JP2005521405A5 - - Google Patents
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- JP2005521405A5 JP2005521405A5 JP2003580528A JP2003580528A JP2005521405A5 JP 2005521405 A5 JP2005521405 A5 JP 2005521405A5 JP 2003580528 A JP2003580528 A JP 2003580528A JP 2003580528 A JP2003580528 A JP 2003580528A JP 2005521405 A5 JP2005521405 A5 JP 2005521405A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- target
- dedifferentiated
- cell
- stem cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000000130 stem cell Anatomy 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000006143 cell culture medium Substances 0.000 claims description 7
- 239000001963 growth medium Substances 0.000 claims description 6
- 230000004069 differentiation Effects 0.000 claims description 2
- 239000000463 material Substances 0.000 claims 9
- 210000001519 tissue Anatomy 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 210000001616 monocyte Anatomy 0.000 claims 6
- 210000001082 somatic cell Anatomy 0.000 claims 5
- 210000001789 adipocyte Anatomy 0.000 claims 4
- 210000004153 islets of langerhan Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 3
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 3
- 239000012876 carrier material Substances 0.000 claims 3
- -1 mercapto compound Chemical class 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 239000003636 conditioned culture medium Substances 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000003494 hepatocyte Anatomy 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 210000002510 keratinocyte Anatomy 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 210000004498 neuroglial cell Anatomy 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 230000008672 reprogramming Effects 0.000 claims 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000024659 Hemostatic disease Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 208000035467 Pancreatic insufficiency Diseases 0.000 claims 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 208000030172 endocrine system disease Diseases 0.000 claims 1
- 239000012894 fetal calf serum Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 210000003709 heart valve Anatomy 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000037380 skin damage Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 239000011324 bead Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10214095A DE10214095C1 (de) | 2002-03-28 | 2002-03-28 | Dedifferenzierte, programmierbare Stammzellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
| US10/372,657 US20040101962A1 (en) | 2002-03-28 | 2003-02-25 | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
| PCT/EP2003/002121 WO2003083091A1 (de) | 2002-03-28 | 2003-02-25 | Dedifferenzierte, programmierbare stammzellen monozytären ursprungs, sowie deren herstellung und verwendung |
| PCT/EP2003/003279 WO2003083092A1 (en) | 2002-03-28 | 2003-03-28 | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007317758A Division JP2008119002A (ja) | 2002-03-28 | 2007-12-07 | 単球を起源に持つ、脱分化したプログラム可能な幹細胞およびそれらの製造と使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005521405A JP2005521405A (ja) | 2005-07-21 |
| JP2005521405A5 true JP2005521405A5 (https=) | 2008-01-31 |
| JP4146802B2 JP4146802B2 (ja) | 2008-09-10 |
Family
ID=30116586
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003580528A Expired - Fee Related JP4146802B2 (ja) | 2002-03-28 | 2003-03-28 | 単球を起源に持つ、脱分化したプログラム可能な幹細胞およびそれらの製造と使用 |
| JP2007317758A Pending JP2008119002A (ja) | 2002-03-28 | 2007-12-07 | 単球を起源に持つ、脱分化したプログラム可能な幹細胞およびそれらの製造と使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007317758A Pending JP2008119002A (ja) | 2002-03-28 | 2007-12-07 | 単球を起源に持つ、脱分化したプログラム可能な幹細胞およびそれらの製造と使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US7138275B2 (https=) |
| EP (2) | EP1506999A1 (https=) |
| JP (2) | JP4146802B2 (https=) |
| CN (1) | CN100347293C (https=) |
| AT (1) | ATE295876T1 (https=) |
| AU (1) | AU2003233950B2 (https=) |
| BR (1) | BR0308919A (https=) |
| CA (1) | CA2479110C (https=) |
| DK (1) | DK1436381T3 (https=) |
| ES (1) | ES2242941T3 (https=) |
| IL (1) | IL163970A0 (https=) |
| NO (1) | NO337668B1 (https=) |
| PT (1) | PT1436381E (https=) |
| TW (1) | TWI288779B (https=) |
| WO (1) | WO2003083092A1 (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9502022D0 (en) * | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
| DE10231655A1 (de) * | 2002-07-12 | 2004-02-26 | Blasticon Biotechnologische Forschung Gmbh | Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
| JP2006512060A (ja) * | 2002-11-07 | 2006-04-13 | ザ ユニヴァーシティ オヴ シカゴ | ヒト幹細胞の材料および方法 |
| US20040136973A1 (en) * | 2002-11-07 | 2004-07-15 | Eliezer Huberman | Human stem cell materials and methods |
| US20060188485A1 (en) * | 2003-07-11 | 2006-08-24 | Bernd Karl Friedrich Kremer | Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations |
| ITRM20030376A1 (it) * | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| WO2005071065A1 (en) * | 2004-01-26 | 2005-08-04 | Cognis France S.A.S | Method for studying functional interactions between sensory neurons and keratinocytes or melanocytes |
| EP1600500A1 (en) * | 2004-05-27 | 2005-11-30 | Georg-August-Universität Göttingen | Method for producing pluripotent cells from monocytes |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| CN101087563A (zh) * | 2004-11-08 | 2007-12-12 | 约翰霍普金斯大学 | 活检钳 |
| WO2006096931A1 (en) * | 2005-03-18 | 2006-09-21 | The University Of Queensland | Renal repair and regeneration |
| US9388382B2 (en) | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
| ITTO20050819A1 (it) | 2005-11-18 | 2007-05-19 | Univ Degli Studi Torino | Linea cellulare staminale pluripotente, linee cellulari derivate, procedimenti per la loro produzione e relativi usi |
| US20100021435A1 (en) * | 2006-05-05 | 2010-01-28 | Winnier Glenn E | Pancreatic islet-like cells |
| CA2651331A1 (en) * | 2006-05-05 | 2007-11-15 | Opexa Therapeutics | Monocyte-derived stem cells |
| US20080050814A1 (en) * | 2006-06-05 | 2008-02-28 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of fetal placental cells |
| US20080064098A1 (en) * | 2006-06-05 | 2008-03-13 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of maternal placental cells |
| ITRM20060498A1 (it) * | 2006-09-20 | 2008-03-21 | Alessandra Gambacurta | Metodo di espansione di cellule staminali adulte da sangue periferico e relativi usi in campo medico |
| CA2666789C (en) | 2006-10-18 | 2016-11-22 | Yong Zhao | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
| EP2087098A4 (en) * | 2006-11-09 | 2010-03-31 | Univ Johns Hopkins | DETERMINATION OF CARDIOMYOCYTES ADULT MAMMALS IN HEART STEM CELLS |
| ITTO20060937A1 (it) * | 2006-12-29 | 2008-06-30 | Medestea Biotech S R L | Linee cellulari immortali differenziate atte a produrre albumina e fattori di crescita, procedimenti per la loro preparazione da una linea cellulare leucemica e loro usi. |
| ES2352046T3 (es) * | 2007-09-21 | 2011-02-15 | Universität Leipzig | Medio de cultivo celular y procedimiento de cultivo de células madre y células progenitor. |
| ITUD20080058A1 (it) | 2008-03-18 | 2009-09-19 | Thankstem S R L | Kit per la raccolta di sangue, preferibilmente periferico, per la produzione di cellule staminali |
| WO2009157610A1 (en) * | 2008-06-26 | 2009-12-30 | Pusan National University Industry-University Cooperation Foundation | Selenium dedifferentiated cell, preparation method and usage thereof |
| BRPI0921371A2 (pt) * | 2008-11-25 | 2014-11-18 | Otsuka Pharmaceutica Co Ltd | Células-tronco para uso terapêutico que são derivados de monócito humano, e método para induzir as mesmas. |
| KR100950195B1 (ko) * | 2009-03-20 | 2010-03-29 | 서울대학교산학협력단 | Ｚｎｆ281을 발현하는 제대혈 유래 만능 줄기세포의 분리방법 |
| US20110091433A1 (en) * | 2009-10-19 | 2011-04-21 | Ilham Mohamed Saleh Saeed Abuljadayel | Treatment using reprogrammed mature adult cells |
| MX2012004522A (es) * | 2009-10-19 | 2012-05-08 | Tristem Trading Cyprus Ltd | Tratamiento que usa celulas adultas maduras reprogramadas. |
| CN101760446B (zh) * | 2009-12-31 | 2012-09-12 | 浙江中赢控股集团有限公司 | 制备单核细胞型干细胞的方法及应用 |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| US8858934B2 (en) * | 2010-08-12 | 2014-10-14 | Abag Verwaltungs Gmbh | Method for producing cells having characteristics of hepatocytes |
| SG10201601853XA (en) | 2011-03-11 | 2016-04-28 | Univ Singapore | Pericyte progenitors from peripheral blood |
| DE13746292T1 (de) * | 2012-02-10 | 2014-10-30 | Hakushinkouseikai Foundation | Proliferationsmittel für monozyten, kulturmedium zur proliferation von monozyten, verfahren zur herstellung von monozyten, verfahren zur herstellung dendritischer zellen und verfahren zur herstellung eines impfstoffs mit dendritischen zellen |
| US20150072416A1 (en) * | 2012-05-29 | 2015-03-12 | Korea Research Institute Of Bioscience And Biotech | Metabolite for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and method of culturing pluripotent stem cell using the same |
| US9884076B2 (en) | 2012-06-05 | 2018-02-06 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
| EP3563859B1 (en) | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| US20150353897A1 (en) * | 2012-12-06 | 2015-12-10 | Fuwan Pty Ltd | Method of generating multilineage potential cells |
| EP2862926B1 (en) | 2013-10-17 | 2018-12-05 | Centre National de la Recherche Scientifique (CNRS) | Method for in vitro differentiation of blood circulating cells into neuronal-like cells and applications thereof |
| US20170007644A1 (en) * | 2013-12-06 | 2017-01-12 | Fuwan Pty Ltd. | A method of treating neoplasia |
| DK3140396T3 (en) * | 2014-05-09 | 2018-11-12 | Thankstem S R L | Procedure for the expansion of adult stem cells from whole blood |
| EP4494699A3 (en) | 2014-10-03 | 2025-04-30 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| WO2016109590A1 (en) | 2014-12-31 | 2016-07-07 | Poet Research, Inc. | Use of a sugar stream in ethanol fermentation for producing further products |
| EP3344755A4 (en) * | 2015-08-31 | 2019-05-22 | I Peace, Inc. | PREPARATION SYSTEM FOR PLURIPOTENTE STEM CELLS AND METHOD FOR THE PRODUCTION OF INDUCED PLURIPOTENTAL STEM CELLS |
| WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| JP7336769B2 (ja) | 2017-04-19 | 2023-09-01 | シーダーズ―シナイ メディカル センター | 骨格筋ジストロフィーを治療する方法及び組成物 |
| CN107904202B (zh) * | 2017-11-22 | 2018-11-20 | 北京恩诺生物科技有限公司 | 一种制备多能干细胞样细胞的方法、组合物和应用 |
| US12233094B2 (en) | 2017-11-29 | 2025-02-25 | Spinalcyte, Llc | Interaction of fibroblasts and immune cells for activation and uses thereof |
| WO2019126068A1 (en) | 2017-12-20 | 2019-06-27 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| EP3749344A4 (en) | 2018-02-05 | 2022-01-26 | Cedars-Sinai Medical Center | METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS |
| CA3175071A1 (en) | 2020-03-11 | 2021-09-16 | Bit Bio Limited | Method of generating hepatic cells |
| JP6826744B1 (ja) * | 2020-07-17 | 2021-02-10 | 医療法人Ｙａｎａｇａ ＣＬｉｎｉｃ | 成熟脂肪細胞含有組成物の製造方法 |
| US20240245832A1 (en) * | 2021-03-18 | 2024-07-25 | The University Of Sydney | Bioengineered endothelial constructs |
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| US20050003534A1 (en) * | 2002-11-07 | 2005-01-06 | Eliezer Huberman | Human stem cell materials and methods |
| US20040136973A1 (en) * | 2002-11-07 | 2004-07-15 | Eliezer Huberman | Human stem cell materials and methods |
| JP2006512060A (ja) | 2002-11-07 | 2006-04-13 | ザ ユニヴァーシティ オヴ シカゴ | ヒト幹細胞の材料および方法 |
| US8271320B2 (en) * | 2002-12-12 | 2012-09-18 | International Business Machines Corporation | Method and system for enabling unregistered users to manage electronic items across sessions |
| US20050260158A1 (en) * | 2003-11-07 | 2005-11-24 | Eliezer Huberman | Human stem cell materials and methods |
-
2003
- 2003-03-27 TW TW092106955A patent/TWI288779B/zh not_active IP Right Cessation
- 2003-03-28 BR BR0308919-3A patent/BR0308919A/pt not_active Application Discontinuation
- 2003-03-28 AT AT03727271T patent/ATE295876T1/de active
- 2003-03-28 US US10/401,026 patent/US7138275B2/en not_active Expired - Fee Related
- 2003-03-28 EP EP04026289A patent/EP1506999A1/en not_active Withdrawn
- 2003-03-28 DK DK03727271T patent/DK1436381T3/da active
- 2003-03-28 CN CNB038071282A patent/CN100347293C/zh not_active Expired - Fee Related
- 2003-03-28 JP JP2003580528A patent/JP4146802B2/ja not_active Expired - Fee Related
- 2003-03-28 AU AU2003233950A patent/AU2003233950B2/en not_active Ceased
- 2003-03-28 PT PT03727271T patent/PT1436381E/pt unknown
- 2003-03-28 WO PCT/EP2003/003279 patent/WO2003083092A1/en not_active Ceased
- 2003-03-28 ES ES03727271T patent/ES2242941T3/es not_active Expired - Lifetime
- 2003-03-28 CA CA2479110A patent/CA2479110C/en not_active Expired - Fee Related
- 2003-03-28 IL IL16397003A patent/IL163970A0/xx unknown
- 2003-03-28 EP EP03727271A patent/EP1436381B1/en not_active Expired - Lifetime
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2004
- 2004-10-26 NO NO20044618A patent/NO337668B1/no not_active IP Right Cessation
-
2005
- 2005-05-26 US US11/137,444 patent/US7553663B2/en not_active Expired - Fee Related
- 2005-05-26 US US11/137,441 patent/US7553660B2/en not_active Expired - Fee Related
- 2005-11-21 US US11/282,684 patent/US7517686B2/en not_active Expired - Lifetime
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2006
- 2006-10-06 US US11/543,922 patent/US20070072291A1/en not_active Abandoned
-
2007
- 2007-12-07 JP JP2007317758A patent/JP2008119002A/ja active Pending
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2009
- 2009-05-28 US US12/474,191 patent/US20090239295A1/en not_active Abandoned
- 2009-05-28 US US12/474,183 patent/US20090233363A1/en not_active Abandoned
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