BR0307421A - Estimulação do cpt-1 como um freio para reduzir peso - Google Patents
Estimulação do cpt-1 como um freio para reduzir pesoInfo
- Publication number
- BR0307421A BR0307421A BR0307421-8A BR0307421A BR0307421A BR 0307421 A BR0307421 A BR 0307421A BR 0307421 A BR0307421 A BR 0307421A BR 0307421 A BR0307421 A BR 0307421A
- Authority
- BR
- Brazil
- Prior art keywords
- cpt
- agent
- administered
- fatty acid
- amount sufficient
- Prior art date
Links
- 101150073133 Cpt1a gene Proteins 0.000 title abstract 4
- 230000000638 stimulation Effects 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 abstract 1
- 101000755720 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) Palmitoyltransferase akr1 Proteins 0.000 abstract 1
- 229960004203 carnitine Drugs 0.000 abstract 1
- 230000004136 fatty acid synthesis Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pediatric Medicine (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
"ESTIMULAçãO DO CPT-1 COMO UM FREIO PARA REDUZIR PESO".Esta invenção provê métodos e composições para indução da perda de peso e mantendo peso ótimo compreendendo a administração de uma agente que estimula a atividade da carnitina-palmitoil-transferase-1 (CPT-1) ao paciente em necessidade, incluindo pacientes humanos. Estes métodos não requerem a inibição da síntese de ácido graxo. Em particular, esta invenção provê métodos desenvolvimento de terapêuticas que seletivamente intensificam a oxidação de ácido graxo, aumenta a produção de energia, e reduz a adiposidade enquanto preserva a massa magra, através da estimulação farmacológica da atividade do CPT-1. Em uma maneira preferida, o agente é administrado em uma quantidade suficiente para aumentar a oxidação de ácido graxo. Em outra maneira preferida, o agente é administrado em uma quantidade suficiente para antagonizar a inibição do malonil-CoA do CPT-1. Em ainda outra maneira preferida, o agente é administrado em uma quantidade suficiente para aumentar o nível de malonil-CoA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35448002P | 2002-02-08 | 2002-02-08 | |
| PCT/US2003/003839 WO2003066043A1 (en) | 2002-02-08 | 2003-02-10 | Stimulation of cpt-1 as a means to reduce weight |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0307421A true BR0307421A (pt) | 2004-12-28 |
Family
ID=27734382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0307421-8A BR0307421A (pt) | 2002-02-08 | 2003-02-10 | Estimulação do cpt-1 como um freio para reduzir peso |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20050143467A1 (pt) |
| EP (1) | EP1471906A4 (pt) |
| JP (2) | JP2005523270A (pt) |
| KR (1) | KR20040082417A (pt) |
| CN (1) | CN1313089C (pt) |
| AU (2) | AU2003215111A1 (pt) |
| BR (1) | BR0307421A (pt) |
| CA (1) | CA2474884A1 (pt) |
| EA (1) | EA007029B1 (pt) |
| IL (1) | IL163312A (pt) |
| MX (1) | MXPA04007556A (pt) |
| WO (1) | WO2003066043A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003066043A1 (en) * | 2002-02-08 | 2003-08-14 | John Hopkins University School Of Medicine | Stimulation of cpt-1 as a means to reduce weight |
| CA2767092C (en) * | 2002-07-09 | 2013-10-15 | Fasgen, Inc. | Novel compounds, pharmaceutical compositions containing same and methods of use for same |
| EP1732572A4 (en) * | 2004-03-18 | 2007-04-18 | Fasgen Llc | REGULATION OF FOOD BEHAVIOR BY MODIFICATION OF THE NEURONAL ENERGY BALANCE |
| CN101022792A (zh) * | 2004-05-26 | 2007-08-22 | 法斯根有限责任公司 | 新化合物、包含该化合物的药物组合物及该化合物的应用方法 |
| ATE466838T1 (de) * | 2005-06-06 | 2010-05-15 | Hoffmann La Roche | Sulfonamid-derivate als lebercarnitin-palmitoyl- transferase-hemmer |
| US20100168218A1 (en) * | 2005-07-26 | 2010-07-01 | Kuhajda Francis P | Method of reducing food intake |
| EP1760147B1 (en) * | 2005-08-29 | 2008-12-24 | F. Hoffmann-La Roche Ag | Crystal structures of carnitine palmitoyltransferase-2 (CPT-2) and uses thereof |
| ES2405259B1 (es) * | 2011-11-25 | 2014-09-29 | Centro De Investigación Biomédica En Red Fisiopatología De La Obesidad Y Nutrición (Ciberobn) | Uso del enantiómero (+)-c75 para el tratamiento de la obesidad. |
| WO2013155528A2 (en) * | 2012-04-13 | 2013-10-17 | Fasgen, Inc. | Methods for reducing brain inflammation, increasing insulin sensitivity, and reducing ceramide levels |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US574639A (en) | 1897-01-05 | Gold-saving device | ||
| DE3026368A1 (de) * | 1980-07-11 | 1982-02-18 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Naehrloesung fuer die vollstaendige parenterale ernaehrung und fuer gesteigerte energieproduktion |
| US5981575A (en) | 1996-11-15 | 1999-11-09 | Johns Hopkins University, The | Inhibition of fatty acid synthase as a means to reduce adipocyte mass |
| US5914326A (en) * | 1997-08-08 | 1999-06-22 | Ambi Inc. | Method for promoting weight and fat loss |
| WO2000012080A1 (en) * | 1998-09-01 | 2000-03-09 | Amway Corporation | Diet composition and method of weight management |
| ATE330598T1 (de) * | 1999-11-12 | 2006-07-15 | Univ Johns Hopkins | Behandlung von krebs durch erhöhung des malonyl- coa-spiegels |
| KR20030016228A (ko) * | 2000-02-16 | 2003-02-26 | 존스 홉킨스 유니버시티 스쿨 오브 메디슨 | 신경펩티드 ｙ 농도의 감소에 의해 유도되는 체중 감량 |
| WO2002079501A1 (en) * | 2001-03-30 | 2002-10-10 | Trustees Of Boston University | Methods and reagents for identifying weight loss promoters and therapeutic uses therefor |
| WO2003066043A1 (en) * | 2002-02-08 | 2003-08-14 | John Hopkins University School Of Medicine | Stimulation of cpt-1 as a means to reduce weight |
| US20040161803A1 (en) * | 2002-04-01 | 2004-08-19 | Corkey Barbara E. | Methods and reagents for identifying weight loss promoters and therpeutic uses therefor |
| BRPI0312413A2 (pt) | 2002-07-01 | 2016-08-02 | Fasgen Llc | compostos, composições farmacêuticas contendo os mesmos, e método de utilização para os mesmos |
| CA2767092C (en) | 2002-07-09 | 2013-10-15 | Fasgen, Inc. | Novel compounds, pharmaceutical compositions containing same and methods of use for same |
-
2003
- 2003-02-10 WO PCT/US2003/003839 patent/WO2003066043A1/en active Application Filing
- 2003-02-10 JP JP2003565467A patent/JP2005523270A/ja active Pending
- 2003-02-10 AU AU2003215111A patent/AU2003215111A1/en not_active Abandoned
- 2003-02-10 EP EP03710928A patent/EP1471906A4/en not_active Withdrawn
- 2003-02-10 CA CA002474884A patent/CA2474884A1/en not_active Abandoned
- 2003-02-10 KR KR10-2004-7012208A patent/KR20040082417A/ko not_active Application Discontinuation
- 2003-02-10 CN CNB038050145A patent/CN1313089C/zh not_active Expired - Fee Related
- 2003-02-10 MX MXPA04007556A patent/MXPA04007556A/es active IP Right Grant
- 2003-02-10 BR BR0307421-8A patent/BR0307421A/pt not_active IP Right Cessation
- 2003-02-10 US US10/503,605 patent/US20050143467A1/en not_active Abandoned
- 2003-02-10 EA EA200401052A patent/EA007029B1/ru unknown
-
2004
- 2004-08-02 IL IL163312A patent/IL163312A/en not_active IP Right Cessation
- 2004-08-13 US US10/917,525 patent/US20050106217A1/en not_active Abandoned
-
2006
- 2006-10-02 US US11/537,968 patent/US7459481B2/en not_active Expired - Fee Related
-
2008
- 2008-11-06 US US12/266,425 patent/US20090124684A1/en not_active Abandoned
- 2008-11-20 AU AU2008249144A patent/AU2008249144A1/en not_active Abandoned
-
2009
- 2009-10-20 JP JP2009241309A patent/JP2010047594A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20050106217A1 (en) | 2005-05-19 |
| MXPA04007556A (es) | 2005-12-05 |
| CN1313089C (zh) | 2007-05-02 |
| US20090124684A1 (en) | 2009-05-14 |
| IL163312A (en) | 2011-12-29 |
| US7459481B2 (en) | 2008-12-02 |
| EP1471906A1 (en) | 2004-11-03 |
| US20070087037A1 (en) | 2007-04-19 |
| KR20040082417A (ko) | 2004-09-24 |
| WO2003066043A1 (en) | 2003-08-14 |
| AU2008249144A1 (en) | 2008-12-11 |
| JP2010047594A (ja) | 2010-03-04 |
| EA200401052A1 (ru) | 2005-02-24 |
| CN1638758A (zh) | 2005-07-13 |
| AU2003215111A1 (en) | 2003-09-02 |
| JP2005523270A (ja) | 2005-08-04 |
| EP1471906A4 (en) | 2006-02-01 |
| EA007029B1 (ru) | 2006-06-30 |
| US20050143467A1 (en) | 2005-06-30 |
| CA2474884A1 (en) | 2003-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. A61K 31/195, 31/198, 31/205, 31/34, 31/381, 45/00; A61P 3/04, 43/00; G01N 33/15, 33/50 Ipc: A61K 31/195 (2011.01), A61K 31/198 (2011.01), A61K |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 9A ANUIDADE. |