JP5288678B2 - レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 - Google Patents
レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 Download PDFInfo
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- JP5288678B2 JP5288678B2 JP2004505094A JP2004505094A JP5288678B2 JP 5288678 B2 JP5288678 B2 JP 5288678B2 JP 2004505094 A JP2004505094 A JP 2004505094A JP 2004505094 A JP2004505094 A JP 2004505094A JP 5288678 B2 JP5288678 B2 JP 5288678B2
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- aliskiren
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- diabetic
- amlodipine
- renal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Description
DOCA埋植の際に、ラットの片側の腎臓を摘出する。左横腹および頚背部の体毛を刈り込み、滅菌アルコール消毒綿およびポビドンヨードで拭う。外科手術中は、体温を37℃に維持するためにラットを電気座布団上に置く。
この方法は、片側性の腎臓切除術およびDOCAならびに塩処置の開始から7〜10日前にラットに無線通信機を埋め込むこと以外は、前記の方法と同様である。これに加えて、ラットには大腿動脈および静脈カテーテル留置のための外科手術は行わない。無線通信機は、M.K. Bazil、C. Krulan and R.L. Webb.、Telemetric monitoring of cardiovascular parameters in conscious spontaneously hypertensive rats、J.Cardiovasc. Pharmacol. 22: 897−905、1993に記載されたように埋め込む。
Claims (25)
- 有効成分として、遊離形または医薬上許容される塩形の、(i)アリスキレン、(ii)アムロジピン、および(iii)ヒドロクロロチアジドを含む、高血圧症の処置のための医薬組成物。
- アリスキレンが1〜1,000mgであり、アムロジピンが1〜40mgであり、そしてヒドロクロロチアジドが5〜200mgである、請求項1に記載の医薬組成物。
- アリスキレンが140〜550mgであり、アムロジピンが2〜12mgであり、そしてヒドロクロロチアジドが5〜30mgである、請求項1または2に記載の医薬組成物。
- アリスキレンが150〜500mgである、請求項2または3に記載の医薬組成物。
- アリスキレンが140〜220mgである、請求項2または3に記載の医薬組成物。
- アリスキレンが150mgである、請求項2または3に記載の医薬組成物。
- アムロジピンが5または10mgである、請求項2〜6のいずれかに記載の医薬組成物。
- ヒドロクロロチアジドが12.5または25mgである、請求項2〜7のいずれかに記載の医薬組成物。
- 有効成分として、遊離形または医薬上許容される塩形の、(i)アリスキレン、(ii)アムロジピン、および(iii)ヒドロクロロチアジドを含む、高血圧症の処置のための医薬的組合せ剤。
- アリスキレンが1〜1,000mgであり、アムロジピンが1〜40mgであり、そしてヒドロクロロチアジドが5〜200mgである、請求項9に記載の組合せ剤。
- アリスキレンが140〜550mgであり、アムロジピンが2〜12mgであり、そしてヒドロクロロチアジドが5〜30mgである、請求項9または10に記載の組合せ剤。
- アリスキレンが150〜500mgである、請求項10または11に記載の組合せ剤。
- アリスキレンが140〜220mgである、請求項10または11に記載の組合せ剤。
- アリスキレンが150mgである、請求項10または11に記載の組合せ剤。
- アムロジピンが5または10mgである、請求項10〜14のいずれかに記載の組合せ剤。
- ヒドロクロロチアジドが12.5または25mgである、請求項10〜15のいずれかに記載の組合せ剤。
- 有効成分として、遊離形または医薬上許容される塩形の、(i)アリスキレン、(ii)アムロジピン、および(iii)ヒドロクロロチアジドを、成分(i)〜(iii)の2つまたは3つの個別単位の形態で含む、高血圧症の処置のためのキット。
- アリスキレンが1〜1,000mgであり、アムロジピンが1〜40mgであり、そしてヒドロクロロチアジドが5〜200mgである、請求項17に記載のキット。
- アリスキレンが140〜550mgであり、アムロジピンが2〜12mgであり、そしてヒドロクロロチアジドが5〜30mgである、請求項17または18に記載のキット。
- アリスキレンが150〜500mgである、請求項18または19に記載のキット。
- アリスキレンが140〜220mgである、請求項18または19に記載のキット。
- アリスキレンが150mgである、請求項18または19に記載のキット。
- アムロジピンが5または10mgである、請求項18〜22のいずれかに記載のキット。
- ヒドロクロロチアジドが12.5または25mgである、請求項18〜23のいずれかに記載のキット。
- 同時的、個別的、または逐次的使用のための説明書をさらに含む、請求項17〜24のいずれかに記載のキット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38154602P | 2002-05-17 | 2002-05-17 | |
US60/381,546 | 2002-05-17 | ||
PCT/EP2003/005188 WO2003097098A1 (en) | 2002-05-17 | 2003-05-16 | Pharmaceutical composition comprising a renin inhibitor, a calcium channel blocker and a diuretic |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010181380A Division JP2010280708A (ja) | 2002-05-17 | 2010-08-13 | レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2005526850A JP2005526850A (ja) | 2005-09-08 |
JP2005526850A5 JP2005526850A5 (ja) | 2010-04-22 |
JP5288678B2 true JP5288678B2 (ja) | 2013-09-11 |
Family
ID=29550141
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004505094A Expired - Fee Related JP5288678B2 (ja) | 2002-05-17 | 2003-05-16 | レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 |
JP2010181380A Withdrawn JP2010280708A (ja) | 2002-05-17 | 2010-08-13 | レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2010181380A Withdrawn JP2010280708A (ja) | 2002-05-17 | 2010-08-13 | レニンインヒビター、カルシウムチャネルブロッカーおよび利尿薬を含む医薬組成物 |
Country Status (25)
Country | Link |
---|---|
US (3) | US20050182042A1 (ja) |
EP (2) | EP2316488A1 (ja) |
JP (2) | JP5288678B2 (ja) |
KR (3) | KR20130109244A (ja) |
CN (1) | CN1655819A (ja) |
AT (1) | ATE520417T1 (ja) |
AU (1) | AU2003240669B2 (ja) |
BR (1) | BR0310084A (ja) |
CA (1) | CA2485081C (ja) |
CY (2) | CY1112013T1 (ja) |
DK (1) | DK1507558T3 (ja) |
EC (1) | ECSP045428A (ja) |
ES (1) | ES2369216T3 (ja) |
HK (1) | HK1074774A1 (ja) |
IL (1) | IL164837A (ja) |
LU (1) | LU92000I2 (ja) |
MX (1) | MXPA04011383A (ja) |
NO (1) | NO334382B1 (ja) |
NZ (1) | NZ536555A (ja) |
PL (1) | PL219032B1 (ja) |
PT (1) | PT1507558E (ja) |
RU (1) | RU2316318C2 (ja) |
SI (1) | SI1507558T1 (ja) |
WO (1) | WO2003097098A1 (ja) |
ZA (1) | ZA200408442B (ja) |
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DK1628663T3 (da) | 2003-05-15 | 2010-03-08 | Roskamp Res Llc | Fremgangsmåde til fremstilling af medikamenter til reduktion af amyloid-aflejring, amyloid-neurotoksicitet og mikrogliose |
TW200538154A (en) * | 2004-02-17 | 2005-12-01 | Novartis Ag | Combination of organic compounds |
AR048431A1 (es) * | 2004-03-17 | 2006-04-26 | Novartis Ag | Formulaciones galenicas de compuestos organicos |
KR20070006774A (ko) * | 2004-03-17 | 2007-01-11 | 노파르티스 아게 | 치료에서 레닌 억제제의 용도 |
MY146830A (en) * | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
WO2006102177A2 (en) * | 2005-03-22 | 2006-09-28 | Novartis Ag | Biomarkers for efficacy of aliskiren as a hypertensive agent |
WO2007056324A2 (en) * | 2005-11-08 | 2007-05-18 | Novartis Ag | Combination of an angiotensin ii receptor blocker, a calcium channel blocker and another active agent |
AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
GB0612540D0 (en) * | 2006-06-23 | 2006-08-02 | Novartis Ag | Galenical formulations of organic compounds |
EP1891937A1 (en) * | 2006-08-25 | 2008-02-27 | Novartis AG | Galenic formulations of aliskiren |
US8119841B2 (en) * | 2006-11-07 | 2012-02-21 | Novartis Ag | Crystalline forms of aliskiren hemifumarate |
US20100130616A1 (en) * | 2006-11-09 | 2010-05-27 | Novartis Ag | Salt of aliskiren with orotic acid |
US8247370B2 (en) * | 2006-12-04 | 2012-08-21 | Promedior, Inc. | Conjoint therapy for treating fibrotic diseases |
WO2008098992A1 (en) * | 2007-02-16 | 2008-08-21 | Novartis Ag | Use of organic compounds |
EP1972335A1 (en) * | 2007-03-23 | 2008-09-24 | Krka | Solid dosage forms comprising aliskiren and pharmaceutically acceptable salts thereof |
US9884899B2 (en) * | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
US8497243B2 (en) * | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
CA2701620C (en) | 2007-10-05 | 2014-12-09 | Alzheimer's Institute Of America, Inc. | Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer |
EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
JO3239B1 (ar) | 2008-09-22 | 2018-03-08 | Novartis Ag | تركيبات جالينية من مركبات عضوية |
SI2189442T1 (sl) | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
CA2755047C (en) * | 2009-03-11 | 2018-12-04 | Promedior, Inc. | Treatment methods for autoimmune disorders |
JP5797565B2 (ja) * | 2009-03-11 | 2015-10-21 | プロメディオール, インコーポレイテッド | 過敏性障害(hypersensitive disorder)に対する処置および診断方法 |
UA110323C2 (en) * | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
ES2552793T3 (es) | 2009-06-17 | 2015-12-02 | Promedior Inc. | Variantes de SAP y su uso |
EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
CN102247344A (zh) * | 2011-05-30 | 2011-11-23 | 北京阜康仁生物制药科技有限公司 | 一种新型降血压组合物 |
CN102552277A (zh) * | 2011-12-02 | 2012-07-11 | 邬林祥 | 氨氯地平、阿利可仑和氢氯噻嗪复方降压药物 |
CN102626391B (zh) * | 2012-04-19 | 2013-07-10 | 海南美兰史克制药有限公司 | 一种阿利克仑氢氯噻嗪药物组合物脂质体固体制剂 |
GB201317373D0 (en) | 2013-10-01 | 2013-11-13 | Univ Dundee | Treatment and prevention of cancer |
CN111789843A (zh) * | 2019-04-08 | 2020-10-20 | 深圳奥萨医药有限公司 | 含氨氯地平、氯噻酮和阿米洛利的药物组合物 |
KR102414285B1 (ko) * | 2020-06-02 | 2022-06-28 | 이화여자대학교 산학협력단 | 플루나리진 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 골질환의 예방 또는 치료용 약학적 조성물 |
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2003
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