JP2006271389A5 - - Google Patents
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- Publication number
- JP2006271389A5 JP2006271389A5 JP2006132306A JP2006132306A JP2006271389A5 JP 2006271389 A5 JP2006271389 A5 JP 2006271389A5 JP 2006132306 A JP2006132306 A JP 2006132306A JP 2006132306 A JP2006132306 A JP 2006132306A JP 2006271389 A5 JP2006271389 A5 JP 2006271389A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- acid molecule
- polypeptide
- brevibacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000007523 nucleic acids Chemical class 0.000 claims 23
- 108020004707 nucleic acids Proteins 0.000 claims 22
- 102000039446 nucleic acids Human genes 0.000 claims 22
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 150000001413 amino acids Chemical group 0.000 claims 15
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 239000012847 fine chemical Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- 230000000295 complement effect Effects 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 241000186146 Brevibacterium Species 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 4
- 241000186216 Corynebacterium Species 0.000 claims 3
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 241000589158 Agrobacterium Species 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- -1 cofactors Natural products 0.000 claims 2
- 150000002009 diols Chemical class 0.000 claims 2
- 206010013023 diphtheria Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 125000003835 nucleoside group Chemical group 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 235000005985 organic acids Nutrition 0.000 claims 2
- 229930001119 polyketide Natural products 0.000 claims 2
- 125000000830 polyketide group Chemical group 0.000 claims 2
- 150000003212 purines Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 235000003441 saturated fatty acids Nutrition 0.000 claims 2
- 150000004671 saturated fatty acids Chemical class 0.000 claims 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 235000012539 Bacterium linens Nutrition 0.000 claims 1
- 241000186310 Brevibacterium linens Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (35)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14103199P | 1999-06-25 | 1999-06-25 | |
| DE19931563 | 1999-07-08 | ||
| DE19931454 | 1999-07-08 | ||
| DE19931478 | 1999-07-08 | ||
| DE19932228 | 1999-07-09 | ||
| DE19932182 | 1999-07-09 | ||
| DE19932125 | 1999-07-09 | ||
| DE19932227 | 1999-07-09 | ||
| DE19932191 | 1999-07-09 | ||
| DE19932229 | 1999-07-09 | ||
| DE19932212 | 1999-07-09 | ||
| DE19932122 | 1999-07-09 | ||
| DE19932128 | 1999-07-09 | ||
| DE19932209 | 1999-07-09 | ||
| DE19932190 | 1999-07-09 | ||
| DE19932180 | 1999-07-09 | ||
| DE19932124 | 1999-07-09 | ||
| DE19932230 | 1999-07-09 | ||
| DE19933006 | 1999-07-14 | ||
| DE19932927 | 1999-07-14 | ||
| DE19933005 | 1999-07-14 | ||
| DE19940830 | 1999-08-27 | ||
| DE19940765 | 1999-08-27 | ||
| DE19940764 | 1999-08-27 | ||
| DE19940766 | 1999-08-27 | ||
| DE19940831 | 1999-08-27 | ||
| DE19940833 | 1999-08-27 | ||
| DE19940832 | 1999-08-27 | ||
| DE19941395 | 1999-08-31 | ||
| DE19941378 | 1999-08-31 | ||
| DE19941379 | 1999-08-31 | ||
| DE19942079 | 1999-09-03 | ||
| DE19942088 | 1999-09-03 | ||
| DE19942078 | 1999-09-03 | ||
| DE19942077 | 1999-09-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001506799A Division JP2004513603A (ja) | 1999-06-25 | 2000-06-23 | 膜合成および膜輸送に関与するタンパク質をコードするコリネバクテリウム−グルタミカム遺伝子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006271389A JP2006271389A (ja) | 2006-10-12 |
| JP2006271389A5 true JP2006271389A5 (enrdf_load_stackoverflow) | 2007-06-14 |
Family
ID=27586932
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001506799A Pending JP2004513603A (ja) | 1999-06-25 | 2000-06-23 | 膜合成および膜輸送に関与するタンパク質をコードするコリネバクテリウム−グルタミカム遺伝子 |
| JP2006132306A Withdrawn JP2006271389A (ja) | 1999-06-25 | 2006-05-11 | 膜合成および膜輸送に関与するタンパク質をコードするコリネバクテリウム−グルタミカム遺伝子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001506799A Pending JP2004513603A (ja) | 1999-06-25 | 2000-06-23 | 膜合成および膜輸送に関与するタンパク質をコードするコリネバクテリウム−グルタミカム遺伝子 |
Country Status (10)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60027161D1 (de) | 1999-07-02 | 2006-05-18 | Ajinomoto Kk | Für das saccharose-pts-enzym ii kodierende dna |
| DE19941478A1 (de) | 1999-09-01 | 2001-03-08 | Degussa | Neue für das thrE-Gen codierende Nukleotidsequenzen und Verfahren zur fermentativen Herstellung von L-Threonin mit coryneformen Bakterien |
| DE10021832A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das cma-Gen kodierende Nukleotidsequenzen |
| DE10021831A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das fadD15-Gen kodierende Nukleotidsequenzen |
| DE10021828A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das cdsA-Gen kodierende Nukleotidsequenzen |
| DE10021826A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das cls-Gen kodierende Nukleotidsequenzen |
| DE10021829A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das pgsA2-Gen kodierende Nukleotidsequenzen |
| US6562607B2 (en) | 2000-05-04 | 2003-05-13 | Degussa-Huls Aktiengesellschaft | Nucleotide sequences coding for the cls gene |
| DE10023400A1 (de) * | 2000-05-12 | 2001-11-15 | Degussa | Neue für das acp-Gen kodierende Nukleotidsequenzen |
| US20020081673A1 (en) | 2000-06-02 | 2002-06-27 | Bettina Mockel | Novel nucleotide sequences coding for the glbO gene |
| DE10032173A1 (de) * | 2000-07-01 | 2002-01-17 | Degussa | Neue für das plsC-Gen kodierende Nukleotidsequenzen |
| DE10045579A1 (de) * | 2000-09-15 | 2002-04-11 | Degussa | Neue für das atr61-Gen kodierende Nukleotidsequenzen |
| WO2002024915A1 (en) * | 2000-09-19 | 2002-03-28 | Degussa Ag | Dcta (c4-dicarboxylate transporter) from corynebacterium glutamicum |
| DE10057801A1 (de) * | 2000-11-22 | 2002-05-23 | Degussa | Neue für das cysQ-Gen kodierende Nukleotidsequenzen |
| DE10154270A1 (de) * | 2001-11-05 | 2003-05-15 | Basf Ag | Gene die für Kohlenstoffmetabolismus- und Energieproduktion-Proteine codieren |
| DE10154179A1 (de) * | 2001-11-05 | 2003-05-08 | Basf Ag | Gene die für membeansynthese-und Membrantransport-Proteine codieren |
| DE10163167A1 (de) * | 2001-12-21 | 2003-07-03 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren und Verwendung coryneformer Bakterien |
| ATE473284T1 (de) * | 2002-05-14 | 2010-07-15 | Martek Biosciences Corp | Carotinsynthase-gen und dessen verwendung |
| US7468262B2 (en) | 2003-05-16 | 2008-12-23 | Ajinomoto Co., Inc. | Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum |
| DE102004009454A1 (de) * | 2004-02-27 | 2005-09-15 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von rekombinanten Mikroorganismen |
| EP2149607B1 (en) * | 2007-04-10 | 2017-12-20 | Ajinomoto Co., Inc. | Method for production of succinic acid |
| KR101694850B1 (ko) * | 2014-10-08 | 2017-01-10 | 씨제이제일제당 주식회사 | L-글루타민을 생산하는 미생물 및 이를 이용한 l-글루타민 생산방법 |
| US10428357B2 (en) * | 2017-04-04 | 2019-10-01 | NNB Nutrition USA, LLC | Preparation of (R)-3-hydroxybutyric acid or its salts by one-step fermentation |
| KR101968317B1 (ko) | 2018-02-23 | 2019-04-11 | 씨제이제일제당 주식회사 | 신규 l-트립토판 배출 단백질 및 이를 이용한 l-트립토판을 생산하는 방법 |
| WO2019228937A1 (en) * | 2018-05-28 | 2019-12-05 | Universitaet Des Saarlandes | Means and methods for the production of glutarate |
| EP3670525A1 (en) * | 2018-12-18 | 2020-06-24 | Evonik Operations GmbH | Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter |
| CN112143676B (zh) * | 2020-09-21 | 2022-03-18 | 山西大学 | 一株产碱性蛋白酶耐盐芽孢杆菌及其产碱性蛋白酶的方法与应用 |
| CN112646766B (zh) * | 2020-12-30 | 2023-08-18 | 内蒙古伊品生物科技有限公司 | 一种改造基因bbd29_04920的产l-谷氨酸的重组菌株及其构建方法与应用 |
| CN114763372B (zh) * | 2021-01-13 | 2024-12-10 | 中国科学院天津工业生物技术研究所 | 具有l-脯氨酸外排功能的蛋白及其应用 |
| KR102261851B1 (ko) * | 2021-01-15 | 2021-06-04 | 씨제이제일제당 (주) | 신규한 abc 트랜스포터 atp-결합 단백질 변이체 및 이를 이용한 l-라이신 생산 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196453B (it) * | 1986-07-04 | 1988-11-16 | Sclavo Spa | Elemento di dna di corynebacterium diphtheriae con proprieta' tipiche di un elemento di inserzione is |
| US6649379B1 (en) * | 1987-06-12 | 2003-11-18 | Massachusetts Institute Of Technology | Method and deregulated enzyme for threonine production |
| JP2967996B2 (ja) * | 1989-06-06 | 1999-10-25 | 協和醗酵工業株式会社 | Ｌ―トリプトファンの製造法 |
| MY113040A (en) * | 1994-02-24 | 2001-11-30 | Ajinomoto Kk | Novel gene derived from coryneform bacteria and use thereof |
| US6737248B2 (en) * | 1996-01-05 | 2004-05-18 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
-
2000
- 2000-06-23 TR TR2006/07443T patent/TR200607443T2/xx unknown
- 2000-06-23 JP JP2001506799A patent/JP2004513603A/ja active Pending
- 2000-06-23 EP EP00939001A patent/EP1255839A2/en not_active Ceased
- 2000-06-23 CA CA002380863A patent/CA2380863A1/en not_active Abandoned
- 2000-06-23 ES ES00939001T patent/ES2177476T1/es active Pending
- 2000-06-23 SK SK1891-2001A patent/SK18912001A3/sk not_active Application Discontinuation
- 2000-06-23 CZ CZ20014660A patent/CZ20014660A3/cs unknown
- 2000-06-23 TR TR2006/07442T patent/TR200607442T2/xx unknown
- 2000-06-23 TR TR2006/07441T patent/TR200607441T2/xx unknown
- 2000-06-23 KR KR1020017016590A patent/KR100834989B1/ko not_active Expired - Fee Related
- 2000-06-23 KR KR1020077015871A patent/KR20070087032A/ko not_active Withdrawn
- 2000-06-23 MX MXPA01012845A patent/MXPA01012845A/es not_active Application Discontinuation
- 2000-06-23 WO PCT/IB2000/000926 patent/WO2001000805A2/en active Application Filing
- 2000-06-23 TR TR2001/03708T patent/TR200103708T2/xx unknown
- 2000-06-23 KR KR1020067022650A patent/KR100878332B1/ko not_active Expired - Fee Related
-
2006
- 2006-05-11 JP JP2006132306A patent/JP2006271389A/ja not_active Withdrawn
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