CN110167915A - 胺基硫醇类化合物及其制备方法和其在辐射防护中的应用 - Google Patents

胺基硫醇类化合物及其制备方法和其在辐射防护中的应用 Download PDF

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CN110167915A
CN110167915A CN201780054275.5A CN201780054275A CN110167915A CN 110167915 A CN110167915 A CN 110167915A CN 201780054275 A CN201780054275 A CN 201780054275A CN 110167915 A CN110167915 A CN 110167915A
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CN110167915B (zh
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田红旗
程瑛
张倩如
朱知梅
王月英
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KECHOW PHARMA, Inc.
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Abstract

本发明公开了胺基硫醇类化合物及其制备方法和其在辐射防护中的应用，所述的化合物具有式I的结构，其中，A1选自：‑C(O)NR8‑、‑S(O)2‑NR8‑、‑S(O)NR8‑和‑R7‑NR8‑；A2选自：羰基、磺酰基、亚硫酰基、取代或未取代的C1‑6烷基；R1、R2、R5、R6可相同或不同，选自：氢、取代或未取代的C1‑C5烷基或杂烷基；n为0‑20000的整数，R3、R4独立地选自：氢、X、取代或未取代的C1‑6烷基；X选自：F、Cl、Br和I；R7选自：取代或未取代的C1‑C6烷基，R8选自：氢、取代或未取代的C1‑C6烷基。所述化合物具有降低电离辐射引起的生物损伤的作用，同时还具有延长被辐射的动物生存期和存活率的作用，对放疗副作用具有明显的缓解作用，且该化合物毒性较低，本发明开辟了电离辐射损伤防护与救治的新途径。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN201780054275.5A 2016-09-05 2017-09-01 胺基硫醇类化合物及其制备方法和其在辐射防护中的应用 Active CN110167915B (zh)

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CN106432014B (zh) 2016-09-05 2019-08-16 中国医学科学院放射医学研究所 胺基硫醇类化合物及其制备方法和其在辐射防护中的应用
CN108658838B (zh) * 2018-06-25 2020-11-03 北京化工大学 一种基于七甲川吲哚菁的甲醛荧光探针及其制备方法和使用方法
JP2022537518A (ja) * 2019-06-13 2022-08-26 シャンハイ ケチョウ ファーマ，インコーポレイテッド 脳神経または心臓保護剤としてのアミノチオール系化合物の使用
CN110256310A (zh) * 2019-07-01 2019-09-20 吉尔生化（上海）有限公司 一种n-芴甲氧羰基-s-(4-甲氧基三苯甲基)-l-高半胱氨酸的制备方法
CN111714483A (zh) * 2020-07-01 2020-09-29 中国医学科学院放射医学研究所 半胱氨酸衍生物作为辐射防护剂的应用
CN113214123A (zh) * 2021-05-20 2021-08-06 康化（上海）新药研发有限公司 一种s-三苯甲基-l-半胱氨酰胺的合成方法

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CN106432014A (zh) 2017-02-22
CA3035989A1 (en) 2018-03-08
EP3508476A4 (en) 2020-06-24
CN106432014B (zh) 2019-08-16
CN110167915B (zh) 2021-11-26
US20190202779A1 (en) 2019-07-04
WO2018041245A1 (zh) 2018-03-08
EP3508476B1 (en) 2023-11-22
AU2017318087B2 (en) 2020-12-10
EP3508476A1 (en) 2019-07-10
CA3035989C (en) 2021-11-30
US11008286B2 (en) 2021-05-18
AU2017318087A1 (en) 2019-04-18

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