JP2004538289A5 - - Google Patents
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- Publication number
- JP2004538289A5 JP2004538289A5 JP2003515228A JP2003515228A JP2004538289A5 JP 2004538289 A5 JP2004538289 A5 JP 2004538289A5 JP 2003515228 A JP2003515228 A JP 2003515228A JP 2003515228 A JP2003515228 A JP 2003515228A JP 2004538289 A5 JP2004538289 A5 JP 2004538289A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- parkinson
- hoehn
- aminomethyl
- study
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000018737 Parkinson disease Diseases 0.000 description 5
- 238000012360 testing method Methods 0.000 description 2
- VPIZQYFZBRGMOJ-LCOAMIHASA-N 1-[(2s)-3,4-dihydro-2h-chromen-2-yl]-2-[5-(4-fluorophenyl)pyridin-3-yl]ethanamine;hydrochloride Chemical compound Cl.NC([C@H]1OC2=CC=CC=C2CC1)CC(C=1)=CN=CC=1C1=CC=C(F)C=C1 VPIZQYFZBRGMOJ-LCOAMIHASA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01118097 | 2001-07-26 | ||
| PCT/EP2002/007660 WO2003009835A2 (en) | 2001-07-26 | 2002-07-10 | Novel use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004538289A JP2004538289A (ja) | 2004-12-24 |
| JP2004538289A5 true JP2004538289A5 (https=) | 2006-01-05 |
Family
ID=8178137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003515228A Pending JP2004538289A (ja) | 2001-07-26 | 2002-07-10 | ２−［５−（４−フルオロフェニル）−３−ピリジルメチルアミノメチル］−クロマンおよびその生理学的に許容し得る塩の新規な使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7872030B2 (https=) |
| EP (1) | EP1408964B1 (https=) |
| JP (1) | JP2004538289A (https=) |
| KR (1) | KR20040029325A (https=) |
| CN (1) | CN1292749C (https=) |
| AR (1) | AR037496A1 (https=) |
| AT (1) | ATE352302T1 (https=) |
| AU (1) | AU2002355170B2 (https=) |
| BR (1) | BR0211358A (https=) |
| CA (1) | CA2455621C (https=) |
| CY (1) | CY1107616T1 (https=) |
| DE (1) | DE60217870T2 (https=) |
| DK (1) | DK1408964T3 (https=) |
| ES (1) | ES2280602T3 (https=) |
| HU (1) | HUP0402092A3 (https=) |
| MX (1) | MXPA04000775A (https=) |
| MY (1) | MY134059A (https=) |
| PE (1) | PE20030277A1 (https=) |
| PL (1) | PL208258B1 (https=) |
| PT (1) | PT1408964E (https=) |
| RU (1) | RU2297833C2 (https=) |
| SI (1) | SI1408964T1 (https=) |
| WO (1) | WO2003009835A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1907382T3 (pl) | 2005-07-26 | 2016-01-29 | Bial Portela & Ca Sa | Pochodne nitrokatecholowe jako inhibitory COMT |
| EP1991677A2 (en) | 2006-01-26 | 2008-11-19 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to huntingtin |
| EP1845097A1 (en) * | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
| BRPI0721213B1 (pt) | 2007-01-31 | 2021-11-09 | Bial - Portela & Ca, S.A. | Uso de nitrocatecóis substituídos, e embalagem |
| WO2009116882A1 (en) | 2008-03-17 | 2009-09-24 | Portela & Ca., S.A. | Crystal forms of 5- [3- (2, 5-dichloro-4, 6-dimethyl-1-oxy-pyridine-3-yl) [1,2,3] oxadiazol-5-yl] -3-nit robenzene-1, 2-diol |
| PT2413912T (pt) | 2009-04-01 | 2019-06-11 | Bial Portela & Ca Sa | Formulações farmacêuticas compreendendo derivados de nitrocatecol e métodos para as produzir |
| NZ714887A (en) | 2009-09-11 | 2019-07-26 | Ionis Pharmaceuticals Inc | Modulation of huntingtin expression |
| US20140045900A1 (en) | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
| JP6456143B2 (ja) | 2011-12-13 | 2019-01-23 | ノヴィファーマ，エス．アー． | カテコール−ｏ−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物 |
| RU2017120184A (ru) | 2014-11-28 | 2018-12-28 | БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. | Лекарства для замедления течения болезни паркинсона |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US576132A (en) * | 1897-02-02 | Current water-wheel | ||
| DE2364685C3 (de) | 1973-12-27 | 1978-06-15 | Beiersdorf Ag, 2000 Hamburg | Phenoxyäthylamine |
| US4438119A (en) * | 1982-12-23 | 1984-03-20 | Mead Johnson & Company | Method for alleviation of extrapyramidal motor disorders |
| CA1337429C (en) | 1983-12-05 | 1995-10-24 | Guy Rosalia Eugene Van Lommen | Derivatives of 2,2'-iminobisethanol |
| SE460947B (sv) * | 1986-08-26 | 1989-12-11 | Lejus Medical Ab | En multiple-unit-dos komposition av l-dopa |
| DE3901814A1 (de) * | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| ATE145208T1 (de) | 1990-07-06 | 1996-11-15 | Yoshitomi Pharmaceutical | Kondensierte thiophenverbindungen und deren verwendung |
| DE4135474A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
| US5314888A (en) * | 1992-02-21 | 1994-05-24 | Trustees Of Tufts College | Veterinary method for treating inappropriate elimination of urine in household pets |
| SI9300097B (en) | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
| JPH07507058A (ja) | 1992-03-11 | 1995-08-03 | インターニューロン ファーマシューティカルズ，インコーポレーテッド | 大型の中性アミノ酸（ｌｎａａ）の血中濃度の食後変動の低減 |
| DE4226527A1 (de) | 1992-08-11 | 1994-02-17 | Merck Patent Gmbh | 1,4-Benzodioxanderivate |
| GB9302622D0 (en) | 1993-02-10 | 1993-03-24 | Wellcome Found | Heteroaromatic compounds |
| WO1995020587A1 (en) * | 1994-01-31 | 1995-08-03 | Pfizer Inc. | Neuroprotective chroman compounds |
| IL114027A (en) | 1994-06-08 | 1999-11-30 | Lundbeck & Co As H | 4-Phenyl piperazine (piperidine or tetrahydropyridine) derivatives serotinin 5-HT1A and dopamin D2 receptor ligand pharmaceutical compositions containing them |
| ATE210657T1 (de) * | 1994-10-14 | 2001-12-15 | Merck Patent Gmbh | Zns wirksames (r)-(-)-2-(5-(4-fluorophenyl)-3- pyridylmethylaminomethyl)chroman |
| US5502080A (en) * | 1994-11-01 | 1996-03-26 | Hitzig; Pietr | Combined use of dopamine and serotonin agonists in the treatment of allergic disorders |
| US5554383A (en) * | 1995-04-06 | 1996-09-10 | Trustees Of Tufts College | Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression |
| US5541199A (en) * | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
| US6114334A (en) * | 1995-07-13 | 2000-09-05 | Knoll Aktiengesellschaft | Piperazine derivatives as therapeutic agents |
| GB9514380D0 (en) * | 1995-07-13 | 1995-09-13 | Knoll Ag | Therapeutic agents |
| US5670667A (en) * | 1995-07-25 | 1997-09-23 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
| US5756521A (en) * | 1996-04-03 | 1998-05-26 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
| DE19648384A1 (de) | 1996-11-22 | 1998-05-28 | Merck Patent Gmbh | Fluorene, Dibenzofurane und Dibenzothiophene |
| EP0900792B1 (en) | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
| ATE253058T1 (de) * | 1997-09-02 | 2003-11-15 | Duphar Int Res | Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten |
| DE19751949A1 (de) * | 1997-11-24 | 1999-05-27 | Bayer Ag | Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration |
| EP1061924A1 (en) | 1998-03-09 | 2000-12-27 | Trustees Of Tufts College | Treatment of compulsive behaviours in man and animals |
| EP1076647A2 (en) | 1998-04-29 | 2001-02-21 | American Home Products Corporation | Antipsychotic indolyl derivatives |
| UA71590C2 (en) | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| UA73981C2 (en) * | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
-
2002
- 2002-07-10 PT PT02790172T patent/PT1408964E/pt unknown
- 2002-07-10 MX MXPA04000775A patent/MXPA04000775A/es active IP Right Grant
- 2002-07-10 RU RU2004105844/15A patent/RU2297833C2/ru not_active IP Right Cessation
- 2002-07-10 AU AU2002355170A patent/AU2002355170B2/en not_active Ceased
- 2002-07-10 BR BR0211358-9A patent/BR0211358A/pt not_active Application Discontinuation
- 2002-07-10 PL PL367291A patent/PL208258B1/pl not_active IP Right Cessation
- 2002-07-10 KR KR10-2003-7016837A patent/KR20040029325A/ko not_active Ceased
- 2002-07-10 CN CNB028146794A patent/CN1292749C/zh not_active Expired - Fee Related
- 2002-07-10 DK DK02790172T patent/DK1408964T3/da active
- 2002-07-10 WO PCT/EP2002/007660 patent/WO2003009835A2/en not_active Ceased
- 2002-07-10 CA CA2455621A patent/CA2455621C/en not_active Expired - Fee Related
- 2002-07-10 JP JP2003515228A patent/JP2004538289A/ja active Pending
- 2002-07-10 SI SI200230518T patent/SI1408964T1/sl unknown
- 2002-07-10 HU HU0402092A patent/HUP0402092A3/hu unknown
- 2002-07-10 US US10/484,697 patent/US7872030B2/en not_active Expired - Fee Related
- 2002-07-10 ES ES02790172T patent/ES2280602T3/es not_active Expired - Lifetime
- 2002-07-10 AT AT02790172T patent/ATE352302T1/de active
- 2002-07-10 EP EP02790172A patent/EP1408964B1/en not_active Expired - Lifetime
- 2002-07-10 DE DE60217870T patent/DE60217870T2/de not_active Expired - Lifetime
- 2002-07-22 MY MYPI20022758A patent/MY134059A/en unknown
- 2002-07-24 PE PE2002000652A patent/PE20030277A1/es not_active Application Discontinuation
- 2002-07-26 AR ARP020102823A patent/AR037496A1/es unknown
-
2007
- 2007-04-19 CY CY20071100526T patent/CY1107616T1/el unknown
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