JP2005531607A5 - - Google Patents
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- Publication number
- JP2005531607A5 JP2005531607A5 JP2004510782A JP2004510782A JP2005531607A5 JP 2005531607 A5 JP2005531607 A5 JP 2005531607A5 JP 2004510782 A JP2004510782 A JP 2004510782A JP 2004510782 A JP2004510782 A JP 2004510782A JP 2005531607 A5 JP2005531607 A5 JP 2005531607A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- group
- heteroaryl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C*(C)(C(C(C1C=CC=*=CC1)=C1C2=**(*)C3/C=C/C=C/C2=CC3)=O)C1=O Chemical compound C*(C)(C(C(C1C=CC=*=CC1)=C1C2=**(*)C3/C=C/C=C/C2=CC3)=O)C1=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38600202P | 2002-06-05 | 2002-06-05 | |
| PCT/US2003/017518 WO2003103663A2 (en) | 2002-06-05 | 2003-06-04 | Substituted pyrrolines as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531607A JP2005531607A (ja) | 2005-10-20 |
| JP2005531607A5 true JP2005531607A5 (https=) | 2006-06-29 |
Family
ID=29736129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004510782A Withdrawn JP2005531607A (ja) | 2002-06-05 | 2003-06-04 | キナーゼ阻害剤として置換ピロリン |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7232906B2 (https=) |
| EP (1) | EP1513520B1 (https=) |
| JP (1) | JP2005531607A (https=) |
| AT (1) | ATE409035T1 (https=) |
| AU (1) | AU2003240517A1 (https=) |
| CA (1) | CA2488798A1 (https=) |
| DE (1) | DE60323749D1 (https=) |
| ES (1) | ES2312785T3 (https=) |
| WO (1) | WO2003103663A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0116468A (pt) * | 2000-12-08 | 2004-06-29 | Ortho Mcneil Pharm Inc | Compostos de pirrolina substituìda por indazolila como inibidores de cinase |
| WO2003095452A1 (en) * | 2002-05-08 | 2003-11-20 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
| JP2005531607A (ja) * | 2002-06-05 | 2005-10-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤として置換ピロリン |
| CA2520590A1 (en) * | 2003-03-27 | 2004-11-04 | Janssen Pharmaceutica, N.V. | Substituted pyrroline kinase inhibitors |
| EP1654255B1 (en) * | 2003-06-13 | 2008-08-27 | Janssen Pharmaceutica N.V. | Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors |
| US7691861B2 (en) * | 2004-01-19 | 2010-04-06 | Novartis Ag | Indolymaleimide derivatives |
| DE102004010194A1 (de) * | 2004-03-02 | 2005-10-13 | Aventis Pharma Deutschland Gmbh | 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate, ihre Herstellung und Verwendung in Arzneimitteln |
| DE102004010207A1 (de) * | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| US8771754B2 (en) * | 2004-09-17 | 2014-07-08 | Vanderbilt University | Use of GSK3 inhibitors in combination with radiation therapies |
| WO2006061212A1 (en) * | 2004-12-08 | 2006-06-15 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
| US20080207594A1 (en) | 2005-05-04 | 2008-08-28 | Davelogen Aktiengesellschaft | Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders |
| MX2008000463A (es) * | 2005-07-11 | 2008-03-11 | Novartis Ag | Derivados de indolil-maleimida. |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009510085A (ja) * | 2005-09-29 | 2009-03-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼインヒビターとしての大型複素環式化合物 |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| CA2658835A1 (en) * | 2006-08-23 | 2008-02-28 | Novartis Ag | Use of pkc inhibitors in ocular diseases |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| ES2410955T3 (es) | 2006-12-19 | 2013-07-04 | Novartis Ag | Derivados de indolilmaleimida como inhibidores de la quinasa |
| AU2008333215B2 (en) | 2007-12-05 | 2013-06-13 | Johannes Gutenberg-Universitat Mainz | Use of 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives in leukemia management |
| FR2927075A1 (fr) * | 2008-02-04 | 2009-08-07 | Centre Nat Rech Scient | Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2343291A1 (en) * | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| EP2338486A1 (en) | 2009-12-18 | 2011-06-29 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma |
| MX2012013197A (es) | 2010-05-12 | 2013-04-03 | Abbvie Inc | Inhibidores de indazol de cinasa. |
| EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| EP2928465B1 (en) | 2012-12-10 | 2020-11-18 | Centogene GmbH | Use of maleimide derivatives for preventing and treating cancer |
| WO2014090398A1 (en) * | 2012-12-10 | 2014-06-19 | Centogene Ag | Use of maleimide derivatives for preventing and treating leukemia |
| EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| MX2021003904A (es) | 2018-10-05 | 2021-10-26 | Annapurna Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj. |
| EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227850A (en) | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| GB8904161D0 (en) | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
| DE4005969A1 (de) | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US5624949A (en) | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| CA2179650C (en) | 1993-12-23 | 2007-10-30 | William Francis Heath, Jr. | Bisindolemaleimides and their use as protein kinase c inhibitors |
| US5919946A (en) | 1996-03-20 | 1999-07-06 | Eli Lilly And Company | Synthesis of indolylmaleimides |
| SE9603283D0 (sv) | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
| AU2548699A (en) | 1998-02-23 | 1999-09-06 | Rei Asakai | Cell death inhibitors |
| ID27510A (id) | 1998-07-30 | 2001-04-12 | Japan Tobacco Inc | Senyawa malimida tersubstitusi dan penggunaan farmasinya |
| AU6111699A (en) | 1998-10-08 | 2000-05-01 | Smithkline Beecham Plc | Novel method and compounds |
| CA2417277A1 (en) * | 2000-07-27 | 2002-02-07 | F. Hoffmann-La Roche Ag | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3.beta. |
| EP2070921A1 (en) * | 2000-11-07 | 2009-06-17 | Novartis Ag | Indolylmaleimide derivatives as protein kinase c inhibitors |
| BR0116468A (pt) | 2000-12-08 | 2004-06-29 | Ortho Mcneil Pharm Inc | Compostos de pirrolina substituìda por indazolila como inibidores de cinase |
| WO2003095452A1 (en) | 2002-05-08 | 2003-11-20 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
| JP2005531607A (ja) * | 2002-06-05 | 2005-10-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤として置換ピロリン |
| EP1513830A1 (en) | 2002-06-05 | 2005-03-16 | Janssen Pharmaceutica N.V. | Bisindolyl-maleimid derivatives as kinase inhibitors |
| CA2520590A1 (en) | 2003-03-27 | 2004-11-04 | Janssen Pharmaceutica, N.V. | Substituted pyrroline kinase inhibitors |
| EP1654255B1 (en) | 2003-06-13 | 2008-08-27 | Janssen Pharmaceutica N.V. | Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors |
-
2003
- 2003-06-04 JP JP2004510782A patent/JP2005531607A/ja not_active Withdrawn
- 2003-06-04 EP EP03731528A patent/EP1513520B1/en not_active Expired - Lifetime
- 2003-06-04 ES ES03731528T patent/ES2312785T3/es not_active Expired - Lifetime
- 2003-06-04 AU AU2003240517A patent/AU2003240517A1/en not_active Abandoned
- 2003-06-04 AT AT03731528T patent/ATE409035T1/de not_active IP Right Cessation
- 2003-06-04 WO PCT/US2003/017518 patent/WO2003103663A2/en not_active Ceased
- 2003-06-04 DE DE60323749T patent/DE60323749D1/de not_active Expired - Fee Related
- 2003-06-04 US US10/454,561 patent/US7232906B2/en not_active Expired - Fee Related
- 2003-06-04 CA CA002488798A patent/CA2488798A1/en not_active Abandoned
-
2007
- 2007-05-08 US US11/800,912 patent/US7608634B2/en not_active Expired - Fee Related
- 2007-05-08 US US11/800,878 patent/US7759380B2/en not_active Expired - Fee Related
-
2010
- 2010-05-25 US US12/787,034 patent/US20100240650A1/en not_active Abandoned
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