JP2005528105A5 - - Google Patents
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- JP2005528105A5 JP2005528105A5 JP2004510393A JP2004510393A JP2005528105A5 JP 2005528105 A5 JP2005528105 A5 JP 2005528105A5 JP 2004510393 A JP2004510393 A JP 2004510393A JP 2004510393 A JP2004510393 A JP 2004510393A JP 2005528105 A5 JP2005528105 A5 JP 2005528105A5
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- Prior art keywords
- pharmaceutical composition
- cells
- stem cells
- compound
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000130 stem cell Anatomy 0.000 claims 51
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 23
- 230000000694 effects Effects 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 210000000265 leukocyte Anatomy 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 210000004700 fetal blood Anatomy 0.000 claims 10
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 10
- 239000003112 inhibitor Substances 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 230000004069 differentiation Effects 0.000 claims 8
- 239000012825 JNK inhibitor Substances 0.000 claims 7
- 229940118135 JNK inhibitor Drugs 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 239000011886 peripheral blood Substances 0.000 claims 5
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 4
- 208000009527 Refractory anemia Diseases 0.000 claims 4
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 210000005259 peripheral blood Anatomy 0.000 claims 4
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 210000001671 embryonic stem cell Anatomy 0.000 claims 3
- -1 hydroxy, carboxy Chemical group 0.000 claims 3
- 210000004976 peripheral blood cell Anatomy 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 210000004991 placental stem cell Anatomy 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 210000004504 adult stem cell Anatomy 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000002798 bone marrow cell Anatomy 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 230000024245 cell differentiation Effects 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- PYAXMGCRUJSCPE-UHFFFAOYSA-N 10h-naphtho[3,2-e][2,1]benzothiazol-9-one Chemical compound C12=CSN=C2C=CC2=C1C=C1CC(=O)C=CC1=C2 PYAXMGCRUJSCPE-UHFFFAOYSA-N 0.000 claims 1
- YONIZQONLRVUOF-UHFFFAOYSA-N 10h-naphtho[3,2-e][2,1]benzoxazol-9-one Chemical compound C12=CON=C2C=CC2=C1C=C1CC(=O)C=CC1=C2 YONIZQONLRVUOF-UHFFFAOYSA-N 0.000 claims 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 claims 1
- HOAGRTLXFSVAFE-UHFFFAOYSA-N 8,10-dihydronaphtho[3,2-e]indazol-9-one Chemical compound C1=C2C=CC3=NN=CC3=C2C=C2C1=CCC(=O)C2 HOAGRTLXFSVAFE-UHFFFAOYSA-N 0.000 claims 1
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010000890 Acute myelomonocytic leukaemia Diseases 0.000 claims 1
- 206010058956 Bicytopenia Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 claims 1
- 208000036566 Erythroleukaemia Diseases 0.000 claims 1
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 208000033835 Myelomonocytic Acute Leukemia Diseases 0.000 claims 1
- 208000033833 Myelomonocytic Chronic Leukemia Diseases 0.000 claims 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
- 206010033661 Pancytopenia Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000013544 Platelet disease Diseases 0.000 claims 1
- 208000007541 Preleukemia Diseases 0.000 claims 1
- 208000021841 acute erythroid leukemia Diseases 0.000 claims 1
- 208000011912 acute myelomonocytic leukemia M4 Diseases 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010902 chronic myelomonocytic leukemia Diseases 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 150000003949 imides Chemical class 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 206010028537 myelofibrosis Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- XGXNTJHZPBRBHJ-UHFFFAOYSA-N n-phenylpyrimidin-2-amine Chemical compound N=1C=CC=NC=1NC1=CC=CC=C1 XGXNTJHZPBRBHJ-UHFFFAOYSA-N 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 238000012261 overproduction Methods 0.000 claims 1
- 210000004214 philadelphia chromosome Anatomy 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 208000037244 polycythemia vera Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000003476 primary myelofibrosis Diseases 0.000 claims 1
- 210000004765 promyelocyte Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 */C1=C(/*)\C(\*)=N\C(\CCCC(C=C2)=C*(C3*C3)C=C2C(N(*)*)=O)=C\C*1 Chemical compound */C1=C(/*)\C(\*)=N\C(\CCCC(C=C2)=C*(C3*C3)C=C2C(N(*)*)=O)=C\C*1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38425002P | 2002-05-30 | 2002-05-30 | |
| US43483302P | 2002-12-19 | 2002-12-19 | |
| PCT/US2003/017319 WO2003102151A2 (en) | 2002-05-30 | 2003-05-30 | Modulating cell differentiation and treating myeloprolifertive disorders with jnk/mkk inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005528105A JP2005528105A (ja) | 2005-09-22 |
| JP2005528105A5 true JP2005528105A5 (https=) | 2006-07-27 |
Family
ID=29715319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004510393A Pending JP2005528105A (ja) | 2002-05-30 | 2003-05-30 | 細胞分化をモジュレートするため、並びに骨髄増殖性疾患及び骨髄異形成症候群を治療するためのｊｎｋ又はｍｋｋ阻害剤の使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040028660A1 (https=) |
| EP (1) | EP1525308A4 (https=) |
| JP (1) | JP2005528105A (https=) |
| KR (1) | KR20050008757A (https=) |
| CN (1) | CN1668733A (https=) |
| AU (1) | AU2003231950A1 (https=) |
| CA (1) | CA2488013A1 (https=) |
| MX (1) | MXPA04011851A (https=) |
| WO (1) | WO2003102151A2 (https=) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| DK1349918T3 (da) | 2000-12-06 | 2014-11-10 | Anthrogenesis Corp | Fremgangsmåde til indsamling af stamceller fra moderkagen |
| EP2316919B1 (en) * | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| EP3246396B1 (en) * | 2001-02-14 | 2020-01-29 | Celularity, Inc. | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| US6942802B2 (en) * | 2001-04-13 | 2005-09-13 | Wyeth Holdings Corporation | Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography |
| WO2003075917A1 (en) * | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| EP1496878A4 (en) * | 2002-04-12 | 2007-12-26 | Celgene Corp | TECHNIQUES FOR IDENTIFYING ANGIOGENESIS MODULATORS, COMPOUNDS DISCOVERED BY THESE TECHNIQUES AND TREATMENT TECHNIQUES USING THESE COMPOUNDS |
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| US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
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| WO2004071283A2 (en) * | 2003-02-13 | 2004-08-26 | Anthrogenesis Corporation | Use of umbilical cord blood to treat individuals having a disease, disorder or condition |
| US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| US8790637B2 (en) * | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| WO2005007838A1 (ja) * | 2003-06-27 | 2005-01-27 | Asahi Kasei Kabushiki Kaisha | 細胞分化抑制剤、これを用いた細胞培養方法、培養液及び培養された細胞株 |
| WO2006071794A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
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| JP2007536223A (ja) * | 2004-05-05 | 2007-12-13 | セルジーン・コーポレーション | 骨髄増殖性疾患の治療及び管理のための免疫調節化合物を含む組成物、及びその使用方法 |
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| US20060258582A1 (en) * | 2004-11-04 | 2006-11-16 | Scios, Inc. | Method of treating myelodysplastic syndromes |
| WO2006071778A2 (en) * | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| AU2011226836B2 (en) * | 2004-12-23 | 2013-09-12 | Ethicon, Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| AU2006265601A1 (en) * | 2005-06-30 | 2007-01-11 | Anthrogenesis Corporation | Repair of tympanic membrane using placenta derived collagen biofabric |
| US20070021762A1 (en) * | 2005-07-13 | 2007-01-25 | Qing Liu | Ocular plug formed from placenta derived collagen biofabric |
| US7928280B2 (en) * | 2005-07-13 | 2011-04-19 | Anthrogenesis Corporation | Treatment of leg ulcers using placenta derived collagen biofabric |
| WO2007011693A2 (en) * | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
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| ES2454021T3 (es) | 2005-10-05 | 2014-04-09 | The Board Of Trustees Of The University Of Illinois | Células madre de tipo embrionario aisladas de sangre de cordón umbilical humano |
| US9388382B2 (en) * | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
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| EP2211870A1 (en) * | 2007-11-01 | 2010-08-04 | Celgene Corporation | Cytidine analogs for treatment of myelodysplastic syndromes |
| KR20170116221A (ko) * | 2007-11-07 | 2017-10-18 | 안트로제네시스 코포레이션 | 조산 합병증의 치료에 있어서의 제대혈의 용도 |
| BRPI0821489A2 (pt) * | 2007-12-27 | 2015-06-16 | Ethicon Inc | Tratamento de degeneração do disco intervetebral com o uso de células derivadas de tecido de cordão umbilical humano |
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| KR20240052847A (ko) | 2008-08-20 | 2024-04-23 | 셀룰래리티 인코포레이티드 | 개선된 세포 조성물 및 그의 제조 방법 |
| CA2734446C (en) * | 2008-08-22 | 2017-06-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
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- 2003-05-30 MX MXPA04011851A patent/MXPA04011851A/es not_active Application Discontinuation
- 2003-05-30 US US10/449,248 patent/US20040028660A1/en not_active Abandoned
- 2003-05-30 KR KR10-2004-7019520A patent/KR20050008757A/ko not_active Withdrawn
- 2003-05-30 JP JP2004510393A patent/JP2005528105A/ja active Pending
- 2003-05-30 CA CA002488013A patent/CA2488013A1/en not_active Abandoned
- 2003-05-30 EP EP03756349A patent/EP1525308A4/en not_active Withdrawn
- 2003-05-30 AU AU2003231950A patent/AU2003231950A1/en not_active Abandoned
- 2003-05-30 WO PCT/US2003/017319 patent/WO2003102151A2/en not_active Ceased
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