AU2003225636A1 - Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein - Google Patents
Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor proteinInfo
- Publication number
- AU2003225636A1 AU2003225636A1 AU2003225636A AU2003225636A AU2003225636A1 AU 2003225636 A1 AU2003225636 A1 AU 2003225636A1 AU 2003225636 A AU2003225636 A AU 2003225636A AU 2003225636 A AU2003225636 A AU 2003225636A AU 2003225636 A1 AU2003225636 A1 AU 2003225636A1
- Authority
- AU
- Australia
- Prior art keywords
- inducing
- immune response
- cleavage site
- response against
- precursor protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title 1
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 title 1
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 title 1
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 title 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
- 238000003776 cleavage reaction Methods 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 230000003053 immunization Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000007017 scission Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36134402P | 2002-03-05 | 2002-03-05 | |
| US60/361,344 | 2002-03-05 | ||
| PCT/US2003/006388 WO2003076455A2 (en) | 2002-03-05 | 2003-03-04 | Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003225636A1 true AU2003225636A1 (en) | 2003-09-22 |
| AU2003225636A8 AU2003225636A8 (en) | 2003-09-22 |
Family
ID=27805031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003225636A Abandoned AU2003225636A1 (en) | 2002-03-05 | 2003-03-04 | Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7494655B2 (enExample) |
| EP (2) | EP2292247A3 (enExample) |
| JP (3) | JP2005532276A (enExample) |
| AU (1) | AU2003225636A1 (enExample) |
| CA (1) | CA2477675C (enExample) |
| ES (1) | ES2392247T3 (enExample) |
| IL (3) | IL163812A0 (enExample) |
| WO (1) | WO2003076455A2 (enExample) |
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| EP1398019A1 (de) | 2002-09-13 | 2004-03-17 | Cognis France S.A. | Verfahren zum Schutz und zur Modulation von Dermal Epidermal Junctions |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| WO2005033278A2 (en) * | 2003-09-30 | 2005-04-14 | Ludwig Institute For Cancer Research | In vivo efficacy of ny-eso-1 plus iscom |
| CN101048662A (zh) * | 2004-10-28 | 2007-10-03 | 三光纯药株式会社 | 阿尔茨海默氏病的检验方法及诊断试剂 |
| US8568753B2 (en) | 2005-10-18 | 2013-10-29 | Starpharma Pty Limited | Delivery system |
| ES2625109T3 (es) | 2005-10-25 | 2017-07-18 | Starpharma Pty Limited | Compuestos macromoleculares que tienen estequiometría controlada |
| CN101506236B (zh) | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| CN104524596B (zh) | 2006-01-20 | 2018-10-09 | 星药股份有限公司 | 经修饰的大分子 |
| EP1996209B1 (en) | 2006-03-22 | 2015-11-04 | Starpharma Pty Limited | Contraceptive composition |
| EP2054515B1 (en) * | 2006-07-21 | 2012-01-11 | Ramot at Tel-Aviv University Ltd. | Use of a phage displaying a peptide from an adhesion protein for treating a disease associated with intracellular formation of protein fibrillar inclusions or aggregates |
| WO2008017125A1 (en) | 2006-08-11 | 2008-02-14 | Starpharma Pty Ltd | Targeted polylysine dendrimer therapeutic agent |
| US8492341B2 (en) | 2006-11-28 | 2013-07-23 | Alzyme Pty Ltd. | Amyloid-β binding peptides |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| ES2554340T3 (es) | 2007-09-27 | 2015-12-18 | Japan Tobacco, Inc. | Factor implicado en la infección latente por herpesvirus, y su uso |
| GB0720912D0 (en) * | 2007-10-25 | 2007-12-05 | Univ Cardiff | Monoclonal Anitbody for APP |
| KR101397554B1 (ko) * | 2007-11-09 | 2014-05-21 | 재단법인서울대학교산학협력재단 | 치매(알츠하이머 병)의 진단, 예방, 치료제 및 이들의스크리닝 방법 |
| NZ586003A (en) | 2007-12-11 | 2012-08-31 | Glaxo Group Ltd | Antigen binding proteins that bind beta-amyloid peptide |
| WO2009124119A2 (en) * | 2008-04-01 | 2009-10-08 | The Trustes of Columbia University in the City of New York | Phosphodiesterase inhibitors and uses thereof |
| WO2009155538A1 (en) * | 2008-06-20 | 2009-12-23 | Merck & Co., Inc. | Compositions and methods of depleting amyloid-beta peptides from cerebrospinal fluid to treat alzheimer's disease |
| TW201014605A (en) | 2008-09-16 | 2010-04-16 | Genentech Inc | Methods for treating progressive multiple sclerosis |
| BRPI0921557A2 (pt) * | 2008-11-24 | 2019-09-24 | Univ Ramot | bacteriófago filamentoso, primeiro e segundo bacteriófago filamentoso para o uso no tratamento do mal de parkinson, composição farmacêutica, e , método para tratar um paciente |
| JP2012513464A (ja) | 2008-12-23 | 2012-06-14 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | ホスホジエステラーゼ阻害剤及びその使用 |
| US8617549B2 (en) | 2009-09-11 | 2013-12-31 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Bispecific nanobodies as a therapeutic for alzheimer's disease |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| CN103298833B (zh) | 2010-08-14 | 2015-12-16 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| WO2015199247A1 (ja) * | 2014-06-27 | 2015-12-30 | 日本たばこ産業株式会社 | 気分障害を診断、治療又は予防する方法 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN106349334A (zh) * | 2015-07-15 | 2017-01-25 | 韩震 | 一种多肽化合物及其制备方法与应用 |
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| CN116063520A (zh) | 2019-01-30 | 2023-05-05 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| CN116157151A (zh) | 2020-05-26 | 2023-05-23 | 真和制药有限公司 | 通过阻断半乳凝素-3治疗炎性疾病的方法 |
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-
2003
- 2003-03-04 EP EP10185941A patent/EP2292247A3/en not_active Withdrawn
- 2003-03-04 CA CA2477675A patent/CA2477675C/en not_active Expired - Fee Related
- 2003-03-04 JP JP2003574670A patent/JP2005532276A/ja active Pending
- 2003-03-04 WO PCT/US2003/006388 patent/WO2003076455A2/en not_active Ceased
- 2003-03-04 EP EP03744143A patent/EP1480666B1/en not_active Expired - Lifetime
- 2003-03-04 AU AU2003225636A patent/AU2003225636A1/en not_active Abandoned
- 2003-03-04 IL IL16381203A patent/IL163812A0/xx unknown
- 2003-03-04 ES ES03744143T patent/ES2392247T3/es not_active Expired - Lifetime
- 2003-03-04 US US10/506,665 patent/US7494655B2/en not_active Expired - Fee Related
-
2004
- 2004-08-30 IL IL163812A patent/IL163812A/en not_active IP Right Cessation
-
2007
- 2007-04-03 US US11/695,948 patent/US7854931B2/en not_active Expired - Fee Related
-
2010
- 2010-05-18 JP JP2010114047A patent/JP2010248197A/ja active Pending
- 2010-12-06 US US12/961,248 patent/US8613928B2/en not_active Expired - Fee Related
-
2011
- 2011-05-08 IL IL212752A patent/IL212752A/en not_active IP Right Cessation
-
2013
- 2013-05-21 JP JP2013107244A patent/JP5717210B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010248197A (ja) | 2010-11-04 |
| CA2477675A1 (en) | 2003-09-18 |
| US20070172484A1 (en) | 2007-07-26 |
| US20110070249A1 (en) | 2011-03-24 |
| WO2003076455A2 (en) | 2003-09-18 |
| EP1480666B1 (en) | 2012-06-13 |
| WO2003076455A3 (en) | 2004-04-08 |
| EP2292247A3 (en) | 2011-10-05 |
| US7854931B2 (en) | 2010-12-21 |
| US20060034855A1 (en) | 2006-02-16 |
| EP1480666A2 (en) | 2004-12-01 |
| IL212752A (en) | 2014-01-30 |
| IL212752A0 (en) | 2011-07-31 |
| IL163812A0 (en) | 2005-12-18 |
| JP2005532276A (ja) | 2005-10-27 |
| US8613928B2 (en) | 2013-12-24 |
| ES2392247T3 (es) | 2012-12-07 |
| US7494655B2 (en) | 2009-02-24 |
| JP5717210B2 (ja) | 2015-05-13 |
| EP2292247A2 (en) | 2011-03-09 |
| AU2003225636A8 (en) | 2003-09-22 |
| IL163812A (en) | 2011-06-30 |
| EP1480666A4 (en) | 2006-06-07 |
| CA2477675C (en) | 2013-05-21 |
| JP2013181034A (ja) | 2013-09-12 |
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