RS20050098A - Acylated arylcycloalkylamines and their use as pharmaceutica ls - Google Patents

Acylated arylcycloalkylamines and their use as pharmaceutica ls

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Publication number
RS20050098A
RS20050098A YUP-2005/0098A YUP20050098A RS20050098A RS 20050098 A RS20050098 A RS 20050098A YU P20050098 A YUP20050098 A YU P20050098A RS 20050098 A RS20050098 A RS 20050098A
Authority
RS
Serbia
Prior art keywords
formula
compounds
level
enzyme
expression
Prior art date
Application number
YUP-2005/0098A
Other languages
English (en)
Inventor
Hartmut Strobel
Paulus Wohlfart
Peter Below
Original Assignee
Sanofi-Aventis Pharma Deutschland Gmbh.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Pharma Deutschland Gmbh., filed Critical Sanofi-Aventis Pharma Deutschland Gmbh.,
Publication of RS20050098A publication Critical patent/RS20050098A/sr

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

Ovaj pronalazak se odnosi na acilovane aricikloalkilamine formule I gde R1, R2 i n imaju značenja naznačena u patentnim zahtevima. Jedinjenja formule I su vredna farmakološki aktivna jedinjenja koja su korisna u tretmanu raznih stanja bolesti, uključujući kardiovaskularne poremećaje, kao što je ateroskleroza, tromboza, bolest koronamih arterija, hipertenzija i srčana insuficijencija. Ona nadregulišu izlučivanje enzima sinteze endotelijumskog azot-monoksida (NO), i mogu se primeniti u stanjima u kojima je poželjno pojačano izličivanje pomenutog enzima ili povišen sadržaj NO, ili normalizacija sniženog sadržaja NO. Ovaj pronalazak se još odnosi na postupke za dobijanje jedinjenja formule I, na njihovu upotrebu kao aktivnih sastojaka u farmaceutskim proizvodima i na farmaceutske preparate koji ih sadrže.
YUP-2005/0098A 2002-08-07 2003-07-24 Acylated arylcycloalkylamines and their use as pharmaceutica ls RS20050098A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02017587A EP1388535A1 (en) 2002-08-07 2002-08-07 Acylated arylcycloalkylamines and their use as pharmaceuticals
PCT/EP2003/008104 WO2004014842A1 (en) 2002-08-07 2003-07-24 Acylated arylcycloalkylamines and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
RS20050098A true RS20050098A (en) 2007-09-21

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EP (2) EP1388535A1 (sr)
JP (1) JP4555683B2 (sr)
KR (1) KR101080627B1 (sr)
CN (1) CN1304365C (sr)
AR (1) AR040791A1 (sr)
AU (1) AU2003250159B2 (sr)
BR (1) BR0313271A (sr)
CA (1) CA2494628C (sr)
HK (1) HK1079186A1 (sr)
HR (1) HRP20050118A2 (sr)
IL (1) IL166491A (sr)
MA (1) MA27330A1 (sr)
ME (1) MEP60508A (sr)
MX (1) MXPA05001371A (sr)
MY (1) MY141885A (sr)
NO (1) NO332654B1 (sr)
NZ (1) NZ538089A (sr)
PL (1) PL210930B1 (sr)
RS (1) RS20050098A (sr)
RU (1) RU2337094C2 (sr)
TW (1) TWI317732B (sr)
WO (1) WO2004014842A1 (sr)
ZA (1) ZA200410273B (sr)

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EP1741708A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
EP1741709A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
KR20110007258A (ko) 2006-03-22 2011-01-21 에프. 호프만-라 로슈 아게 11-베타-ｈｓｄ-1로서의 피라졸
WO2007134799A1 (en) * 2006-05-18 2007-11-29 Syngenta Participations Ag Novel microbiocides
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ES2300223B1 (es) * 2006-07-07 2009-09-11 Universidad De Granada 3-benzoilpirazoles inhibidores de la oxido nitrico sintasa (nos) con actividad neuroprotectora.
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