MXPA04007556A - Estimulacion de cpt-1 como medio para reducir peso. - Google Patents
Estimulacion de cpt-1 como medio para reducir peso.Info
- Publication number
- MXPA04007556A MXPA04007556A MXPA04007556A MXPA04007556A MXPA04007556A MX PA04007556 A MXPA04007556 A MX PA04007556A MX PA04007556 A MXPA04007556 A MX PA04007556A MX PA04007556 A MXPA04007556 A MX PA04007556A MX PA04007556 A MXPA04007556 A MX PA04007556A
- Authority
- MX
- Mexico
- Prior art keywords
- cpt
- agent
- administered
- fatty acid
- amount sufficient
- Prior art date
Links
- 230000000638 stimulation Effects 0.000 title abstract 2
- 101150073133 Cpt1a gene Proteins 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 102000002666 Carnitine O-palmitoyltransferase Human genes 0.000 abstract 1
- 108010018424 Carnitine O-palmitoyltransferase Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000004136 fatty acid synthesis Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Pediatric Medicine (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Esta invencion proporciona metodos y composiciones para inducir la perdida de peso y mantener el peso optimo que comprenden administrar un agentes que estimula la actividad de la carnitina palmitoil transferasa-1 (CPT-1) al paciente que la necesita, incluyendo pacientes humanos. Estos metodos no requieren la inhibicion de la sintesis de acidos grasos. En particular, esta invencion proporciona metodos para desarrollar terapias que selectivamente potencian la oxidacion de acidos grasos, incrementan la produccion de energia y reducen la adiposidad mientras que preservan la masa sin grasa, a traves de la estimulacion farmacologica de la actividad de CPT-1. En una modalidad preferida, el agente es administrado en una cantidad suficiente para incrementar la oxidacion de acidos grasos. En otra modalidad preferida, el agente es administrado en una cantidad suficiente para antagonizar la inhibicion de la malonil CoA de CPT-1. Aun, en otra modalidad preferida, el agente es administrado en una cantidad suficiente para incrementar el nivel de la malonil CoA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35448002P | 2002-02-08 | 2002-02-08 | |
PCT/US2003/003839 WO2003066043A1 (en) | 2002-02-08 | 2003-02-10 | Stimulation of cpt-1 as a means to reduce weight |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04007556A true MXPA04007556A (es) | 2005-12-05 |
Family
ID=27734382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04007556A MXPA04007556A (es) | 2002-02-08 | 2003-02-10 | Estimulacion de cpt-1 como medio para reducir peso. |
Country Status (12)
Country | Link |
---|---|
US (4) | US20050143467A1 (es) |
EP (1) | EP1471906A4 (es) |
JP (2) | JP2005523270A (es) |
KR (1) | KR20040082417A (es) |
CN (1) | CN1313089C (es) |
AU (2) | AU2003215111A1 (es) |
BR (1) | BR0307421A (es) |
CA (1) | CA2474884A1 (es) |
EA (1) | EA007029B1 (es) |
IL (1) | IL163312A (es) |
MX (1) | MXPA04007556A (es) |
WO (1) | WO2003066043A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003066043A1 (en) * | 2002-02-08 | 2003-08-14 | John Hopkins University School Of Medicine | Stimulation of cpt-1 as a means to reduce weight |
WO2004005277A1 (en) * | 2002-07-09 | 2004-01-15 | Fasgen, Inc. | Novel compunds, pharmaceutical compositions containing same, and methods of use for same |
US20080119548A1 (en) * | 2004-03-18 | 2008-05-22 | Ronnett Gabrielle V | Control Of Feeding Behavior By Changing Neuronal Energy Balance |
RU2006146051A (ru) * | 2004-05-26 | 2008-07-10 | Фасджен | Новые соединения, фармацевтические композиции на их основе и способы применения |
AU2006256825B2 (en) * | 2005-06-06 | 2010-02-18 | F. Hoffmann-La Roche Ag | Sulfonamide derivatives useful as liver carnitine palmitoyl transferase (L-CPT1) inhibitors |
US20100168218A1 (en) * | 2005-07-26 | 2010-07-01 | Kuhajda Francis P | Method of reducing food intake |
EP1760147B1 (en) * | 2005-08-29 | 2008-12-24 | F. Hoffmann-La Roche Ag | Crystal structures of carnitine palmitoyltransferase-2 (CPT-2) and uses thereof |
ES2405259B1 (es) * | 2011-11-25 | 2014-09-29 | Centro De Investigación Biomédica En Red Fisiopatología De La Obesidad Y Nutrición (Ciberobn) | Uso del enantiómero (+)-c75 para el tratamiento de la obesidad. |
WO2013155528A2 (en) * | 2012-04-13 | 2013-10-17 | Fasgen, Inc. | Methods for reducing brain inflammation, increasing insulin sensitivity, and reducing ceramide levels |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US574639A (en) | 1897-01-05 | Gold-saving device | ||
DE3026368A1 (de) * | 1980-07-11 | 1982-02-18 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Naehrloesung fuer die vollstaendige parenterale ernaehrung und fuer gesteigerte energieproduktion |
US5981575A (en) * | 1996-11-15 | 1999-11-09 | Johns Hopkins University, The | Inhibition of fatty acid synthase as a means to reduce adipocyte mass |
US5914326A (en) * | 1997-08-08 | 1999-06-22 | Ambi Inc. | Method for promoting weight and fat loss |
AU5802499A (en) * | 1998-09-01 | 2000-03-21 | Amway Corporation | Diet composition and method of weight management |
KR20020060736A (ko) * | 1999-11-12 | 2002-07-18 | 추후보정 | 세포내 말로닐 조효소 에이의 수준을 증가시킴에 의한암의 치료 방법 |
CA2400136A1 (en) * | 2000-02-16 | 2001-08-23 | The Johns Hopkins University School Of Medicine | Weight loss induced by reduction in neuropeptide y level |
WO2002079501A1 (en) * | 2001-03-30 | 2002-10-10 | Trustees Of Boston University | Methods and reagents for identifying weight loss promoters and therapeutic uses therefor |
WO2003066043A1 (en) * | 2002-02-08 | 2003-08-14 | John Hopkins University School Of Medicine | Stimulation of cpt-1 as a means to reduce weight |
US20040161803A1 (en) * | 2002-04-01 | 2004-08-19 | Corkey Barbara E. | Methods and reagents for identifying weight loss promoters and therpeutic uses therefor |
US20060241177A1 (en) | 2002-07-01 | 2006-10-26 | Kuhadja Francis P | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
WO2004005277A1 (en) | 2002-07-09 | 2004-01-15 | Fasgen, Inc. | Novel compunds, pharmaceutical compositions containing same, and methods of use for same |
-
2003
- 2003-02-10 WO PCT/US2003/003839 patent/WO2003066043A1/en active Application Filing
- 2003-02-10 US US10/503,605 patent/US20050143467A1/en not_active Abandoned
- 2003-02-10 KR KR10-2004-7012208A patent/KR20040082417A/ko not_active Application Discontinuation
- 2003-02-10 EP EP03710928A patent/EP1471906A4/en not_active Withdrawn
- 2003-02-10 EA EA200401052A patent/EA007029B1/ru unknown
- 2003-02-10 JP JP2003565467A patent/JP2005523270A/ja active Pending
- 2003-02-10 CA CA002474884A patent/CA2474884A1/en not_active Abandoned
- 2003-02-10 CN CNB038050145A patent/CN1313089C/zh not_active Expired - Fee Related
- 2003-02-10 AU AU2003215111A patent/AU2003215111A1/en not_active Abandoned
- 2003-02-10 MX MXPA04007556A patent/MXPA04007556A/es active IP Right Grant
- 2003-02-10 BR BR0307421-8A patent/BR0307421A/pt not_active IP Right Cessation
-
2004
- 2004-08-02 IL IL163312A patent/IL163312A/en not_active IP Right Cessation
- 2004-08-13 US US10/917,525 patent/US20050106217A1/en not_active Abandoned
-
2006
- 2006-10-02 US US11/537,968 patent/US7459481B2/en not_active Expired - Fee Related
-
2008
- 2008-11-06 US US12/266,425 patent/US20090124684A1/en not_active Abandoned
- 2008-11-20 AU AU2008249144A patent/AU2008249144A1/en not_active Abandoned
-
2009
- 2009-10-20 JP JP2009241309A patent/JP2010047594A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR0307421A (pt) | 2004-12-28 |
EP1471906A1 (en) | 2004-11-03 |
US20050106217A1 (en) | 2005-05-19 |
IL163312A (en) | 2011-12-29 |
CN1638758A (zh) | 2005-07-13 |
US7459481B2 (en) | 2008-12-02 |
EA200401052A1 (ru) | 2005-02-24 |
US20090124684A1 (en) | 2009-05-14 |
JP2010047594A (ja) | 2010-03-04 |
EP1471906A4 (en) | 2006-02-01 |
CN1313089C (zh) | 2007-05-02 |
CA2474884A1 (en) | 2003-08-14 |
US20050143467A1 (en) | 2005-06-30 |
AU2008249144A1 (en) | 2008-12-11 |
JP2005523270A (ja) | 2005-08-04 |
EA007029B1 (ru) | 2006-06-30 |
AU2003215111A1 (en) | 2003-09-02 |
KR20040082417A (ko) | 2004-09-24 |
WO2003066043A1 (en) | 2003-08-14 |
US20070087037A1 (en) | 2007-04-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |