JP2005535342A5 - - Google Patents

Download PDF

Info

Publication number
JP2005535342A5
JP2005535342A5 JP2004529297A JP2004529297A JP2005535342A5 JP 2005535342 A5 JP2005535342 A5 JP 2005535342A5 JP 2004529297 A JP2004529297 A JP 2004529297A JP 2004529297 A JP2004529297 A JP 2004529297A JP 2005535342 A5 JP2005535342 A5 JP 2005535342A5
Authority
JP
Japan
Prior art keywords
nad
increase
flow
stress
pnc1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004529297A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005535342A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/025016 external-priority patent/WO2004016726A2/en
Publication of JP2005535342A publication Critical patent/JP2005535342A/ja
Publication of JP2005535342A5 publication Critical patent/JP2005535342A5/ja
Pending legal-status Critical Current

Links

JP2004529297A 2002-08-09 2003-08-08 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 Pending JP2005535342A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40225402P 2002-08-09 2002-08-09
US42861402P 2002-11-22 2002-11-22
PCT/US2003/025016 WO2004016726A2 (en) 2002-08-09 2003-08-08 Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010162637A Division JP2011015682A (ja) 2002-08-09 2010-07-20 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物

Publications (2)

Publication Number Publication Date
JP2005535342A JP2005535342A (ja) 2005-11-24
JP2005535342A5 true JP2005535342A5 (enExample) 2010-03-04

Family

ID=31720582

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2004529297A Pending JP2005535342A (ja) 2002-08-09 2003-08-08 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物
JP2010162637A Pending JP2011015682A (ja) 2002-08-09 2010-07-20 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物
JP2015117465A Expired - Fee Related JP6602561B2 (ja) 2002-08-09 2015-06-10 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2010162637A Pending JP2011015682A (ja) 2002-08-09 2010-07-20 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物
JP2015117465A Expired - Fee Related JP6602561B2 (ja) 2002-08-09 2015-06-10 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物

Country Status (5)

Country Link
EP (2) EP2431480A3 (enExample)
JP (3) JP2005535342A (enExample)
AU (2) AU2003264037B2 (enExample)
CA (2) CA2421269A1 (enExample)
WO (1) WO2004016726A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US20050096256A1 (en) 2003-07-01 2005-05-05 President And Fellows Of Harvard College Compositions for manipulating the lifespan and stress response of cells and organisms
US20060025337A1 (en) 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
AU2004324323A1 (en) * 2003-10-31 2006-06-15 Robarts Research Institute Methods and formulations for protecting cells, and for treating diseases and conditions by optimising the intracellular concentration of NAD
CN101247793B (zh) 2003-12-29 2013-04-10 哈佛大学校长及研究员协会 治疗或预防肥胖和胰岛素抗性病症的组合物
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
CN1964627B (zh) * 2004-06-04 2011-10-19 华盛顿大学 治疗神经病变的方法和组合物
EP1794306B1 (en) 2004-09-24 2009-12-16 Bayer BioScience N.V. Stress resistant plants
US20090012130A1 (en) * 2005-01-25 2009-01-08 The Johns Hopkins University Strategies for Designing Drugs that Target the Sir2 Family of Enzymes
EP1877054A2 (en) 2005-03-30 2008-01-16 Sirtris Pharmaceuticals, Inc. Nicotinamide riboside and analogues thereof
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
PL1893759T3 (pl) * 2005-06-15 2010-01-29 Bayer Bioscience Nv Sposób zwiększania odporności roślin na warunki niedotlenienia
CA2646476A1 (en) * 2006-03-21 2007-09-27 Bayer Bioscience N.V. Stress resistant plants
RU2415573C2 (ru) 2006-12-11 2011-04-10 Джапэн Сайенс Энд Текнолоджи Эйдженси Регулятор роста растений и его применение
WO2009063806A1 (ja) * 2007-11-13 2009-05-22 Japan Science And Technology Agency 糖度が向上した植物体を作出するための組成物及びその利用
JP5570731B2 (ja) * 2008-02-28 2014-08-13 旭化成ファーマ株式会社 ピロリン酸の測定方法
JP5684578B2 (ja) 2008-03-03 2015-03-11 エヌエーディー ライフ プロプライエタリー リミテッド リスベラトロールの医薬製剤、および細胞障害を治療するためのその使用方法
JP2011115098A (ja) * 2009-12-04 2011-06-16 Nippon Menaade Keshohin Kk 加齢による皮膚明度の低下を予測する皮膚評価方法
CN103987249B (zh) 2011-12-12 2015-10-21 冈山县 用于提高植物的氨基酸含量的化合物及其应用
WO2014059034A2 (en) 2012-10-09 2014-04-17 President And Fellows Of Harvard College Nad biosynthesis and precursors for the treatment and prevention of cancer and proliferation
US20160287621A1 (en) * 2013-11-06 2016-10-06 President And Fellows Of Harvard College Biological production of nad precursors and analogs
CN106536535A (zh) 2014-06-02 2017-03-22 葛兰素史密斯克莱知识产权（第2 号）有限公司 结晶的β‑D‑烟酰胺核苷的制备和用途
WO2015186114A1 (en) 2014-06-06 2015-12-10 Glaxosmithkline Intellectual Property (No.2) Limited Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
JP6623015B2 (ja) * 2014-09-29 2019-12-18 国立研究開発法人理化学研究所 植物の耐塩性向上剤
WO2020097116A1 (en) * 2018-11-05 2020-05-14 Rejuvenation Therapeutics Compositions and methods for culturing yeast cells
JP7702934B2 (ja) * 2019-08-14 2025-07-04 メトロ インターナショナル バイオテック，エルエルシー ニコチンアミドアデニンジヌクレオチドの差次的モジュレーションのための化合物及び組成物
CN111394268B (zh) * 2019-12-20 2021-06-18 合肥康诺生物制药有限公司 基因工程菌及其构建方法、应用，生产nad+的方法
CN112451673A (zh) * 2020-12-10 2021-03-09 汤臣倍健股份有限公司 线粒体功能干预材料在制备改善线粒体功能的保健品或药品中的应用及其筛选方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6131086A (en) 1985-07-05 1987-01-30 Whitehead Institute For Biomedical Research Epithelial cells expressing foreign genetic material
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
DE3852823T2 (de) 1987-09-11 1995-05-24 Hughes Howard Med Inst Transduktionsveränderte fibroblasten und ihre anwendung.
JP2914692B2 (ja) 1987-12-11 1999-07-05 ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ 内皮細胞の遺伝子修飾
EP0400047B1 (en) 1988-02-05 1997-04-23 Whitehead Institute For Biomedical Research Modified hepatocytes and uses therefor
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
EP0556345B2 (en) 1990-10-31 2005-10-12 Cell Genesys, Inc. Retroviral vectors useful for gene therapy
JPH07507689A (ja) 1992-06-08 1995-08-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 特定組織のターゲティング方法及び組成物
AU689755B2 (en) 1992-09-22 1998-04-09 Biofocus Discovery Limited Recombinant viruses displaying a nonviral polypeptide on their external surface
EP0746625B1 (en) 1992-11-09 2004-03-31 THE UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Targetable vector particles
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
CN1115414C (zh) 1993-07-13 2003-07-23 罗纳-布朗克罗莱尔股份有限公司 用于基因治疗的病毒载体
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5698443A (en) 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
CA2192442C (en) 1994-06-10 2007-09-25 Imre Kovesdi Complementary adenoviral vector systems and cell lines
US5856152A (en) 1994-10-28 1999-01-05 The Trustees Of The University Of Pennsylvania Hybrid adenovirus-AAV vector and methods of use therefor
DK0787200T3 (da) 1994-10-28 2005-08-15 Univ Pennsylvania Forbedret adenovirus og fremgangsmåder til anvendelse heraf
US5872005A (en) 1994-11-03 1999-02-16 Cell Genesys Inc. Packaging cell lines for adeno-associated viral vectors
CA2206683A1 (en) 1994-12-12 1996-06-20 Genetic Therapy, Inc. Improved adenoviral vectors and producer cells
DK0811073T3 (da) 1995-02-24 2007-05-21 Univ Pennsylvania Avendelse af immunmodulatorer til fremstilling af medikamenter til inhibering af immunresponser mod co-administrerede rekombinanter
US5688676A (en) 1995-06-07 1997-11-18 Research Foundation Of State University Of New York In vitro packaging of adeno-associated virus DNA
AU722196B2 (en) 1995-08-30 2000-07-27 Genzyme Corporation Chromatographic purification of adenovirus and AAV
GB9816781D0 (en) 1998-07-31 1998-09-30 Univ London Herpes virus vectors for dendritic cells
KR20030040518A (ko) * 2000-10-03 2003-05-22 다카라 바이오 가부시키가이샤 생리활성 물질의 스크리닝 방법
US7977049B2 (en) * 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
EP1794306B1 (en) * 2004-09-24 2009-12-16 Bayer BioScience N.V. Stress resistant plants
US9515947B1 (en) 2013-03-15 2016-12-06 EMC IP Holding Company LLC Method and system for providing a virtual network-aware storage array
KR20160071054A (ko) 2014-12-11 2016-06-21 에스케이하이닉스 주식회사 반도체 메모리 장치 및 그의 동작 방법
US9609948B2 (en) 2015-04-28 2017-04-04 Qianglong Furniture Co., Ltd. Rotating armrest apparatus

Similar Documents

Publication Publication Date Title
WO2007014127A3 (en) Fuel cell system with partial recycling of anode exhaust
EP0999605A3 (en) Fuel cell stack
CA2428959A1 (en) Fuel cell stack structure
AU2003263796A1 (en) Pem fuel cell stack without gas diffusion media
CL2008001865A1 (es) Método para identificar una muestra de germoplasma vegetal con un genotipo que modula el rendimiento de una caracteristica, y célula vegetal que contiene al menos una región genómatica identificada para modular el rendiemiento de transgenes.
Monard et al. Relationship between bacterial diversity and function under biotic control: the soil pesticide degraders as a case study
AU2003304194A1 (en) Fuel cell electrode comprising carbon nanotubes
JP2002535008A5 (enExample)
JP2007506790A5 (enExample)
PE20020172A1 (es) Metodo para producir una sustancia que utiliza un microrganismo
ATE403238T1 (de) Brennstoffzellen-gasseparator
WO2005060029A3 (en) Fuel cell and fuel cell stack
JP2009521795A5 (enExample)
JP2005226007A5 (enExample)
WO2005103566A3 (en) Online bakeout of regenerative oxidizers
AU2003219561A8 (en) Fuel cell electrode employing porous graphite film, membrane-electrode assembly and fuel cell
TW200721579A (en) Electrode catalyst with improved longevity properties and fuel cell using the same
EP1253655A4 (en) FUEL CELL
Maarof et al. Enhancing PV/T efficiency using PCM-integrated single-finned tube cooling system
NO20040656L (no) Modulaert innfagninskammer for flyktige organiske forbindelser (VOC) for en regenerativ oksidator med to kamre.
PE20010017A1 (es) Metodo para producir xilitol
JP2005529469A5 (enExample)
林讚標 et al. Low genetic diversity of Cycas taitungensis (Cycadaceae), an endemic species in Taiwan, revealed by allozyme analysis
JP2005149977A (ja) Ｎａｓ電池電力貯蔵システム
JP2005054170A5 (enExample)