JP2005539030A5 - - Google Patents
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- Publication number
- JP2005539030A5 JP2005539030A5 JP2004529001A JP2004529001A JP2005539030A5 JP 2005539030 A5 JP2005539030 A5 JP 2005539030A5 JP 2004529001 A JP2004529001 A JP 2004529001A JP 2004529001 A JP2004529001 A JP 2004529001A JP 2005539030 A5 JP2005539030 A5 JP 2005539030A5
- Authority
- JP
- Japan
- Prior art keywords
- diazabicyclo
- methanone
- oxygen
- sulfur
- propenone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 benzo [b] thiophen-3-yl Chemical group 0.000 claims 21
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 13
- 239000001301 oxygen Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 229910052717 sulfur Inorganic materials 0.000 claims 12
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 11
- 239000011593 sulfur Substances 0.000 claims 11
- 125000005842 heteroatom Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 3
- FTTATHOUSOIFOQ-UHFFFAOYSA-N 1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2-a]pyrazine Chemical compound C1NCCN2CCCC21 FTTATHOUSOIFOQ-UHFFFAOYSA-N 0.000 claims 3
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 230000006735 deficit Effects 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- OGZLAVDBQCWTRH-UHFFFAOYSA-N (3-bromophenyl)-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound BrC1=CC=CC(C(=O)N2C3CCN(CC3)CC2)=C1 OGZLAVDBQCWTRH-UHFFFAOYSA-N 0.000 claims 1
- NPSLXGZIVXPEGH-UHFFFAOYSA-N (3-chlorophenyl)-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound ClC1=CC=CC(C(=O)N2C3CCN(CC3)CC2)=C1 NPSLXGZIVXPEGH-UHFFFAOYSA-N 0.000 claims 1
- CSIFTQTVMGTFIA-UHFFFAOYSA-N (4-bromophenyl)-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound C1=CC(Br)=CC=C1C(=O)N1C(CC2)CCN2CC1 CSIFTQTVMGTFIA-UHFFFAOYSA-N 0.000 claims 1
- OJBBHPROSJCEJI-UHFFFAOYSA-N (4-chlorophenyl)-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1C(CC2)CCN2CC1 OJBBHPROSJCEJI-UHFFFAOYSA-N 0.000 claims 1
- GNPQLYUSJOCBMA-UHFFFAOYSA-N (5-bromofuran-2-yl)-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound O1C(Br)=CC=C1C(=O)N1C(CC2)CCN2CC1 GNPQLYUSJOCBMA-UHFFFAOYSA-N 0.000 claims 1
- MAHVNHLHABGUTJ-UHFFFAOYSA-N (5-chlorofuran-2-yl)-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound O1C(Cl)=CC=C1C(=O)N1C(CC2)CCN2CC1 MAHVNHLHABGUTJ-UHFFFAOYSA-N 0.000 claims 1
- QQZXQGIHFZZQFA-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl(1h-indol-5-yl)methanone Chemical compound C=1C=C2NC=CC2=CC=1C(=O)N1CCN2CCC1CC2 QQZXQGIHFZZQFA-UHFFFAOYSA-N 0.000 claims 1
- QAQZGYOOSFWULK-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl(furan-2-yl)methanone Chemical compound C1CN(CC2)CCC2N1C(=O)C1=CC=CO1 QAQZGYOOSFWULK-UHFFFAOYSA-N 0.000 claims 1
- UCLKOOMKBIIIOY-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl(naphthalen-2-yl)methanone Chemical compound C=1C=C2C=CC=CC2=CC=1C(=O)N1CCN2CCC1CC2 UCLKOOMKBIIIOY-UHFFFAOYSA-N 0.000 claims 1
- KSQYHMYVSVAPGG-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl(phenyl)methanone Chemical compound C1CN(CC2)CCC2N1C(=O)C1=CC=CC=C1 KSQYHMYVSVAPGG-UHFFFAOYSA-N 0.000 claims 1
- MKNCIBZGNWCSND-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(1-methylindol-2-yl)methanone Chemical compound C=1C2=CC=CC=C2N(C)C=1C(=O)N1CCN2CCC1CC2 MKNCIBZGNWCSND-UHFFFAOYSA-N 0.000 claims 1
- VTNUKUQMFOWCAB-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(3,4-dichlorophenyl)methanone Chemical compound C1=C(Cl)C(Cl)=CC=C1C(=O)N1C(CC2)CCN2CC1 VTNUKUQMFOWCAB-UHFFFAOYSA-N 0.000 claims 1
- QQJPCHYWBWDSTE-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(3-fluorophenyl)methanone Chemical compound FC1=CC=CC(C(=O)N2C3CCN(CC3)CC2)=C1 QQJPCHYWBWDSTE-UHFFFAOYSA-N 0.000 claims 1
- UVZLCLJQMZJFJL-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(3-iodophenyl)methanone Chemical compound IC1=CC=CC(C(=O)N2C3CCN(CC3)CC2)=C1 UVZLCLJQMZJFJL-UHFFFAOYSA-N 0.000 claims 1
- WYNAEWYQFWMJLP-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(4-fluorophenyl)methanone Chemical compound C1=CC(F)=CC=C1C(=O)N1C(CC2)CCN2CC1 WYNAEWYQFWMJLP-UHFFFAOYSA-N 0.000 claims 1
- HAXPXNGBJPFDGV-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(4-iodophenyl)methanone Chemical compound C1=CC(I)=CC=C1C(=O)N1C(CC2)CCN2CC1 HAXPXNGBJPFDGV-UHFFFAOYSA-N 0.000 claims 1
- YYUJHPFFBNOQAE-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(4-methoxyphenyl)methanone Chemical compound C1=CC(OC)=CC=C1C(=O)N1C(CC2)CCN2CC1 YYUJHPFFBNOQAE-UHFFFAOYSA-N 0.000 claims 1
- RWTDNRYQFGSPDO-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(5-iodofuran-2-yl)methanone Chemical compound O1C(I)=CC=C1C(=O)N1C(CC2)CCN2CC1 RWTDNRYQFGSPDO-UHFFFAOYSA-N 0.000 claims 1
- NFDGJXVLTLRAIN-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-[4-(trifluoromethoxy)phenyl]methanone Chemical compound C1=CC(OC(F)(F)F)=CC=C1C(=O)N1C(CC2)CCN2CC1 NFDGJXVLTLRAIN-UHFFFAOYSA-N 0.000 claims 1
- QROHVOFVAVOLIX-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-[4-(trifluoromethyl)phenyl]methanone Chemical compound C1=CC(C(F)(F)F)=CC=C1C(=O)N1C(CC2)CCN2CC1 QROHVOFVAVOLIX-UHFFFAOYSA-N 0.000 claims 1
- DPGGKYZMVCMQHO-UHFFFAOYSA-N 1-benzofuran-2-yl(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound C=1C2=CC=CC=C2OC=1C(=O)N1CCN2CCC1CC2 DPGGKYZMVCMQHO-UHFFFAOYSA-N 0.000 claims 1
- FCEUZOVGAYQLRM-UHFFFAOYSA-N 1-benzothiophen-2-yl(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound C=1C2=CC=CC=C2SC=1C(=O)N1CCN2CCC1CC2 FCEUZOVGAYQLRM-UHFFFAOYSA-N 0.000 claims 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000003935 attention Effects 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 125000004244 benzofuran-2-yl group Chemical group [H]C1=C(*)OC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
- 125000004532 benzofuran-3-yl group Chemical group O1C=C(C2=C1C=CC=C2)* 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000001713 cholinergic effect Effects 0.000 claims 1
- 230000007278 cognition impairment Effects 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000005586 smoking cessation Effects 0.000 claims 1
- 210000000225 synapse Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0202465A SE0202465D0 (sv) | 2002-08-14 | 2002-08-14 | New compounds |
| PCT/SE2003/001276 WO2004016616A1 (en) | 2002-08-14 | 2003-08-13 | Aryl-substituted diazabicycloalkanes as nicotinic acetylcholine agonists. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005539030A JP2005539030A (ja) | 2005-12-22 |
| JP2005539030A5 true JP2005539030A5 (https=) | 2006-07-20 |
Family
ID=20288753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004529001A Pending JP2005539030A (ja) | 2002-08-14 | 2003-08-13 | ニコチン性アセチルコリン作用剤としてのアリール置換ジアザビシクロアルカン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20060052368A1 (https=) |
| EP (1) | EP1539764B1 (https=) |
| JP (1) | JP2005539030A (https=) |
| KR (1) | KR20060005334A (https=) |
| CN (1) | CN100436453C (https=) |
| AT (1) | ATE430152T1 (https=) |
| AU (1) | AU2003248590B2 (https=) |
| BR (1) | BR0313233A (https=) |
| CA (1) | CA2493246A1 (https=) |
| DE (1) | DE60327441D1 (https=) |
| IL (1) | IL166425A0 (https=) |
| MX (1) | MXPA05001584A (https=) |
| NO (1) | NO20051260L (https=) |
| SE (1) | SE0202465D0 (https=) |
| WO (1) | WO2004016616A1 (https=) |
| ZA (1) | ZA200501227B (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| MXPA05003317A (es) | 2002-09-25 | 2005-07-05 | Memory Pharm Corp | Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos. |
| US7456171B2 (en) * | 2002-10-08 | 2008-11-25 | Sanofi-Aventis | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| MXPA05006861A (es) * | 2003-02-27 | 2005-12-12 | Neurosearch As | Derivados arildiazabiciclicos novedosos. |
| CN100445285C (zh) * | 2003-12-22 | 2008-12-24 | 阿斯利康(瑞典)有限公司 | 烟碱性乙酰胆碱受体配体 |
| DE602004010299T2 (de) | 2003-12-22 | 2008-09-18 | Memory Pharmaceuticals Corp. | Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen |
| TW200529860A (en) * | 2003-12-22 | 2005-09-16 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| FR2865208B1 (fr) * | 2004-01-16 | 2009-01-16 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo[3.2.1]octanecarboxmique, leur preparation et leur application en therapeutique |
| EP1713810B1 (en) * | 2004-02-04 | 2010-12-29 | NeuroSearch A/S | Diazabicyclic aryl derivatives as nicotinic acetylcholine receptor ligands |
| US20090253908A1 (en) * | 2004-03-11 | 2009-10-08 | Glaxo Group Limited | Novel m3 muscarinic acetylchoine receptor antagonists |
| NZ550534A (en) | 2004-03-25 | 2009-07-31 | Memory Pharm Corp | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| WO2006001894A1 (en) | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| JP2007538011A (ja) * | 2004-05-07 | 2007-12-27 | メモリー・ファーマシューティカルズ・コーポレイション | １ｈ−インダゾール、ベンゾチアゾール、１，２−ベンゾイソキサゾール、１，２−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用 |
| CA2588961A1 (en) * | 2004-11-30 | 2006-06-08 | Neurosearch A/S | Novel diazabicyclic aryl derivatives as cholinergy ligands |
| RU2418797C2 (ru) | 2004-12-22 | 2011-05-20 | Мемори Фармасьютиклз Корпорейшн | Лиганды никотинового рецептора альфа-7, их получение и применение |
| WO2007056582A1 (en) * | 2005-11-09 | 2007-05-18 | Memory Pharmaceuticals Corporation | 1 h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof |
| JP2009526777A (ja) * | 2006-02-14 | 2009-07-23 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体作用薬としての３，９−ジアザビシクロ（３．３．１）ノナ−３−イル−アリールメタノン誘導体 |
| US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
| TWI405763B (zh) | 2006-11-02 | 2013-08-21 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| JP2011513421A (ja) * | 2008-03-05 | 2011-04-28 | ターガセプト，インコーポレイテッド | サブタイプ選択的なジアザビシクロアルカンのアミド |
| MX2010014203A (es) | 2008-06-20 | 2011-02-22 | Astrazeneca Ab | Derivados de dibenzotiazepina y sus usos - 424. |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| AR081402A1 (es) | 2010-05-17 | 2012-08-29 | Envivo Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato |
| PL2657237T3 (pl) * | 2010-12-22 | 2015-11-30 | Tosoh Corp | Cykliczny związek aminowy i proces produkcji żywicy poliuretanowej z jego zastosowaniem |
| GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
| GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| US10214476B2 (en) | 2011-12-30 | 2019-02-26 | Ecole Nationale Superieure De Chimie De Clermont Ferrand | Pain relief compounds |
| CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
| GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
| US8609162B2 (en) | 2012-10-04 | 2013-12-17 | Invivo Beverages Llc | Integrated neuromodulation system for mood enhancement of a living human subject |
| WO2014122474A1 (en) | 2013-02-07 | 2014-08-14 | Takeda Pharmaceutical Company Limited | Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists |
| HK1219722A1 (zh) | 2013-06-21 | 2017-04-13 | Takeda Pharmaceutical Company Limited | 1-磺酰基派啶衍生物作为前动力蛋白受体的调节剂 |
| GB201314286D0 (en) | 2013-08-08 | 2013-09-25 | Takeda Pharmaceutical | Therapeutic Compounds |
| GB201318222D0 (en) | 2013-10-15 | 2013-11-27 | Takeda Pharmaceutical | Novel compounds |
| GB201320905D0 (en) | 2013-11-27 | 2014-01-08 | Takeda Pharmaceutical | Therapeutic compounds |
| TW201613864A (en) | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
| GB201616839D0 (en) | 2016-10-04 | 2016-11-16 | Takeda Pharmaceutical Company Limited | Therapeutic compounds |
| GB201619514D0 (en) | 2016-11-18 | 2017-01-04 | Takeda Pharmaceuticals Co | Novel compounds |
| WO2019005874A1 (en) | 2017-06-26 | 2019-01-03 | The Trustees Of Columbia University In The City Of New York | CHOLINERGIC AGONISM FOR THE TREATMENT OF PANCREATIC CANCER |
| JP2021138648A (ja) | 2020-03-04 | 2021-09-16 | 武田薬品工業株式会社 | 経口固形製剤 |
| GB202414197D0 (en) | 2024-09-27 | 2024-11-13 | Addex Pharmaceuticals Sa | Novel compounds |
| GB202414193D0 (en) | 2024-09-27 | 2024-11-13 | Addex Pharmaceuticals Sa | Novel compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3281423A (en) * | 1964-02-03 | 1966-10-25 | Merck & Co Inc | 1, 3-ethanopiperazines and process |
| US4895943A (en) * | 1988-10-25 | 1990-01-23 | Pfizer Inc. | Preparation of 1,4-diazabicyclo(3.2.2)nonane |
| US5679673A (en) * | 1992-09-24 | 1997-10-21 | The United States Of America, Represented By The Department Of Health And Human Services | Aralkyl bridged diazabicycloalkane derivatives for CNS disorders |
| FR2791678B1 (fr) * | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
| FR2809732B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE |
| FR2809731B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique |
| FR2809730B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique |
| US20020086871A1 (en) * | 2000-12-29 | 2002-07-04 | O'neill Brian Thomas | Pharmaceutical composition for the treatment of CNS and other disorders |
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| MXPA05006861A (es) * | 2003-02-27 | 2005-12-12 | Neurosearch As | Derivados arildiazabiciclicos novedosos. |
| TW200529860A (en) * | 2003-12-22 | 2005-09-16 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| CN100445285C (zh) * | 2003-12-22 | 2008-12-24 | 阿斯利康(瑞典)有限公司 | 烟碱性乙酰胆碱受体配体 |
-
2002
- 2002-08-14 SE SE0202465A patent/SE0202465D0/xx unknown
-
2003
- 2003-08-13 AT AT03788213T patent/ATE430152T1/de not_active IP Right Cessation
- 2003-08-13 CN CNB038192578A patent/CN100436453C/zh not_active Expired - Fee Related
- 2003-08-13 WO PCT/SE2003/001276 patent/WO2004016616A1/en not_active Ceased
- 2003-08-13 KR KR1020057002266A patent/KR20060005334A/ko not_active Ceased
- 2003-08-13 JP JP2004529001A patent/JP2005539030A/ja active Pending
- 2003-08-13 MX MXPA05001584A patent/MXPA05001584A/es unknown
- 2003-08-13 DE DE60327441T patent/DE60327441D1/de not_active Expired - Fee Related
- 2003-08-13 AU AU2003248590A patent/AU2003248590B2/en not_active Expired - Fee Related
- 2003-08-13 EP EP03788213A patent/EP1539764B1/en not_active Expired - Lifetime
- 2003-08-13 BR BR0313233-1A patent/BR0313233A/pt not_active IP Right Cessation
- 2003-08-13 CA CA002493246A patent/CA2493246A1/en not_active Abandoned
- 2003-08-13 US US10/524,482 patent/US20060052368A1/en not_active Abandoned
-
2005
- 2005-01-20 IL IL16642505A patent/IL166425A0/xx unknown
- 2005-02-10 ZA ZA200501227A patent/ZA200501227B/en unknown
- 2005-03-11 NO NO20051260A patent/NO20051260L/no not_active Application Discontinuation
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