JP2005527468A - 薬学的に上品な局所軟膏に使用するための脂質中に分散した硬化ヒマシ油 - Google Patents
薬学的に上品な局所軟膏に使用するための脂質中に分散した硬化ヒマシ油 Download PDFInfo
- Publication number
- JP2005527468A JP2005527468A JP2003524517A JP2003524517A JP2005527468A JP 2005527468 A JP2005527468 A JP 2005527468A JP 2003524517 A JP2003524517 A JP 2003524517A JP 2003524517 A JP2003524517 A JP 2003524517A JP 2005527468 A JP2005527468 A JP 2005527468A
- Authority
- JP
- Japan
- Prior art keywords
- castor oil
- drugs
- composition
- oil
- hardened castor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
【解決手段】親油性基剤、薬学的に活性な物質、及び該基剤に分散した全組成物の約1重量%から約50重量%までの粉末状の非融解硬化ヒマシ油を用いる局所軟膏医薬組成物を提供する。粉末状の非融解硬化ヒマシ油を使用した結果、硬化ヒマシ油を融解することにより製造された軟膏よりもきめがより滑らかで且つ伸展性がよりすぐれていると感じられる驚くほど薬学的に上品な局所軟膏が得られる。
Description
親油性基剤、医薬活性物質、及び該基剤中に分散した全組成物の約1重量%から約50重量%までの粉末状の非融解硬化ヒマシ油を用いる局所軟膏医薬組成物。粉末状の非融解硬化ヒマシ油を用いた成果は、硬化ヒマシ油を融解することにより調製した軟膏と比べより優れたきめ(texture)の滑らかさ及びより優れた伸展可能性を持つことが感じられる驚くべき薬学的上品さである。
ヒマシ油 90.0
硬化ヒマシ油(CUTINA(登録商標)HR) 10.0
この硬化ヒマシ油は高剪断力ミキサーで混合しながらヒマシ油に添加し、そして半固体が形成されるまで混合した。それを記録し、上品さについて試験した。特に、この調製物の感触試験及び視覚試験から、滑らかな、クリーム様のきめが明らかとなり、それは皮膚の上に伸展可能であった。
%w/w
ヒマシ油 68.8
硬化ヒマシ油 10.0
バルサム・ペルー油 8.70
ステアリン酸アルミニウム/マグネシウムヒドロキシド 2.00
トリプシン 0.018
ベニバナ油 充分量
(100%まで添加)
酵素を含む創傷被覆剤である実施例2の組成の調製品では、ステアリン酸アルミニウム/マグネシウムヒドロキシドをヒマシ油に分散させた。その後、硬化ヒマシ油を高剪断力ミキサーで混合しながら添加した。特に、リー・トリ−ミックス・ターボ−シェア・ミキサーが用いられた。混合は、半固体が形成されるまで続けた。次いで残りの成分を該半固体に混ぜ、均一な混合が達成されるまで混合した。
Claims (6)
- 植物油、脂肪酸、グリセリド、及びそれらの組合せからなる群より選択される親油性基剤、少量であるが薬学的に有効な量の局所的に活性な薬物、局所軟膏医薬組成物に分散した粉末状の非融解硬化ヒマシ油からなる約1重量%から50重量%までの全医薬組成物、を含む局所軟膏医薬組成物。
- 局所軟膏組成物中に分散した粉末状の非融解硬化ヒマシ油の量が全組成物の約1重量%から全組成物の約25重量%までである、請求項1記載の局所軟膏医薬組成物。
- 局所軟膏組成物中に分散した粉末状の非融解硬化ヒマシ油の量が全組成物の約1重量%から全組成物の約15重量%までである、請求項1記載の局所軟膏医薬組成物。
- 親油性基剤がヒマワリ油、ベニバナ油、ヒマシ油、ナタネ油、トウモロコシ油、バルサム・ペルー油、大豆油、脂肪酸、脂肪酸エステル、高級アルコール、及びグリセリドから成る群より選択されるものである、請求項1記載の局所軟膏医薬組成物。
- 局所的に活性な薬物が、にきび治療薬、鎮痛薬、麻酔薬、肛門直腸薬、抗ヒスタミン薬、抗炎症薬、抗生物質、抗真菌薬、抗ウイルス薬、抗微生物薬、抗疥癬薬、シラミ撲滅薬、抗腫瘍薬、抗発汗薬、抗掻痒薬、抗突発性疾患薬、抗脂蝋症薬、生物活性タンパク質及びぺプチド、火傷治療薬、消毒薬(cauterizing agents) 、脱色薬、おむつ負け治療薬、酵素、育毛薬、ケロトリティクス薬(kerotolytics) 、口内炎治療薬、ヘルペス治療薬、歯治療薬、唾液治療薬(saliva actives) 、光線感作性薬、皮膚保護/ 遮蔽薬、ステロイド類、日焼け止め薬、日焼け止め、疣治療薬、創傷被覆剤、及びレチノール、レチノイン酸、及びレチノイン酸誘導体から成る群より選択されるものである、請求項1記載の組成物。
- 植物油、脂肪酸、グリセリド及びそれらの組合せから成る群より選択される親油性基剤を、少量であるが薬学的に有効な量の局所的に活性な薬物及び全組成物の約1重量%から50重量%までの粉末状の非融解硬化ヒマシ油と混合する工程を含む局所軟膏医薬組成物を製造する方法であって、該混合工程が粉末状の非融解硬化ヒマシ油の融点より低い温度で高剪断力ミキサー中で行なわれるものである方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/945,903 US6479060B1 (en) | 2001-09-04 | 2001-09-04 | Elegant hydrogenated castor oil ointments |
PCT/US2002/023954 WO2003020203A2 (en) | 2001-09-04 | 2002-07-29 | Hydrogenated castor oil dispersed in a lipid for pharmaceutically elegant topical ointments |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005527468A true JP2005527468A (ja) | 2005-09-15 |
JP4115391B2 JP4115391B2 (ja) | 2008-07-09 |
Family
ID=25483673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003524517A Expired - Fee Related JP4115391B2 (ja) | 2001-09-04 | 2002-07-29 | 薬学的に上品な局所軟膏に使用するための脂質中に分散した硬化ヒマシ油 |
Country Status (16)
Country | Link |
---|---|
US (1) | US6479060B1 (ja) |
EP (1) | EP1423154B1 (ja) |
JP (1) | JP4115391B2 (ja) |
KR (2) | KR100638417B1 (ja) |
CN (1) | CN100463697C (ja) |
AT (1) | ATE413861T1 (ja) |
AU (1) | AU2002330929B2 (ja) |
BR (1) | BR0212286A (ja) |
CA (1) | CA2459239C (ja) |
DE (1) | DE60229855D1 (ja) |
DK (1) | DK1423154T3 (ja) |
ES (1) | ES2315400T3 (ja) |
HK (1) | HK1065963A1 (ja) |
MX (1) | MXPA04001969A (ja) |
PT (1) | PT1423154E (ja) |
WO (1) | WO2003020203A2 (ja) |
Cited By (2)
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JP2010518918A (ja) * | 2007-02-16 | 2010-06-03 | ザ プロクター アンド ギャンブル カンパニー | ポリプロピレングリコール材料を含むローションを備える吸収性物品 |
JP2014505733A (ja) * | 2011-02-15 | 2014-03-06 | アラーガン インコーポレイテッド | 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 |
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US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
US7785584B2 (en) * | 2003-08-13 | 2010-08-31 | Healthpoint, Ltd. | Ointment wound spray |
US20050048105A1 (en) * | 2003-08-29 | 2005-03-03 | Mcnulty Amy K. | Protease inhibitor compositions for prevention and treatment of skin conditions |
US20050100621A1 (en) * | 2003-11-07 | 2005-05-12 | Popp Karl F. | Dermatological compositions |
US20060264505A1 (en) * | 2003-11-07 | 2006-11-23 | Stiefel Laboratories, Inc. | Dermatological compositions |
US20050281806A1 (en) * | 2004-06-16 | 2005-12-22 | Collegium Pharmaceutical, Inc., Delaware | Compositions for topical enzymatic debridement |
US8211449B2 (en) * | 2004-06-24 | 2012-07-03 | Dpt Laboratories, Ltd. | Pharmaceutically elegant, topical anhydrous aerosol foam |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
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CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
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US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
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US20130053353A1 (en) * | 2010-05-04 | 2013-02-28 | Foamix Ltd. | Compositions, gels and foams with rheology modulators and uses |
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2001
- 2001-09-04 US US09/945,903 patent/US6479060B1/en not_active Expired - Lifetime
-
2002
- 2002-07-29 JP JP2003524517A patent/JP4115391B2/ja not_active Expired - Fee Related
- 2002-07-29 EP EP02768363A patent/EP1423154B1/en not_active Expired - Lifetime
- 2002-07-29 KR KR1020047003208A patent/KR100638417B1/ko not_active IP Right Cessation
- 2002-07-29 WO PCT/US2002/023954 patent/WO2003020203A2/en active Application Filing
- 2002-07-29 DE DE60229855T patent/DE60229855D1/de not_active Expired - Lifetime
- 2002-07-29 CN CNB028221044A patent/CN100463697C/zh not_active Expired - Fee Related
- 2002-07-29 ES ES02768363T patent/ES2315400T3/es not_active Expired - Lifetime
- 2002-07-29 CA CA002459239A patent/CA2459239C/en not_active Expired - Fee Related
- 2002-07-29 AT AT02768363T patent/ATE413861T1/de active
- 2002-07-29 KR KR1020067014425A patent/KR100764278B1/ko not_active IP Right Cessation
- 2002-07-29 PT PT02768363T patent/PT1423154E/pt unknown
- 2002-07-29 BR BRPI0212286-3A patent/BR0212286A/pt not_active IP Right Cessation
- 2002-07-29 MX MXPA04001969A patent/MXPA04001969A/es active IP Right Grant
- 2002-07-29 AU AU2002330929A patent/AU2002330929B2/en not_active Ceased
- 2002-07-29 DK DK02768363T patent/DK1423154T3/da active
-
2004
- 2004-11-15 HK HK04108999.0A patent/HK1065963A1/xx not_active IP Right Cessation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010518918A (ja) * | 2007-02-16 | 2010-06-03 | ザ プロクター アンド ギャンブル カンパニー | ポリプロピレングリコール材料を含むローションを備える吸収性物品 |
JP2014505733A (ja) * | 2011-02-15 | 2014-03-06 | アラーガン インコーポレイテッド | 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 |
JP2017066162A (ja) * | 2011-02-15 | 2017-04-06 | アラーガン、インコーポレイテッドAllergan,Incorporated | 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 |
Also Published As
Publication number | Publication date |
---|---|
JP4115391B2 (ja) | 2008-07-09 |
KR20040041597A (ko) | 2004-05-17 |
KR100764278B1 (ko) | 2007-10-05 |
HK1065963A1 (en) | 2005-03-11 |
DE60229855D1 (de) | 2008-12-24 |
AU2002330929B2 (en) | 2005-06-16 |
KR20060086460A (ko) | 2006-07-31 |
DK1423154T3 (da) | 2009-01-26 |
BR0212286A (pt) | 2006-05-23 |
EP1423154B1 (en) | 2008-11-12 |
CA2459239A1 (en) | 2003-03-13 |
EP1423154A2 (en) | 2004-06-02 |
CA2459239C (en) | 2005-06-14 |
MXPA04001969A (es) | 2004-07-08 |
EP1423154A4 (en) | 2007-08-15 |
ATE413861T1 (de) | 2008-11-15 |
PT1423154E (pt) | 2009-01-30 |
ES2315400T3 (es) | 2009-04-01 |
WO2003020203A3 (en) | 2003-07-10 |
KR100638417B1 (ko) | 2006-10-24 |
WO2003020203A2 (en) | 2003-03-13 |
CN1610563A (zh) | 2005-04-27 |
US6479060B1 (en) | 2002-11-12 |
CN100463697C (zh) | 2009-02-25 |
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