JP2006056881A5 - - Google Patents

Info

Publication number

JP2006056881A5

JP2006056881A5 JP2005210382A JP2005210382A JP2006056881A5 JP 2006056881 A5 JP2006056881 A5 JP 2006056881A5 JP 2005210382 A JP2005210382 A JP 2005210382A JP 2005210382 A JP2005210382 A JP 2005210382A JP 2006056881 A5 JP2006056881 A5 JP 2006056881A5

Authority

JP

Japan

Prior art keywords

ring

optionally substituted

compound according

methylene group

agent

Prior art date

2005-07-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 10
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 6
• 125000003118 aryl group Chemical group 0.000 claims 3
• 150000001555 benzenes Chemical group 0.000 claims 3
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 239000000651 prodrug Substances 0.000 claims 3
• 229940002612 prodrug Drugs 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 2
• 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• IGRCWJPBLWGNPX-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-(4-chlorophenyl)-n,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound C=1C=C(Cl)C=CC=1N(C)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl IGRCWJPBLWGNPX-UHFFFAOYSA-N 0.000 claims 1
• 208000009304 Acute Kidney Injury Diseases 0.000 claims 1
• 206010002383 Angina Pectoris Diseases 0.000 claims 1
• 206010003210 Arteriosclerosis Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 206010009900 Colitis ulcerative Diseases 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 1
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 1
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 1
• 206010019280 Heart failures Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• 229940122199 Insulin secretagogue Drugs 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
• 208000033626 Renal failure acute Diseases 0.000 claims 1
• 208000007107 Stomach Ulcer Diseases 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
• 201000011040 acute kidney failure Diseases 0.000 claims 1
• 208000012998 acute renal failure Diseases 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 239000002830 appetite depressant Substances 0.000 claims 1
• 206010003119 arrhythmia Diseases 0.000 claims 1
• 230000006793 arrhythmia Effects 0.000 claims 1
• 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 230000024245 cell differentiation Effects 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 230000016396 cytokine production Effects 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 208000016253 exhaustion Diseases 0.000 claims 1
• 201000005917 gastric ulcer Diseases 0.000 claims 1
• 230000010030 glucose lowering effect Effects 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 230000000521 hyperimmunizing effect Effects 0.000 claims 1
• 239000003018 immunosuppressive agent Substances 0.000 claims 1
• 229940125721 immunosuppressive agent Drugs 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 230000003914 insulin secretion Effects 0.000 claims 1
• 206010025135 lupus erythematosus Diseases 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 210000000496 pancreas Anatomy 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 230000001172 regenerating effect Effects 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1

Cited By (2)