JP2005534706A5 - - Google Patents
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- Publication number
- JP2005534706A5 JP2005534706A5 JP2004526766A JP2004526766A JP2005534706A5 JP 2005534706 A5 JP2005534706 A5 JP 2005534706A5 JP 2004526766 A JP2004526766 A JP 2004526766A JP 2004526766 A JP2004526766 A JP 2004526766A JP 2005534706 A5 JP2005534706 A5 JP 2005534706A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- heteroaryl
- phenyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 claims description 48
- 125000001072 heteroaryl group Chemical group 0.000 claims description 42
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 35
- 229910052799 carbon Inorganic materials 0.000 claims description 30
- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 150000002367 halogens Chemical class 0.000 claims description 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- -1 4H-thieno [3,2-b] pyrrol-5-yl Chemical class 0.000 claims description 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 4
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims description 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 2
- 125000002757 morpholinyl group Chemical group 0.000 claims description 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims description 2
- 125000003386 piperidinyl group Chemical group 0.000 claims description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims description 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 229920001577 copolymer Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 2
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 230000003511 endothelial effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000002249 Diabetes Complications Diseases 0.000 claims 1
- 206010012655 Diabetic complications Diseases 0.000 claims 1
- 206010048554 Endothelial dysfunction Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 208000007530 Essential hypertension Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 201000001068 Prinzmetal angina Diseases 0.000 claims 1
- 201000003099 Renovascular Hypertension Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 201000004239 Secondary hypertension Diseases 0.000 claims 1
- 208000007718 Stable Angina Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 208000009325 Variant Angina Pectoris Diseases 0.000 claims 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000008694 endothelial dysfunction Effects 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02017587A EP1388535A1 (en) | 2002-08-07 | 2002-08-07 | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| PCT/EP2003/008104 WO2004014842A1 (en) | 2002-08-07 | 2003-07-24 | Acylated arylcycloalkylamines and their use as pharmaceuticals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005534706A JP2005534706A (ja) | 2005-11-17 |
| JP2005534706A5 true JP2005534706A5 (enExample) | 2006-08-31 |
| JP4555683B2 JP4555683B2 (ja) | 2010-10-06 |
Family
ID=30129195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004526766A Expired - Fee Related JP4555683B2 (ja) | 2002-08-07 | 2003-07-24 | アシル化されたアリールシクロアルキルアミンおよび医薬としてのそれらの使用 |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP1388535A1 (enExample) |
| JP (1) | JP4555683B2 (enExample) |
| KR (1) | KR101080627B1 (enExample) |
| CN (1) | CN1304365C (enExample) |
| AR (1) | AR040791A1 (enExample) |
| AU (1) | AU2003250159B2 (enExample) |
| BR (1) | BR0313271A (enExample) |
| CA (1) | CA2494628C (enExample) |
| HR (1) | HRP20050118A2 (enExample) |
| IL (1) | IL166491A (enExample) |
| MA (1) | MA27330A1 (enExample) |
| ME (1) | MEP60508A (enExample) |
| MX (1) | MXPA05001371A (enExample) |
| MY (1) | MY141885A (enExample) |
| NO (1) | NO332654B1 (enExample) |
| NZ (1) | NZ538089A (enExample) |
| PL (1) | PL210930B1 (enExample) |
| RS (1) | RS20050098A (enExample) |
| RU (1) | RU2337094C2 (enExample) |
| TW (1) | TWI317732B (enExample) |
| WO (1) | WO2004014842A1 (enExample) |
| ZA (1) | ZA200410273B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1972914A (zh) | 2004-03-31 | 2007-05-30 | 詹森药业有限公司 | 作为组胺h3受体配合体的非咪唑杂环化合物 |
| EP1741709A1 (en) * | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals |
| EP1741708A1 (en) * | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals |
| WO2007107470A2 (en) | 2006-03-22 | 2007-09-27 | F. Hoffmann-La Roche Ag | Pyrazoles as 11-beta-hsd-1 |
| ES2335319T3 (es) * | 2006-05-18 | 2010-03-24 | Syngenta Participations Ag | Nuevos microbiocidas. |
| MX339668B (es) | 2006-05-30 | 2016-06-02 | Janssen Pharmaceutica N V * | Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina. |
| ES2300223B1 (es) * | 2006-07-07 | 2009-09-11 | Universidad De Granada | 3-benzoilpirazoles inhibidores de la oxido nitrico sintasa (nos) con actividad neuroprotectora. |
| EP1905764A1 (en) * | 2006-09-30 | 2008-04-02 | Sanofi-Aventis | Substituted 2-Phenyl-benzimidazoles and their use as pharmaceuticals |
| EP1923062A1 (en) | 2006-11-16 | 2008-05-21 | sanofi-aventis | Imidazo[2,1-b]thiazoles and their use as pharmaceuticals |
| EP1942104A1 (en) * | 2006-12-20 | 2008-07-09 | sanofi-aventis | Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals |
| EP1939180A1 (en) * | 2006-12-20 | 2008-07-02 | sanofi-aventis | Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase |
| EP1939181A1 (en) | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase |
| EP1964840A1 (en) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]pyridines and their use as pharmaceuticals |
| EP1964841A1 (en) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine and their use as pharmaceuticals |
| WO2009043784A1 (en) * | 2007-10-04 | 2009-04-09 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
| CA2706328C (en) | 2007-11-20 | 2016-04-19 | Janssen Pharmaceutica N.V. | Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor |
| WO2009152356A2 (en) * | 2008-06-11 | 2009-12-17 | Irm Llc | Compounds and compositions useful for the treatment of malaria |
| WO2012156537A2 (en) * | 2011-05-19 | 2012-11-22 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for thrombosis and cardiovascular diseases |
| WO2012156531A2 (en) * | 2011-05-19 | 2012-11-22 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for inflammatory diseases or conditions |
| CA2841911A1 (en) * | 2011-07-26 | 2013-01-31 | Sanofi | Substituted 3 - (thiazole - 4 - carbonyl) - or 3 - (thiazole - 2 - carbonyl) - aminopropionic acid derivatives and their use as pharmaceuticals |
| ITMI20111971A1 (it) * | 2011-10-28 | 2013-04-29 | Mesogenics Srl | Inibitori dell'enzima lsd-1 per l'induzione del differenziamento osteogenico |
| CN104114025B (zh) | 2012-02-14 | 2017-11-07 | 先正达参股股份有限公司 | 杀线虫的顺式(杂)芳基环丙基甲酰胺衍生物 |
| EP2644595A1 (en) | 2012-03-26 | 2013-10-02 | Syngenta Participations AG. | N-Cyclylamides as nematicides |
| UY35543A (es) * | 2013-04-30 | 2014-11-28 | Bayer Cropscience Ag | N-(fenilcicloalquil)carboxamidas y n-(fenilcicloalquil)tiocarboxamidas nematicidas |
| PL3019476T3 (pl) * | 2013-07-08 | 2018-05-30 | Syngenta Participations Ag | Związki karboksyamidowe o 4-członowym pierścieniu jako nematocydy |
| WO2015040141A1 (en) | 2013-09-23 | 2015-03-26 | Syngenta Participations Ag | Cyclobutylcarboxamides as nematicides |
| HRP20241236T1 (hr) | 2014-05-13 | 2024-12-06 | Novartis Ag | Spojevi i pripravci za induciranje hondrogeneze |
| US20200087271A1 (en) | 2016-12-20 | 2020-03-19 | Syngenta Participations Ag | N-cyclobutyl-thiazol-5-carboxamides with nematicidal activity |
| WO2020239853A1 (en) * | 2019-05-29 | 2020-12-03 | Syngenta Crop Protection Ag | Microbiocidal derivatives |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3192229A (en) * | 1962-07-03 | 1965-06-29 | Colgate Palmolive Co | Phenylcyclopropyl amides |
| US4625040A (en) * | 1984-09-24 | 1986-11-25 | Pennwalt Corporation | N-(phenyl) or N-(phenylcyclopropyl)-2,5-dihydro-2-oxo-4[(substituted phenyl)amino]-3-furancarboxamide derivatives |
| US4614810A (en) * | 1984-09-24 | 1986-09-30 | Pennwalt Corporation | 4,5-dihydro-4-oxo-2-[(2-trans-phenylcyclopropyl)amino]-3-furancarboxylic acids and derivatives thereof |
| IL84944A (en) * | 1987-01-19 | 1992-02-16 | Ici Plc | Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation |
| BR9509297A (pt) * | 1995-08-10 | 1998-07-07 | Astra Ab | Composto composição farmacêutica utilização de um composto e processos de tratamento ou prolifaxia de uma doença ou condição na qual a síntese ou suprasintese da sintetase de óxido nitrico forma uma parte contribuinte e desordens neurodegenerativas ou de enxaqueca ou de prevenção e reversão da tolerância a opiatos e diazepinas ou de tratamento do vicio em tóxicos e de preparação de um composto |
| JP3844533B2 (ja) * | 1995-12-15 | 2006-11-15 | 日本曹達株式会社 | ２，６−ジクロロイソニコチン酸フェネチルアミド誘導体及び植物病害防除剤 |
| US5945431A (en) * | 1996-03-15 | 1999-08-31 | Biochem Therapeutics Incorporated | Cytomegalovirus inhibiting compounds |
| US6048877A (en) * | 1997-02-21 | 2000-04-11 | Bristol-Myers Squibb Company | Tetralone derivatives as antiarrhythmic agents |
| WO1999029318A1 (en) * | 1997-12-11 | 1999-06-17 | Biochem Pharma Inc. | Antiviral compounds |
| US6271390B1 (en) * | 1998-05-22 | 2001-08-07 | Avanir Pharmaceuticals | Suppression of the IgE-dependent allergic response by benzimidazole analogs |
| US6326379B1 (en) * | 1998-09-16 | 2001-12-04 | Bristol-Myers Squibb Co. | Fused pyridine inhibitors of cGMP phosphodiesterase |
| EP1134214A4 (en) * | 1998-11-04 | 2004-12-15 | Meiji Seika Kaisha | PICOLINAMIDE DERIVATIVES AND PESTICIDES CONTAINING THESE DERIVATIVES AS ACTIVE INGREDIENT |
| SE9904652D0 (sv) * | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
| GB0021831D0 (en) * | 2000-09-06 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| AU1152702A (en) * | 2000-10-12 | 2002-04-22 | Merck & Co Inc | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| JP2004528304A (ja) * | 2001-03-12 | 2004-09-16 | アバニール・ファーマシューティカルズ | ＩｇＥを調節し、細胞増殖を阻害するためのベンゾイミダゾール化合物 |
| DE10128331A1 (de) * | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| WO2003037274A2 (en) * | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Pyrazole-amides and-sulfonamides |
-
2002
- 2002-08-07 EP EP02017587A patent/EP1388535A1/en not_active Withdrawn
-
2003
- 2003-07-24 EP EP03784056A patent/EP1529031A1/en not_active Withdrawn
- 2003-07-24 ME MEP-605/08A patent/MEP60508A/xx unknown
- 2003-07-24 CA CA2494628A patent/CA2494628C/en not_active Expired - Fee Related
- 2003-07-24 HR HR20050118A patent/HRP20050118A2/xx not_active Application Discontinuation
- 2003-07-24 AU AU2003250159A patent/AU2003250159B2/en not_active Ceased
- 2003-07-24 MX MXPA05001371A patent/MXPA05001371A/es active IP Right Grant
- 2003-07-24 NZ NZ538089A patent/NZ538089A/en not_active IP Right Cessation
- 2003-07-24 BR BR0313271-4A patent/BR0313271A/pt not_active IP Right Cessation
- 2003-07-24 RS YUP-2005/0098A patent/RS20050098A/sr unknown
- 2003-07-24 JP JP2004526766A patent/JP4555683B2/ja not_active Expired - Fee Related
- 2003-07-24 KR KR1020057002078A patent/KR101080627B1/ko not_active Expired - Fee Related
- 2003-07-24 CN CNB038191237A patent/CN1304365C/zh not_active Expired - Fee Related
- 2003-07-24 WO PCT/EP2003/008104 patent/WO2004014842A1/en not_active Ceased
- 2003-07-24 PL PL373068A patent/PL210930B1/pl not_active IP Right Cessation
- 2003-07-24 RU RU2005106256/04A patent/RU2337094C2/ru not_active IP Right Cessation
- 2003-08-05 AR AR20030102804A patent/AR040791A1/es unknown
- 2003-08-05 TW TW092121313A patent/TWI317732B/zh not_active IP Right Cessation
- 2003-08-06 MY MYPI20032960A patent/MY141885A/en unknown
-
2004
- 2004-12-21 ZA ZA200410273A patent/ZA200410273B/en unknown
-
2005
- 2005-01-25 IL IL166491A patent/IL166491A/en not_active IP Right Cessation
- 2005-02-01 MA MA28082A patent/MA27330A1/fr unknown
- 2005-03-01 NO NO20051110A patent/NO332654B1/no not_active IP Right Cessation
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