JP2006500391A - サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン - Google Patents

サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン Download PDF

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JP2006500391A
JP2006500391A JP2004534490A JP2004534490A JP2006500391A JP 2006500391 A JP2006500391 A JP 2006500391A JP 2004534490 A JP2004534490 A JP 2004534490A JP 2004534490 A JP2004534490 A JP 2004534490A JP 2006500391 A JP2006500391 A JP 2006500391A
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aryl
alkyl
group
compound
cycloalkyl
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JP2006500391A5 (enExample
Inventor
ティモシー ジェイ． グジ，
カミル パルク，
マイケル ピー． ドゥイヤー，
ドール，　ロナルド　ジェイ．
ビッヨール ムーピル ギリジャヴァラバン，
チャド ナットソン，
ブライアン マックキットリック，
ローレンス ダブリュー． ディラード，
ヴィン ディー． トラン，
ゼン ミン ヘー，
レイ アンソニー ジェームス，
ヘンスーン パーク，
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of JP2006500391A publication Critical patent/JP2006500391A/ja
Publication of JP2006500391A5 publication Critical patent/JP2006500391A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
JP2004534490A 2002-09-04 2003-09-03 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン Ceased JP2006500391A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40818202P 2002-09-04 2002-09-04
PCT/US2003/027564 WO2004022062A1 (en) 2002-09-04 2003-09-03 Pyrazolopyrimidines as cyclin dependent kinase inhibitors

Related Child Applications (1)

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JP2011005344A Division JP2011074088A (ja) 2002-09-04 2011-01-13 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン

Publications (2)

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JP2006500391A true JP2006500391A (ja) 2006-01-05
JP2006500391A5 JP2006500391A5 (enExample) 2006-09-07

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JP2004534490A Ceased JP2006500391A (ja) 2002-09-04 2003-09-03 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
JP2011005344A Withdrawn JP2011074088A (ja) 2002-09-04 2011-01-13 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン

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Country Status (14)

Country Link
US (2) US7084271B2 (enExample)
EP (1) EP1545533A1 (enExample)
JP (2) JP2006500391A (enExample)
KR (1) KR20050057072A (enExample)
CN (1) CN1694705A (enExample)
AR (1) AR041135A1 (enExample)
AU (1) AU2003265901B2 (enExample)
CA (1) CA2497539A1 (enExample)
MX (1) MXPA05002574A (enExample)
NZ (1) NZ539163A (enExample)
PE (1) PE20040998A1 (enExample)
TW (1) TW200412966A (enExample)
WO (1) WO2004022062A1 (enExample)
ZA (1) ZA200501854B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007519662A (ja) * 2004-01-22 2007-07-19 ノバルティス アクチエンゲゼルシャフト タンパク質キナーゼ依存性疾患の処置に使用するためのピラゾロ［１，５−ａ］ピリミジン−７−イル−アミン誘導体
JP2010504933A (ja) * 2006-09-29 2010-02-18 ノバルティス アーゲー Ｐｉ３ｋ脂質キナーゼ阻害剤としてのピラゾロピリミジン
JP2017516778A (ja) * 2014-05-28 2017-06-22 ノバルティス アーゲー 新規なピラゾロピリミジン誘導体およびｍａｌｔ１阻害剤としてのその使用

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) * 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US7649006B2 (en) * 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2496477C (en) 2002-08-23 2012-10-16 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
WO2005112936A1 (en) * 2004-05-14 2005-12-01 The Regents Of The University Of Michigan Compositions and methods relating to protein kinase inhibitors
JP5117189B2 (ja) * 2004-08-27 2013-01-09 サイクラセル リミテッド プリン及びピリミジンｃｄｋ阻害剤、並びに自己免疫疾患の治療のためのそれらの使用
AU2005281704A1 (en) 2004-09-06 2006-03-16 Nycomed Gmbh Novel pyrazolopyrimidines
EA012505B1 (ru) 2005-01-05 2009-10-30 Никомед Гмбх Триазолофталазины в качестве ингибиторов pde-2
JP5130053B2 (ja) 2005-01-05 2013-01-30 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング トリアゾロフタラジン
US20100075993A1 (en) * 2005-06-30 2010-03-25 Drexel University Small molecule inhibitors against west nile virus replication
CN101300233A (zh) * 2005-09-09 2008-11-05 先灵公司 氮杂稠合的细胞周期蛋白依赖性激酶抑制剂
US20100008912A1 (en) * 2006-10-06 2010-01-14 Takeda Pharmaceutical Company Limited Combination drug
EP2473041B1 (en) 2009-09-04 2018-03-07 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
EP2608669B1 (en) * 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
WO2012149157A2 (en) 2011-04-26 2012-11-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
WO2014066743A1 (en) 2012-10-25 2014-05-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
WO2014066795A1 (en) 2012-10-25 2014-05-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
EP2970307B1 (en) * 2013-03-13 2020-03-11 Genentech, Inc. Pyrazolo compounds and uses thereof
EP3377908B1 (en) 2015-11-18 2020-08-05 Genzyme Corporation Biomarker of polycystic kidney disease and uses thereof
DK3658557T3 (da) 2017-07-28 2024-07-29 Takeda Pharmaceuticals Co Tyk2-inhibitorer og anvendelser deraf
CN113248500B (zh) * 2021-06-10 2021-10-19 中国药科大学 氮杂吲哚嘧啶胺杂环化合物及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4116288Y1 (enExample) 1964-11-07 1966-07-28
WO1992018504A1 (en) 1991-04-22 1992-10-29 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
EP0628559B1 (en) 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
GB9325074D0 (en) * 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
PT714898E (pt) * 1994-06-21 2002-04-29 Otsuka Pharma Co Ltd Derivado de pirazolo¬1,5-a|pirimidina
US5502137A (en) 1994-11-25 1996-03-26 Eastman Chemical Company Polyether glycols and alcohols derived from 3,4-epoxy-1-butene, tetrahydrofuran and an initiator
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6262096B1 (en) * 1997-11-12 2001-07-17 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6413974B1 (en) * 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
CA2369895C (en) 1999-01-11 2010-12-21 Princeton University High affinity inhibitors for target validation and uses thereof
WO2001007411A1 (en) 1999-07-26 2001-02-01 Banyu Pharmaceutical Co., Ltd. Biarylurea derivatives
FR2805160B1 (fr) 2000-02-23 2002-04-05 Oreal Compositions pour la teinture d'oxydation des fibres keratiniques comprenant un n(2-hydroxybenzene)-carbramate ou un n-(2-hydroxybenzene)-uree et une pyrazolopyrimidine, et procedes de teinture
PL365170A1 (en) 2000-07-26 2004-12-27 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases
US7067520B2 (en) 2000-11-17 2006-06-27 Ishihara Sangyo Kaisha, Ltd. Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts
FR2817469B1 (fr) 2000-12-04 2003-04-18 Oreal Composition de coloration, procede d'obtention et utilisation pour la coloration de fibres keratiniques
WO2002050079A1 (fr) 2000-12-20 2002-06-27 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Inhibiteurs de kinases dependantes des cylines (cdk) et de la glycogene synthase kinase-3 (gsk-3)
WO2003091256A1 (en) 2002-04-23 2003-11-06 Shionogi & Co., Ltd. PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND NAD(P)H OXIDASE INHIBITOR CONTAINING THE SAME
DE10223917A1 (de) 2002-05-29 2003-12-11 Bayer Cropscience Ag Pyrazolopyrimidine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007519662A (ja) * 2004-01-22 2007-07-19 ノバルティス アクチエンゲゼルシャフト タンパク質キナーゼ依存性疾患の処置に使用するためのピラゾロ［１，５−ａ］ピリミジン−７−イル−アミン誘導体
JP2010504933A (ja) * 2006-09-29 2010-02-18 ノバルティス アーゲー Ｐｉ３ｋ脂質キナーゼ阻害剤としてのピラゾロピリミジン
JP2017516778A (ja) * 2014-05-28 2017-06-22 ノバルティス アーゲー 新規なピラゾロピリミジン誘導体およびｍａｌｔ１阻害剤としてのその使用

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US7084271B2 (en) 2006-08-01
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AR041135A1 (es) 2005-05-04
CN1694705A (zh) 2005-11-09
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CA2497539A1 (en) 2004-03-18
US20060173017A1 (en) 2006-08-03
US7468372B2 (en) 2008-12-23
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TW200412966A (en) 2004-08-01
ZA200501854B (en) 2005-09-12

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