JP2005527510A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005527510A5 JP2005527510A5 JP2003572598A JP2003572598A JP2005527510A5 JP 2005527510 A5 JP2005527510 A5 JP 2005527510A5 JP 2003572598 A JP2003572598 A JP 2003572598A JP 2003572598 A JP2003572598 A JP 2003572598A JP 2005527510 A5 JP2005527510 A5 JP 2005527510A5
- Authority
- JP
- Japan
- Prior art keywords
- type
- phosphodiesterase
- inhibitor
- phosphodiesterase inhibitor
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 24
- 238000000034 method Methods 0.000 claims 21
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 19
- 206010028980 Neoplasm Diseases 0.000 claims 18
- 201000011510 cancer Diseases 0.000 claims 12
- 102000030621 adenylate cyclase Human genes 0.000 claims 11
- 108060000200 adenylate cyclase Proteins 0.000 claims 11
- 229940126513 cyclase activator Drugs 0.000 claims 11
- 230000003211 malignant effect Effects 0.000 claims 10
- 230000005747 tumor angiogenesis Effects 0.000 claims 6
- 206010058314 Dysplasia Diseases 0.000 claims 5
- 206010020880 Hypertrophy Diseases 0.000 claims 5
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000001747 exhibiting effect Effects 0.000 claims 5
- 206010020718 hyperplasia Diseases 0.000 claims 5
- OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 claims 4
- 230000036210 malignancy Effects 0.000 claims 4
- 230000009826 neoplastic cell growth Effects 0.000 claims 4
- 206010027476 Metastases Diseases 0.000 claims 3
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 claims 3
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 claims 3
- 230000009876 antimalignant effect Effects 0.000 claims 3
- OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 230000009401 metastasis Effects 0.000 claims 3
- -1 tanadafil Chemical compound 0.000 claims 3
- GRVCTHTXJDYIHB-UHFFFAOYSA-N 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid Chemical compound C1=CC(OC)=CC=C1C(=C(CCC(O)=O)C#N)C1=CC=C(OC)C=C1 GRVCTHTXJDYIHB-UHFFFAOYSA-N 0.000 claims 2
- SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 claims 2
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000001934 delay Effects 0.000 claims 2
- 230000009977 dual effect Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- NVGOUBIJVPSVSL-UHFFFAOYSA-N methyl 2-(4-aminophenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)isoquinoline-3-carboxylate;sulfuric acid Chemical compound OS(O)(=O)=O.C12=CC=C(OCC=3N=CC=CC=3)C=C2C(=O)N(C=2C=CC(N)=CC=2)C(C(=O)OC)=C1C1=CC(OC)=C(OC)C(OC)=C1 NVGOUBIJVPSVSL-UHFFFAOYSA-N 0.000 claims 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 claims 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 2
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- CLLFEJLEDNXZNR-UUOKFMHZSA-N (4ar,6r,7r,7as)-6-(6-amino-8-chloropurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1Cl CLLFEJLEDNXZNR-UUOKFMHZSA-N 0.000 claims 1
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 claims 1
- HFJWFZAFJZGSAO-UHFFFAOYSA-N 3-(1-benzofuran-2-carbonyl)pyrrolo[2,3-h]quinolin-2-one Chemical compound C1=C2N=CC=C2C2=NC(=O)C(C(C=3OC4=CC=CC=C4C=3)=O)=CC2=C1 HFJWFZAFJZGSAO-UHFFFAOYSA-N 0.000 claims 1
- IOSAAWHGJUZBOG-UHFFFAOYSA-N 3-(6-amino-9h-purin-9-yl)nonan-2-ol Chemical compound N1=CN=C2N(C(C(C)O)CCCCCC)C=NC2=C1N IOSAAWHGJUZBOG-UHFFFAOYSA-N 0.000 claims 1
- UTUUPXBCDMQYRR-HSZRJFAPSA-N 4-[(2r)-2-(3-cyclopentyloxy-4-methoxyphenyl)-2-phenylethyl]pyridine Chemical compound COC1=CC=C([C@H](CC=2C=CN=CC=2)C=2C=CC=CC=2)C=C1OC1CCCC1 UTUUPXBCDMQYRR-HSZRJFAPSA-N 0.000 claims 1
- CFBUZOUXXHZCFB-UHFFFAOYSA-N 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)-1-cyclohexanecarboxylic acid Chemical compound COC1=CC=C(C2(CCC(CC2)C(O)=O)C#N)C=C1OC1CCCC1 CFBUZOUXXHZCFB-UHFFFAOYSA-N 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- RTAPDZBZLSXHQQ-UHFFFAOYSA-N 8-methyl-3,7-dihydropurine-2,6-dione Chemical class N1C(=O)NC(=O)C2=C1N=C(C)N2 RTAPDZBZLSXHQQ-UHFFFAOYSA-N 0.000 claims 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 claims 1
- SMPNJFHAPJOHPP-JOILOJCLSA-N Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate] Chemical class C([C@H]1O2)OP(O)(=S)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 SMPNJFHAPJOHPP-JOILOJCLSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
- CNODHOSDWZLJGA-UHFFFAOYSA-N N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-4-quinazolinamine Chemical compound C1=C2OCOC2=CC(CNC2=NC=NC3=CC=C(C=C32)Cl)=C1 CNODHOSDWZLJGA-UHFFFAOYSA-N 0.000 claims 1
- CEHQLKSLMFIHBF-UHFFFAOYSA-N N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine Chemical compound ClC1=CC=CC(NC=2C3=CC=CC=C3C(C=3C=CC=CC=3)=NN=2)=C1 CEHQLKSLMFIHBF-UHFFFAOYSA-N 0.000 claims 1
- 229940088382 Nitric oxide scavenger Drugs 0.000 claims 1
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims 1
- 229960003556 aminophylline Drugs 0.000 claims 1
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 claims 1
- 229940035674 anesthetics Drugs 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 229960005263 bucladesine Drugs 0.000 claims 1
- 229960001948 caffeine Drugs 0.000 claims 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- CFBUZOUXXHZCFB-OYOVHJISSA-N chembl511115 Chemical compound COC1=CC=C([C@@]2(CC[C@H](CC2)C(O)=O)C#N)C=C1OC1CCCC1 CFBUZOUXXHZCFB-OYOVHJISSA-N 0.000 claims 1
- 229940117229 cialis Drugs 0.000 claims 1
- 229950005210 colforsin Drugs 0.000 claims 1
- PCCPERGCFKIYIS-AWEZNQCLSA-N daxalipram Chemical compound C1=C(OC)C(OCCC)=CC([C@@]2(C)OC(=O)NC2)=C1 PCCPERGCFKIYIS-AWEZNQCLSA-N 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 229960002819 diprophylline Drugs 0.000 claims 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims 1
- 229960002768 dipyridamole Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- KSCFJBIXMNOVSH-UHFFFAOYSA-N dyphylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)CO)C=N2 KSCFJBIXMNOVSH-UHFFFAOYSA-N 0.000 claims 1
- 238000011010 flushing procedure Methods 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000005741 malignant process Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 208000021039 metastatic melanoma Diseases 0.000 claims 1
- RBJCBXAXUHCWBR-UHFFFAOYSA-N methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate;hydrochloride Chemical compound Cl.C12=CC=NC(OCC=3N=CC=CN=3)=C2C(=O)N(CC=2C=C(C)N=CC=2)C(C(=O)OC)=C1C1=CC(OC)=C(OC)C(OC)=C1 RBJCBXAXUHCWBR-UHFFFAOYSA-N 0.000 claims 1
- JPAWFIIYTJQOKW-UHFFFAOYSA-N olprinone Chemical compound N1C(=O)C(C#N)=CC(C2=CN3C=CN=C3C=C2)=C1C JPAWFIIYTJQOKW-UHFFFAOYSA-N 0.000 claims 1
- 229950005421 olprinone Drugs 0.000 claims 1
- 229960001789 papaverine Drugs 0.000 claims 1
- 229960001476 pentoxifylline Drugs 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000002831 pharmacologic agent Substances 0.000 claims 1
- 239000002570 phosphodiesterase III inhibitor Substances 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims 1
- RRRUXBQSQLKHEL-UHFFFAOYSA-N piclamilast Chemical compound COC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OC1CCCC1 RRRUXBQSQLKHEL-UHFFFAOYSA-N 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 201000005825 prostate adenocarcinoma Diseases 0.000 claims 1
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 1
- 229960002586 roflumilast Drugs 0.000 claims 1
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 claims 1
- 229950005741 rolipram Drugs 0.000 claims 1
- 229950007628 satigrel Drugs 0.000 claims 1
- 229960003310 sildenafil Drugs 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- WOXKDUGGOYFFRN-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C(C4=CC=CC=C4N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 WOXKDUGGOYFFRN-IIBYNOLFSA-N 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 229960004559 theobromine Drugs 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 239000000439 tumor marker Substances 0.000 claims 1
- 229960002381 vardenafil Drugs 0.000 claims 1
- 230000024883 vasodilation Effects 0.000 claims 1
- REZGGXNDEMKIQB-UHFFFAOYSA-N zaprinast Chemical compound CCCOC1=CC=CC=C1C1=NC(=O)C2=NNNC2=N1 REZGGXNDEMKIQB-UHFFFAOYSA-N 0.000 claims 1
- 229950005371 zaprinast Drugs 0.000 claims 1
- HJMQDJPMQIHLPB-UHFFFAOYSA-N zardaverine Chemical compound C1=C(OC(F)F)C(OC)=CC(C2=NNC(=O)C=C2)=C1 HJMQDJPMQIHLPB-UHFFFAOYSA-N 0.000 claims 1
- 229950001080 zardaverine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36296902P | 2002-03-06 | 2002-03-06 | |
| US36262002P | 2002-03-07 | 2002-03-07 | |
| PCT/CA2003/000313 WO2003074082A1 (en) | 2002-03-06 | 2003-03-06 | Formulations and methods of using nitric oxide mimetics in cancer treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527510A JP2005527510A (ja) | 2005-09-15 |
| JP2005527510A5 true JP2005527510A5 (enExample) | 2006-04-20 |
Family
ID=27791719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003572598A Pending JP2005527510A (ja) | 2002-03-06 | 2003-03-06 | 癌の治療において一酸化窒素模倣体を使用するための製剤および方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1492567A1 (enExample) |
| JP (1) | JP2005527510A (enExample) |
| AU (1) | AU2003208228A1 (enExample) |
| CA (1) | CA2478145A1 (enExample) |
| WO (1) | WO2003074082A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10135815A1 (de) * | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
| PL2348114T3 (pl) | 2004-04-21 | 2019-08-30 | Alexion Pharmaceuticals, Inc. | Koniugaty do dostarczania do kości i sposób ich wykorzystania do nakierowywania białek na kość |
| US7329495B2 (en) | 2004-06-09 | 2008-02-12 | Board Of Regents, The University Of Texas System | Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors |
| WO2005120493A1 (en) * | 2004-06-10 | 2005-12-22 | Tohoku University | Anticancer effect enhancer |
| AU2005274546B2 (en) * | 2004-08-19 | 2011-02-03 | Switch Biotech, Llc | Use of a PDE5 inhibitor for treating and preventing hypopigmentary disorders |
| EP1759700B1 (en) * | 2004-08-19 | 2009-08-05 | Switch Biotech, LLC | Use of a PDE5 inhibitor for treating and preventing hypopigmentary disorders |
| US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
| AU2012203798B2 (en) * | 2005-08-12 | 2013-11-07 | Northrop Grumman Systems Corporation | O-nitro compounds, pharmaceutical compositons thereof and uses thereof |
| CA2710349A1 (en) * | 2007-12-27 | 2009-07-09 | Aires Pharmaceuticals, Inc. | Aerosolized nitrite and nitric oxide -donating compounds and uses thereof |
| JP5467259B2 (ja) * | 2008-03-13 | 2014-04-09 | 国立大学法人 千葉大学 | シスプラチン効果増強剤及び抗癌剤キット |
| WO2009137071A1 (en) * | 2008-05-09 | 2009-11-12 | Duke University | Treatment for diseases relying on discovery that thioredoxin mediates nitric oxide release in cells |
| EP2658979B1 (en) | 2010-12-27 | 2018-02-14 | Alexion Pharmaceuticals, Inc. | Compositions comprising natriuretic peptides and methods of use thereof |
| WO2012118042A1 (ja) * | 2011-02-28 | 2012-09-07 | 独立行政法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
| JP5842367B2 (ja) * | 2011-04-07 | 2016-01-13 | ニプロ株式会社 | 抗癌剤増感剤 |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| EP3129015B1 (en) | 2014-04-08 | 2021-07-14 | The Methodist Hospital | Inos-inhibitory compositions and their use as breast cancer therapeutics |
| US10822596B2 (en) | 2014-07-11 | 2020-11-03 | Alexion Pharmaceuticals, Inc. | Compositions and methods for treating craniosynostosis |
| MX389350B (es) | 2014-12-05 | 2025-03-19 | Alexion Pharma Inc | Fosfatasas alcalinas recombinantes y usos de las mismas para el tratamiento de convulsiones. |
| US10603361B2 (en) | 2015-01-28 | 2020-03-31 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| KR102644116B1 (ko) | 2015-08-17 | 2024-03-05 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼린 포스파타제의 제조 |
| WO2017058822A1 (en) | 2015-09-28 | 2017-04-06 | Alexion Pharmaceuticals, Inc. | Identifying effective dosage regimens for tissue non-specific alkaline phosphatase (tnsalp)-enzyme replacement therapy of hypophosphatasia |
| JP2018533571A (ja) | 2015-10-30 | 2018-11-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者の頭蓋縫合早期癒合症を治療するための方法 |
| WO2017155569A1 (en) | 2016-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| CA3019726A1 (en) | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Treating muscle weakness with alkaline phosphatases |
| EP3436020A4 (en) | 2016-04-01 | 2019-12-25 | Alexion Pharmaceuticals, Inc. | METHOD FOR TREATING HYPOPHOSPHATASIE IN TEENS AND ADULTS |
| EP3464573A4 (en) | 2016-06-06 | 2020-02-19 | Alexion Pharmaceuticals, Inc. | EFFECTS OF METALS ON THE PRODUCTION OF ALKALINE PHOSPHATASES |
| WO2018035420A1 (en) | 2016-08-18 | 2018-02-22 | Alexion Pharmaceuticals, Inc. | Methods for treating tracheobronchomalacia |
| JP2020512363A (ja) | 2017-03-31 | 2020-04-23 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法 |
| US11913039B2 (en) | 2018-03-30 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Method for producing recombinant alkaline phosphatase |
| US12268733B2 (en) | 2018-08-10 | 2025-04-08 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| JP2023504208A (ja) | 2019-12-09 | 2023-02-01 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼポリペプチド及びその使用方法 |
| US12083169B2 (en) | 2021-02-12 | 2024-09-10 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| CN114869894A (zh) * | 2022-05-10 | 2022-08-09 | 福州大学 | 一种小分子化合物在制备作为尿激酶受体抑制剂药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LV11542B (en) * | 1995-03-30 | 1997-02-20 | Latvijas Organiskas Sintezes Instituts | Substituted 1,3,9,11-tetraoxa-4,5,7,8-tetraazaundecadien-4,7-dioxides-5,7, preparation and use thereof |
| WO1999003462A1 (en) * | 1997-07-14 | 1999-01-28 | Brigham And Women's Hospital | Modification of nitric oxide activity to treat fas-induced pathologies |
| JP2004508279A (ja) * | 2000-01-26 | 2004-03-18 | シーダース シナイ メディカル センター | 薬剤を異常脳領域及び／又は悪性腫瘍にデリバリーするためにカリウムチャンネル活性化を用いる方法 |
| US20010038832A1 (en) * | 2000-04-11 | 2001-11-08 | Benjamin Bonavida | Nitric oxide and analogues thereof effectuate sensitization of neoplasm and immunologically undesired tissues to cytotoxicity |
| DE60106905T2 (de) * | 2000-04-26 | 2005-12-01 | Cellegy Pharmaceuticals, Inc., South San Francisco | Formulierungen und verfahren zur verwendung von stickstoffmonoxid mimetika gegen einen malignen zellphänotyp |
-
2003
- 2003-03-06 CA CA002478145A patent/CA2478145A1/en not_active Abandoned
- 2003-03-06 JP JP2003572598A patent/JP2005527510A/ja active Pending
- 2003-03-06 AU AU2003208228A patent/AU2003208228A1/en not_active Abandoned
- 2003-03-06 EP EP03706181A patent/EP1492567A1/en not_active Withdrawn
- 2003-03-06 WO PCT/CA2003/000313 patent/WO2003074082A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005527510A5 (enExample) | ||
| Chollet et al. | Phase II trial with S-1 in chemotherapy-naıve patients with gastric cancer. A trial performed by the EORTC early clinical studies group (ECSG) | |
| US6649645B1 (en) | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia | |
| US8202242B2 (en) | Method of using vasoconstrictive agents during energy-based tissue therapy | |
| TWI592157B (zh) | 治療增生性疾病及其他由ｂｃｒ－ａｂｌ、ｃ－ｋｉｔ、ｄｄｒ１、ｄｄｒ２或ｐｄｇｆ－ｒ激酶活性所調節之病症之方法 | |
| CA2644841C (en) | Use of c-src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia | |
| JP2007505938A (ja) | Ｖｅｇｆ受容体阻害剤と化学療法剤の組み合わせ | |
| BR112020005039A2 (pt) | combinação de um inibidor de btk e um inibidor de cdk9 para tratar câncer | |
| KR20070073813A (ko) | Ａｚｄ2171 및 이마티닙을 포함하는 암의 병합 요법 | |
| CN101484443B (zh) | 放射线治疗增强剂 | |
| JP2013107893A (ja) | 神経線維腫症の処置のためのピリミジルアミノベンズアミド誘導体 | |
| JP2009511450A (ja) | ニロチニブとファルネシルトランスフェラーゼ阻害剤の組合せ | |
| US20250064824A1 (en) | Administration of aurora kinase inhibitor and chemotherapeutic agents | |
| CA2606716C (en) | Use of pyrimidylaminobenzamide derivatives for the treatment of systematic mastocytosis | |
| JP2009520787A (ja) | Ａｚｄ２１７１およびペメトレキセドの組み合わせ | |
| US7767686B2 (en) | Method of using adenosine receptor blockers during tissue ablation | |
| JP2005526821A (ja) | 癌の処置におけるグリベック（ｓｔｉ５７１）とサイクリン依存性キナーゼインヒビター、とりわけフラボピリドールとの組合せ剤 | |
| WO2002022127A1 (en) | Use of phosphodiesterase inhibitors for the treatment of anorectal disorders | |
| JP2005255643A (ja) | 抗腫瘍効果増強方法および抗腫瘍効果増強剤 | |
| US20240173323A1 (en) | Combination therapy for cancer treatment | |
| EP2186514B1 (en) | Treatment of Malignant Peripheral Nerve Sheath Tumors | |
| AU2011202950B2 (en) | Use of c-Src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia | |
| Saiko et al. | Heterodinucleoside phosphates of 5-fluorodeoxyuridine and arabinofuranosylcytosine-New drugs in cancer chemotherapy? | |
| JPH06107548A (ja) | 癌の肝転移抑制剤及び肝癌の治療剤 | |
| JP2013525296A (ja) | 内分泌療法抵抗性乳癌の処置 |