JP2005533861A5 - - Google Patents
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- Publication number
- JP2005533861A5 JP2005533861A5 JP2004524853A JP2004524853A JP2005533861A5 JP 2005533861 A5 JP2005533861 A5 JP 2005533861A5 JP 2004524853 A JP2004524853 A JP 2004524853A JP 2004524853 A JP2004524853 A JP 2004524853A JP 2005533861 A5 JP2005533861 A5 JP 2005533861A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibodies
- hmpv
- rsv
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 136
- 102000036639 antigens Human genes 0.000 claims 136
- 108091007433 antigens Proteins 0.000 claims 136
- 239000012634 fragment Substances 0.000 claims 63
- 125000003275 alpha amino acid group Chemical group 0.000 claims 23
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 102000007982 Phosphoproteins Human genes 0.000 claims 14
- 108010089430 Phosphoproteins Proteins 0.000 claims 14
- 102000011931 Nucleoproteins Human genes 0.000 claims 13
- 108010061100 Nucleoproteins Proteins 0.000 claims 13
- 108091006027 G proteins Proteins 0.000 claims 12
- 102000030782 GTP binding Human genes 0.000 claims 12
- 108091000058 GTP-Binding Proteins 0.000 claims 12
- 108060003393 Granulin Proteins 0.000 claims 12
- 108060004795 Methyltransferase Proteins 0.000 claims 12
- 101710200413 Small hydrophobic protein Proteins 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 208000015181 infectious disease Diseases 0.000 claims 9
- 241001519465 Avian metapneumovirus Species 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 6
- 208000036142 Viral infection Diseases 0.000 claims 5
- 230000036039 immunity Effects 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 241000021522 Avian metapneumovirus type B Species 0.000 claims 3
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 3
- 206010062106 Respiratory tract infection viral Diseases 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 101710117545 C protein Proteins 0.000 claims 2
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims 2
- 102000003886 Glycoproteins Human genes 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229960000402 palivizumab Drugs 0.000 claims 2
- 102000007999 Nuclear Proteins Human genes 0.000 claims 1
- 108010089610 Nuclear Proteins Proteins 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39847502P | 2002-07-25 | 2002-07-25 | |
| PCT/US2003/023376 WO2004010935A2 (en) | 2002-07-25 | 2003-07-25 | Methods of treating and preventing rsv, hmpv, and piv using anti-rsv, anti-hmpv, and anti-piv antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533861A JP2005533861A (ja) | 2005-11-10 |
| JP2005533861A5 true JP2005533861A5 (enExample) | 2006-08-31 |
Family
ID=31188405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004524853A Pending JP2005533861A (ja) | 2002-07-25 | 2003-07-25 | 抗RSV、抗hMPV、および抗PIV抗体を使用するRSV、hMPV、およびPIVの治療法と予防法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20040096451A1 (enExample) |
| EP (1) | EP1534327A4 (enExample) |
| JP (1) | JP2005533861A (enExample) |
| AU (1) | AU2003256823B9 (enExample) |
| CA (1) | CA2494485A1 (enExample) |
| TW (1) | TW200501985A (enExample) |
| WO (1) | WO2004010935A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6855493B2 (en) | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| WO2002057302A2 (en) | 2001-01-19 | 2002-07-25 | Vironovative B.V. | A virus causing respiratory tract illness in susceptible mammals |
| EP2327418A1 (en) | 2002-02-21 | 2011-06-01 | MedImmune, LLC | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from other viruses |
| US20050152899A1 (en) * | 2002-05-10 | 2005-07-14 | Kinch Michael S. | EphA2 agonistic monoclonal antibodies and methods of use thereof |
| EP1575509B1 (en) * | 2002-05-10 | 2011-10-26 | Purdue Research Foundation | Epha2 agonistic monoclonal antibodies and methods of use thereof |
| WO2003094859A2 (en) * | 2002-05-10 | 2003-11-20 | Medimmune, Inc. | Epha2 monoclonal antibodies and methods of use thereof |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| JP2006524693A (ja) * | 2003-04-11 | 2006-11-02 | メディミューン,インコーポレーテッド | EphA2および非腫瘍性過増殖性細胞障害 |
| EP1473037A1 (en) * | 2003-05-02 | 2004-11-03 | Vironovative B.V. | Treatment of hPMV infections with Ribavirin |
| US20060083741A1 (en) * | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
| US20060115485A1 (en) * | 2004-10-29 | 2006-06-01 | Medimmune, Inc. | Methods of preventing and treating RSV infections and related conditions |
| WO2006110214A2 (en) * | 2005-04-08 | 2006-10-19 | Medimmune, Inc. | Antibodies against mammalian metapneumovirus |
| JP2008546805A (ja) | 2005-06-23 | 2008-12-25 | メディミューン,エルエルシー | 最適な凝集および断片化プロフィールを有する抗体製剤 |
| US20090053790A1 (en) | 2006-01-31 | 2009-02-26 | Ishihara Sangyo Kaisha, Ltd. | Polypeptide Having Affinity for Envelope Virus Constituent and Use Thereof in Transferring Substance Into Cell |
| KR20080113223A (ko) * | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
| WO2008106980A2 (en) * | 2007-03-06 | 2008-09-12 | Symphogen A/S | Recombinant antibodies for treatment of respiratory syncytial virus infections |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| MX2012000036A (es) * | 2009-06-24 | 2012-02-28 | Glaxosmithkline Biolog Sa | Vacuna. |
| US8840889B2 (en) | 2009-08-13 | 2014-09-23 | The Johns Hopkins University | Methods of modulating immune function |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| NZ703035A (en) | 2010-07-09 | 2016-06-24 | Crucell Holland Bv | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
| WO2012089231A1 (en) * | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
| NZ630920A (en) * | 2012-03-20 | 2017-01-27 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
| EP2836505B1 (en) * | 2012-04-10 | 2019-01-23 | The Trustees Of The University Of Pennsylvania | Human respiratory syncytial virus concensus antigens, nucleic acid constructs and vaccines made thereform, and methods of using same |
| EA039682B1 (ru) * | 2012-06-04 | 2022-02-28 | Хумабс Биомед Са | Антитела, нейтрализующие rsv, mpv и pvm, и их применения |
| AU2014243756B2 (en) | 2013-03-13 | 2018-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| CL2015002152A1 (es) * | 2015-07-31 | 2016-06-03 | Pontificia Universidad Católica De Chile | Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh |
| EP3718565B1 (en) | 2015-10-22 | 2022-04-27 | ModernaTX, Inc. | Respiratory virus vaccines |
| CN109069611B (zh) | 2016-03-29 | 2022-11-04 | 美国政府(由卫生和人类服务部的部长所代表) | 取代修饰的融合前rsv f蛋白及其用途 |
| US11103578B2 (en) | 2016-12-08 | 2021-08-31 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| WO2018109220A2 (en) | 2016-12-16 | 2018-06-21 | Institute For Research In Biomedicine | Novel recombinant prefusion rsv f proteins and uses thereof |
| EP3375876A1 (en) * | 2017-03-13 | 2018-09-19 | Evonetix Ltd | Method for producing double stranded polynucleotides based on oligonucleotides with selected and different melting temperatures |
| MA51230A (fr) | 2018-01-29 | 2021-05-05 | Merck Sharp & Dohme | Protéines f rsv stabilisées et leurs utilisations |
| WO2020033742A1 (en) | 2018-08-08 | 2020-02-13 | Trellis Bioscience, Llc | Improved rsv passive and active vaccines |
| EP3848389A4 (en) * | 2018-09-03 | 2022-04-13 | Pontificia Universidad Católica De Chile | SPECIFIC MONOCLONAL ANTIBODIES AGAINST HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) N-ANTIGEN FOR TREATMENT, DETECTION AND DIAGNOSIS OF INFECTION |
| CL2018003869A1 (es) | 2018-12-28 | 2021-01-15 | Univ Pontificia Catolica Chile | Anticuerpos monoclonales específicos para la proteína quimérica l del virus de la parainfluenza humana (piv), secuencias nucleotídicas; método y kit de diagnóstico de infección producida por piv |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| JP7274904B2 (ja) * | 2019-03-26 | 2023-05-17 | 田中貴金属工業株式会社 | ヒトメタニューモウイルス検出用試薬 |
| JP2024512215A (ja) * | 2021-02-12 | 2024-03-19 | メルク・シャープ・アンド・ドーム・エルエルシー | メタニューモウイルス、抗原性メタニューモウイルスタンパク質に結合する抗体、及びその使用 |
| US20230174632A1 (en) * | 2021-12-08 | 2023-06-08 | IgGenix, Inc. | Combinations for allergy therapy |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3378250D1 (en) * | 1982-04-22 | 1988-11-24 | Ici Plc | Continuous release formulations |
| US5128326A (en) * | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
| US4880078A (en) * | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5854037A (en) * | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US5166057A (en) * | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| CA2071867A1 (en) * | 1989-11-06 | 1991-05-07 | Edith Mathiowitz | Method for producing protein microspheres |
| WO1991016074A1 (en) * | 1990-04-19 | 1991-10-31 | Medimmune, Inc. | Administration of monoclonal antibodies against respiratory viruses |
| DE69232706T2 (de) * | 1991-05-01 | 2002-11-28 | Henry M. Jackson Foundation For The Advancement Of Military Medicine, Rockville | Verfahren zur behandlung infektiöser respiratorischer erkrankungen |
| US6800738B1 (en) * | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| US5824307A (en) * | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| US20020102257A1 (en) * | 1998-09-21 | 2002-08-01 | Leslie Sid Johnson | Human-murine chimeric antibodies against respiratory syncytial virus |
| GB9200117D0 (en) * | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
| US5667988A (en) * | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5912015A (en) * | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
| US5934272A (en) * | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| US6019968A (en) * | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US5811524A (en) * | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| JP2000507912A (ja) * | 1995-08-31 | 2000-06-27 | アルカームズ コントロールド セラピューティックス,インコーポレイテッド | 作用剤の徐放性組成物 |
| JP2000506165A (ja) * | 1996-03-04 | 2000-05-23 | ザ ペン ステイト リサーチ ファウンデーション | 細胞インターナリゼーションを増強するための物質および方法 |
| US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5989463A (en) * | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| CA2338147A1 (en) * | 1998-07-20 | 2000-02-03 | Kuo-Long Yu | Substituted benzimidazole antiviral agents |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| EP2289550A3 (en) * | 2000-01-27 | 2012-02-15 | MedImmune, LLC | Ultra high affinity neutralizing antibodies |
| DK1259547T3 (da) * | 2000-03-01 | 2012-10-15 | Medimmune Inc | Højpotente, rekombinante antistoffer og fremgangsmåde til fremstilling heraf |
| US6565849B2 (en) * | 2000-03-02 | 2003-05-20 | Medimmune, Inc. | Methods of enhancing activity of vaccines and vaccine compositions |
| DE60141274D1 (de) * | 2000-05-03 | 2010-03-25 | Medimmune Inc | Kombinationstherapie zur behandlung respiratorischer krankheiten mittels antikörper und anti-entzündungs wirkstoffe |
| AU5937901A (en) * | 2000-05-03 | 2001-11-12 | Med Immune Inc | Combination therapy of respiratory diseases using antibodies |
| WO2001089562A1 (en) * | 2000-05-25 | 2001-11-29 | Medimmune, Inc. | F-protein epitope-based vaccine for respiratory syncytial virus infection |
| EP1345625B1 (en) * | 2000-11-28 | 2013-07-17 | MedImmune, LLC | Methods of administering/dosing anti-rsv antibodies for prophylaxis and treatment |
| US20030232061A1 (en) * | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| WO2002057302A2 (en) * | 2001-01-19 | 2002-07-25 | Vironovative B.V. | A virus causing respiratory tract illness in susceptible mammals |
| EP2327418A1 (en) * | 2002-02-21 | 2011-06-01 | MedImmune, LLC | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from other viruses |
| US6605283B1 (en) * | 2002-11-01 | 2003-08-12 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleotide sequence for the Avian Metapneumovirus (Colorado) attachment glycoprotein gene |
| JP2006524511A (ja) * | 2003-04-25 | 2006-11-02 | メッドイミューン バクシーンズ,インコーポレイティド | メタニューモウイルス由来の異種抗原を含む組換えパラインフルエンザウイルス発現系およびワクチン |
| EP2494987A1 (en) * | 2003-04-25 | 2012-09-05 | MedImmune Vaccines, Inc. | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
| KR20070110924A (ko) * | 2005-03-10 | 2007-11-20 | 메드이뮨 백신즈 인코포레이티드 | 메타뉴모바이러스주 및 항원성 서열의 발현용 벡터 및 백신제제로서의 이의 용도 및 바이러스의 증식 방법 |
| WO2006110214A2 (en) * | 2005-04-08 | 2006-10-19 | Medimmune, Inc. | Antibodies against mammalian metapneumovirus |
-
2003
- 2003-07-25 TW TW092120397A patent/TW200501985A/zh unknown
- 2003-07-25 US US10/628,088 patent/US20040096451A1/en not_active Abandoned
- 2003-07-25 JP JP2004524853A patent/JP2005533861A/ja active Pending
- 2003-07-25 AU AU2003256823A patent/AU2003256823B9/en not_active Ceased
- 2003-07-25 WO PCT/US2003/023376 patent/WO2004010935A2/en not_active Ceased
- 2003-07-25 CA CA002494485A patent/CA2494485A1/en not_active Abandoned
- 2003-07-25 EP EP03771876A patent/EP1534327A4/en not_active Withdrawn
-
2007
- 2007-12-11 US US12/001,458 patent/US20100278813A1/en not_active Abandoned
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