JP2005523270A5 - - Google Patents
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- Publication number
- JP2005523270A5 JP2005523270A5 JP2003565467A JP2003565467A JP2005523270A5 JP 2005523270 A5 JP2005523270 A5 JP 2005523270A5 JP 2003565467 A JP2003565467 A JP 2003565467A JP 2003565467 A JP2003565467 A JP 2003565467A JP 2005523270 A5 JP2005523270 A5 JP 2005523270A5
- Authority
- JP
- Japan
- Prior art keywords
- cooc
- cpt
- therapeutic composition
- composition according
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 9
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 claims description 8
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 claims description 8
- 230000005764 inhibitory process Effects 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 5
- 230000004580 weight loss Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 101000755720 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) Palmitoyltransferase akr1 Proteins 0.000 claims description 2
- 229960004203 carnitine Drugs 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 5
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 3
- 235000016709 nutrition Nutrition 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 102000015303 Fatty Acid Synthases Human genes 0.000 description 4
- 108010039731 Fatty Acid Synthases Proteins 0.000 description 4
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35448002P | 2002-02-08 | 2002-02-08 | |
| PCT/US2003/003839 WO2003066043A1 (en) | 2002-02-08 | 2003-02-10 | Stimulation of cpt-1 as a means to reduce weight |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009241309A Division JP2010047594A (ja) | 2002-02-08 | 2009-10-20 | 体重を減少させる方法としてのｃｐｔ−１の促進 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005523270A JP2005523270A (ja) | 2005-08-04 |
| JP2005523270A5 true JP2005523270A5 (https=) | 2006-03-30 |
Family
ID=27734382
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565467A Pending JP2005523270A (ja) | 2002-02-08 | 2003-02-10 | 体重を減少させる方法としてのｃｐｔ−１の促進 |
| JP2009241309A Pending JP2010047594A (ja) | 2002-02-08 | 2009-10-20 | 体重を減少させる方法としてのｃｐｔ−１の促進 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009241309A Pending JP2010047594A (ja) | 2002-02-08 | 2009-10-20 | 体重を減少させる方法としてのｃｐｔ−１の促進 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20050143467A1 (https=) |
| EP (1) | EP1471906A4 (https=) |
| JP (2) | JP2005523270A (https=) |
| KR (1) | KR20040082417A (https=) |
| CN (1) | CN1313089C (https=) |
| AU (2) | AU2003215111A1 (https=) |
| BR (1) | BR0307421A (https=) |
| CA (1) | CA2474884A1 (https=) |
| EA (1) | EA007029B1 (https=) |
| IL (1) | IL163312A (https=) |
| MX (1) | MXPA04007556A (https=) |
| WO (1) | WO2003066043A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2474884A1 (en) * | 2002-02-08 | 2003-08-14 | John Hopkins University School Of Medicine | Stimulation of cpt-1 as a means to reduce weight |
| EA013371B1 (ru) * | 2002-07-09 | 2010-04-30 | Фасджен, Ллс. | Новые соединения, содержащие их фармацевтические композиции и способы их применения |
| WO2005089773A1 (en) * | 2004-03-18 | 2005-09-29 | Fasgen, Llc | Control of feeding behavior by changing neuronal energy balance |
| MXPA06013687A (es) * | 2004-05-26 | 2007-10-18 | Fasgen Llc | Compuestos novedosos, composiciones farmaceuticas que los contienen y metodos para utilizar los mismos. |
| BRPI0610877A2 (pt) * | 2005-06-06 | 2010-08-03 | Hoffmann La Roche | compostos, processo para a manufatura dos compostos, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de l-cpt1 e utilização dos mesmos |
| WO2007014248A2 (en) * | 2005-07-26 | 2007-02-01 | Johns Hopkins University | Method of reducing food intake |
| ATE418603T1 (de) * | 2005-08-29 | 2009-01-15 | Hoffmann La Roche | Kristallstrukturen von carnitine palmitoyltransferase-2 (cpt-2) und deren verwendung |
| ES2405259B1 (es) * | 2011-11-25 | 2014-09-29 | Centro De Investigación Biomédica En Red Fisiopatología De La Obesidad Y Nutrición (Ciberobn) | Uso del enantiómero (+)-c75 para el tratamiento de la obesidad. |
| WO2013155528A2 (en) * | 2012-04-13 | 2013-10-17 | Fasgen, Inc. | Methods for reducing brain inflammation, increasing insulin sensitivity, and reducing ceramide levels |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US574639A (en) | 1897-01-05 | Gold-saving device | ||
| DE3026368A1 (de) * | 1980-07-11 | 1982-02-18 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Naehrloesung fuer die vollstaendige parenterale ernaehrung und fuer gesteigerte energieproduktion |
| US5981575A (en) | 1996-11-15 | 1999-11-09 | Johns Hopkins University, The | Inhibition of fatty acid synthase as a means to reduce adipocyte mass |
| US5914326A (en) * | 1997-08-08 | 1999-06-22 | Ambi Inc. | Method for promoting weight and fat loss |
| US6413545B1 (en) * | 1998-09-01 | 2002-07-02 | Access Business Group International Llc | Diet composition and method of weight management |
| KR20090031957A (ko) * | 1999-11-12 | 2009-03-30 | 더 존스 홉킨스 유니버시티 | 세포내 말로닐 ＣｏＡ의 수준을 증가시킴에 의한 암의 치료방법 |
| WO2001060174A2 (en) * | 2000-02-16 | 2001-08-23 | The Johns Hopkins University School Of Medicine | Weight loss induced by reduction in neuropeptide y level |
| WO2002079501A1 (en) * | 2001-03-30 | 2002-10-10 | Trustees Of Boston University | Methods and reagents for identifying weight loss promoters and therapeutic uses therefor |
| CA2474884A1 (en) * | 2002-02-08 | 2003-08-14 | John Hopkins University School Of Medicine | Stimulation of cpt-1 as a means to reduce weight |
| US20040161803A1 (en) * | 2002-04-01 | 2004-08-19 | Corkey Barbara E. | Methods and reagents for identifying weight loss promoters and therpeutic uses therefor |
| US20060241177A1 (en) | 2002-07-01 | 2006-10-26 | Kuhadja Francis P | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
| EA013371B1 (ru) | 2002-07-09 | 2010-04-30 | Фасджен, Ллс. | Новые соединения, содержащие их фармацевтические композиции и способы их применения |
-
2003
- 2003-02-10 CA CA002474884A patent/CA2474884A1/en not_active Abandoned
- 2003-02-10 AU AU2003215111A patent/AU2003215111A1/en not_active Abandoned
- 2003-02-10 JP JP2003565467A patent/JP2005523270A/ja active Pending
- 2003-02-10 BR BR0307421-8A patent/BR0307421A/pt not_active IP Right Cessation
- 2003-02-10 WO PCT/US2003/003839 patent/WO2003066043A1/en not_active Ceased
- 2003-02-10 CN CNB038050145A patent/CN1313089C/zh not_active Expired - Fee Related
- 2003-02-10 EA EA200401052A patent/EA007029B1/ru unknown
- 2003-02-10 MX MXPA04007556A patent/MXPA04007556A/es active IP Right Grant
- 2003-02-10 KR KR10-2004-7012208A patent/KR20040082417A/ko not_active Ceased
- 2003-02-10 US US10/503,605 patent/US20050143467A1/en not_active Abandoned
- 2003-02-10 EP EP03710928A patent/EP1471906A4/en not_active Withdrawn
-
2004
- 2004-08-02 IL IL163312A patent/IL163312A/en not_active IP Right Cessation
- 2004-08-13 US US10/917,525 patent/US20050106217A1/en not_active Abandoned
-
2006
- 2006-10-02 US US11/537,968 patent/US7459481B2/en not_active Expired - Fee Related
-
2008
- 2008-11-06 US US12/266,425 patent/US20090124684A1/en not_active Abandoned
- 2008-11-20 AU AU2008249144A patent/AU2008249144A1/en not_active Abandoned
-
2009
- 2009-10-20 JP JP2009241309A patent/JP2010047594A/ja active Pending
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