ATE330598T1 - Behandlung von krebs durch erhöhung des malonyl- coa-spiegels - Google Patents

Behandlung von krebs durch erhöhung des malonyl- coa-spiegels

Info

Publication number
ATE330598T1
ATE330598T1 AT00978553T AT00978553T ATE330598T1 AT E330598 T1 ATE330598 T1 AT E330598T1 AT 00978553 T AT00978553 T AT 00978553T AT 00978553 T AT00978553 T AT 00978553T AT E330598 T1 ATE330598 T1 AT E330598T1
Authority
AT
Austria
Prior art keywords
fatty acid
inhibition
cpt
fas
malonyl
Prior art date
Application number
AT00978553T
Other languages
English (en)
Inventor
Ellen S Pizer
Craig A Townsend
Francis P Kuhajda
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE330598T1 publication Critical patent/ATE330598T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Epoxy Compounds (AREA)
AT00978553T 1999-11-12 2000-11-13 Behandlung von krebs durch erhöhung des malonyl- coa-spiegels ATE330598T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16476899P 1999-11-12 1999-11-12
US16476599P 1999-11-12 1999-11-12

Publications (1)

Publication Number Publication Date
ATE330598T1 true ATE330598T1 (de) 2006-07-15

Family

ID=26860829

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00978553T ATE330598T1 (de) 1999-11-12 2000-11-13 Behandlung von krebs durch erhöhung des malonyl- coa-spiegels

Country Status (12)

Country Link
US (1) US20020187534A1 (de)
EP (1) EP1227810B8 (de)
JP (1) JP2003513920A (de)
KR (4) KR20090031957A (de)
AT (1) ATE330598T1 (de)
AU (3) AU784495B2 (de)
CA (1) CA2391277A1 (de)
DE (1) DE60028996T2 (de)
DK (1) DK1227810T3 (de)
ES (1) ES2267587T3 (de)
PT (1) PT1227810E (de)
WO (1) WO2001034145A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322929B1 (de) * 2000-11-27 2016-04-06 Minerva Biotechnologies Corporation Diagnostika, Drogenscreening und Behandlung für Krebs
WO2003037323A2 (en) * 2001-10-26 2003-05-08 MEDIGENE AG Gesellschaft für Molekularbiologische Kardiologie und Onkologie Inhibitors of the fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction
AU2003215111A1 (en) 2002-02-08 2003-09-02 The Johns Hopkins University School Of Medicine Stimulation of cpt-1 as a means to reduce weight
BRPI0312413A2 (pt) * 2002-07-01 2016-08-02 Fasgen Llc compostos, composições farmacêuticas contendo os mesmos, e método de utilização para os mesmos
MXPA05004390A (es) * 2002-10-31 2005-11-23 Fasgen Llc Metodo para inhibicion del desarrollo del cancer por inhibidores de la sintasa de acidos grasos.
CA2515368A1 (en) 2003-02-13 2004-08-26 Luciano Rossetti Regulation of food intake and glucose production by modulation of long-chain fatty acyl-coa levels in the hypothalamus
EP2377528B1 (de) * 2003-06-12 2014-02-19 The Board of Regents of the University of Colorado Fettsäure-Stoffwechsel-Hemmer zur Verwendung in der Behandlung von Krebs
US7510710B2 (en) 2004-01-08 2009-03-31 The Regents Of The University Of Colorado Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor
ITMI20040230A1 (it) * 2004-02-12 2004-05-12 Defiante Farmaceutica Lda Composti ad attivita' antitumorale
CA2611735A1 (en) * 2005-04-28 2006-11-02 The Regents Of The University Of Colorado Therapeutic bifunctional compounds
US8329753B2 (en) 2005-05-02 2012-12-11 The Regents Of The University Of Colorado Combination of compounds, or a bifunctional compound, that provides fatty acid metabolism and glycolysis inhibition
EP2018873A4 (de) * 2006-04-07 2009-12-09 Japan Found Cancer Mittel zur prophylaxe/behandlung von krebs
WO2008106796A1 (en) * 2007-03-08 2008-09-12 University Health Network Induction of apoptosis and inhibition of cell proliferation through modulation of carnitine palmitoyltransferase 1c activity
CA2680366C (en) 2007-03-09 2016-06-21 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
EP3048168A1 (de) * 2007-07-27 2016-07-27 Vesta Therapeutics, Inc. Verfahren zur reduzierung intrazellulärer fette aus säugerzellen
WO2009015485A1 (en) * 2007-08-01 2009-02-05 University Health Network Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
US8394377B2 (en) 2008-02-21 2013-03-12 The Regents Of The University Of Colorado Methods for treating cancer using combination therapy
US9073985B2 (en) 2008-07-14 2015-07-07 The Regents Of The University Of Colorado, A Body Corporate Methods and products for treating proliferative diseases
JP5317919B2 (ja) * 2009-10-05 2013-10-16 花王株式会社 Ｇｉｐ上昇抑制剤の評価又は選択方法
JP6895890B2 (ja) 2015-02-10 2021-06-30 ミネルバ バイオテクノロジーズ コーポレーション ヒト化抗ｍｕｃ１＊ 抗体
CA3040637C (en) * 2016-10-17 2023-02-28 Keio University Undifferentiated stem cell-removing agent, and method for removing undifferentiated stem cells
WO2020212362A1 (en) * 2019-04-15 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) A method of profiling the energetic metabolism of a population of cells
CN113604573A (zh) * 2021-09-14 2021-11-05 北京大学第三医院（北京大学第三临床医学院） 一种使用至少八种脂肪酸代谢关键酶基因检测方法以及试剂盒
CN113549702A (zh) * 2021-09-14 2021-10-26 北京大学第三医院（北京大学第三临床医学院） 一种人脂肪酸代谢关键酶基因检测方法以及试剂盒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759837A (en) * 1989-01-17 1998-06-02 John Hopkins University Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
WO1994002108A1 (en) * 1992-07-24 1994-02-03 The Johns Hopkins University Chemotherapy for cancer
US5539132A (en) * 1994-01-24 1996-07-23 Johns Hopkins University Cerulenin compounds for fatty acid synthesis inhibition
US5981575A (en) * 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass

Also Published As

Publication number Publication date
DK1227810T3 (da) 2006-10-23
EP1227810B1 (de) 2006-06-21
PT1227810E (pt) 2006-11-30
KR20070106648A (ko) 2007-11-02
EP1227810A1 (de) 2002-08-07
CA2391277A1 (en) 2001-05-17
DE60028996D1 (de) 2006-08-03
WO2001034145A1 (en) 2001-05-17
KR20090130151A (ko) 2009-12-17
US20020187534A1 (en) 2002-12-12
KR20090031957A (ko) 2009-03-30
EP1227810B8 (de) 2006-08-16
ES2267587T3 (es) 2007-03-16
DE60028996T2 (de) 2007-02-08
AU1600701A (en) 2001-06-06
KR20020060736A (ko) 2002-07-18
AU784495B2 (en) 2006-04-13
AU2006203005A1 (en) 2006-08-10
JP2003513920A (ja) 2003-04-15
AU2009227836A1 (en) 2009-11-05

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