JP2005532276A - 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ開裂部位に対する免疫応答を誘発する方法 - Google Patents

免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ開裂部位に対する免疫応答を誘発する方法 Download PDF

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JP2005532276A
JP2005532276A JP2003574670A JP2003574670A JP2005532276A JP 2005532276 A JP2005532276 A JP 2005532276A JP 2003574670 A JP2003574670 A JP 2003574670A JP 2003574670 A JP2003574670 A JP 2003574670A JP 2005532276 A JP2005532276 A JP 2005532276A
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aβpp
cleavage site
secretase cleavage
antigen
molecule
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ソロモン,ベカ
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ラモト アト テル−アヴィヴ ユニバーシティ リミテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0007Nervous system antigens; Prions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/64Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645Dendrimers; Multiple antigen peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2003574670A 2002-03-05 2003-03-04 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ開裂部位に対する免疫応答を誘発する方法 Pending JP2005532276A (ja)

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US36134402P 2002-03-05 2002-03-05
PCT/US2003/006388 WO2003076455A2 (en) 2002-03-05 2003-03-04 Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein

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JP2010114047A Division JP2010248197A (ja) 2002-03-05 2010-05-18 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法

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JP2003574670A Pending JP2005532276A (ja) 2002-03-05 2003-03-04 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ開裂部位に対する免疫応答を誘発する方法
JP2010114047A Pending JP2010248197A (ja) 2002-03-05 2010-05-18 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法
JP2013107244A Expired - Fee Related JP5717210B2 (ja) 2002-03-05 2013-05-21 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法

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JP2010114047A Pending JP2010248197A (ja) 2002-03-05 2010-05-18 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法
JP2013107244A Expired - Fee Related JP5717210B2 (ja) 2002-03-05 2013-05-21 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法

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EP (2) EP2292247A3 (enExample)
JP (3) JP2005532276A (enExample)
AU (1) AU2003225636A1 (enExample)
CA (1) CA2477675C (enExample)
ES (1) ES2392247T3 (enExample)
IL (3) IL163812A0 (enExample)
WO (1) WO2003076455A2 (enExample)

Cited By (6)

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JP2009523738A (ja) * 2006-01-20 2009-06-25 スターファーマ・プロプライエタリー・リミテッド 修飾高分子
JP2012509672A (ja) * 2008-11-24 2012-04-26 ラモト アト テル−アヴィヴ ユニバーシティ リミテッド 繊維状バクテリオファージを使用してパーキンソン病を処置するための方法
US8193248B2 (en) 2006-03-22 2012-06-05 Starpharma Pty Limited Contraceptive composition
US8258259B2 (en) 2005-10-25 2012-09-04 Starpharma Pty Limited Macromolecular compounds having controlled stoichiometry
US8420067B2 (en) 2006-08-11 2013-04-16 Starpharma Pty Ltd Targeted polylysine dendrimer therapeutic agent
US8568753B2 (en) 2005-10-18 2013-10-29 Starpharma Pty Limited Delivery system

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RU2442793C2 (ru) 2005-11-30 2012-02-20 Эбботт Лэборетриз АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ
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KR101397554B1 (ko) * 2007-11-09 2014-05-21 재단법인서울대학교산학협력재단 치매(알츠하이머 병)의 진단, 예방, 치료제 및 이들의스크리닝 방법
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US8617549B2 (en) 2009-09-11 2013-12-31 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Bispecific nanobodies as a therapeutic for alzheimer's disease
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
CN103298833B (zh) 2010-08-14 2015-12-16 Abbvie公司 β淀粉样蛋白结合蛋白
WO2015199247A1 (ja) * 2014-06-27 2015-12-30 日本たばこ産業株式会社 気分障害を診断、治療又は予防する方法
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN106349334A (zh) * 2015-07-15 2017-01-25 韩震 一种多肽化合物及其制备方法与应用
US10539578B2 (en) 2015-12-28 2020-01-21 Japan Tobacco Inc. Method for diagnosing, treating, or preventing mood disorders
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CN116063520A (zh) 2019-01-30 2023-05-05 真和制药有限公司 抗gal3抗体及其用途
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法

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US8568753B2 (en) 2005-10-18 2013-10-29 Starpharma Pty Limited Delivery system
US8258259B2 (en) 2005-10-25 2012-09-04 Starpharma Pty Limited Macromolecular compounds having controlled stoichiometry
US8586705B2 (en) 2005-10-25 2013-11-19 Starpharma Pty Limited Macromolecular compounds having controlled stoichiometry
JP2009523738A (ja) * 2006-01-20 2009-06-25 スターファーマ・プロプライエタリー・リミテッド 修飾高分子
US8337823B2 (en) 2006-01-20 2012-12-25 Starpharma Pty Limited Modified macromolecule
US8703116B2 (en) 2006-01-20 2014-04-22 Starpharma Pty Limited Modified macromolecule
US8193248B2 (en) 2006-03-22 2012-06-05 Starpharma Pty Limited Contraceptive composition
US8420067B2 (en) 2006-08-11 2013-04-16 Starpharma Pty Ltd Targeted polylysine dendrimer therapeutic agent
JP2012509672A (ja) * 2008-11-24 2012-04-26 ラモト アト テル−アヴィヴ ユニバーシティ リミテッド 繊維状バクテリオファージを使用してパーキンソン病を処置するための方法

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JP2010248197A (ja) 2010-11-04
CA2477675A1 (en) 2003-09-18
US20070172484A1 (en) 2007-07-26
US20110070249A1 (en) 2011-03-24
WO2003076455A2 (en) 2003-09-18
EP1480666B1 (en) 2012-06-13
WO2003076455A3 (en) 2004-04-08
EP2292247A3 (en) 2011-10-05
US7854931B2 (en) 2010-12-21
US20060034855A1 (en) 2006-02-16
EP1480666A2 (en) 2004-12-01
IL212752A (en) 2014-01-30
IL212752A0 (en) 2011-07-31
IL163812A0 (en) 2005-12-18
AU2003225636A1 (en) 2003-09-22
US8613928B2 (en) 2013-12-24
ES2392247T3 (es) 2012-12-07
US7494655B2 (en) 2009-02-24
JP5717210B2 (ja) 2015-05-13
EP2292247A2 (en) 2011-03-09
AU2003225636A8 (en) 2003-09-22
IL163812A (en) 2011-06-30
EP1480666A4 (en) 2006-06-07
CA2477675C (en) 2013-05-21
JP2013181034A (ja) 2013-09-12

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