CA2488798A1 - Substituted pyrrolines as kinase inhibitors - Google Patents
Substituted pyrrolines as kinase inhibitors Download PDFInfo
- Publication number
- CA2488798A1 CA2488798A1 CA002488798A CA2488798A CA2488798A1 CA 2488798 A1 CA2488798 A1 CA 2488798A1 CA 002488798 A CA002488798 A CA 002488798A CA 2488798 A CA2488798 A CA 2488798A CA 2488798 A1 CA2488798 A1 CA 2488798A1
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- Prior art keywords
- alkyl
- 8alkyl
- aryl
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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| US38600202P | 2002-06-05 | 2002-06-05 | |
| US60/386,002 | 2002-06-05 | ||
| PCT/US2003/017518 WO2003103663A2 (en) | 2002-06-05 | 2003-06-04 | Substituted pyrrolines as kinase inhibitors |
Publications (1)
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| CA2488798A1 true CA2488798A1 (en) | 2003-12-18 |
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| ES (1) | ES2312785T3 (https=) |
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| IL156339A0 (en) | 2000-12-08 | 2004-01-04 | Ortho Mcneil Pharm Inc | Indazolyl-substituted pyrroline compounds as kinase inhibitors |
| ES2300573T3 (es) * | 2002-05-08 | 2008-06-16 | Janssen Pharmaceutica Nv | Inhibidores de cinasa sustituidos con pirrolina. |
| DE60323749D1 (de) * | 2002-06-05 | 2008-11-06 | Janssen Pharmaceutica Nv | Substituierte pyrroline als kinase inhibitoren |
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| CA2529353A1 (en) * | 2003-06-13 | 2005-01-06 | Janssen Pharmaceutica N.V. | Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors |
| BRPI0506939A (pt) * | 2004-01-19 | 2007-06-12 | Novartis Ag | derivados de indolilmaleimida como inibidores de pkc |
| DE102004010194A1 (de) * | 2004-03-02 | 2005-10-13 | Aventis Pharma Deutschland Gmbh | 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate, ihre Herstellung und Verwendung in Arzneimitteln |
| DE102004010207A1 (de) * | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| WO2006034207A2 (en) * | 2004-09-17 | 2006-03-30 | Vanderbilt University | Use of gsk3 inhibitors in combination with radiation therapies |
| US8008320B2 (en) * | 2004-12-08 | 2011-08-30 | Johannes Gutenberg-Universitatis | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
| US20080207594A1 (en) | 2005-05-04 | 2008-08-28 | Davelogen Aktiengesellschaft | Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders |
| AU2006268908A1 (en) | 2005-07-11 | 2007-01-18 | Novartis Ag | Indolylmaleimide derivatives |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| US20070088019A1 (en) * | 2005-09-29 | 2007-04-19 | Han-Cheng Zhang | Macroheterocyclic compounds as kinase inhibitors |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| CA2658835A1 (en) * | 2006-08-23 | 2008-02-28 | Novartis Ag | Use of pkc inhibitors in ocular diseases |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| ES2410955T3 (es) | 2006-12-19 | 2013-07-04 | Novartis Ag | Derivados de indolilmaleimida como inhibidores de la quinasa |
| JP5576290B2 (ja) | 2007-12-05 | 2014-08-20 | ヨハネス、グーテンベルク−ウニフェルジテート、マインツ | 白血病の管理における３−（インドリル）−または３−（アザインドリル）−４−アリールマレイミド誘導体の用途 |
| FR2927075A1 (fr) * | 2008-02-04 | 2009-08-07 | Centre Nat Rech Scient | Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2343291A1 (en) | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| EP2338486A1 (en) * | 2009-12-18 | 2011-06-29 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma |
| CA2799154A1 (en) | 2010-05-12 | 2011-11-17 | Abbvie Inc. | Indazole inhibitors of kinase |
| EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| JP2016508962A (ja) * | 2012-12-10 | 2016-03-24 | セントジーン アーゲー | ガンを予防および治療するためのマレイミド誘導体の使用 |
| JP2016504299A (ja) * | 2012-12-10 | 2016-02-12 | セントジーン アーゲー | 白血病を予防および治療するためのマレイミド誘導体の使用 |
| EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| JP7640458B2 (ja) | 2018-10-05 | 2025-03-05 | アンナプルナ バイオ インコーポレイテッド | Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物 |
| EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
Family Cites Families (18)
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| CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| GB8904161D0 (en) * | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
| DE4005969A1 (de) | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| ES2236702T3 (es) | 1993-12-23 | 2005-07-16 | Eli Lilly And Company | Inhibidores de la proteina quinasa c. |
| EP0888339A4 (en) * | 1996-03-20 | 2001-02-28 | Lilly Co Eli | SYNTHESIS OF INDOLYLMALEINIMIDES |
| SE9603283D0 (sv) | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
| AU2548699A (en) | 1998-02-23 | 1999-09-06 | Rei Asakai | Cell death inhibitors |
| CA2338866A1 (en) | 1998-07-30 | 2000-02-10 | Japan Tobacco Inc. | Disubstituted maleimide compound and pharmaceutical use thereof |
| ATE284387T1 (de) | 1998-10-08 | 2004-12-15 | Smithkline Beecham Plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
| YU4403A (sh) * | 2000-07-27 | 2006-05-25 | F. Hoffmann-La Roche Ag. | Derivati 3-indolil-4-fenil-1h-pirol-2,5-diona, kao inhibitori glikogen sintaza kinaze-3 beta |
| AU2002221810B2 (en) | 2000-11-07 | 2005-06-23 | Novartis Ag | Indolylmaleimide derivatives as protein kinase C inhibitors |
| IL156339A0 (en) * | 2000-12-08 | 2004-01-04 | Ortho Mcneil Pharm Inc | Indazolyl-substituted pyrroline compounds as kinase inhibitors |
| ES2300573T3 (es) * | 2002-05-08 | 2008-06-16 | Janssen Pharmaceutica Nv | Inhibidores de cinasa sustituidos con pirrolina. |
| MXPA04012188A (es) * | 2002-06-05 | 2005-07-25 | Johnson & Johnson | Derivados de bisindolil-maleimida como inhibidores de cinasa. |
| DE60323749D1 (de) * | 2002-06-05 | 2008-11-06 | Janssen Pharmaceutica Nv | Substituierte pyrroline als kinase inhibitoren |
| CA2520590A1 (en) * | 2003-03-27 | 2004-11-04 | Janssen Pharmaceutica, N.V. | Substituted pyrroline kinase inhibitors |
| CA2529353A1 (en) * | 2003-06-13 | 2005-01-06 | Janssen Pharmaceutica N.V. | Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors |
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2007
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2010
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Also Published As
| Publication number | Publication date |
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| DE60323749D1 (de) | 2008-11-06 |
| US20070213387A1 (en) | 2007-09-13 |
| WO2003103663A3 (en) | 2004-07-08 |
| AU2003240517A1 (en) | 2003-12-22 |
| US7608634B2 (en) | 2009-10-27 |
| US7759380B2 (en) | 2010-07-20 |
| WO2003103663A2 (en) | 2003-12-18 |
| EP1513520B1 (en) | 2008-09-24 |
| ES2312785T3 (es) | 2009-03-01 |
| US20040054180A1 (en) | 2004-03-18 |
| US20100240650A1 (en) | 2010-09-23 |
| ATE409035T1 (de) | 2008-10-15 |
| US20070213386A1 (en) | 2007-09-13 |
| US7232906B2 (en) | 2007-06-19 |
| JP2005531607A (ja) | 2005-10-20 |
| EP1513520A2 (en) | 2005-03-16 |
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| FZDE | Discontinued |