ES2420405T3 - Inhibidores de la señalización de PDK-1/AKT - Google Patents
Inhibidores de la señalización de PDK-1/AKT Download PDFInfo
- Publication number
- ES2420405T3 ES2420405T3 ES04816902T ES04816902T ES2420405T3 ES 2420405 T3 ES2420405 T3 ES 2420405T3 ES 04816902 T ES04816902 T ES 04816902T ES 04816902 T ES04816902 T ES 04816902T ES 2420405 T3 ES2420405 T3 ES 2420405T3
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- Prior art keywords
- compound
- phenyl
- cancer
- group
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 101001117144 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial Proteins 0.000 title description 37
- 230000007730 Akt signaling Effects 0.000 title description 13
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- 150000001875 compounds Chemical class 0.000 claims abstract description 109
- -1 antryl Chemical group 0.000 claims abstract description 98
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- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 13
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- 125000001624 naphthyl group Chemical group 0.000 claims abstract description 7
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 claims abstract description 7
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Classifications
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50861903P | 2003-10-03 | 2003-10-03 | |
| US508619P | 2003-10-03 | ||
| US50981403P | 2003-10-08 | 2003-10-08 | |
| US509814P | 2003-10-08 | ||
| PCT/US2004/032723 WO2005044130A1 (en) | 2003-10-03 | 2004-10-04 | Pdk-1/akt signaling inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2420405T3 true ES2420405T3 (es) | 2013-08-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04816902T Expired - Lifetime ES2420405T3 (es) | 2003-10-03 | 2004-10-04 | Inhibidores de la señalización de PDK-1/AKT |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1696907B1 (enExample) |
| JP (1) | JP4745971B2 (enExample) |
| KR (1) | KR101217427B1 (enExample) |
| CN (1) | CN1889949B (enExample) |
| CA (1) | CA2566846C (enExample) |
| DK (1) | DK1696907T3 (enExample) |
| ES (1) | ES2420405T3 (enExample) |
| SI (1) | SI1696907T1 (enExample) |
| WO (1) | WO2005044130A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060079566A1 (en) | 2003-10-03 | 2006-04-13 | Ching-Shih Chen | PDK-1/Akt signaling inhibitors |
| CA2613522A1 (en) | 2005-06-27 | 2007-01-04 | Exelixis, Inc. | Imidazole based lxr modulators |
| JP2009519336A (ja) | 2005-12-13 | 2009-05-14 | ワイス | ジベンゾナフチリジン誘導体およびそれらの使用方法 |
| JP5399262B2 (ja) * | 2006-12-08 | 2014-01-29 | エグゼリクシス パテント カンパニー エルエルシー | Ｌｘｒおよびｆｘｒのモジュレーター |
| US8039502B2 (en) | 2007-07-24 | 2011-10-18 | The Ohio State University Research Foundation | Anti-infective agents against intracellular pathogens |
| US20120108823A1 (en) * | 2009-04-22 | 2012-05-03 | The Ohio State University Research Foundation | Anti-francisella agents |
| DE102009043260A1 (de) | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolonderivate |
| RU2432112C1 (ru) * | 2010-05-27 | 2011-10-27 | Федеральное государственное учреждение "Саратовский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "СарНИИТО" Минздравсоцразвития России) | Способ прогнозирования послеоперационных осложнений у больных с дегенеративно-дистрофическими поражениями суставов нижних конечностей |
| DE102010049877A1 (de) * | 2010-11-01 | 2012-05-03 | Merck Patent Gmbh | 7-((1,2,3)Triazol-4-yl)-pyrrolo(2,3) pyrazinderivate |
| CA2818871A1 (en) * | 2010-11-24 | 2012-05-31 | The Ohio State University Research Foundation | Integrin-linked kinase inhibitors |
| US10028933B2 (en) * | 2015-07-22 | 2018-07-24 | Ohio State Innovation Foundation | Compositions and methods for inhibiting the growth of multi-drug resistant microbes |
| CN116462606B (zh) * | 2022-01-12 | 2025-11-28 | 南京宁丹新药技术股份有限公司 | 一类酰胺衍生化合物及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL104311A (en) | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5401765A (en) * | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
| KR100263817B1 (ko) * | 1993-11-30 | 2000-08-16 | 윌리암스 로저 에이 | 염증치료용 치환 피라졸일벤젠술폰아미드 |
| US5660273A (en) * | 1994-07-13 | 1997-08-26 | Centrix, Inc. | Single patient dose medicament dispenser with applicator |
| AU2003230836A1 (en) * | 2002-04-08 | 2003-10-27 | The Ohio State University Research Foundation | Compounds and methods for inducing apoptosis in proliferating cells |
| US7201577B2 (en) * | 2002-04-24 | 2007-04-10 | Gosmile, Inc. | Tooth whitener applicator and method |
-
2004
- 2004-10-04 EP EP04816902.3A patent/EP1696907B1/en not_active Expired - Lifetime
- 2004-10-04 JP JP2006534245A patent/JP4745971B2/ja not_active Expired - Fee Related
- 2004-10-04 CA CA2566846A patent/CA2566846C/en not_active Expired - Lifetime
- 2004-10-04 DK DK04816902.3T patent/DK1696907T3/da active
- 2004-10-04 CN CN2004800360073A patent/CN1889949B/zh not_active Expired - Lifetime
- 2004-10-04 SI SI200432057T patent/SI1696907T1/sl unknown
- 2004-10-04 ES ES04816902T patent/ES2420405T3/es not_active Expired - Lifetime
- 2004-10-04 WO PCT/US2004/032723 patent/WO2005044130A1/en not_active Ceased
-
2006
- 2006-05-03 KR KR1020067008622A patent/KR101217427B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1696907B1 (en) | 2013-04-17 |
| KR101217427B1 (ko) | 2013-01-02 |
| WO2005044130A1 (en) | 2005-05-19 |
| DK1696907T3 (da) | 2013-06-24 |
| CN1889949B (zh) | 2010-06-16 |
| EP1696907A1 (en) | 2006-09-06 |
| EP1696907A4 (en) | 2007-09-05 |
| JP2007527408A (ja) | 2007-09-27 |
| CA2566846C (en) | 2012-08-28 |
| CN1889949A (zh) | 2007-01-03 |
| JP4745971B2 (ja) | 2011-08-10 |
| KR20060108651A (ko) | 2006-10-18 |
| CA2566846A1 (en) | 2005-05-19 |
| WO2005044130A9 (en) | 2005-09-15 |
| SI1696907T1 (sl) | 2013-12-31 |
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