior De Investigaciones Científicas (Csic) | Nuevas sesquiterpeno sintasas aisladas de la piel de naranja. |
| SG11201701278RA (en) * | 2014-08-21 | 2017-03-30 | Manus Biosynthesis Inc | Methods for production of oxygenated terpenes |
| WO2017077125A1 (en) * | 2015-11-05 | 2017-05-11 | Firmenich S.A | Drimenol synthases iii |
| CN105524908B (zh) * | 2016-02-04 | 2018-12-28 | 中国农业科学院植物保护研究所 | 一种与(E)-β-石竹烯和(E)-a-律草烯合成相关的蛋白及其应用 |
| CN110093329B (zh) * | 2018-01-30 | 2023-07-04 | 深圳艾格鑫科技有限公司 | 萜类合酶及其应用 |
| CN108977426B (zh) * | 2018-06-29 | 2020-08-14 | 中国林业科学研究院热带林业研究所 | 一种油楠倍半萜合成酶及其编码基因和应用 |
| CN109852600B (zh) * | 2018-12-25 | 2021-12-31 | 天津大学 | 一种小萼苔倍半萜合成酶MTb及其基因序列 |
| CN109666668B (zh) * | 2019-01-24 | 2022-04-15 | 天津大学 | 一种小萼苔倍半萜合成酶MTa及其基因序列 |
| CN109837266B (zh) * | 2019-01-24 | 2021-12-31 | 天津大学 | 一种小萼苔倍半萜合成酶MTc及其基因序列 |
| CN109929828A (zh) * | 2019-01-30 | 2019-06-25 | 天津大学 | 一种苦皮藤倍半萜合成酶CaTPS1及其基因序列 |
| CN111004763B (zh) * | 2019-12-26 | 2022-06-03 | 中国科学院青岛生物能源与过程研究所 | 一种生产β-石竹烯的工程菌及其构建方法与应用 |
| CN115404228B (zh) * | 2021-05-28 | 2024-03-08 | 中国中医科学院中药研究所 | 山沉香倍半萜合酶蛋白tps1及其编码基因和应用 |
| CN116004490A (zh) * | 2022-07-12 | 2023-04-25 | 华东理工大学 | 一种生物合成右旋-双环吉玛烯的重组大肠杆菌、构建方法及应用 |
| CN116555238B (zh) * | 2023-06-09 | 2023-10-20 | 中国中医科学院中药研究所 | SoSTPS1在作为倍半萜合酶中的应用 |
| CN117126835B (zh) * | 2023-08-11 | 2025-04-25 | 武汉合生科技有限公司 | 瓦伦烯合成酶及其应用 |
| CN119899828B (zh) * | 2025-01-17 | 2026-01-30 | 中国药科大学 | 利用SsDMS突变体高效生产新颖drimane型倍半萜化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| ES2272209T3 (es) * | 1999-03-31 | 2007-05-01 | Firmenich Sa | Utilizacion de cubebol como ingrediente aromatizante. |
-
2003
- 2003-10-02 EP EP10177152.5A patent/EP2365070B1/en not_active Expired - Lifetime
- 2003-10-02 CN CN2003801009412A patent/CN1703507B/zh not_active Expired - Fee Related
- 2003-10-02 CN CN2010102392305A patent/CN101914559B/zh not_active Expired - Fee Related
- 2003-10-02 AU AU2003278478A patent/AU2003278478A1/en not_active Abandoned
- 2003-10-02 EP EP03769780A patent/EP1554379B1/en not_active Expired - Lifetime
- 2003-10-02 WO PCT/IB2003/005072 patent/WO2004031376A2/en not_active Ceased
- 2003-10-02 CN CN2010102391730A patent/CN101914558B/zh not_active Expired - Fee Related
- 2003-10-02 EP EP16182020.4A patent/EP3109319A1/en not_active Withdrawn
- 2003-10-02 RU RU2005113300/13A patent/RU2005113300A/ru not_active Application Discontinuation
- 2003-10-02 JP JP2004541126A patent/JP4571862B2/ja not_active Expired - Fee Related
- 2003-10-02 BR BR0314979-0A patent/BR0314979A/pt active IP Right Grant
-
2005
- 2005-04-03 IL IL167832A patent/IL167832A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2546877C2 (ru) * | 2008-12-05 | 2015-04-10 | Кинджин Н.В. | Фарнезен-синтаза |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3109319A1 (en) | 2016-12-28 |
| EP2365070B1 (en) | 2016-09-14 |
| EP2365070A1 (en) | 2011-09-14 |
| AU2003278478A1 (en) | 2004-04-23 |
| IL167832A (en) | 2010-11-30 |
| CN101914559B (zh) | 2012-04-04 |
| EP1554379A2 (en) | 2005-07-20 |
| WO2004031376A2 (en) | 2004-04-15 |
| CN1703507A (zh) | 2005-11-30 |
| CN101914559A (zh) | 2010-12-15 |
| BR0314979A (pt) | 2005-08-02 |
| CN1703507B (zh) | 2010-09-29 |
| CN101914558B (zh) | 2013-05-29 |
| JP4571862B2 (ja) | 2010-10-27 |
| JP2006500942A (ja) | 2006-01-12 |
| EP1554379B1 (en) | 2012-02-22 |
| AU2003278478A8 (en) | 2004-04-23 |
| WO2004031376A3 (en) | 2005-05-26 |
| CN101914558A (zh) | 2010-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20090301 |