CA2476434A1 - Method of treating trx mediated diseases - Google Patents

Method of treating trx mediated diseases Download PDF

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Publication number
CA2476434A1
CA2476434A1 CA002476434A CA2476434A CA2476434A1 CA 2476434 A1 CA2476434 A1 CA 2476434A1 CA 002476434 A CA002476434 A CA 002476434A CA 2476434 A CA2476434 A CA 2476434A CA 2476434 A1 CA2476434 A1 CA 2476434A1
Authority
CA
Canada
Prior art keywords
hdac inhibitor
trx
binding
thioredoxin
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002476434A
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English (en)
French (fr)
Inventor
Victoria M. Richon
Paul A. Marks
Richard A. Rifkind
Lisa M. Butler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2476434A1 publication Critical patent/CA2476434A1/en
Abandoned legal-status Critical Current

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
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CA002476434A 2002-02-15 2003-02-14 Method of treating trx mediated diseases Abandoned CA2476434A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35738302P 2002-02-15 2002-02-15
US60/357,383 2002-02-15
PCT/US2003/004924 WO2003070188A2 (en) 2002-02-15 2003-02-14 Method of treating trx mediated diseases

Publications (1)

Publication Number Publication Date
CA2476434A1 true CA2476434A1 (en) 2003-08-28

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ID=27757609

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002476434A Abandoned CA2476434A1 (en) 2002-02-15 2003-02-14 Method of treating trx mediated diseases

Country Status (6)

Country Link
US (3) US20030235588A1 (enExample)
EP (1) EP1482962A4 (enExample)
JP (1) JP2005525345A (enExample)
AU (1) AU2003219803B8 (enExample)
CA (1) CA2476434A1 (enExample)
WO (1) WO2003070188A2 (enExample)

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ATE517624T1 (de) * 2001-10-16 2011-08-15 Sloan Kettering Inst Cancer Behandlung von neurodegenerativen erkrankungen und krebs im gehirn
EP1482962A4 (en) * 2002-02-15 2009-12-23 Sloan Kettering Inst Cancer METHOD OF TREATING THIOREDOXIN-MEDIATED DISEASES (TRX)
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US20060276547A1 (en) * 2002-03-04 2006-12-07 Bacopoulos Nicholas G Methods of treating cancer with HDAC inhibitors
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RU2394022C2 (ru) * 2002-03-04 2010-07-10 МЕРК ЭйчДиЭйСи Рисерч, ЛЛС Способы индукции конечной дифференцировки
US7456219B2 (en) 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
US20070060614A1 (en) * 2002-03-04 2007-03-15 Bacopoulos Nicholas G Methods of treating cancer with hdac inhibitors
US20040077591A1 (en) * 2002-03-28 2004-04-22 The Brigham And Women's Hospital, Inc. Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and Alzheimer's Disease
MXPA04010199A (es) * 2002-04-15 2005-07-05 Sloan Kettering Inst Cancer Terapia en combinacion para el tratamiento de cancer.
US8946295B2 (en) * 2002-07-25 2015-02-03 Sunny Pharmtech Inc. Histone hyperacetylating agents for promoting wound healing and preventing scar formation
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7375228B2 (en) 2003-03-17 2008-05-20 Takeda San Diego, Inc. Histone deacetylase inhibitors
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