JP2006213732A5 - - Google Patents
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- Publication number
- JP2006213732A5 JP2006213732A5 JP2006134026A JP2006134026A JP2006213732A5 JP 2006213732 A5 JP2006213732 A5 JP 2006213732A5 JP 2006134026 A JP2006134026 A JP 2006134026A JP 2006134026 A JP2006134026 A JP 2006134026A JP 2006213732 A5 JP2006213732 A5 JP 2006213732A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituent
- acyl
- carbamoyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 claims 64
- 125000003118 aryl group Chemical group 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000002252 acyl group Chemical group 0.000 claims 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 16
- -1 lactam compound Chemical class 0.000 claims 16
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 15
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- 125000004423 acyloxy group Chemical group 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 125000003282 alkyl amino group Chemical group 0.000 claims 13
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 13
- 125000004414 alkyl thio group Chemical group 0.000 claims 13
- 125000003277 amino group Chemical group 0.000 claims 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 13
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 13
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000001769 aryl amino group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000003609 aryl vinyl group Chemical group 0.000 claims 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 206010059245 Angiopathy Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940126904 hypoglycaemic agent Drugs 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006134026A JP4505753B2 (ja) | 2000-12-01 | 2006-05-12 | ラクタム化合物及びその医薬用途 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000367175 | 2000-12-01 | ||
| JP2006134026A JP4505753B2 (ja) | 2000-12-01 | 2006-05-12 | ラクタム化合物及びその医薬用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546550A Division JP3826400B2 (ja) | 2000-12-01 | 2001-11-29 | ラクタム化合物及びその医薬用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006213732A JP2006213732A (ja) | 2006-08-17 |
| JP2006213732A5 true JP2006213732A5 (https=) | 2007-02-22 |
| JP4505753B2 JP4505753B2 (ja) | 2010-07-21 |
Family
ID=18837660
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546550A Expired - Lifetime JP3826400B2 (ja) | 2000-12-01 | 2001-11-29 | ラクタム化合物及びその医薬用途 |
| JP2006134026A Expired - Fee Related JP4505753B2 (ja) | 2000-12-01 | 2006-05-12 | ラクタム化合物及びその医薬用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546550A Expired - Lifetime JP3826400B2 (ja) | 2000-12-01 | 2001-11-29 | ラクタム化合物及びその医薬用途 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US7153850B2 (https=) |
| EP (1) | EP1346993B1 (https=) |
| JP (2) | JP3826400B2 (https=) |
| KR (1) | KR100826818B1 (https=) |
| CN (2) | CN100577651C (https=) |
| AT (1) | ATE446297T1 (https=) |
| AU (3) | AU1850202A (https=) |
| BG (1) | BG107857A (https=) |
| BR (1) | BR0115852A (https=) |
| CA (1) | CA2430124C (https=) |
| CZ (1) | CZ20031520A3 (https=) |
| DE (1) | DE60140270D1 (https=) |
| ES (1) | ES2331299T3 (https=) |
| HU (1) | HUP0400806A3 (https=) |
| IL (1) | IL156158A0 (https=) |
| MX (1) | MXPA03004876A (https=) |
| NO (1) | NO325401B1 (https=) |
| NZ (1) | NZ526164A (https=) |
| PL (1) | PL362835A1 (https=) |
| RU (1) | RU2287530C2 (https=) |
| SK (1) | SK6582003A3 (https=) |
| TW (1) | TWI241302B (https=) |
| UA (1) | UA76969C2 (https=) |
| WO (1) | WO2002044180A1 (https=) |
| YU (1) | YU42603A (https=) |
| ZA (1) | ZA200304100B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL362835A1 (en) * | 2000-12-01 | 2004-11-02 | Ajinomoto Co,Inc. | Lactam compounds and medicinal use thereof |
| CN1771040B (zh) * | 2003-02-07 | 2010-06-16 | 味之素株式会社 | 糖尿病治疗药 |
| CA2544310A1 (en) | 2003-10-31 | 2005-05-12 | Ajinomoto Co., Inc. | New fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof |
| JPWO2005068467A1 (ja) | 2004-01-14 | 2007-12-27 | 味の素株式会社 | 新規縮環化合物 |
| KR100858262B1 (ko) * | 2004-10-13 | 2008-09-11 | 에프. 호프만-라 로슈 아게 | Ｃｄｋ2 및 혈관신생에 대한 저해제로서 유용하고, 유방암,대장암, 폐암 및 전립선암의 치료용으로 유용한이중치환된 피라졸로벤조디아제핀 |
| NZ563131A (en) | 2005-04-28 | 2010-09-30 | Ajinomoto Kk | Tricyclic lactam compound as a hypoglycemic agent |
| EP2157092A4 (en) * | 2007-04-11 | 2011-04-13 | Ajinomoto Kk | Remedy for diabetes |
| WO2008139575A1 (ja) * | 2007-04-27 | 2008-11-20 | Ajinomoto Co., Inc. | 経口投与用製剤 |
| WO2008139574A1 (ja) * | 2007-04-27 | 2008-11-20 | Ajinomoto Co., Inc. | ラクタム化合物の結晶形およびその製造方法 |
| WO2008136392A1 (ja) * | 2007-04-27 | 2008-11-13 | Ajinomoto Co., Inc. | 経口投与用製剤 |
| CN101619041B (zh) * | 2008-07-02 | 2012-07-04 | 重庆华邦制药股份有限公司 | 一种二酮基含氮环化合物的合成方法及其中间体 |
| JP2012180282A (ja) * | 2009-07-02 | 2012-09-20 | Ajinomoto Co Inc | ラクタム化合物の製造方法およびその製造中間体 |
| JP2012180283A (ja) * | 2009-07-02 | 2012-09-20 | Ajinomoto Co Inc | ラクタム化合物の製造方法およびその製造中間体 |
| RU2017126027A (ru) * | 2014-12-22 | 2019-01-24 | ЕА Фарма Ко., Лтд. | Лекарственное средство для лечения расстройств эпителия роговицы |
| CA3011538A1 (en) | 2016-01-18 | 2017-07-27 | Arisan Therapeutics | Adamantane derivatives for the treatment of filovirus infection |
| WO2019018185A1 (en) | 2017-07-15 | 2019-01-24 | Arisan Therapeutics Inc. | ENANTIOMERICALLY PURE ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTIONS |
| JP7566338B2 (ja) * | 2019-01-23 | 2024-10-15 | ▲たん▼解生醫股分有限公司 | グルコース代謝障害の長時間作用型の予防または治療に使用するためのβ－ラクタム化合物またはその塩 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US189597A (en) * | 1877-04-17 | Improvement in portable wash-stands | ||
| US48847A (en) * | 1865-07-18 | Improvement in vessels for reception and transportation of night-soil | ||
| GB8720414D0 (en) * | 1987-08-28 | 1987-10-07 | Roussel Lab Ltd | Chemical compounds |
| US5719296A (en) * | 1995-10-30 | 1998-02-17 | Merck & Co., Inc. | Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins |
| AU8592598A (en) | 1997-07-30 | 1999-02-22 | Wyeth | Tricyclic vasopressin agonists |
| JP4204657B2 (ja) | 1997-12-05 | 2009-01-07 | 有限会社ケムフィズ | 糖尿病の予防・治療剤 |
| PL362835A1 (en) * | 2000-12-01 | 2004-11-02 | Ajinomoto Co,Inc. | Lactam compounds and medicinal use thereof |
| CN1771040B (zh) * | 2003-02-07 | 2010-06-16 | 味之素株式会社 | 糖尿病治疗药 |
-
2001
- 2001-11-29 PL PL01362835A patent/PL362835A1/xx not_active Application Discontinuation
- 2001-11-29 TW TW090129582A patent/TWI241302B/zh not_active IP Right Cessation
- 2001-11-29 RU RU2003116126/04A patent/RU2287530C2/ru not_active IP Right Cessation
- 2001-11-29 NZ NZ526164A patent/NZ526164A/en unknown
- 2001-11-29 CA CA2430124A patent/CA2430124C/en not_active Expired - Fee Related
- 2001-11-29 MX MXPA03004876A patent/MXPA03004876A/es active IP Right Grant
- 2001-11-29 HU HU0400806A patent/HUP0400806A3/hu unknown
- 2001-11-29 IL IL15615801A patent/IL156158A0/xx unknown
- 2001-11-29 YU YU42603A patent/YU42603A/sh unknown
- 2001-11-29 AT AT01998549T patent/ATE446297T1/de not_active IP Right Cessation
- 2001-11-29 DE DE60140270T patent/DE60140270D1/de not_active Expired - Lifetime
- 2001-11-29 AU AU1850202A patent/AU1850202A/xx active Pending
- 2001-11-29 WO PCT/JP2001/010435 patent/WO2002044180A1/ja not_active Ceased
- 2001-11-29 ES ES01998549T patent/ES2331299T3/es not_active Expired - Lifetime
- 2001-11-29 UA UA2003055026A patent/UA76969C2/uk unknown
- 2001-11-29 CN CN200610095903A patent/CN100577651C/zh not_active Expired - Fee Related
- 2001-11-29 CZ CZ20031520A patent/CZ20031520A3/cs unknown
- 2001-11-29 EP EP01998549A patent/EP1346993B1/en not_active Expired - Lifetime
- 2001-11-29 JP JP2002546550A patent/JP3826400B2/ja not_active Expired - Lifetime
- 2001-11-29 KR KR1020037007327A patent/KR100826818B1/ko not_active Expired - Fee Related
- 2001-11-29 AU AU2002218502A patent/AU2002218502B2/en not_active Ceased
- 2001-11-29 CN CNB018223559A patent/CN1269818C/zh not_active Expired - Fee Related
- 2001-11-29 BR BR0115852-0A patent/BR0115852A/pt not_active Application Discontinuation
- 2001-11-29 SK SK658-2003A patent/SK6582003A3/sk unknown
-
2003
- 2003-05-27 ZA ZA200304100A patent/ZA200304100B/en unknown
- 2003-05-28 NO NO20032439A patent/NO325401B1/no not_active IP Right Cessation
- 2003-05-29 BG BG107857A patent/BG107857A/bg unknown
- 2003-06-02 US US10/449,774 patent/US7153850B2/en not_active Expired - Fee Related
-
2006
- 2006-04-06 US US11/398,675 patent/US7326701B2/en not_active Expired - Fee Related
- 2006-05-12 JP JP2006134026A patent/JP4505753B2/ja not_active Expired - Fee Related
- 2006-11-24 AU AU2006241377A patent/AU2006241377B2/en not_active Ceased
-
2007
- 2007-11-30 US US11/948,288 patent/US7632830B2/en not_active Expired - Fee Related
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