JP2007527408A5 - - Google Patents

Info

Publication number

JP2007527408A5

JP2007527408A5 JP2006534245A JP2006534245A JP2007527408A5 JP 2007527408 A5 JP2007527408 A5 JP 2007527408A5 JP 2006534245 A JP2006534245 A JP 2006534245A JP 2006534245 A JP2006534245 A JP 2006534245A JP 2007527408 A5 JP2007527408 A5 JP 2007527408A5

Authority

JP

Japan

Prior art keywords

phenyl

group

compound

pharmaceutically acceptable

acceptable salt

Prior art date

2004-10-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• -1 C 1 -C 4 alkyl Chemical group 0.000 claims 40
• 150000001875 compounds Chemical class 0.000 claims 26
• 150000003839 salts Chemical class 0.000 claims 17
• 239000002207 metabolite Substances 0.000 claims 13
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 8
• ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical group NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 6
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 125000000217 alkyl group Chemical group 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• 125000001188 haloalkyl group Chemical group 0.000 claims 5
• 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims 4
• 235000010290 biphenyl Nutrition 0.000 claims 4
• 239000004305 biphenyl Substances 0.000 claims 4
• 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims 4
• 125000001624 naphthyl group Chemical group 0.000 claims 4
• 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 claims 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• 125000001424 substituent group Chemical group 0.000 claims 4
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 3
• CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Chemical group CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 3
• SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Chemical group CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 3
• BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical group NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 claims 3
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 206010009944 Colon cancer Diseases 0.000 claims 2
• FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 claims 2
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 206010060862 Prostate cancer Diseases 0.000 claims 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
• 206010038389 Renal cancer Diseases 0.000 claims 2
• 201000007455 central nervous system cancer Diseases 0.000 claims 2
• 208000029742 colonic neoplasm Diseases 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 201000010982 kidney cancer Diseases 0.000 claims 2
• 208000032839 leukemia Diseases 0.000 claims 2
• 201000001441 melanoma Diseases 0.000 claims 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
• 230000002062 proliferating effect Effects 0.000 claims 2
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
• MNCMBBIFTVWHIP-UHFFFAOYSA-N 1-anthracen-9-yl-2,2,2-trifluoroethanone Chemical group C1=CC=C2C(C(=O)C(F)(F)F)=C(C=CC=C3)C3=CC2=C1 MNCMBBIFTVWHIP-UHFFFAOYSA-N 0.000 claims 1
• 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 1
• 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 1
• 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
• 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
• 238000002399 angioplasty Methods 0.000 claims 1
• 230000006907 apoptotic process Effects 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
• 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
• 150000002357 guanidines Chemical group 0.000 claims 1
• 125000006492 halo alkyl aryl group Chemical group 0.000 claims 1
• 125000003106 haloaryl group Chemical group 0.000 claims 1
• 125000001475 halogen functional group Chemical group 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
• 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
• 208000037803 restenosis Diseases 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• ALNXLWMJGLCJCX-UHFFFAOYSA-N CCCCC(CN)=O Chemical compound CCCCC(CN)=O ALNXLWMJGLCJCX-UHFFFAOYSA-N 0.000 description 1
• HMOKGJYQIWMNBN-UHFFFAOYSA-N CC[IH]1=NNC(C)=N1 Chemical compound CC[IH]1=NNC(C)=N1 HMOKGJYQIWMNBN-UHFFFAOYSA-N 0.000 description 1
• XZGLNCKSNVGDNX-UHFFFAOYSA-N Cc1nnn[nH]1 Chemical compound Cc1nnn[nH]1 XZGLNCKSNVGDNX-UHFFFAOYSA-N 0.000 description 1