JP2005528384A5 - - Google Patents
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- Publication number
- JP2005528384A5 JP2005528384A5 JP2003583314A JP2003583314A JP2005528384A5 JP 2005528384 A5 JP2005528384 A5 JP 2005528384A5 JP 2003583314 A JP2003583314 A JP 2003583314A JP 2003583314 A JP2003583314 A JP 2003583314A JP 2005528384 A5 JP2005528384 A5 JP 2005528384A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- trifluoromethyl
- pyrazol
- cancer
- benzenecarboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 C 1 -C 4 alkyl Chemical group 0.000 claims 150
- 150000001875 compounds Chemical class 0.000 claims 21
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 20
- 206010028980 Neoplasm Diseases 0.000 claims 18
- 201000011510 cancer Diseases 0.000 claims 18
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 206010060862 Prostate cancer Diseases 0.000 claims 12
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 150000003857 carboxamides Chemical class 0.000 claims 7
- 125000001188 haloalkyl group Chemical group 0.000 claims 7
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 6
- MNCMBBIFTVWHIP-UHFFFAOYSA-N 1-anthracen-9-yl-2,2,2-trifluoroethanone Chemical group C1=CC=C2C(C(=O)C(F)(F)F)=C(C=CC=C3)C3=CC2=C1 MNCMBBIFTVWHIP-UHFFFAOYSA-N 0.000 claims 5
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 5
- 230000002062 proliferating effect Effects 0.000 claims 5
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 4
- 230000006907 apoptotic process Effects 0.000 claims 4
- 201000011199 bladder lymphoma Diseases 0.000 claims 4
- 201000007455 central nervous system cancer Diseases 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 208000032839 leukemia Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 150000003254 radicals Chemical class 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 201000005112 urinary bladder cancer Diseases 0.000 claims 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 3
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 150000005840 aryl radicals Chemical group 0.000 claims 3
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 3
- 235000010290 biphenyl Nutrition 0.000 claims 3
- 239000004305 biphenyl Substances 0.000 claims 3
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims 3
- 125000006492 halo alkyl aryl group Chemical group 0.000 claims 3
- 125000003106 haloaryl group Chemical group 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 150000003456 sulfonamides Chemical class 0.000 claims 3
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 2
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 2
- 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- 239000003098 androgen Substances 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- NTFOSUUWGCDXEF-UHFFFAOYSA-N 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide Chemical compound CC1=CC=C(C)C(C=2N(N=C(C=2)C(F)(F)F)C=2C=CC(=CC=2)S(N)(=O)=O)=C1 NTFOSUUWGCDXEF-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37066402P | 2002-04-08 | 2002-04-08 | |
| PCT/US2003/010738 WO2003086287A2 (en) | 2002-04-08 | 2003-04-08 | Compounds and methods for inducing apoptosis in proliferating cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005528384A JP2005528384A (ja) | 2005-09-22 |
| JP2005528384A5 true JP2005528384A5 (enExample) | 2006-05-25 |
Family
ID=29250564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583314A Pending JP2005528384A (ja) | 2002-04-08 | 2003-04-08 | 増殖性細胞においてアポトーシスを誘導するための化合物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7026346B2 (enExample) |
| EP (1) | EP1499597A4 (enExample) |
| JP (1) | JP2005528384A (enExample) |
| AU (1) | AU2003230836A1 (enExample) |
| CA (1) | CA2485679A1 (enExample) |
| WO (1) | WO2003086287A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE432306T1 (de) * | 2003-03-07 | 2009-06-15 | Merck Patent Gmbh | Fluorene und arylgruppen enthaltende mono-, oligo-und polymere |
| US20060142368A1 (en) * | 2003-04-08 | 2006-06-29 | Ching-Shih Chen | Compounds and methods for inducing apoptosis in proliferating cells |
| US20060079566A1 (en) * | 2003-10-03 | 2006-04-13 | Ching-Shih Chen | PDK-1/Akt signaling inhibitors |
| EP1696907B1 (en) * | 2003-10-03 | 2013-04-17 | The Ohio State University Research Foundation | Pdk-1/akt signaling inhibitors |
| WO2005037271A2 (en) * | 2003-10-17 | 2005-04-28 | Tanabe Seiyaku Co., Ltd. | Large conductance calcium-activated k channel opener |
| CA2613522A1 (en) | 2005-06-27 | 2007-01-04 | Exelixis, Inc. | Imidazole based lxr modulators |
| US8426355B2 (en) * | 2006-03-15 | 2013-04-23 | Theralogics, Inc. | Methods of treating muscular wasting diseases using NF-κB activation inhibitors |
| JP5399262B2 (ja) | 2006-12-08 | 2014-01-29 | エグゼリクシス パテント カンパニー エルエルシー | Ｌｘｒおよびｆｘｒのモジュレーター |
| CN101918843A (zh) | 2007-03-26 | 2010-12-15 | 南加州大学 | 用于通过刺激内质网应激来诱导细胞凋亡的方法和组合物 |
| US8039502B2 (en) | 2007-07-24 | 2011-10-18 | The Ohio State University Research Foundation | Anti-infective agents against intracellular pathogens |
| US20120108823A1 (en) * | 2009-04-22 | 2012-05-03 | The Ohio State University Research Foundation | Anti-francisella agents |
| CA2818871A1 (en) | 2010-11-24 | 2012-05-31 | The Ohio State University Research Foundation | Integrin-linked kinase inhibitors |
| SG11201600726QA (en) * | 2013-07-29 | 2016-03-30 | Merck Patent Gmbh | 1,3-disubstituted cyclopentane derivatives |
| CN104177294A (zh) * | 2014-08-27 | 2014-12-03 | 齐鲁天和惠世制药有限公司 | 一种塞来昔布的制备方法 |
| US20190290656A1 (en) | 2015-12-30 | 2019-09-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Pt(iv) prodrugs |
| EP4663242A1 (en) | 2024-06-11 | 2025-12-17 | Helmholtz-Zentrum für Infektionsforschung GmbH | Targeting the energy coupling factor (ecf) transporters as novel antimicrobial target |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550147A (en) * | 1992-02-05 | 1996-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| KR100263817B1 (ko) * | 1993-11-30 | 2000-08-16 | 윌리암스 로저 에이 | 염증치료용 치환 피라졸일벤젠술폰아미드 |
| US5756529A (en) * | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| US5972986A (en) * | 1997-10-14 | 1999-10-26 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia |
| US6025353A (en) * | 1997-11-19 | 2000-02-15 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents |
| NZ532346A (en) * | 2001-09-18 | 2005-10-28 | Onconova Therapeutics Inc | Processes for the preparation of 1,5-diaryl-3-substituted-pyrazoles |
-
2003
- 2003-04-08 AU AU2003230836A patent/AU2003230836A1/en not_active Abandoned
- 2003-04-08 JP JP2003583314A patent/JP2005528384A/ja active Pending
- 2003-04-08 CA CA002485679A patent/CA2485679A1/en not_active Abandoned
- 2003-04-08 WO PCT/US2003/010738 patent/WO2003086287A2/en not_active Ceased
- 2003-04-08 EP EP03723936A patent/EP1499597A4/en not_active Withdrawn
- 2003-04-08 US US10/409,502 patent/US7026346B2/en not_active Expired - Fee Related
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