JP2005535342A5 - - Google Patents

Download PDF

Info

Publication number
JP2005535342A5
JP2005535342A5 JP2004529297A JP2004529297A JP2005535342A5 JP 2005535342 A5 JP2005535342 A5 JP 2005535342A5 JP 2004529297 A JP2004529297 A JP 2004529297A JP 2004529297 A JP2004529297 A JP 2004529297A JP 2005535342 A5 JP2005535342 A5 JP 2005535342A5
Authority
JP
Japan
Prior art keywords
nad
increase
flow
stress
pnc1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004529297A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005535342A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/025016 external-priority patent/WO2004016726A2/en
Publication of JP2005535342A publication Critical patent/JP2005535342A/ja
Publication of JP2005535342A5 publication Critical patent/JP2005535342A5/ja
Pending legal-status Critical Current

Links

JP2004529297A 2002-08-09 2003-08-08 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 Pending JP2005535342A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40225402P 2002-08-09 2002-08-09
US42861402P 2002-11-22 2002-11-22
PCT/US2003/025016 WO2004016726A2 (en) 2002-08-09 2003-08-08 Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010162637A Division JP2011015682A (ja) 2002-08-09 2010-07-20 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物

Publications (2)

Publication Number Publication Date
JP2005535342A JP2005535342A (ja) 2005-11-24
JP2005535342A5 true JP2005535342A5 (OSRAM) 2010-03-04

Family

ID=31720582

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2004529297A Pending JP2005535342A (ja) 2002-08-09 2003-08-08 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物
JP2010162637A Pending JP2011015682A (ja) 2002-08-09 2010-07-20 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物
JP2015117465A Expired - Fee Related JP6602561B2 (ja) 2002-08-09 2015-06-10 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2010162637A Pending JP2011015682A (ja) 2002-08-09 2010-07-20 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物
JP2015117465A Expired - Fee Related JP6602561B2 (ja) 2002-08-09 2015-06-10 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物

Country Status (5)

Country Link
EP (2) EP1551964A4 (OSRAM)
JP (3) JP2005535342A (OSRAM)
AU (2) AU2003264037B2 (OSRAM)
CA (2) CA2421269A1 (OSRAM)
WO (1) WO2004016726A2 (OSRAM)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7977049B2 (en) * 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US20060025337A1 (en) 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
WO2005002672A2 (en) 2003-07-01 2005-01-13 President And Fellows Of Harvard College Sirt1 modulators for manipulating cells/organism lifespan/stress response
WO2006072809A2 (en) * 2003-10-31 2006-07-13 Robarts Research Institute Formulations that optimize intracellular concentration of nicotinamide adenine (nad+) and methods of use to protect cells and treat diseases and conditions
US8017634B2 (en) * 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
EP1708689A2 (en) 2003-12-29 2006-10-11 The President and Fellows of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
ES2557810T3 (es) * 2004-06-04 2016-01-28 Washington University Métodos y composiciones para tratar neuropatías
KR20120138840A (ko) * 2004-09-24 2012-12-26 바이엘 크롭사이언스 엔.브이. 스트레스 내성 식물
WO2006081329A2 (en) * 2005-01-25 2006-08-03 The Johns Hopkins University Strategies for designing drugs that target the sir2 family of enzymes
EP2805719A1 (en) 2005-03-30 2014-11-26 Glaxosmithkline LLC Nicotinamide riboside and analogues thereof
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
MX2007016199A (es) * 2005-06-15 2008-03-11 Bayer Bioscience Nv Metodos para aumentar la resistencia de plantas a condiciones hipoxicas.
US8158856B2 (en) * 2006-03-21 2012-04-17 Bayer Cropscience Nv Stress resistant plants
EP2103212B1 (en) 2006-12-11 2014-08-06 Japan Science and Technology Agency Plant growth regulator and use thereof
AU2008321944B2 (en) * 2007-11-13 2011-01-27 Japan Science And Technology Agency Composition for production of plant body having improved sugar content, and use thereof
JP5570731B2 (ja) * 2008-02-28 2014-08-13 旭化成ファーマ株式会社 ピロリン酸の測定方法
JP5684578B2 (ja) 2008-03-03 2015-03-11 エヌエーディー ライフ プロプライエタリー リミテッド リスベラトロールの医薬製剤、および細胞障害を治療するためのその使用方法
JP2011115098A (ja) * 2009-12-04 2011-06-16 Nippon Menaade Keshohin Kk 加齢による皮膚明度の低下を予測する皮膚評価方法
CN103987249B (zh) 2011-12-12 2015-10-21 冈山县 用于提高植物的氨基酸含量的化合物及其应用
WO2014059034A2 (en) 2012-10-09 2014-04-17 President And Fellows Of Harvard College Nad biosynthesis and precursors for the treatment and prevention of cancer and proliferation
WO2015069860A1 (en) * 2013-11-06 2015-05-14 President And Fellows Of Harvard College Biological production of nad precursors and analogs
US10316054B2 (en) 2014-06-02 2019-06-11 Glaxosmithkline Intellectual Property (No. 2) Limited Preparation and use of crystalline beta-D-nicotinamide riboside
EP3152220A1 (en) 2014-06-06 2017-04-12 Glaxosmithkline Intellectual Property (No. 2) Limited Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
JP6623015B2 (ja) * 2014-09-29 2019-12-18 国立研究開発法人理化学研究所 植物の耐塩性向上剤
WO2020097116A1 (en) * 2018-11-05 2020-05-14 Rejuvenation Therapeutics Compositions and methods for culturing yeast cells
CN114555619A (zh) * 2019-08-14 2022-05-27 麦德龙国际生物科技有限责任公司 用于烟酰胺腺嘌呤二核苷酸的差分调节的化合物和组合物
CN111394268B (zh) 2019-12-20 2021-06-18 合肥康诺生物制药有限公司 基因工程菌及其构建方法、应用，生产nad+的方法
CN112451673A (zh) * 2020-12-10 2021-03-09 汤臣倍健股份有限公司 线粒体功能干预材料在制备改善线粒体功能的保健品或药品中的应用及其筛选方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6131086A (en) 1985-07-05 1987-01-30 Whitehead Institute For Biomedical Research Epithelial cells expressing foreign genetic material
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
EP0378576B1 (en) 1987-09-11 1995-01-18 Whitehead Institute For Biomedical Research Transduced fibroblasts and uses therefor
HK1008400A1 (en) 1987-12-11 1999-05-07 Whitehead Institute For Biomedical Research Genetic modification of endothelial cells
DE68927996T2 (de) 1988-02-05 1997-12-04 Hughes Howard Med Inst Modifizierte hepatozyten und deren anwendung
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
AU656544B2 (en) 1990-10-31 1995-02-09 Brigham And Women's Hospital Genetic modification of endothelial cells
WO1993025234A1 (en) 1992-06-08 1993-12-23 The Regents Of The University Of California Methods and compositions for targeting specific tissue
AU689755B2 (en) 1992-09-22 1998-04-09 Biofocus Discovery Limited Recombinant viruses displaying a nonviral polypeptide on their external surface
CA2148934C (en) 1992-11-09 2005-08-02 French W. Anderson Targetable vector particles
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
SK282843B6 (sk) 1993-07-13 2002-12-03 Rhone-Poulenc Rorer S. A. Defektný rekombinantný adenovírus a farmaceutický prostriedok s jeho obsahom
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5698443A (en) 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
DE69535178T2 (de) 1994-06-10 2006-12-14 Genvec, Inc. Adenoviren-vektor systeme und zelllinien
JP3565859B2 (ja) 1994-10-28 2004-09-15 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 改良されたアデノウイルスおよびその使用法
US5856152A (en) 1994-10-28 1999-01-05 The Trustees Of The University Of Pennsylvania Hybrid adenovirus-AAV vector and methods of use therefor
US5872005A (en) 1994-11-03 1999-02-16 Cell Genesys Inc. Packaging cell lines for adeno-associated viral vectors
WO1996018418A1 (en) 1994-12-12 1996-06-20 Genetic Therapy, Inc. Improved adenoviral vectors and producer cells
JPH11500736A (ja) 1995-02-24 1999-01-19 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 遺伝子治療ベクターを投与するための方法及び組成物
US5688676A (en) 1995-06-07 1997-11-18 Research Foundation Of State University Of New York In vitro packaging of adeno-associated virus DNA
CA2625279A1 (en) 1995-08-30 1997-03-06 Genzyme Corporation Chromatographic purification of adenovirus and aav
GB9816781D0 (en) 1998-07-31 1998-09-30 Univ London Herpes virus vectors for dendritic cells
JPWO2002029099A1 (ja) * 2000-10-03 2004-02-12 タカラバイオ株式会社 生理活性物質のスクリーニング方法
US7977049B2 (en) * 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
KR20120138840A (ko) * 2004-09-24 2012-12-26 바이엘 크롭사이언스 엔.브이. 스트레스 내성 식물
US9515947B1 (en) 2013-03-15 2016-12-06 EMC IP Holding Company LLC Method and system for providing a virtual network-aware storage array
KR20160071054A (ko) 2014-12-11 2016-06-21 에스케이하이닉스 주식회사 반도체 메모리 장치 및 그의 동작 방법
US9609948B2 (en) 2015-04-28 2017-04-04 Qianglong Furniture Co., Ltd. Rotating armrest apparatus

Similar Documents

Publication Publication Date Title
JP2005535342A5 (OSRAM)
Bald et al. From isolated molecules through clusters and condensates to the building blocks of life
AU2003297244A1 (en) Methods and compositions for purification of nucleic acid from a host cell
Chen et al. The genome and transcriptome of a newly described psychrophilic archaeon, M ethanolobus psychrophilus R 15, reveal its cold adaptive characteristics
CA2428959A1 (en) Fuel cell stack structure
AU2003263796A1 (en) Pem fuel cell stack without gas diffusion media
CL2008001865A1 (es) Método para identificar una muestra de germoplasma vegetal con un genotipo que modula el rendimiento de una caracteristica, y célula vegetal que contiene al menos una región genómatica identificada para modular el rendiemiento de transgenes.
AU2003270441A1 (en) One piece sleeve gas manifold for cell stack assemblies such as fuel cells
JP2008500940A5 (OSRAM)
WO2005058002A3 (en) High efficiency fullerene-based radical scavengers
JP2005226007A5 (OSRAM)
WO2005103566A3 (en) Online bakeout of regenerative oxidizers
WO2007057534A3 (fr) Cuve d'electrolyse avec echangeur thermique
JP2006508646A5 (OSRAM)
PE20010017A1 (es) Metodo para producir xilitol
EP1524712A3 (en) Fuel cell system and operation method thereof
林讚標 et al. Low genetic diversity of Cycas taitungensis (Cycadaceae), an endemic species in Taiwan, revealed by allozyme analysis
CN104046635B (zh) 特异响应逆境信号的nfiS基因的用途及其使用方法
WO2009120929A8 (en) Method for amplifying locus in bacterial cell
WO2009051110A1 (ja) 燃料電池及びそれに使用する担持触媒
ATE398340T1 (de) System aus brennstoffzelle, nachbrenner und wärmetauscher
WO2006068317A3 (en) Fuel cell system
WO2005055333A3 (en) Cathode saturation arrangement for fuel cell power plant
JP2003509058A5 (OSRAM)
JP2008519111A5 (OSRAM)