JP2005528384A - 増殖性細胞においてアポトーシスを誘導するための化合物および方法 - Google Patents

増殖性細胞においてアポトーシスを誘導するための化合物および方法 Download PDF

Info

Publication number
JP2005528384A
JP2005528384A JP2003583314A JP2003583314A JP2005528384A JP 2005528384 A JP2005528384 A JP 2005528384A JP 2003583314 A JP2003583314 A JP 2003583314A JP 2003583314 A JP2003583314 A JP 2003583314A JP 2005528384 A JP2005528384 A JP 2005528384A
Authority
JP
Japan
Prior art keywords
phenyl
trifluoromethyl
pyrazol
cancer
benzenecarboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003583314A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005528384A5 (enExample
Inventor
チン−シン チェン，
シェキン ソン，
ホ−ピ リン，
Original Assignee
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション filed Critical ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
Publication of JP2005528384A publication Critical patent/JP2005528384A/ja
Publication of JP2005528384A5 publication Critical patent/JP2005528384A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2003583314A 2002-04-08 2003-04-08 増殖性細胞においてアポトーシスを誘導するための化合物および方法 Pending JP2005528384A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37066402P 2002-04-08 2002-04-08
PCT/US2003/010738 WO2003086287A2 (en) 2002-04-08 2003-04-08 Compounds and methods for inducing apoptosis in proliferating cells

Publications (2)

Publication Number Publication Date
JP2005528384A true JP2005528384A (ja) 2005-09-22
JP2005528384A5 JP2005528384A5 (enExample) 2006-05-25

Family

ID=29250564

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003583314A Pending JP2005528384A (ja) 2002-04-08 2003-04-08 増殖性細胞においてアポトーシスを誘導するための化合物および方法

Country Status (6)

Country Link
US (1) US7026346B2 (enExample)
EP (1) EP1499597A4 (enExample)
JP (1) JP2005528384A (enExample)
AU (1) AU2003230836A1 (enExample)
CA (1) CA2485679A1 (enExample)
WO (1) WO2003086287A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010522763A (ja) * 2007-03-26 2010-07-08 ユニヴァーシティー オブ サザン カリフォルニア Ｅｒストレスを刺激することによりアポトーシスを誘導するための方法および化合物
JP2011225575A (ja) * 2003-03-07 2011-11-10 Merck Patent Gmbh フルオレンおよびアリール基を含むモノマー、オリゴマーおよびポリマー
JP2016527256A (ja) * 2013-07-29 2016-09-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ １，３−二置換シクロペンタン誘導体

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060142368A1 (en) * 2003-04-08 2006-06-29 Ching-Shih Chen Compounds and methods for inducing apoptosis in proliferating cells
US20060079566A1 (en) * 2003-10-03 2006-04-13 Ching-Shih Chen PDK-1/Akt signaling inhibitors
EP1696907B1 (en) * 2003-10-03 2013-04-17 The Ohio State University Research Foundation Pdk-1/akt signaling inhibitors
WO2005037271A2 (en) * 2003-10-17 2005-04-28 Tanabe Seiyaku Co., Ltd. Large conductance calcium-activated k channel opener
CA2613522A1 (en) 2005-06-27 2007-01-04 Exelixis, Inc. Imidazole based lxr modulators
US8426355B2 (en) * 2006-03-15 2013-04-23 Theralogics, Inc. Methods of treating muscular wasting diseases using NF-κB activation inhibitors
JP5399262B2 (ja) 2006-12-08 2014-01-29 エグゼリクシス パテント カンパニー エルエルシー Ｌｘｒおよびｆｘｒのモジュレーター
US8039502B2 (en) 2007-07-24 2011-10-18 The Ohio State University Research Foundation Anti-infective agents against intracellular pathogens
US20120108823A1 (en) * 2009-04-22 2012-05-03 The Ohio State University Research Foundation Anti-francisella agents
CA2818871A1 (en) 2010-11-24 2012-05-31 The Ohio State University Research Foundation Integrin-linked kinase inhibitors
CN104177294A (zh) * 2014-08-27 2014-12-03 齐鲁天和惠世制药有限公司 一种塞来昔布的制备方法
US20190290656A1 (en) 2015-12-30 2019-09-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Pt(iv) prodrugs
EP4663242A1 (en) 2024-06-11 2025-12-17 Helmholtz-Zentrum für Infektionsforschung GmbH Targeting the energy coupling factor (ecf) transporters as novel antimicrobial target

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09506350A (ja) * 1993-11-30 1997-06-24 ジー．ディー．サール アンド カンパニー 炎症の治療のための置換ピラゾリルベンゼンスルホンアミド
JPH11514991A (ja) * 1995-09-29 1999-12-21 ジー．ディー．サール アンド カンパニー 動物医療で使用するための置換ピラゾリルベンゼンスルホンアミド化合物
JP2005508320A (ja) * 2001-09-18 2005-03-31 オンコノバ・セラピューティックス・インコーポレーテッド １，５−ジアリール−３−置換ピラゾールの調製方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550147A (en) * 1992-02-05 1996-08-27 Fujisawa Pharmaceutical Co., Ltd. Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US5972986A (en) * 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
US6025353A (en) * 1997-11-19 2000-02-15 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09506350A (ja) * 1993-11-30 1997-06-24 ジー．ディー．サール アンド カンパニー 炎症の治療のための置換ピラゾリルベンゼンスルホンアミド
JPH11514991A (ja) * 1995-09-29 1999-12-21 ジー．ディー．サール アンド カンパニー 動物医療で使用するための置換ピラゾリルベンゼンスルホンアミド化合物
JP2005508320A (ja) * 2001-09-18 2005-03-31 オンコノバ・セラピューティックス・インコーポレーテッド １，５−ジアリール−３−置換ピラゾールの調製方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011225575A (ja) * 2003-03-07 2011-11-10 Merck Patent Gmbh フルオレンおよびアリール基を含むモノマー、オリゴマーおよびポリマー
JP2010522763A (ja) * 2007-03-26 2010-07-08 ユニヴァーシティー オブ サザン カリフォルニア Ｅｒストレスを刺激することによりアポトーシスを誘導するための方法および化合物
JP2014208663A (ja) * 2007-03-26 2014-11-06 ユニヴァーシティー オブ サザン カリフォルニア Ｅｒストレスを刺激することによりアポトーシスを誘導するための方法および化合物
US9486461B2 (en) 2007-03-26 2016-11-08 University Of Southern California Methods and compositions for inducing apoptosis by stimulating ER stress
JP2017226673A (ja) * 2007-03-26 2017-12-28 ユニヴァーシティー オブ サザン カリフォルニア Ｅｒストレスを刺激することによりアポトーシスを誘導するための方法および化合物
JP2016527256A (ja) * 2013-07-29 2016-09-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ １，３−二置換シクロペンタン誘導体

Also Published As

Publication number Publication date
US7026346B2 (en) 2006-04-11
WO2003086287A2 (en) 2003-10-23
CA2485679A1 (en) 2003-10-23
AU2003230836A1 (en) 2003-10-27
WO2003086287A3 (en) 2004-03-25
EP1499597A2 (en) 2005-01-26
US20030236294A1 (en) 2003-12-25
EP1499597A4 (en) 2006-01-25

Similar Documents

Publication Publication Date Title
US7098336B2 (en) FXR NR1H4 nuclear receptor binding compounds
JP2005528384A (ja) 増殖性細胞においてアポトーシスを誘導するための化合物および方法
US5780496A (en) Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions
KR102166665B1 (ko) 벤질리덴구아니딘 유도체들 및 단백질 미스폴딩 질환들의 치료를 위한 치료적 용도
US20050261319A1 (en) Novel 2-amino-4-quinazolinones and 2-amino-4-oxoquinazolones as LXR nuclear receptor binding compounds with partial agonistic properties
HU222181B1 (hu) Pirrolo/2,3-d/pirimidinek, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
KR20090088430A (ko) 술폰아미드 및 약제로서 이들의 용도
JP7062643B2 (ja) 化合物およびｐｄｅ４活性剤としてのそれらの使用
CA2710461A1 (en) Benzimidazole compounds
US9061994B1 (en) Materials and methods useful to induce vacuolization, cell death, or a combination thereof
JP4799562B2 (ja) 置換ｎ−スルホニルアミノベンジル−２−フェノキシアセトアミド化合物
Wu et al. The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions
JP5153621B2 (ja) Ｓｈｐ−２阻害剤、それらを含む薬剤組成物及びホスファターゼ媒介性疾患を治療するためのその使用
EP1696907B1 (en) Pdk-1/akt signaling inhibitors
US7507742B2 (en) Spirocyclic derivatives
US11084789B2 (en) Mast-cell modulators and uses thereof
US20060142368A1 (en) Compounds and methods for inducing apoptosis in proliferating cells
US11345692B1 (en) 3-vinylquinolines as cancer cells inhibitors
EP2642856B1 (en) Integrin-linked kinase inhibitors
JP2022530244A (ja) Ｇｒｋ２タンパク質インヒビター化合物および同化合物を含む医薬組成物
TW202513542A (zh) 用於治療及/或預防腫瘤或細胞增生及纖維化疾病之吲哚啉衍生物
CN102020588B (zh) 具有组蛋白去乙酰化酶抑制活性的三环化合物、其制备方法及应用
JP2003207507A (ja) スクリーニング方法
WO2017152570A1 (zh) 新型gvs系列化合物及其用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060330

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060330

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091102

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100326