JP2005535342A5 - - Google Patents

Download PDF

Info

Publication number
JP2005535342A5
JP2005535342A5 JP2004529297A JP2004529297A JP2005535342A5 JP 2005535342 A5 JP2005535342 A5 JP 2005535342A5 JP 2004529297 A JP2004529297 A JP 2004529297A JP 2004529297 A JP2004529297 A JP 2004529297A JP 2005535342 A5 JP2005535342 A5 JP 2005535342A5
Authority
JP
Japan
Prior art keywords
nad
increase
flow
stress
pnc1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004529297A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005535342A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/025016 external-priority patent/WO2004016726A2/en
Publication of JP2005535342A publication Critical patent/JP2005535342A/ja
Publication of JP2005535342A5 publication Critical patent/JP2005535342A5/ja
Pending legal-status Critical Current

Links

JP2004529297A 2002-08-09 2003-08-08 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 Pending JP2005535342A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40225402P 2002-08-09 2002-08-09
US42861402P 2002-11-22 2002-11-22
PCT/US2003/025016 WO2004016726A2 (en) 2002-08-09 2003-08-08 Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010162637A Division JP2011015682A (ja) 2002-08-09 2010-07-20 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物

Publications (2)

Publication Number Publication Date
JP2005535342A JP2005535342A (ja) 2005-11-24
JP2005535342A5 true JP2005535342A5 (enExample) 2010-03-04

Family

ID=31720582

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2004529297A Pending JP2005535342A (ja) 2002-08-09 2003-08-08 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物
JP2010162637A Pending JP2011015682A (ja) 2002-08-09 2010-07-20 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物
JP2015117465A Expired - Fee Related JP6602561B2 (ja) 2002-08-09 2015-06-10 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2010162637A Pending JP2011015682A (ja) 2002-08-09 2010-07-20 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物
JP2015117465A Expired - Fee Related JP6602561B2 (ja) 2002-08-09 2015-06-10 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物

Country Status (5)

Country Link
EP (2) EP1551964A4 (enExample)
JP (3) JP2005535342A (enExample)
AU (2) AU2003264037B2 (enExample)
CA (2) CA2421269A1 (enExample)
WO (1) WO2004016726A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US20060025337A1 (en) 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
JP2007530417A (ja) 2003-07-01 2007-11-01 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞及び生物の寿命及びストレス応答を操作するための組成物
US20090035275A1 (en) * 2003-10-31 2009-02-05 John Geoffrey Pickering Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of NAD
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US20050171027A1 (en) 2003-12-29 2005-08-04 President And Fellows Of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
CN1964627B (zh) * 2004-06-04 2011-10-19 华盛顿大学 治疗神经病变的方法和组合物
KR20120138840A (ko) * 2004-09-24 2012-12-26 바이엘 크롭사이언스 엔.브이. 스트레스 내성 식물
EP1844157A4 (en) * 2005-01-25 2009-11-25 Univ Johns Hopkins STRATEGIES FOR THE DESIGN OF SUBSTANCES TO BE TAKEN ON THE SIR2 FAMILY OF ENZYMES
EP2805719A1 (en) 2005-03-30 2014-11-26 Glaxosmithkline LLC Nicotinamide riboside and analogues thereof
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
PT1893759E (pt) * 2005-06-15 2009-10-29 Bayer Bioscience Nv Métodos para aumentar a resistência de plantas a condições hipóxicas
CA2646476A1 (en) * 2006-03-21 2007-09-27 Bayer Bioscience N.V. Stress resistant plants
JP5452022B2 (ja) 2006-12-11 2014-03-26 独立行政法人科学技術振興機構 植物生長調整剤及びその利用
BRPI0811404B1 (pt) * 2007-11-13 2022-02-08 Japan Science And Technology Agency Método para produzir uma planta com teor de açúcar da fruta aumentado
JP5570731B2 (ja) * 2008-02-28 2014-08-13 旭化成ファーマ株式会社 ピロリン酸の測定方法
WO2009108999A1 (en) 2008-03-03 2009-09-11 Ross Stewart Grant Pharmaceutical formulations of resveratrol and methods of use thereof for treating cell disorders
JP2011115098A (ja) * 2009-12-04 2011-06-16 Nippon Menaade Keshohin Kk 加齢による皮膚明度の低下を予測する皮膚評価方法
KR101703180B1 (ko) 2011-12-12 2017-02-06 오카야마켄 식물의 아미노산 함량을 높이기 위한 화합물 및 그 이용
US9877981B2 (en) 2012-10-09 2018-01-30 President And Fellows Of Harvard College NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation
WO2015069860A1 (en) * 2013-11-06 2015-05-14 President And Fellows Of Harvard College Biological production of nad precursors and analogs
KR20170012449A (ko) 2014-06-02 2017-02-02 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 결정질 베타-d-니코틴아미드 리보시드의 제조 및 용도
CA2951287A1 (en) 2014-06-06 2015-12-10 Glaxosmithkline Intellectual Property (No. 2) Limited Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
JP6623015B2 (ja) * 2014-09-29 2019-12-18 国立研究開発法人理化学研究所 植物の耐塩性向上剤
WO2020097116A1 (en) * 2018-11-05 2020-05-14 Rejuvenation Therapeutics Compositions and methods for culturing yeast cells
US20220324899A1 (en) * 2019-08-14 2022-10-13 Metro International Biotech, Llc Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide
CN111394268B (zh) 2019-12-20 2021-06-18 合肥康诺生物制药有限公司 基因工程菌及其构建方法、应用，生产nad+的方法
CN112451673A (zh) * 2020-12-10 2021-03-09 汤臣倍健股份有限公司 线粒体功能干预材料在制备改善线粒体功能的保健品或药品中的应用及其筛选方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79289A (en) 1985-07-05 1992-01-15 Whitehead Biomedical Inst Introduction and expression of foreign genetic material into keratinocytes using a recombinant retrovirus
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
ATE117375T1 (de) 1987-09-11 1995-02-15 Whitehead Biomedical Inst Transduktionsveränderte fibroblasten und ihre anwendung.
JP2914692B2 (ja) 1987-12-11 1999-07-05 ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ 内皮細胞の遺伝子修飾
WO1989007136A2 (en) 1988-02-05 1989-08-10 Whitehead Institute For Biomedical Research Modified hepatocytes and uses therefor
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
ES2096750T3 (es) 1990-10-31 1997-03-16 Somatix Therapy Corp Vectores retroviricos utiles para la terapia genica.
EP0650370A4 (en) 1992-06-08 1995-11-22 Univ California METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES.
DE69333115D1 (de) 1992-09-22 2003-08-28 Biofocus Discovery Ltd Rekombinante viren, die an ihrer äusseren oberfläche ein nichtvirales polypeptid präsentieren
DE69333471T2 (de) 1992-11-09 2005-02-24 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Erzielbare vektorenpartikel
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
SK282843B6 (sk) 1993-07-13 2002-12-03 Rhone-Poulenc Rorer S. A. Defektný rekombinantný adenovírus a farmaceutický prostriedok s jeho obsahom
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5698443A (en) 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
ATE336587T1 (de) 1994-06-10 2006-09-15 Genvec Inc Adenoviren-vektor systeme und zelllinien
DE69534166T2 (de) 1994-10-28 2006-03-09 Trustees Of The University Of Pennsylvania Rekombinanter adenovirus und methoden zu dessen verwendung
US5856152A (en) 1994-10-28 1999-01-05 The Trustees Of The University Of Pennsylvania Hybrid adenovirus-AAV vector and methods of use therefor
US5872005A (en) 1994-11-03 1999-02-16 Cell Genesys Inc. Packaging cell lines for adeno-associated viral vectors
WO1996018418A1 (en) 1994-12-12 1996-06-20 Genetic Therapy, Inc. Improved adenoviral vectors and producer cells
DE69636863T2 (de) 1995-02-24 2007-11-15 Trustees Of The University Of Pennsylvania Benutzung von immunmodulatoren zur herstellung von medikamenten zur inhibierung einer immunantwort gegen gleichzeitig verabreichte rekombinante viren
US5688676A (en) 1995-06-07 1997-11-18 Research Foundation Of State University Of New York In vitro packaging of adeno-associated virus DNA
WO1997008298A1 (en) 1995-08-30 1997-03-06 Genzyme Corporation Chromatographic purification of adenovirus and aav
GB9816781D0 (en) 1998-07-31 1998-09-30 Univ London Herpes virus vectors for dendritic cells
WO2002029099A1 (fr) * 2000-10-03 2002-04-11 Takara Bio Inc. Technique de criblage de substance physiologiquement active
US7977049B2 (en) * 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
KR20120138840A (ko) * 2004-09-24 2012-12-26 바이엘 크롭사이언스 엔.브이. 스트레스 내성 식물
US9515947B1 (en) 2013-03-15 2016-12-06 EMC IP Holding Company LLC Method and system for providing a virtual network-aware storage array
KR20160071054A (ko) 2014-12-11 2016-06-21 에스케이하이닉스 주식회사 반도체 메모리 장치 및 그의 동작 방법
US9609948B2 (en) 2015-04-28 2017-04-04 Qianglong Furniture Co., Ltd. Rotating armrest apparatus

Similar Documents

Publication Publication Date Title
JP2005535342A5 (enExample)
AU2003297244A8 (en) Methods and compositions for purification of nucleic acid from a host cell
ES2585477T3 (es) Células modificadas metabólicamente para la producción de pinosilvina
EP0999605A3 (en) Fuel cell stack
CA2428959A1 (en) Fuel cell stack structure
AU2003263796A1 (en) Pem fuel cell stack without gas diffusion media
CL2008001865A1 (es) Método para identificar una muestra de germoplasma vegetal con un genotipo que modula el rendimiento de una caracteristica, y célula vegetal que contiene al menos una región genómatica identificada para modular el rendiemiento de transgenes.
Monard et al. Relationship between bacterial diversity and function under biotic control: the soil pesticide degraders as a case study
PE20020172A1 (es) Metodo para producir una sustancia que utiliza un microrganismo
EP1416559A3 (en) Fuel cell stack with heat exchanger
WO2006116638A3 (en) Compact solid oxide fuel cell apparatus
JP2009521795A5 (enExample)
NO20082380L (no) Elektrolysecelle med varmeveksler
JP2005226007A5 (enExample)
WO2005103566A3 (en) Online bakeout of regenerative oxidizers
EP1253655A4 (en) FUEL CELL
Maarof et al. Enhancing PV/T efficiency using PCM-integrated single-finned tube cooling system
WO2006108139A3 (en) Generation of materials with enhanced hydrogen content from microbial consortia including thermotoga
JP2005529469A5 (enExample)
林讚標 et al. Low genetic diversity of Cycas taitungensis (Cycadaceae), an endemic species in Taiwan, revealed by allozyme analysis
WO2002027836A3 (de) Brennstoffzellenmodul
WO2009120929A8 (en) Method for amplifying locus in bacterial cell
Dudgeon et al. Polymorphic microsatellite loci for the zebra shark Stegostoma fasciatum
WO2009051110A1 (ja) 燃料電池及びそれに使用する担持触媒
WO2006068315A3 (en) Electrode catalyst for fuel cell and fuel cell