JP2005526814A5 - - Google Patents
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- Publication number
- JP2005526814A5 JP2005526814A5 JP2003580319A JP2003580319A JP2005526814A5 JP 2005526814 A5 JP2005526814 A5 JP 2005526814A5 JP 2003580319 A JP2003580319 A JP 2003580319A JP 2003580319 A JP2003580319 A JP 2003580319A JP 2005526814 A5 JP2005526814 A5 JP 2005526814A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- alkyl
- compound
- hydroxy
- indol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0200979A SE0200979D0 (sv) | 2002-03-28 | 2002-03-28 | New compounds |
| PCT/SE2003/000508 WO2003082853A1 (en) | 2002-03-28 | 2003-03-28 | New compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007155810A Division JP2007224051A (ja) | 2002-03-28 | 2007-06-13 | 新規な化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005526814A JP2005526814A (ja) | 2005-09-08 |
| JP2005526814A5 true JP2005526814A5 (https=) | 2007-03-29 |
| JP3989444B2 JP3989444B2 (ja) | 2007-10-10 |
Family
ID=20287447
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003580319A Expired - Fee Related JP3989444B2 (ja) | 2002-03-28 | 2003-03-28 | 新規な化合物 |
| JP2007155810A Pending JP2007224051A (ja) | 2002-03-28 | 2007-06-13 | 新規な化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007155810A Pending JP2007224051A (ja) | 2002-03-28 | 2007-06-13 | 新規な化合物 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7399780B2 (https=) |
| EP (2) | EP1492785B9 (https=) |
| JP (2) | JP3989444B2 (https=) |
| KR (1) | KR101014525B1 (https=) |
| CN (2) | CN100519550C (https=) |
| AR (1) | AR038996A1 (https=) |
| AT (1) | ATE416171T1 (https=) |
| AU (1) | AU2003216026B2 (https=) |
| BR (1) | BR0308196A (https=) |
| CA (1) | CA2476343C (https=) |
| CY (1) | CY1108823T1 (https=) |
| DE (1) | DE60325032D1 (https=) |
| DK (1) | DK1492785T3 (https=) |
| ES (1) | ES2316784T3 (https=) |
| IL (2) | IL163894A0 (https=) |
| IS (1) | IS7471A (https=) |
| MX (1) | MXPA04009163A (https=) |
| MY (1) | MY144659A (https=) |
| NO (1) | NO329884B1 (https=) |
| NZ (1) | NZ534664A (https=) |
| PL (1) | PL211096B1 (https=) |
| PT (1) | PT1492785E (https=) |
| RU (1) | RU2338742C2 (https=) |
| SA (1) | SA03240054B1 (https=) |
| SE (1) | SE0200979D0 (https=) |
| SI (1) | SI1492785T1 (https=) |
| TW (1) | TWI330081B (https=) |
| UA (1) | UA79447C2 (https=) |
| UY (1) | UY27740A1 (https=) |
| WO (1) | WO2003082853A1 (https=) |
| ZA (1) | ZA200407665B (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302546D0 (sv) * | 2003-09-24 | 2003-09-24 | Astrazeneca Ab | New compounds |
| US20040067985A1 (en) * | 2002-10-04 | 2004-04-08 | Fortuna Haviv | Method of inhibiting angiogenesis |
| WO2006023931A2 (en) | 2004-08-18 | 2006-03-02 | Takeda San Diego, Inc. | Kinase inhibitors |
| EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US8046280B2 (en) * | 2005-06-10 | 2011-10-25 | Pioneer Hi-Bred International, Inc. | Method for using environmental classification to assist in financial management and services |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| WO2007089193A1 (en) * | 2006-02-02 | 2007-08-09 | Astrazeneca Ab | A process for preparing 2-hydroxy-3- [5- (morpholin-4-ylmethyl)pyridin-2-yl] lh-indole-5-carbonitrile as a free base or salts thereof |
| SA07280004B1 (ar) * | 2006-02-02 | 2011-10-29 | استرازينيكا ايه بي | ملح سترات من مركب 2- هيدروكسي –3- [5- (مورفولين –4- يل ميثيل) بيريدين –2- يل] 1h- إندول –5- كربونيتريل سترات |
| EP1981500A4 (en) * | 2006-02-02 | 2010-08-25 | Astrazeneca Ab | PHARMACEUTICAL USE OF 2-HYDROXY-3- [5- (MORPHOLIN-4-YLMETHYL) PYRIDINE-2-YL] -1H-INDOL-5-CARBONITRIL AS FREE BASE OR SALT |
| JP2009528344A (ja) * | 2006-02-28 | 2009-08-06 | アストラゼネカ・アクチエボラーグ | インドール誘導体の新規な塩及び医薬におけるその使用 |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007120102A1 (en) * | 2006-04-19 | 2007-10-25 | Astrazeneca Ab | New substituted oxindole derivatives |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20080086340A1 (en) * | 2006-10-04 | 2008-04-10 | Pioneer Hi-Bred International, Inc. | Crop quality insurance |
| SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
| CN101573352A (zh) | 2006-10-21 | 2009-11-04 | 艾博特股份有限两合公司 | 杂环化合物和其作为糖原合酶激酶3抑制剂的用途 |
| WO2008083062A1 (en) | 2006-12-29 | 2008-07-10 | Pioneer Hi-Bred International, Inc. | Automated location-based information recall |
| BRPI0810216A2 (pt) | 2007-04-18 | 2014-10-21 | Astrazeneca Ab | Processo para a preparação de composto, composto, e, método de tratamento de distúrbio bipolar |
| WO2009017453A1 (en) * | 2007-07-30 | 2009-02-05 | Astrazeneca Ab | New therapeutic combination of an antipsychotic and a gsk3 inhibitor 958 |
| WO2009017454A1 (en) * | 2007-07-30 | 2009-02-05 | Astrazeneca Ab | New therapeutic combination of a gsk3 inhibitor and an a7-nicotinic agonist 960 |
| WO2009017455A1 (en) * | 2007-07-30 | 2009-02-05 | Astrazeneca Ab | A new combination of (a) an alpha-4-beta-2 -neuronal nicotinic agonist and (b) a gsk3 inhibitor |
| CN101772497A (zh) * | 2007-07-30 | 2010-07-07 | 阿斯利康(瑞典)有限公司 | 2-羟基-3-[5-(吗啉-4-基甲基)吡啶-2-基]1h-吲哚-5-腈柠檬酸盐的新结晶形式 |
| CA2736177A1 (en) * | 2007-09-06 | 2009-03-12 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
| US20090291982A1 (en) * | 2008-05-22 | 2009-11-26 | Astrazeneca Ab | New Substituted Oxindole Derivative 352 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| TW201040191A (en) | 2009-03-27 | 2010-11-16 | Abbott Gmbh & Co Kg | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
| WO2010143803A2 (en) * | 2009-06-08 | 2010-12-16 | Industry Foundation Of Chonnam National University | New nicotinamide derivatives with anti-androgen effects, processes of preparing, and antiandrogens comprising the same |
| JP2011178752A (ja) * | 2010-03-03 | 2011-09-15 | Nagoya Univ | 含窒素複素環化合物及びその製造方法 |
| MX336726B (es) | 2010-09-27 | 2016-01-27 | Abbott Gmbh & Co Kg | Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3. |
| CA2819373A1 (en) | 2010-12-09 | 2012-06-14 | Amgen Inc. | Bicyclic compounds as pim inhibitors |
| WO2012084855A2 (de) | 2010-12-21 | 2012-06-28 | Bayer Cropscience Ag | Verfahren zur herstellung von triazinylsubstituierten oxindolen |
| US9090592B2 (en) | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
| JP2014510105A (ja) | 2011-03-22 | 2014-04-24 | アムジエン・インコーポレーテツド | Ｐｉｍ阻害剤としてのアゾール化合物 |
| PL2970890T3 (pl) | 2013-03-14 | 2020-11-16 | The Brigham And Women's Hospital, Inc. | Kompozycje i sposoby ekspansji i hodowli nabłonkowych komórek macierzystych |
| EP3741375A1 (en) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| EP3189134A1 (en) | 2014-09-03 | 2017-07-12 | The Brigham and Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| US11021687B2 (en) | 2016-01-08 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| RU2648820C2 (ru) * | 2016-04-14 | 2018-03-28 | Общество с ограниченной ответственностью "Научно-исследовательский центр "Парк активных молекул" | Средство, обладающее противоклоногенной активностью в отношении опухолевых клеток человека |
| EP3562827A1 (en) | 2016-12-30 | 2019-11-06 | Frequency Therapeutics, Inc. | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
| CN108440401A (zh) * | 2018-04-13 | 2018-08-24 | 华东理工大学 | 5-[(4-乙基哌嗪-1-基)甲基]吡啶-2-胺的制备方法 |
| JP2021533788A (ja) | 2018-08-17 | 2021-12-09 | フリークエンシー セラピューティクス インコーポレイテッド | Ｊａｇ−１を上方制御することにより有毛細胞を生成するための組成物及び方法 |
| US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
| EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3948910A (en) * | 1973-12-28 | 1976-04-06 | The Dow Chemical Company | Aminohalopyridine-N-oxides |
| AU511411B2 (en) * | 1976-08-10 | 1980-08-21 | Sumitomo Chemical Co | Microbicide |
| NZ192948A (en) * | 1979-03-09 | 1982-02-23 | Ishihara Sangyo Kaisha | Preparation of beta-trifuloromethyl-pyridine derivatives directly from beta-picoline |
| GB8401288D0 (en) * | 1984-01-18 | 1984-02-22 | Pfizer Ltd | Therapeutic agents |
| US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| FR2686878B1 (fr) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
| FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5565580A (en) | 1994-01-27 | 1996-10-15 | Neurosearch A/S | Glutamate Antagonists |
| RU2137762C1 (ru) | 1994-02-23 | 1999-09-20 | Пфайзер Инк. | 4-гетероциклил-замещенные производные хиназолина, фармацевтическая композиция |
| TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
| GB9707800D0 (en) * | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
| ES2289791T3 (es) | 1997-08-22 | 2008-02-01 | Astrazeneca Ab | Derivados de oxindolilquinazolina como inhibidores de la angiogenesis. |
| CA2340701C (en) | 1998-08-20 | 2009-05-26 | Sumitomo Pharmaceuticals Co., Ltd. | Oxindole derivatives as growth hormone releasers |
| JP4649046B2 (ja) * | 1999-05-21 | 2011-03-09 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼのピロロトリアジン阻害剤 |
| MXPA02003436A (es) * | 1999-10-07 | 2002-08-20 | Amgen Inc | Inhibidores de triazina cinasa. |
| US6455525B1 (en) * | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
| EP1136493A1 (en) | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives |
| CA2417277A1 (en) * | 2000-07-27 | 2002-02-07 | F. Hoffmann-La Roche Ag | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3.beta. |
| EP1330426A4 (en) | 2000-10-13 | 2005-09-14 | Bristol Myers Squibb Co | SELECTIVE MAXI-K CALIUM CHANNEL OPENING OPERATORS UNDER CONDITIONS OF HIGH INTRA-CELLULAR CALCIUM CONCENTRATIONS, METHOD AND THEIR USE |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| SE0104341D0 (sv) * | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New use |
| TW200301123A (en) | 2001-12-21 | 2003-07-01 | Astrazeneca Uk Ltd | New use |
| EP1458711B1 (en) | 2001-12-21 | 2007-07-18 | AstraZeneca AB | Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer s disease and conditions associated with glycogen synthase kinase-3 |
| SE0302546D0 (sv) * | 2003-09-24 | 2003-09-24 | Astrazeneca Ab | New compounds |
| EP1513830A1 (en) * | 2002-06-05 | 2005-03-16 | Janssen Pharmaceutica N.V. | Bisindolyl-maleimid derivatives as kinase inhibitors |
-
2002
- 2002-03-28 SE SE0200979A patent/SE0200979D0/xx unknown
-
2003
- 2003-03-17 AR ARP030100931A patent/AR038996A1/es unknown
- 2003-03-19 TW TW092106042A patent/TWI330081B/zh not_active IP Right Cessation
- 2003-03-26 SA SA03240054A patent/SA03240054B1/ar unknown
- 2003-03-26 MY MYPI20031117A patent/MY144659A/en unknown
- 2003-03-28 CA CA2476343A patent/CA2476343C/en not_active Expired - Fee Related
- 2003-03-28 NZ NZ534664A patent/NZ534664A/en not_active IP Right Cessation
- 2003-03-28 UA UA20040806742A patent/UA79447C2/uk unknown
- 2003-03-28 CN CNB038073897A patent/CN100519550C/zh not_active Expired - Fee Related
- 2003-03-28 EP EP03745498A patent/EP1492785B9/en not_active Expired - Lifetime
- 2003-03-28 RU RU2004125146/04A patent/RU2338742C2/ru not_active IP Right Cessation
- 2003-03-28 SI SI200331526T patent/SI1492785T1/sl unknown
- 2003-03-28 PT PT03745498T patent/PT1492785E/pt unknown
- 2003-03-28 CN CNA2006101537141A patent/CN1923812A/zh active Pending
- 2003-03-28 BR BR0308196-6A patent/BR0308196A/pt not_active IP Right Cessation
- 2003-03-28 KR KR1020047015389A patent/KR101014525B1/ko not_active Expired - Fee Related
- 2003-03-28 IL IL16389403A patent/IL163894A0/xx unknown
- 2003-03-28 ES ES03745498T patent/ES2316784T3/es not_active Expired - Lifetime
- 2003-03-28 US US10/509,268 patent/US7399780B2/en not_active Expired - Lifetime
- 2003-03-28 EP EP08157461A patent/EP1961748A3/en not_active Withdrawn
- 2003-03-28 DK DK03745498T patent/DK1492785T3/da active
- 2003-03-28 PL PL372966A patent/PL211096B1/pl not_active IP Right Cessation
- 2003-03-28 AT AT03745498T patent/ATE416171T1/de active
- 2003-03-28 AU AU2003216026A patent/AU2003216026B2/en not_active Ceased
- 2003-03-28 UY UY27740A patent/UY27740A1/es not_active Application Discontinuation
- 2003-03-28 JP JP2003580319A patent/JP3989444B2/ja not_active Expired - Fee Related
- 2003-03-28 DE DE60325032T patent/DE60325032D1/de not_active Expired - Lifetime
- 2003-03-28 MX MXPA04009163A patent/MXPA04009163A/es active IP Right Grant
- 2003-03-28 WO PCT/SE2003/000508 patent/WO2003082853A1/en not_active Ceased
-
2004
- 2004-09-02 IL IL163894A patent/IL163894A/en not_active IP Right Cessation
- 2004-09-22 ZA ZA200407665A patent/ZA200407665B/en unknown
- 2004-09-27 IS IS7471A patent/IS7471A/is unknown
- 2004-10-19 NO NO20044432A patent/NO329884B1/no not_active IP Right Cessation
-
2007
- 2007-06-13 JP JP2007155810A patent/JP2007224051A/ja active Pending
-
2008
- 2008-06-17 US US12/140,510 patent/US20090149460A1/en not_active Abandoned
-
2009
- 2009-02-19 CY CY20091100196T patent/CY1108823T1/el unknown
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