JP2006045240A5 - - Google Patents
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- Publication number
- JP2006045240A5 JP2006045240A5 JP2005253346A JP2005253346A JP2006045240A5 JP 2006045240 A5 JP2006045240 A5 JP 2006045240A5 JP 2005253346 A JP2005253346 A JP 2005253346A JP 2005253346 A JP2005253346 A JP 2005253346A JP 2006045240 A5 JP2006045240 A5 JP 2006045240A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- carbamoyl
- methylthio
- carbamoylmethoxy
- dioxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 23
- -1 carboxyl hydroxy group Chemical group 0.000 claims 18
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000006239 protecting group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 229940125922 IBAT inhibitor Drugs 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- CWHZHSAJEOKUOJ-SFHVURJKSA-N (2s)-2-ethoxy-3-[4-[2-[[2-fluoro-4-(trifluoromethyl)phenyl]methylamino]-2-oxoethoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCC(=O)NCC1=CC=C(C(F)(F)F)C=C1F CWHZHSAJEOKUOJ-SFHVURJKSA-N 0.000 claims 1
- OZIFULIQIAYMBA-SFHVURJKSA-N (2s)-2-ethoxy-3-[4-[2-oxo-2-[[4-(trifluoromethoxy)phenyl]methylamino]ethoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCC(=O)NCC1=CC=C(OC(F)(F)F)C=C1 OZIFULIQIAYMBA-SFHVURJKSA-N 0.000 claims 1
- QVGLWHSPHJQMLW-SFHVURJKSA-N (2s)-3-[4-[2-[(4-chlorophenyl)methylamino]-2-oxoethoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCC(=O)NCC1=CC=C(Cl)C=C1 QVGLWHSPHJQMLW-SFHVURJKSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 1
- 239000003529 anticholesteremic agent Substances 0.000 claims 1
- 229940127226 anticholesterol agent Drugs 0.000 claims 1
- 229960005370 atorvastatin Drugs 0.000 claims 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 1
- 239000012351 deprotecting agent Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 229960000672 rosuvastatin Drugs 0.000 claims 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- BXVYJQULAWJPSR-UHFFFAOYSA-N thiadiazepine Chemical compound S1C=CC=CN=N1 BXVYJQULAWJPSR-UHFFFAOYSA-N 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 0 CCc1cc(*=*)c(*NC(COc2ccc(CC(C(O*)=O)OCC)cc2)=*)cc1 Chemical compound CCc1cc(*=*)c(*NC(COc2ccc(CC(C(O*)=O)OCC)cc2)=*)cc1 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0229931.1A GB0229931D0 (en) | 2002-12-21 | 2002-12-21 | Therapeutic agents |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004561668A Division JP3786945B2 (ja) | 2002-12-21 | 2003-12-19 | 治療薬剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006045240A JP2006045240A (ja) | 2006-02-16 |
| JP2006045240A5 true JP2006045240A5 (https=) | 2006-08-24 |
Family
ID=9950253
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004561668A Expired - Fee Related JP3786945B2 (ja) | 2002-12-21 | 2003-12-19 | 治療薬剤 |
| JP2005253346A Pending JP2006045240A (ja) | 2002-12-21 | 2005-09-01 | 治療薬剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004561668A Expired - Fee Related JP3786945B2 (ja) | 2002-12-21 | 2003-12-19 | 治療薬剤 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7462644B2 (https=) |
| EP (1) | EP1572626A1 (https=) |
| JP (2) | JP3786945B2 (https=) |
| KR (1) | KR20050089065A (https=) |
| CN (1) | CN1308291C (https=) |
| AR (1) | AR042632A1 (https=) |
| AU (1) | AU2003290309B2 (https=) |
| BR (1) | BR0317458A (https=) |
| CA (1) | CA2508851A1 (https=) |
| CL (1) | CL2003002683A1 (https=) |
| CO (1) | CO5580820A2 (https=) |
| GB (1) | GB0229931D0 (https=) |
| IS (1) | IS7946A (https=) |
| MX (1) | MXPA05006812A (https=) |
| NO (1) | NO20052914L (https=) |
| PL (1) | PL377144A1 (https=) |
| RU (1) | RU2005117792A (https=) |
| TW (1) | TW200508180A (https=) |
| UA (1) | UA80729C2 (https=) |
| WO (1) | WO2004056748A1 (https=) |
| ZA (1) | ZA200504730B (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| SE0104334D0 (sv) * | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| GB0314079D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| HRP20040805A2 (en) | 2002-03-13 | 2005-04-30 | Janssen Pharmaceutica N.V. | Carbonylamino derivatives as novel inhibitors histone deacetylase |
| EA007099B1 (ru) | 2002-03-13 | 2006-06-30 | Янссен Фармацевтика Н. В. | Сульфонилпроизводные в качестве ингибиторов гистон-деацетилазы |
| CA2475766C (en) | 2002-03-13 | 2012-06-05 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
| MXPA04008797A (es) | 2002-03-13 | 2004-11-26 | Janssen Pharmaceutica Nv | Inhibidores de histona desacetilasa. |
| BR0311932A (pt) | 2002-06-20 | 2005-03-22 | Astrazeneca Ab | Composto, formulação farmacêutica, método para tratar ou prevenir resistência à insulina, uso de um composto, processo para preparar um composto, e, tratamento combinado |
| MXPA05007485A (es) | 2003-01-14 | 2006-01-30 | Arena Pharm Inc | Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia. |
| RS20060018A (sr) | 2003-07-14 | 2007-12-31 | Arena Pharmaceuticals Inc., | Derivati spojenih arila i heteroarila kao modulatori metabolizma u profilaksi i lečenju sa njima povezanih stanja |
| KR101261305B1 (ko) | 2004-07-28 | 2013-05-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로의 치환된 인돌릴알킬 아미노 유도체 |
| EP1811991B1 (en) * | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis |
| MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| ES2553178T3 (es) | 2005-05-18 | 2015-12-04 | Janssen Pharmaceutica N.V. | Derivados sustituidos de aminopropenil piperidina o morfolina como nuevos inhibidores de histona deacetilasa |
| EP1893583B1 (en) | 2005-05-31 | 2012-04-04 | Pfizer Inc. | Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists |
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| EP1981875B1 (en) | 2006-01-19 | 2014-04-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| CA2631876C (en) | 2006-01-19 | 2014-05-27 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as inhibitors of histone deacetylase |
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| WO2007082874A1 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
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| ES2687027T3 (es) | 2010-11-04 | 2018-10-23 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepáticas |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| CN106659726A (zh) | 2014-06-25 | 2017-05-10 | Ea制药株式会社 | 固体制剂及其着色防止或着色减少方法 |
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| PL3242666T3 (pl) | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
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| ES2874669T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| CN108601739B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 考来烯胺丸剂及其制备方法 |
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| MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
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| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| PL3810581T3 (pl) | 2018-06-20 | 2025-04-28 | Albireo Ab | Modyfikacje kryształu odewiksibatu |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
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| TWI835997B (zh) | 2019-02-06 | 2024-03-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其用作膽酸調節劑之用途 |
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| JP2001261612A (ja) | 2000-03-22 | 2001-09-26 | Mitsui Chemicals Inc | カテコールプロピオン酸誘導体およびそれを有効成分として含有する核内レセプター作動薬 |
| WO2002044130A1 (fr) | 2000-11-29 | 2002-06-06 | Kyorin Pharmaceutical Co., Ltd. | Dérivés d'acide carboxylique substitués |
| AU2002222552A1 (en) | 2000-11-29 | 2002-06-11 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
| BR0207285A (pt) | 2001-02-15 | 2004-02-10 | Pfizer Producs Inc | Agonistas de ppar |
| WO2002083616A1 (en) | 2001-04-10 | 2002-10-24 | Sankyo Company, Limited | α-SUBSTITUTED φ-ARYLFATTY ACID DERIVATIVE |
| GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| GB0314079D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| SE0104334D0 (sv) * | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| JP2005529975A (ja) * | 2002-06-19 | 2005-10-06 | イーライ・リリー・アンド・カンパニー | アミドリンカーペルオキシソーム増殖因子活性化受容体調節因子 |
| GB0314134D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314136D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314129D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
-
2002
- 2002-12-21 GB GBGB0229931.1A patent/GB0229931D0/en not_active Ceased
-
2003
- 2003-12-10 TW TW092134839A patent/TW200508180A/zh unknown
- 2003-12-18 CL CL200302683A patent/CL2003002683A1/es unknown
- 2003-12-19 BR BR0317458-1A patent/BR0317458A/pt not_active IP Right Cessation
- 2003-12-19 CN CNB2003801098952A patent/CN1308291C/zh not_active Expired - Fee Related
- 2003-12-19 RU RU2005117792/04A patent/RU2005117792A/ru not_active Application Discontinuation
- 2003-12-19 JP JP2004561668A patent/JP3786945B2/ja not_active Expired - Fee Related
- 2003-12-19 CA CA002508851A patent/CA2508851A1/en not_active Abandoned
- 2003-12-19 KR KR1020057011714A patent/KR20050089065A/ko not_active Withdrawn
- 2003-12-19 MX MXPA05006812A patent/MXPA05006812A/es unknown
- 2003-12-19 AR ARP030104752A patent/AR042632A1/es unknown
- 2003-12-19 WO PCT/GB2003/005602 patent/WO2004056748A1/en not_active Ceased
- 2003-12-19 US US10/499,893 patent/US7462644B2/en not_active Expired - Fee Related
- 2003-12-19 EP EP03782668A patent/EP1572626A1/en not_active Withdrawn
- 2003-12-19 PL PL377144A patent/PL377144A1/pl not_active Application Discontinuation
- 2003-12-19 UA UAA200505596A patent/UA80729C2/uk unknown
- 2003-12-19 AU AU2003290309A patent/AU2003290309B2/en not_active Ceased
-
2005
- 2005-06-15 NO NO20052914A patent/NO20052914L/no not_active Application Discontinuation
- 2005-06-22 ZA ZA200504730A patent/ZA200504730B/en unknown
- 2005-07-19 CO CO05071340A patent/CO5580820A2/es not_active Application Discontinuation
- 2005-07-19 IS IS7946A patent/IS7946A/is unknown
- 2005-09-01 JP JP2005253346A patent/JP2006045240A/ja active Pending
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