JP2005526850A5 - - Google Patents
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- Publication number
- JP2005526850A5 JP2005526850A5 JP2004505094A JP2004505094A JP2005526850A5 JP 2005526850 A5 JP2005526850 A5 JP 2005526850A5 JP 2004505094 A JP2004505094 A JP 2004505094A JP 2004505094 A JP2004505094 A JP 2004505094A JP 2005526850 A5 JP2005526850 A5 JP 2005526850A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- diabetic
- failure
- aliskiren
- amlodipine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 claims description 10
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims description 10
- 229960004601 aliskiren Drugs 0.000 claims description 10
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims description 10
- 229960000528 amlodipine Drugs 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 206010012601 diabetes mellitus Diseases 0.000 claims 12
- 206010019280 Heart failures Diseases 0.000 claims 9
- 229960002003 hydrochlorothiazide Drugs 0.000 claims 9
- 206010002383 Angina Pectoris Diseases 0.000 claims 6
- 206010020772 Hypertension Diseases 0.000 claims 6
- 208000001647 Renal Insufficiency Diseases 0.000 claims 6
- 201000006370 kidney failure Diseases 0.000 claims 6
- 230000002792 vascular Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 3
- 206010003662 Atrial flutter Diseases 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 3
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 3
- 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 206010018364 Glomerulonephritis Diseases 0.000 claims 3
- 206010019668 Hepatic fibrosis Diseases 0.000 claims 3
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 3
- 206010021263 IgA nephropathy Diseases 0.000 claims 3
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 208000021642 Muscular disease Diseases 0.000 claims 3
- 201000009623 Myopathy Diseases 0.000 claims 3
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 3
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 3
- 208000003782 Raynaud disease Diseases 0.000 claims 3
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 3
- 206010039710 Scleroderma Diseases 0.000 claims 3
- 208000006011 Stroke Diseases 0.000 claims 3
- 206010042600 Supraventricular arrhythmias Diseases 0.000 claims 3
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 3
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 3
- 238000009825 accumulation Methods 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 230000000747 cardiac effect Effects 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 230000001149 cognitive effect Effects 0.000 claims 3
- 208000033679 diabetic kidney disease Diseases 0.000 claims 3
- 210000002744 extracellular matrix Anatomy 0.000 claims 3
- 230000003176 fibrotic effect Effects 0.000 claims 3
- 206010061989 glomerulosclerosis Diseases 0.000 claims 3
- 206010020718 hyperplasia Diseases 0.000 claims 3
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims 3
- 208000017169 kidney disease Diseases 0.000 claims 3
- 201000010260 leiomyoma Diseases 0.000 claims 3
- 206010027599 migraine Diseases 0.000 claims 3
- 208000010125 myocardial infarction Diseases 0.000 claims 3
- 201000008312 primary pulmonary hypertension Diseases 0.000 claims 3
- 201000001474 proteinuria Diseases 0.000 claims 3
- 230000002685 pulmonary effect Effects 0.000 claims 3
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 3
- 201000002793 renal fibrosis Diseases 0.000 claims 3
- 150000003839 salts Chemical group 0.000 claims 3
- 208000037812 secondary pulmonary hypertension Diseases 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 206010039808 Secondary aldosteronism Diseases 0.000 claims 2
- 208000032594 Vascular Remodeling Diseases 0.000 claims 2
- 230000001627 detrimental effect Effects 0.000 claims 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 2
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 229960002478 aldosterone Drugs 0.000 claims 1
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N aldosterone group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C=O)C(=O)CO PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
- 208000015891 sexual disease Diseases 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 206010005746 Blood pressure fluctuation Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38154602P | 2002-05-17 | 2002-05-17 | |
| US60/381,546 | 2002-05-17 | ||
| PCT/EP2003/005188 WO2003097098A1 (en) | 2002-05-17 | 2003-05-16 | Pharmaceutical composition comprising a renin inhibitor, a calcium channel blocker and a diuretic |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010181380A Division JP2010280708A (ja) | 2002-05-17 | 2010-08-13 | レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005526850A JP2005526850A (ja) | 2005-09-08 |
| JP2005526850A5 true JP2005526850A5 (https=) | 2010-04-22 |
| JP5288678B2 JP5288678B2 (ja) | 2013-09-11 |
Family
ID=29550141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004505094A Expired - Fee Related JP5288678B2 (ja) | 2002-05-17 | 2003-05-16 | レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 |
| JP2010181380A Withdrawn JP2010280708A (ja) | 2002-05-17 | 2010-08-13 | レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010181380A Withdrawn JP2010280708A (ja) | 2002-05-17 | 2010-08-13 | レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20050182042A1 (https=) |
| EP (2) | EP1507558B8 (https=) |
| JP (2) | JP5288678B2 (https=) |
| KR (3) | KR20050008717A (https=) |
| CN (1) | CN1655819A (https=) |
| AT (1) | ATE520417T1 (https=) |
| AU (1) | AU2003240669B2 (https=) |
| BR (1) | BR0310084A (https=) |
| CA (1) | CA2485081C (https=) |
| CY (2) | CY1112013T1 (https=) |
| DK (1) | DK1507558T3 (https=) |
| EC (1) | ECSP045428A (https=) |
| ES (1) | ES2369216T3 (https=) |
| IL (1) | IL164837A (https=) |
| LU (1) | LU92000I2 (https=) |
| MX (1) | MXPA04011383A (https=) |
| NO (1) | NO334382B1 (https=) |
| NZ (1) | NZ536555A (https=) |
| PL (1) | PL219032B1 (https=) |
| PT (1) | PT1507558E (https=) |
| RU (1) | RU2316318C2 (https=) |
| SI (1) | SI1507558T1 (https=) |
| WO (1) | WO2003097098A1 (https=) |
| ZA (1) | ZA200408442B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| US8168616B1 (en) * | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
| BR0310084A (pt) * | 2002-05-17 | 2005-02-15 | Novartis Ag | Composição farmacêutica compreendendo um inibidor de renina, um bloqueador de canal de cálcio e um diurético |
| EP1628663B1 (en) | 2003-05-15 | 2009-07-29 | Roskamp Research llc | Method for producing medicaments for reducing amyloid deposition, amyloid neurotoxicity and microgliosis |
| AR047880A1 (es) * | 2004-02-17 | 2006-03-01 | Novartis Ag | COMBINACIoN DE UN INHIBIDOR DE RENINA Y DIURÉTICOS |
| PE20142101A1 (es) * | 2004-03-17 | 2014-12-27 | Novartis Ag | Composiciones farmaceuticas de aliskiren |
| NZ549535A (en) * | 2004-03-17 | 2010-11-26 | Novartis Ag | Use of aliskiren for treating renal and other disorders |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| PT1891974E (pt) * | 2004-05-31 | 2010-09-27 | Almirall Sa | Combinações que compreendem agentes anti-muscarínicos e inibidores de pde4 |
| MY146830A (en) * | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
| US20100240760A1 (en) * | 2005-03-22 | 2010-09-23 | Jessie Gu | Biomarkers for Efficacy of Aliskiren as a Hypertensive Agent |
| KR20080066776A (ko) * | 2005-11-08 | 2008-07-16 | 노파르티스 아게 | 안지오텐신 ⅱ 수용체 봉쇄제, 칼슘 채널 봉쇄제 및 다른활성 약제의 조합물 |
| AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| GB0612540D0 (en) * | 2006-06-23 | 2006-08-02 | Novartis Ag | Galenical formulations of organic compounds |
| EP1891937A1 (en) * | 2006-08-25 | 2008-02-27 | Novartis AG | Galenic formulations of aliskiren |
| PE20081157A1 (es) * | 2006-11-07 | 2008-09-26 | Novartis Ag | Forma cristalina de hemifumarato de alisquireno |
| MX2009004628A (es) * | 2006-11-09 | 2009-05-15 | Novartis Ag | Sal de alisquireno con acido orotico. |
| ES2409756T3 (es) * | 2006-12-04 | 2013-06-27 | Promedior, Inc. | Combinación de SAP y de enalapril para su uso en tratamiento de trastornos fibróticos o fibroproliferativos |
| US20100292335A1 (en) * | 2007-02-16 | 2010-11-18 | Campbell Duncan J | Use of organic compounds |
| EP1972335A1 (en) * | 2007-03-23 | 2008-09-24 | Krka | Solid dosage forms comprising aliskiren and pharmaceutically acceptable salts thereof |
| RU2363472C2 (ru) * | 2007-05-22 | 2009-08-10 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова Федерального агентства по здравоохранению и социальному развитию" | Способ профилактики и лечения кардиоваскулярных осложнений у больных с хронической болезнью почек, находящихся на гемодиализе, имеющих анурию |
| US8497243B2 (en) * | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
| US9884899B2 (en) | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
| NZ584729A (en) | 2007-10-05 | 2012-12-21 | Alzheimer S Inst Of America Inc | Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer |
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| RU2373932C1 (ru) * | 2008-05-20 | 2009-11-27 | Илья Николаевич Медведев | Способ коррекции уровня микровезикул в крови при артериальной гипертонии |
| RU2372079C1 (ru) * | 2008-05-20 | 2009-11-10 | Илья Николаевич Медведев | Способ коррекции уровня микровезикул в крови при артериальной гипертонии, дислипидемии и нарушении толерантности к глюкозе |
| JO3239B1 (ar) | 2008-09-22 | 2018-03-08 | Novartis Ag | تركيبات جالينية من مركبات عضوية |
| RU2382644C1 (ru) * | 2008-11-05 | 2010-02-27 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гипертрофии левого желудочка у больных ибс в сочетании с гипертонической болезнью |
| EP2189442B1 (en) | 2008-11-20 | 2014-10-01 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of aliskiren |
| EP2405929B1 (en) * | 2009-03-11 | 2018-06-06 | Promedior Inc. | A sap polypeptide for use in the treatment of autoimmune disorders and graft vs host disease |
| CA2754961C (en) * | 2009-03-11 | 2018-04-10 | Promedior, Inc. | Treatment and diagnostic methods for hypersensitive disorders |
| UA110323C2 (en) * | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
| EP2987803B1 (en) * | 2009-06-17 | 2018-08-29 | Promedior Inc. | Sap variants and their use |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| CN102247344A (zh) * | 2011-05-30 | 2011-11-23 | 北京阜康仁生物制药科技有限公司 | 一种新型降血压组合物 |
| CN102552277A (zh) * | 2011-12-02 | 2012-07-11 | 邬林祥 | 氨氯地平、阿利可仑和氢氯噻嗪复方降压药物 |
| CN102626391B (zh) * | 2012-04-19 | 2013-07-10 | 海南美兰史克制药有限公司 | 一种阿利克仑氢氯噻嗪药物组合物脂质体固体制剂 |
| GB201317373D0 (en) | 2013-10-01 | 2013-11-13 | Univ Dundee | Treatment and prevention of cancer |
| CN111789843A (zh) * | 2019-04-08 | 2020-10-20 | 深圳奥萨医药有限公司 | 含氨氯地平、氯噻酮和阿米洛利的药物组合物 |
| KR102414285B1 (ko) * | 2020-06-02 | 2022-06-28 | 이화여자대학교 산학협력단 | 플루나리진 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 골질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5350771A (en) * | 1989-03-22 | 1994-09-27 | Peter K. T. Pang | Method and treatment for hypertension using combination therapy involving exogenous calcium and calcium channel blockers |
| KR100222252B1 (ko) * | 1990-12-14 | 1999-10-01 | 스튜어트 알. 수터 | 안지오텐신 ii 수용체 차단 조성물 |
| US5656650A (en) * | 1990-12-14 | 1997-08-12 | Smithkline Beecham Corp. | Angiotensin II receptor blocking compositions |
| US5178877A (en) * | 1991-01-04 | 1993-01-12 | Abbott Laboratories | Encapsulated renin inhibitor composition |
| US5114925A (en) * | 1991-01-22 | 1992-05-19 | Merck & Co., Inc. | Renin inhibitors containing the 2-[[(2R,3S)-3-amino-4-cyclohexyl-2-hydroxy-1-butyl]thio)alkanoyl moiety and the corresponding sulfoxide and sulfone derivatives |
| US5256667A (en) * | 1991-09-25 | 1993-10-26 | Merck & Co., Inc. | Quinazolinones and pyridopyrimidinones |
| US5202322A (en) * | 1991-09-25 | 1993-04-13 | Merck & Co., Inc. | Quinazolinone and pyridopyrimidine a-II antagonists |
| US5292741A (en) * | 1992-08-18 | 1994-03-08 | Merck & Co., Inc. | Macrocycles incorporating quinazolinones |
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| EP0795327A1 (en) * | 1996-03-13 | 1997-09-17 | Pfizer Inc. | Use of Amlodipine for the treatment and prophylaxis of congestive cardiac failure of non-ischaemic origin |
| US8168616B1 (en) * | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
| AU2002226365A1 (en) * | 2000-12-01 | 2002-06-11 | Novartis Ag | Combinations of an angiotensin receptor antagonist and an anti-hypertensive drug or a statin, for the treatment of sexual dysfunction |
| WO2003024457A1 (en) * | 2001-09-11 | 2003-03-27 | Asahi Kasei Kabushiki Kaisha | Medicinal composition for prevention of or treatment for cerebrovascular disorder and cardiopathy |
| US7019010B2 (en) * | 2001-09-27 | 2006-03-28 | Novertis Ag | Combinations |
| BR0310084A (pt) * | 2002-05-17 | 2005-02-15 | Novartis Ag | Composição farmacêutica compreendendo um inibidor de renina, um bloqueador de canal de cálcio e um diurético |
-
2003
- 2003-05-16 BR BR0310084-7A patent/BR0310084A/pt not_active Application Discontinuation
- 2003-05-16 AU AU2003240669A patent/AU2003240669B2/en not_active Ceased
- 2003-05-16 PT PT03730064T patent/PT1507558E/pt unknown
- 2003-05-16 EP EP03730064A patent/EP1507558B8/en not_active Expired - Lifetime
- 2003-05-16 MX MXPA04011383A patent/MXPA04011383A/es active IP Right Grant
- 2003-05-16 US US10/514,683 patent/US20050182042A1/en not_active Abandoned
- 2003-05-16 DK DK03730064.7T patent/DK1507558T3/da active
- 2003-05-16 RU RU2004137104/15A patent/RU2316318C2/ru not_active IP Right Cessation
- 2003-05-16 EP EP10177741A patent/EP2316488A1/en not_active Withdrawn
- 2003-05-16 KR KR10-2004-7018479A patent/KR20050008717A/ko not_active Ceased
- 2003-05-16 CN CNA03811237XA patent/CN1655819A/zh active Pending
- 2003-05-16 KR KR1020107028689A patent/KR20100137026A/ko not_active Ceased
- 2003-05-16 PL PL372203A patent/PL219032B1/pl unknown
- 2003-05-16 KR KR1020137023159A patent/KR20130109244A/ko not_active Ceased
- 2003-05-16 NZ NZ536555A patent/NZ536555A/en not_active IP Right Cessation
- 2003-05-16 JP JP2004505094A patent/JP5288678B2/ja not_active Expired - Fee Related
- 2003-05-16 SI SI200332071T patent/SI1507558T1/sl unknown
- 2003-05-16 WO PCT/EP2003/005188 patent/WO2003097098A1/en not_active Ceased
- 2003-05-16 ES ES03730064T patent/ES2369216T3/es not_active Expired - Lifetime
- 2003-05-16 CA CA2485081A patent/CA2485081C/en not_active Expired - Fee Related
- 2003-05-16 AT AT03730064T patent/ATE520417T1/de active
-
2004
- 2004-10-19 ZA ZA200408442A patent/ZA200408442B/en unknown
- 2004-10-25 IL IL164837A patent/IL164837A/en not_active IP Right Cessation
- 2004-11-12 EC EC2004005428A patent/ECSP045428A/es unknown
- 2004-12-15 NO NO20045459A patent/NO334382B1/no not_active IP Right Cessation
-
2008
- 2008-08-08 US US12/188,604 patent/US8183295B2/en not_active Expired - Fee Related
-
2010
- 2010-08-13 JP JP2010181380A patent/JP2010280708A/ja not_active Withdrawn
-
2011
- 2011-11-07 CY CY20111101071T patent/CY1112013T1/el unknown
- 2011-11-30 US US13/307,567 patent/US20120071470A1/en not_active Abandoned
-
2012
- 2012-05-14 CY CY2012011C patent/CY2012011I1/el unknown
- 2012-05-14 LU LU92000C patent/LU92000I2/fr unknown
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