CY1118230T1 - Μεθοδος παραγωγης μοσχευματων κυτταρων μεσοσπονδυλιων δισκων και η χρηση τους ως υλικο μεταμοσχευσης - Google Patents

Μεθοδος παραγωγης μοσχευματων κυτταρων μεσοσπονδυλιων δισκων και η χρηση τους ως υλικο μεταμοσχευσης

Info

Publication number
CY1118230T1
CY1118230T1 CY20161101173T CY161101173T CY1118230T1 CY 1118230 T1 CY1118230 T1 CY 1118230T1 CY 20161101173 T CY20161101173 T CY 20161101173T CY 161101173 T CY161101173 T CY 161101173T CY 1118230 T1 CY1118230 T1 CY 1118230T1
Authority
CY
Cyprus
Prior art keywords
grafts
transfer material
disc cells
intermediate disc
manufacturing cell
Prior art date
Application number
CY20161101173T
Other languages
English (en)
Inventor
Olivera Josimovic-Alasevic
Jeanette Libera
Vilma Methner
Hans-Jörg Meisel
Original Assignee
Co.Don Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004043449.2A external-priority patent/DE102004043449B4/de
Application filed by Co.Don Ag filed Critical Co.Don Ag
Publication of CY1118230T1 publication Critical patent/CY1118230T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A61L27/3658—Intervertebral discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3612—Cartilage, synovial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A61L27/3856—Intervertebral discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/4445—Means for culturing intervertebral disc tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/445—Intervertebral disc tissue harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Η εφεύρεση αναφέρεται σε μια μέθοδο για την παρασκευή in vitro μοσχευμάτων χονδρικών κυττάρων μεσοσπονδύλιου δίσκου, από άρρωστους ιστούς μεσοσπονδύλιου δίσκου από ασθενείς και η χρήση τους ως υλικό μεταμόσχευσης για τη θεραπεία άρρωστων μεσοσπονδύλιων δίσκων. Η εφεύρεση αναφέρεται περαιτέρω σε τρισδιάστατο, ζωτικό και μηχανικά σταθερό ιστό χόνδρων μεσοσπονδύλιων δίσκων και στη χρήση του ως υλικό μεταμόσχευσης για τη θεραπεία άρρωστων μεσοσπονδύλιων δίσκων καθώς και για τη δοκιμή δραστικών υλικών. Αντικείμενο της εφεύρεσης είναι περαιτέρω η τεχνική εγχείρησης για την εισαγωγή των μοσχευμάτων, τα δημιουργημένα μοσχεύματα κυττάρων μεσοσπονδύλιων δίσκων και οι δημιουργημένοι χονδρικοί ιστοί μεσοσπονδύλιου δίσκου και θεραπευτικά παρασκευάσματα, για παράδειγμα διαλύματα έγχυσης, τα οποία περιέχουν αυτόν τον ιστό και τα μοσχεύματα κυττάρων.
CY20161101173T 2003-12-12 2016-11-16 Μεθοδος παραγωγης μοσχευματων κυτταρων μεσοσπονδυλιων δισκων και η χρηση τους ως υλικο μεταμοσχευσης CY1118230T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10359830 2003-12-12
US54431504P 2004-02-17 2004-02-17
DE102004043449.2A DE102004043449B4 (de) 2004-09-06 2004-09-06 Verfahren zur Herstellung von Bandscheibenzelltransplantaten und deren Anwendung als Transplantationsmaterial
PCT/DE2004/002761 WO2005055877A2 (de) 2003-12-12 2004-12-13 Verfahren zur herstellung von bandscheibengewebe aus degeneriertem bandscheibengewebe

Publications (1)

Publication Number Publication Date
CY1118230T1 true CY1118230T1 (el) 2017-06-28

Family

ID=34681804

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161101173T CY1118230T1 (el) 2003-12-12 2016-11-16 Μεθοδος παραγωγης μοσχευματων κυτταρων μεσοσπονδυλιων δισκων και η χρηση τους ως υλικο μεταμοσχευσης

Country Status (4)

Country Link
US (2) US8148150B2 (el)
EP (1) EP1706157B1 (el)
CY (1) CY1118230T1 (el)
WO (1) WO2005055877A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8137405B2 (en) * 2008-10-08 2012-03-20 K2M, Inc. Spinal interbody spacer
WO2010129692A1 (en) 2009-05-05 2010-11-11 Cornell University Composite tissue-engineered intervertebral disc with self-assembled annular alignment
EP2496162B1 (en) * 2009-11-05 2018-10-31 K2M, Inc. Semi-constrained bone screw
US9468535B2 (en) 2010-12-17 2016-10-18 K2M, Inc. Interbody spacer
US9358122B2 (en) 2011-01-07 2016-06-07 K2M, Inc. Interbody spacer
US9017409B2 (en) 2011-04-22 2015-04-28 K2M, Inc. Spinal interbody spacer with semi-constrained screws
US10292832B2 (en) 2013-03-14 2019-05-21 Ohio State Innovation Foundation Spinal fixation device
US9707096B2 (en) 2013-03-14 2017-07-18 K2M, Inc. Spinal fixation device
WO2014143870A1 (en) * 2013-03-15 2014-09-18 Discgenics, Inc. Isolated discogenic cells, methods of using, and methods of preparing same from mammalian tissue
AU2016324333B2 (en) 2015-09-18 2021-03-18 K2M, Inc. Corpectomy device and method of use thereof
EP3346000A1 (de) 2017-01-05 2018-07-11 co.don AG Verfahren zur selektion von bandscheibenzellen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080579A (en) * 1997-11-26 2000-06-27 Charlotte-Mecklenburg Hospital Authority Method for producing human intervertebral disc cells
US6340369B1 (en) * 1999-08-13 2002-01-22 Bret A. Ferree Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix
DE10013223C2 (de) * 2000-03-13 2002-07-18 Co Don Ag Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial
EP1320391B1 (en) * 2000-09-18 2007-06-13 Organogenesis Inc. Method for treating a patient using a cultured connective tissue construct
US20030165473A1 (en) * 2001-11-09 2003-09-04 Rush-Presbyterian-St. Luke's Medical Center Engineered intervertebral disc tissue
US7931687B2 (en) * 2002-05-13 2011-04-26 Articular Engineering, Llc Tissue engineered osteochondral implant

Also Published As

Publication number Publication date
US8148150B2 (en) 2012-04-03
WO2005055877A2 (de) 2005-06-23
US20080249624A1 (en) 2008-10-09
EP1706157B1 (de) 2016-08-17
EP1706157A2 (de) 2006-10-04
WO2005055877A3 (de) 2005-11-10
US20120219533A1 (en) 2012-08-30

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