JP2005531607A5 - - Google Patents

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Publication number
JP2005531607A5
JP2005531607A5 JP2004510782A JP2004510782A JP2005531607A5 JP 2005531607 A5 JP2005531607 A5 JP 2005531607A5 JP 2004510782 A JP2004510782 A JP 2004510782A JP 2004510782 A JP2004510782 A JP 2004510782A JP 2005531607 A5 JP2005531607 A5 JP 2005531607A5
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JP
Japan
Prior art keywords
alkyl
aryl
group
heteroaryl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2004510782A
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English (en)
Japanese (ja)
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JP2005531607A (ja
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Publication date
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Priority claimed from PCT/US2003/017518 external-priority patent/WO2003103663A2/en
Publication of JP2005531607A publication Critical patent/JP2005531607A/ja
Publication of JP2005531607A5 publication Critical patent/JP2005531607A5/ja
Withdrawn legal-status Critical Current

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JP2004510782A 2002-06-05 2003-06-04 キナーゼ阻害剤として置換ピロリン Withdrawn JP2005531607A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38600202P 2002-06-05 2002-06-05
PCT/US2003/017518 WO2003103663A2 (en) 2002-06-05 2003-06-04 Substituted pyrrolines as kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2005531607A JP2005531607A (ja) 2005-10-20
JP2005531607A5 true JP2005531607A5 (https=) 2006-06-29

Family

ID=29736129

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004510782A Withdrawn JP2005531607A (ja) 2002-06-05 2003-06-04 キナーゼ阻害剤として置換ピロリン

Country Status (9)

Country Link
US (4) US7232906B2 (https=)
EP (1) EP1513520B1 (https=)
JP (1) JP2005531607A (https=)
AT (1) ATE409035T1 (https=)
AU (1) AU2003240517A1 (https=)
CA (1) CA2488798A1 (https=)
DE (1) DE60323749D1 (https=)
ES (1) ES2312785T3 (https=)
WO (1) WO2003103663A2 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL156339A0 (en) 2000-12-08 2004-01-04 Ortho Mcneil Pharm Inc Indazolyl-substituted pyrroline compounds as kinase inhibitors
ES2300573T3 (es) * 2002-05-08 2008-06-16 Janssen Pharmaceutica Nv Inhibidores de cinasa sustituidos con pirrolina.
DE60323749D1 (de) * 2002-06-05 2008-11-06 Janssen Pharmaceutica Nv Substituierte pyrroline als kinase inhibitoren
CA2520590A1 (en) * 2003-03-27 2004-11-04 Janssen Pharmaceutica, N.V. Substituted pyrroline kinase inhibitors
CA2529353A1 (en) * 2003-06-13 2005-01-06 Janssen Pharmaceutica N.V. Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors
BRPI0506939A (pt) * 2004-01-19 2007-06-12 Novartis Ag derivados de indolilmaleimida como inibidores de pkc
DE102004010194A1 (de) * 2004-03-02 2005-10-13 Aventis Pharma Deutschland Gmbh 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate, ihre Herstellung und Verwendung in Arzneimitteln
DE102004010207A1 (de) * 2004-03-02 2005-09-15 Aventis Pharma S.A. Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate
MX2007001155A (es) * 2004-07-29 2007-08-14 Creabilis Therapeutics Spa Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.
WO2006034207A2 (en) * 2004-09-17 2006-03-30 Vanderbilt University Use of gsk3 inhibitors in combination with radiation therapies
US8008320B2 (en) * 2004-12-08 2011-08-30 Johannes Gutenberg-Universitatis 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
US20080207594A1 (en) 2005-05-04 2008-08-28 Davelogen Aktiengesellschaft Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders
AU2006268908A1 (en) 2005-07-11 2007-01-18 Novartis Ag Indolylmaleimide derivatives
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
US20070088019A1 (en) * 2005-09-29 2007-04-19 Han-Cheng Zhang Macroheterocyclic compounds as kinase inhibitors
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
CA2658835A1 (en) * 2006-08-23 2008-02-28 Novartis Ag Use of pkc inhibitors in ocular diseases
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
ES2410955T3 (es) 2006-12-19 2013-07-04 Novartis Ag Derivados de indolilmaleimida como inhibidores de la quinasa
JP5576290B2 (ja) 2007-12-05 2014-08-20 ヨハネス、グーテンベルク−ウニフェルジテート、マインツ 白血病の管理における３−（インドリル）−または３−（アザインドリル）−４−アリールマレイミド誘導体の用途
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2343291A1 (en) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
EP2338486A1 (en) * 2009-12-18 2011-06-29 Johannes Gutenberg-Universität Mainz 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma
CA2799154A1 (en) 2010-05-12 2011-11-17 Abbvie Inc. Indazole inhibitors of kinase
EP2474541A1 (en) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
JP2016508962A (ja) * 2012-12-10 2016-03-24 セントジーン アーゲー ガンを予防および治療するためのマレイミド誘導体の使用
JP2016504299A (ja) * 2012-12-10 2016-02-12 セントジーン アーゲー 白血病を予防および治療するためのマレイミド誘導体の使用
EP3187495A1 (en) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment
JP7640458B2 (ja) 2018-10-05 2025-03-05 アンナプルナ バイオ インコーポレイテッド Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物
EP3920885A1 (en) 2019-02-08 2021-12-15 Frequency Therapeutics, Inc. Valproic acid compounds and wnt agonists for treating ear disorders

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
GB8904161D0 (en) * 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
DE4005969A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
ES2236702T3 (es) 1993-12-23 2005-07-16 Eli Lilly And Company Inhibidores de la proteina quinasa c.
EP0888339A4 (en) * 1996-03-20 2001-02-28 Lilly Co Eli SYNTHESIS OF INDOLYLMALEINIMIDES
SE9603283D0 (sv) 1996-09-10 1996-09-10 Astra Ab New compounds
AU2548699A (en) 1998-02-23 1999-09-06 Rei Asakai Cell death inhibitors
CA2338866A1 (en) 1998-07-30 2000-02-10 Japan Tobacco Inc. Disubstituted maleimide compound and pharmaceutical use thereof
ATE284387T1 (de) 1998-10-08 2004-12-15 Smithkline Beecham Plc 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3)
YU4403A (sh) * 2000-07-27 2006-05-25 F. Hoffmann-La Roche Ag. Derivati 3-indolil-4-fenil-1h-pirol-2,5-diona, kao inhibitori glikogen sintaza kinaze-3 beta
AU2002221810B2 (en) 2000-11-07 2005-06-23 Novartis Ag Indolylmaleimide derivatives as protein kinase C inhibitors
IL156339A0 (en) * 2000-12-08 2004-01-04 Ortho Mcneil Pharm Inc Indazolyl-substituted pyrroline compounds as kinase inhibitors
ES2300573T3 (es) * 2002-05-08 2008-06-16 Janssen Pharmaceutica Nv Inhibidores de cinasa sustituidos con pirrolina.
MXPA04012188A (es) * 2002-06-05 2005-07-25 Johnson & Johnson Derivados de bisindolil-maleimida como inhibidores de cinasa.
DE60323749D1 (de) * 2002-06-05 2008-11-06 Janssen Pharmaceutica Nv Substituierte pyrroline als kinase inhibitoren
CA2520590A1 (en) * 2003-03-27 2004-11-04 Janssen Pharmaceutica, N.V. Substituted pyrroline kinase inhibitors
CA2529353A1 (en) * 2003-06-13 2005-01-06 Janssen Pharmaceutica N.V. Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors

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