JP2005525345A - Trx媒介性疾患を処置する方法 - Google Patents
Trx媒介性疾患を処置する方法 Download PDFInfo
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- JP2005525345A JP2005525345A JP2003569148A JP2003569148A JP2005525345A JP 2005525345 A JP2005525345 A JP 2005525345A JP 2003569148 A JP2003569148 A JP 2003569148A JP 2003569148 A JP2003569148 A JP 2003569148A JP 2005525345 A JP2005525345 A JP 2005525345A
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- JP
- Japan
- Prior art keywords
- group
- hdac inhibitor
- trx
- hydrate
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- VRZWCYZJGUYTKU-UHFFFAOYSA-N C[n]1c(ncnc2)c2nc1 Chemical compound C[n]1c(ncnc2)c2nc1 VRZWCYZJGUYTKU-UHFFFAOYSA-N 0.000 description 1
- WESDBLALURHRDL-UHFFFAOYSA-N Cc1ncnc2c1nccn2 Chemical compound Cc1ncnc2c1nccn2 WESDBLALURHRDL-UHFFFAOYSA-N 0.000 description 1
- 0 ONC(*C(Nc1cnccc1)=O)=O Chemical compound ONC(*C(Nc1cnccc1)=O)=O 0.000 description 1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35738302P | 2002-02-15 | 2002-02-15 | |
| PCT/US2003/004924 WO2003070188A2 (en) | 2002-02-15 | 2003-02-14 | Method of treating trx mediated diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005525345A true JP2005525345A (ja) | 2005-08-25 |
| JP2005525345A5 JP2005525345A5 (enExample) | 2006-03-30 |
Family
ID=27757609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569148A Pending JP2005525345A (ja) | 2002-02-15 | 2003-02-14 | Trx媒介性疾患を処置する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20030235588A1 (enExample) |
| EP (1) | EP1482962A4 (enExample) |
| JP (1) | JP2005525345A (enExample) |
| AU (1) | AU2003219803B8 (enExample) |
| CA (1) | CA2476434A1 (enExample) |
| WO (1) | WO2003070188A2 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012500283A (ja) * | 2008-08-19 | 2012-01-05 | ノップ ニューロサイエンシーズ、インク. | (r)−プラミペキソールを使用した組成物並びにその方法 |
| JP2016520293A (ja) * | 2013-03-18 | 2016-07-14 | キアゲン ゲーエムベーハー | 細胞外核酸の安定化および単離 |
| US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US10028940B2 (en) | 2013-08-13 | 2018-07-24 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
| US10195183B2 (en) | 2013-08-13 | 2019-02-05 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| US10383857B2 (en) | 2013-07-12 | 2019-08-20 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils |
| KR20200021145A (ko) * | 2018-08-20 | 2020-02-28 | 주식회사 휴젝스 | 산발적 파킨슨병 진단의 정보제공방법 및 약물 스크리닝 방법 |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0202707A3 (en) * | 1999-09-08 | 2003-11-28 | Univ Columbia | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and pharmaceutical compositions containing them and use thereof |
| WO2002060933A2 (en) * | 2001-01-30 | 2002-08-08 | The Provost, Fellows And Scholars Of The College Of The Holy And Unidivided Trinity Of Queen Elizabeht | Thioredoxin derived from h. pylori, which is capable of inhibiting nf-kappa b activation |
| AU2002340253C1 (en) * | 2001-10-16 | 2011-03-31 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
| AU2003219803B8 (en) * | 2002-02-15 | 2005-08-25 | Sloan-Kettering Institute For Cancer Research | Method of treating TRX mediated diseases |
| US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
| US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
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|---|---|
| US20060009526A1 (en) | 2006-01-12 |
| WO2003070188A3 (en) | 2004-02-19 |
| AU2003219803B8 (en) | 2005-08-25 |
| US20060009527A1 (en) | 2006-01-12 |
| AU2003219803B2 (en) | 2005-07-28 |
| EP1482962A2 (en) | 2004-12-08 |
| CA2476434A1 (en) | 2003-08-28 |
| AU2003219803A1 (en) | 2003-09-09 |
| EP1482962A4 (en) | 2009-12-23 |
| WO2003070188A2 (en) | 2003-08-28 |
| US20030235588A1 (en) | 2003-12-25 |
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