ATE295876T1 - Dedifferenzierte, programmierbare stammzellen monozytären ursprungs, sowie deren herstellung und verwendung - Google Patents

Dedifferenzierte, programmierbare stammzellen monozytären ursprungs, sowie deren herstellung und verwendung

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Publication number
ATE295876T1
ATE295876T1 AT03727271T AT03727271T ATE295876T1 AT E295876 T1 ATE295876 T1 AT E295876T1 AT 03727271 T AT03727271 T AT 03727271T AT 03727271 T AT03727271 T AT 03727271T AT E295876 T1 ATE295876 T1 AT E295876T1
Authority
AT
Austria
Prior art keywords
stem cells
production
differentiated
programmable stem
monocytic origin
Prior art date
Application number
AT03727271T
Other languages
German (de)
English (en)
Inventor
Bernd Karl Friedrich Kremer
Fred Faendrich
Maren Ruhnke
Original Assignee
Blasticon Biotech Forschung
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30116586&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE295876(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10214095A external-priority patent/DE10214095C1/de
Application filed by Blasticon Biotech Forschung filed Critical Blasticon Biotech Forschung
Application granted granted Critical
Publication of ATE295876T1 publication Critical patent/ATE295876T1/de

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AT03727271T 2002-03-28 2003-03-28 Dedifferenzierte, programmierbare stammzellen monozytären ursprungs, sowie deren herstellung und verwendung ATE295876T1 (de)

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DE10214095A DE10214095C1 (de) 2002-03-28 2002-03-28 Dedifferenzierte, programmierbare Stammzellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
US10/372,657 US20040101962A1 (en) 2002-03-28 2003-02-25 Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
PCT/EP2003/002121 WO2003083091A1 (de) 2002-03-28 2003-02-25 Dedifferenzierte, programmierbare stammzellen monozytären ursprungs, sowie deren herstellung und verwendung
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Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9502022D0 (en) * 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
DE10231655A1 (de) * 2002-07-12 2004-02-26 Blasticon Biotechnologische Forschung Gmbh Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
JP2006512060A (ja) * 2002-11-07 2006-04-13 ザ ユニヴァーシティ オヴ シカゴ ヒト幹細胞の材料および方法
US20040136973A1 (en) * 2002-11-07 2004-07-15 Eliezer Huberman Human stem cell materials and methods
US20060188485A1 (en) * 2003-07-11 2006-08-24 Bernd Karl Friedrich Kremer Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations
ITRM20030376A1 (it) * 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
WO2005071065A1 (en) * 2004-01-26 2005-08-04 Cognis France S.A.S Method for studying functional interactions between sensory neurons and keratinocytes or melanocytes
EP1600500A1 (en) * 2004-05-27 2005-11-30 Georg-August-Universität Göttingen Method for producing pluripotent cells from monocytes
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
CN101087563A (zh) * 2004-11-08 2007-12-12 约翰霍普金斯大学 活检钳
WO2006096931A1 (en) * 2005-03-18 2006-09-21 The University Of Queensland Renal repair and regeneration
US9388382B2 (en) 2005-10-05 2016-07-12 The Board Of Trustees Of The University Of Illinois Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells
ITTO20050819A1 (it) 2005-11-18 2007-05-19 Univ Degli Studi Torino Linea cellulare staminale pluripotente, linee cellulari derivate, procedimenti per la loro produzione e relativi usi
US20100021435A1 (en) * 2006-05-05 2010-01-28 Winnier Glenn E Pancreatic islet-like cells
CA2651331A1 (en) * 2006-05-05 2007-11-15 Opexa Therapeutics Monocyte-derived stem cells
US20080050814A1 (en) * 2006-06-05 2008-02-28 Cryo-Cell International, Inc. Procurement, isolation and cryopreservation of fetal placental cells
US20080064098A1 (en) * 2006-06-05 2008-03-13 Cryo-Cell International, Inc. Procurement, isolation and cryopreservation of maternal placental cells
ITRM20060498A1 (it) * 2006-09-20 2008-03-21 Alessandra Gambacurta Metodo di espansione di cellule staminali adulte da sangue periferico e relativi usi in campo medico
CA2666789C (en) 2006-10-18 2016-11-22 Yong Zhao Embryonic-like stem cells derived from adult human peripheral blood and methods of use
EP2087098A4 (en) * 2006-11-09 2010-03-31 Univ Johns Hopkins DETERMINATION OF CARDIOMYOCYTES ADULT MAMMALS IN HEART STEM CELLS
ITTO20060937A1 (it) * 2006-12-29 2008-06-30 Medestea Biotech S R L Linee cellulari immortali differenziate atte a produrre albumina e fattori di crescita, procedimenti per la loro preparazione da una linea cellulare leucemica e loro usi.
ES2352046T3 (es) * 2007-09-21 2011-02-15 Universität Leipzig Medio de cultivo celular y procedimiento de cultivo de células madre y células progenitor.
ITUD20080058A1 (it) 2008-03-18 2009-09-19 Thankstem S R L Kit per la raccolta di sangue, preferibilmente periferico, per la produzione di cellule staminali
WO2009157610A1 (en) * 2008-06-26 2009-12-30 Pusan National University Industry-University Cooperation Foundation Selenium dedifferentiated cell, preparation method and usage thereof
BRPI0921371A2 (pt) * 2008-11-25 2014-11-18 Otsuka Pharmaceutica Co Ltd Células-tronco para uso terapêutico que são derivados de monócito humano, e método para induzir as mesmas.
KR100950195B1 (ko) * 2009-03-20 2010-03-29 서울대학교산학협력단 Znf281을 발현하는 제대혈 유래 만능 줄기세포의 분리방법
US20110091433A1 (en) * 2009-10-19 2011-04-21 Ilham Mohamed Saleh Saeed Abuljadayel Treatment using reprogrammed mature adult cells
MX2012004522A (es) * 2009-10-19 2012-05-08 Tristem Trading Cyprus Ltd Tratamiento que usa celulas adultas maduras reprogramadas.
CN101760446B (zh) * 2009-12-31 2012-09-12 浙江中赢控股集团有限公司 制备单核细胞型干细胞的方法及应用
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US8858934B2 (en) * 2010-08-12 2014-10-14 Abag Verwaltungs Gmbh Method for producing cells having characteristics of hepatocytes
SG10201601853XA (en) 2011-03-11 2016-04-28 Univ Singapore Pericyte progenitors from peripheral blood
DE13746292T1 (de) * 2012-02-10 2014-10-30 Hakushinkouseikai Foundation Proliferationsmittel für monozyten, kulturmedium zur proliferation von monozyten, verfahren zur herstellung von monozyten, verfahren zur herstellung dendritischer zellen und verfahren zur herstellung eines impfstoffs mit dendritischen zellen
US20150072416A1 (en) * 2012-05-29 2015-03-12 Korea Research Institute Of Bioscience And Biotech Metabolite for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and method of culturing pluripotent stem cell using the same
US9884076B2 (en) 2012-06-05 2018-02-06 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP3563859B1 (en) 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Cardiosphere-derived exosomes for tissue regeneration
US20150353897A1 (en) * 2012-12-06 2015-12-10 Fuwan Pty Ltd Method of generating multilineage potential cells
EP2862926B1 (en) 2013-10-17 2018-12-05 Centre National de la Recherche Scientifique (CNRS) Method for in vitro differentiation of blood circulating cells into neuronal-like cells and applications thereof
US20170007644A1 (en) * 2013-12-06 2017-01-12 Fuwan Pty Ltd. A method of treating neoplasia
DK3140396T3 (en) * 2014-05-09 2018-11-12 Thankstem S R L Procedure for the expansion of adult stem cells from whole blood
EP4494699A3 (en) 2014-10-03 2025-04-30 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
WO2016109590A1 (en) 2014-12-31 2016-07-07 Poet Research, Inc. Use of a sugar stream in ethanol fermentation for producing further products
EP3344755A4 (en) * 2015-08-31 2019-05-22 I Peace, Inc. PREPARATION SYSTEM FOR PLURIPOTENTE STEM CELLS AND METHOD FOR THE PRODUCTION OF INDUCED PLURIPOTENTAL STEM CELLS
WO2017123662A1 (en) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
JP7336769B2 (ja) 2017-04-19 2023-09-01 シーダーズ―シナイ メディカル センター 骨格筋ジストロフィーを治療する方法及び組成物
CN107904202B (zh) * 2017-11-22 2018-11-20 北京恩诺生物科技有限公司 一种制备多能干细胞样细胞的方法、组合物和应用
US12233094B2 (en) 2017-11-29 2025-02-25 Spinalcyte, Llc Interaction of fibroblasts and immune cells for activation and uses thereof
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
CA3175071A1 (en) 2020-03-11 2021-09-16 Bit Bio Limited Method of generating hepatic cells
JP6826744B1 (ja) * 2020-07-17 2021-02-10 医療法人Yanaga CLinic 成熟脂肪細胞含有組成物の製造方法
US20240245832A1 (en) * 2021-03-18 2024-07-25 The University Of Sydney Bioengineered endothelial constructs

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US4761421A (en) * 1985-05-08 1988-08-02 Merck & Co., Inc. Use of certain compounds in livestock food as growth promotants for better feed utilization and improved carcass composition
US4783220A (en) * 1986-12-18 1988-11-08 Xerox Corporation Vesicle ink compositions
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
IL105324A0 (en) * 1992-04-06 1993-08-18 Univ Florida Stem cell proliferation factor
US5866373A (en) * 1995-04-21 1999-02-02 Human Genome Sciences, Inc. Polynucleotide encoding a human chemotactic protein
JPH10506530A (ja) * 1994-09-23 1998-06-30 ザ ジェネラル ホスピタル コーポレーション 哺乳類細胞において外来遺伝子を発現する非哺乳類dnaウイルスの使用
US5871986A (en) * 1994-09-23 1999-02-16 The General Hospital Corporation Use of a baculovirus to express and exogenous gene in a mammalian cell
US7410773B2 (en) * 1995-02-02 2008-08-12 Ghazi Jaswinder Dhoot Method of preparing an undifferentiated cell
US9068164B1 (en) * 1995-02-02 2015-06-30 Tristem Trading (Cyprus) Limited Method of preparing an undifferentiated cell
US7112440B2 (en) * 1995-02-02 2006-09-26 Ghazi Jaswinder Dhoot Method of increasing the relative number of CD45 low cells in a cell population
GB9502022D0 (en) 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US5650309A (en) * 1995-05-16 1997-07-22 The Regents Of The University Of California Viral vectors
US6043092A (en) * 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
US5827740A (en) * 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
US6008004A (en) * 1996-10-04 1999-12-28 Becton Dickinson & Company Identification of a CD34+ bone marrow precursor for dendritic cells in blood and lymphoid tissues
EP0983345A1 (en) * 1997-05-21 2000-03-08 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells
US6336098B1 (en) * 1997-12-11 2002-01-01 International Business Machines Corp. Method for electronic distribution and redemption of coupons on the world wide web
WO2000070022A2 (en) 1999-05-14 2000-11-23 City Of Hope Ex vivo expansion of mammalian hematopoietic stem cells
US20010032130A1 (en) * 1999-12-28 2001-10-18 Gabos John S. Marketing information system for remote computing platforms
US7160724B2 (en) * 2000-03-09 2007-01-09 University Of South Florida Human cord blood as a source of neural tissue for repair of the brain and spinal cord
US20010049139A1 (en) * 2000-03-23 2001-12-06 Eric Lagasse Hepatic regeneration from hematopoietic stem cells
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
WO2002014469A2 (en) 2000-08-15 2002-02-21 Geron Corporation Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells
US20040064365A1 (en) * 2001-02-17 2004-04-01 Sjoblom Johan Sjobl Electronic coupons
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
US7617122B2 (en) * 2002-08-28 2009-11-10 International Business Machines Corporation Targeted online marketing
US20040088218A1 (en) * 2002-11-04 2004-05-06 Abraham Daniel M. Coupon discounts redemption/cash back program
US20050003534A1 (en) * 2002-11-07 2005-01-06 Eliezer Huberman Human stem cell materials and methods
US20040136973A1 (en) * 2002-11-07 2004-07-15 Eliezer Huberman Human stem cell materials and methods
JP2006512060A (ja) 2002-11-07 2006-04-13 ザ ユニヴァーシティ オヴ シカゴ ヒト幹細胞の材料および方法
US8271320B2 (en) * 2002-12-12 2012-09-18 International Business Machines Corporation Method and system for enabling unregistered users to manage electronic items across sessions
US20050260158A1 (en) * 2003-11-07 2005-11-24 Eliezer Huberman Human stem cell materials and methods

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