JP2005521405A5 - - Google Patents
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- JP2005521405A5 JP2005521405A5 JP2003580528A JP2003580528A JP2005521405A5 JP 2005521405 A5 JP2005521405 A5 JP 2005521405A5 JP 2003580528 A JP2003580528 A JP 2003580528A JP 2003580528 A JP2003580528 A JP 2003580528A JP 2005521405 A5 JP2005521405 A5 JP 2005521405A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- target
- dedifferentiated
- cell
- stem cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000000130 stem cell Anatomy 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000006143 cell culture medium Substances 0.000 claims description 7
- 239000001963 growth medium Substances 0.000 claims description 6
- 230000004069 differentiation Effects 0.000 claims description 2
- 239000000463 material Substances 0.000 claims 9
- 210000001519 tissue Anatomy 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 210000001616 monocyte Anatomy 0.000 claims 6
- 210000001082 somatic cell Anatomy 0.000 claims 5
- 210000001789 adipocyte Anatomy 0.000 claims 4
- 210000004153 islets of langerhan Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 3
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 3
- 239000012876 carrier material Substances 0.000 claims 3
- -1 mercapto compound Chemical class 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 239000003636 conditioned culture medium Substances 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000003494 hepatocyte Anatomy 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 210000002510 keratinocyte Anatomy 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 210000004498 neuroglial cell Anatomy 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 230000008672 reprogramming Effects 0.000 claims 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000024659 Hemostatic disease Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 208000035467 Pancreatic insufficiency Diseases 0.000 claims 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 208000030172 endocrine system disease Diseases 0.000 claims 1
- 239000012894 fetal calf serum Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 210000003709 heart valve Anatomy 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000037380 skin damage Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 239000011324 bead Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10214095A DE10214095C1 (de) | 2002-03-28 | 2002-03-28 | Dedifferenzierte, programmierbare Stammzellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
| US10/372,657 US20040101962A1 (en) | 2002-03-28 | 2003-02-25 | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
| PCT/EP2003/002121 WO2003083091A1 (de) | 2002-03-28 | 2003-02-25 | Dedifferenzierte, programmierbare stammzellen monozytären ursprungs, sowie deren herstellung und verwendung |
| PCT/EP2003/003279 WO2003083092A1 (en) | 2002-03-28 | 2003-03-28 | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007317758A Division JP2008119002A (ja) | 2002-03-28 | 2007-12-07 | 単球を起源に持つ、脱分化したプログラム可能な幹細胞およびそれらの製造と使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005521405A JP2005521405A (ja) | 2005-07-21 |
| JP2005521405A5 true JP2005521405A5 (enExample) | 2008-01-31 |
| JP4146802B2 JP4146802B2 (ja) | 2008-09-10 |
Family
ID=30116586
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003580528A Expired - Fee Related JP4146802B2 (ja) | 2002-03-28 | 2003-03-28 | 単球を起源に持つ、脱分化したプログラム可能な幹細胞およびそれらの製造と使用 |
| JP2007317758A Pending JP2008119002A (ja) | 2002-03-28 | 2007-12-07 | 単球を起源に持つ、脱分化したプログラム可能な幹細胞およびそれらの製造と使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007317758A Pending JP2008119002A (ja) | 2002-03-28 | 2007-12-07 | 単球を起源に持つ、脱分化したプログラム可能な幹細胞およびそれらの製造と使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US7138275B2 (enExample) |
| EP (2) | EP1436381B1 (enExample) |
| JP (2) | JP4146802B2 (enExample) |
| CN (1) | CN100347293C (enExample) |
| AT (1) | ATE295876T1 (enExample) |
| AU (1) | AU2003233950B2 (enExample) |
| BR (1) | BR0308919A (enExample) |
| CA (1) | CA2479110C (enExample) |
| DK (1) | DK1436381T3 (enExample) |
| ES (1) | ES2242941T3 (enExample) |
| IL (1) | IL163970A0 (enExample) |
| NO (1) | NO337668B1 (enExample) |
| PT (1) | PT1436381E (enExample) |
| TW (1) | TWI288779B (enExample) |
| WO (1) | WO2003083092A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9502022D0 (en) * | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
| DE10231655A1 (de) * | 2002-07-12 | 2004-02-26 | Blasticon Biotechnologische Forschung Gmbh | Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
| EP1581637A4 (en) * | 2002-11-07 | 2007-04-25 | Univ Chicago | MATERIALS AND METHODS WITH HUMAN STEM CELLS |
| US20040136973A1 (en) * | 2002-11-07 | 2004-07-15 | Eliezer Huberman | Human stem cell materials and methods |
| JP2007525473A (ja) * | 2003-07-11 | 2007-09-06 | ブラスティコン ビオテクノロギッシュ フォーシュング ゲーエムベーハー | 単球由来の自己寛容誘導性自家細胞および薬学的組成物におけるその使用 |
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| WO2005071065A1 (en) * | 2004-01-26 | 2005-08-04 | Cognis France S.A.S | Method for studying functional interactions between sensory neurons and keratinocytes or melanocytes |
| EP1600500A1 (en) * | 2004-05-27 | 2005-11-30 | Georg-August-Universität Göttingen | Method for producing pluripotent cells from monocytes |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US20080267921A1 (en) * | 2004-11-08 | 2008-10-30 | Johns Hopkins University | Cardiac Stem Cells |
| WO2006096931A1 (en) * | 2005-03-18 | 2006-09-21 | The University Of Queensland | Renal repair and regeneration |
| US9388382B2 (en) | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
| WO2008048671A1 (en) | 2006-10-18 | 2008-04-24 | University Of Illinois | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
| ITTO20050819A1 (it) | 2005-11-18 | 2007-05-19 | Univ Degli Studi Torino | Linea cellulare staminale pluripotente, linee cellulari derivate, procedimenti per la loro produzione e relativi usi |
| WO2007131200A2 (en) * | 2006-05-05 | 2007-11-15 | Opexa Therapeutics | Monocyte-derived stem cells |
| CA2651326A1 (en) * | 2006-05-05 | 2007-11-15 | Opexa Therapeutics | Pancreatic islet-like cells |
| US20080064098A1 (en) * | 2006-06-05 | 2008-03-13 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of maternal placental cells |
| US20080050814A1 (en) * | 2006-06-05 | 2008-02-28 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of fetal placental cells |
| ITRM20060498A1 (it) * | 2006-09-20 | 2008-03-21 | Alessandra Gambacurta | Metodo di espansione di cellule staminali adulte da sangue periferico e relativi usi in campo medico |
| WO2008058273A2 (en) * | 2006-11-09 | 2008-05-15 | The Johns Hopkins University | Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells |
| ITTO20060937A1 (it) * | 2006-12-29 | 2008-06-30 | Medestea Biotech S R L | Linee cellulari immortali differenziate atte a produrre albumina e fattori di crescita, procedimenti per la loro preparazione da una linea cellulare leucemica e loro usi. |
| ES2352046T3 (es) * | 2007-09-21 | 2011-02-15 | Universität Leipzig | Medio de cultivo celular y procedimiento de cultivo de células madre y células progenitor. |
| ITUD20080058A1 (it) | 2008-03-18 | 2009-09-19 | Thankstem S R L | Kit per la raccolta di sangue, preferibilmente periferico, per la produzione di cellule staminali |
| WO2009157610A1 (en) * | 2008-06-26 | 2009-12-30 | Pusan National University Industry-University Cooperation Foundation | Selenium dedifferentiated cell, preparation method and usage thereof |
| CN102245757B (zh) | 2008-11-25 | 2014-11-26 | 大塚制药株式会社 | 来自人单核细胞的治疗用干细胞及其诱导方法 |
| KR100950195B1 (ko) * | 2009-03-20 | 2010-03-29 | 서울대학교산학협력단 | Ｚｎｆ281을 발현하는 제대혈 유래 만능 줄기세포의 분리방법 |
| US20110091433A1 (en) * | 2009-10-19 | 2011-04-21 | Ilham Mohamed Saleh Saeed Abuljadayel | Treatment using reprogrammed mature adult cells |
| WO2011048350A1 (en) * | 2009-10-19 | 2011-04-28 | Tristem Trading (Cyprus) Limited | Treatment using reprogrammed mature adult cells |
| CN101760446B (zh) * | 2009-12-31 | 2012-09-12 | 浙江中赢控股集团有限公司 | 制备单核细胞型干细胞的方法及应用 |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| JP6000950B2 (ja) * | 2010-08-12 | 2016-10-05 | アーベーアーゲー フェアヴァルトゥングス ゲーエムベーハーＡｂａｇ Ｖｅｒｗａｌｔｕｎｇｓ Ｇｍｂｈ | 肝細胞の特徴を有する細胞を産生するための方法並びに同方法により産生された細胞及びその使用 |
| SG192862A1 (en) | 2011-03-11 | 2013-09-30 | Univ Singapore | Pericyte progenitors from peripheral blood |
| WO2013118899A1 (ja) * | 2012-02-10 | 2013-08-15 | 医療法人社団博心厚生会 | 単球増殖剤、単球増殖用培地、単球の製造方法、樹状細胞の製造方法、及び樹状細胞ワクチンの製造方法 |
| US20150072416A1 (en) * | 2012-05-29 | 2015-03-12 | Korea Research Institute Of Bioscience And Biotech | Metabolite for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and method of culturing pluripotent stem cell using the same |
| WO2013184527A1 (en) | 2012-06-05 | 2013-12-12 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
| JP6433896B2 (ja) | 2012-08-13 | 2018-12-05 | シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ | 組織再生のためのエキソソームおよびマイクロリボ核酸 |
| EP2929016A4 (en) * | 2012-12-06 | 2016-06-29 | Fuwan Pty Ltd | PROCESS FOR GENERATING MULTIPOTENTIAL CELLS |
| EP2862926B1 (en) * | 2013-10-17 | 2018-12-05 | Centre National de la Recherche Scientifique (CNRS) | Method for in vitro differentiation of blood circulating cells into neuronal-like cells and applications thereof |
| EP3076980A4 (en) * | 2013-12-06 | 2017-08-16 | Fuwan Pty Ltd | A method of treating neoplasia |
| CN106574247A (zh) | 2014-05-09 | 2017-04-19 | 善克思腾(股份)责任有限公司 | 从全血中扩增成体干细胞的方法 |
| JP6878274B2 (ja) | 2014-10-03 | 2021-05-26 | シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ | 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム |
| BR112017014195B1 (pt) | 2014-12-31 | 2023-04-11 | Poet Research, Inc | Processos para produzir uma corrente (slip stream) de açúcar e sistemas para produzir uma corrente (slip stream) de açúcar |
| EP3344755A4 (en) | 2015-08-31 | 2019-05-22 | I Peace, Inc. | PREPARATION SYSTEM FOR PLURIPOTENTE STEM CELLS AND METHOD FOR THE PRODUCTION OF INDUCED PLURIPOTENTAL STEM CELLS |
| WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| EP3515459A4 (en) | 2016-09-20 | 2020-08-05 | Cedars-Sinai Medical Center | CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS |
| CA3059910A1 (en) | 2017-04-19 | 2018-10-25 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| CN107904202B (zh) * | 2017-11-22 | 2018-11-20 | 北京恩诺生物科技有限公司 | 一种制备多能干细胞样细胞的方法、组合物和应用 |
| JP7387603B2 (ja) * | 2017-11-29 | 2023-11-28 | フィジーン、エルエルシー | 活性化のための線維芽細胞と免疫細胞との相互作用及びそれらの使用 |
| EP3727351A4 (en) | 2017-12-20 | 2021-10-06 | Cedars-Sinai Medical Center | MANIPULATED EXTRACELLULAR VESICLES FOR ENHANCED RELEASE INTO TISSUE |
| WO2019152549A1 (en) | 2018-02-05 | 2019-08-08 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and y-rnas |
| CN115551994A (zh) | 2020-03-11 | 2022-12-30 | 倍特博有限公司 | 产生肝细胞的方法 |
| JP6826744B1 (ja) * | 2020-07-17 | 2021-02-10 | 医療法人Ｙａｎａｇａ ＣＬｉｎｉｃ | 成熟脂肪細胞含有組成物の製造方法 |
| JP2024510296A (ja) * | 2021-03-18 | 2024-03-06 | ザ・ユニバーシティ・オブ・シドニー | バイオエンジニアリングされた内皮構築物 |
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| US20010049139A1 (en) * | 2000-03-23 | 2001-12-06 | Eric Lagasse | Hepatic regeneration from hematopoietic stem cells |
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| US20040064365A1 (en) * | 2001-02-17 | 2004-04-01 | Sjoblom Johan Sjobl | Electronic coupons |
| TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
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| US20050003534A1 (en) * | 2002-11-07 | 2005-01-06 | Eliezer Huberman | Human stem cell materials and methods |
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-
2003
- 2003-03-27 TW TW092106955A patent/TWI288779B/zh not_active IP Right Cessation
- 2003-03-28 BR BR0308919-3A patent/BR0308919A/pt not_active Application Discontinuation
- 2003-03-28 AT AT03727271T patent/ATE295876T1/de active
- 2003-03-28 JP JP2003580528A patent/JP4146802B2/ja not_active Expired - Fee Related
- 2003-03-28 ES ES03727271T patent/ES2242941T3/es not_active Expired - Lifetime
- 2003-03-28 US US10/401,026 patent/US7138275B2/en not_active Expired - Fee Related
- 2003-03-28 PT PT03727271T patent/PT1436381E/pt unknown
- 2003-03-28 WO PCT/EP2003/003279 patent/WO2003083092A1/en not_active Ceased
- 2003-03-28 DK DK03727271T patent/DK1436381T3/da active
- 2003-03-28 IL IL16397003A patent/IL163970A0/xx unknown
- 2003-03-28 CA CA2479110A patent/CA2479110C/en not_active Expired - Fee Related
- 2003-03-28 CN CNB038071282A patent/CN100347293C/zh not_active Expired - Fee Related
- 2003-03-28 AU AU2003233950A patent/AU2003233950B2/en not_active Ceased
- 2003-03-28 EP EP03727271A patent/EP1436381B1/en not_active Expired - Lifetime
- 2003-03-28 EP EP04026289A patent/EP1506999A1/en not_active Withdrawn
-
2004
- 2004-10-26 NO NO20044618A patent/NO337668B1/no not_active IP Right Cessation
-
2005
- 2005-05-26 US US11/137,444 patent/US7553663B2/en not_active Expired - Fee Related
- 2005-05-26 US US11/137,441 patent/US7553660B2/en not_active Expired - Fee Related
- 2005-11-21 US US11/282,684 patent/US7517686B2/en not_active Expired - Lifetime
-
2006
- 2006-10-06 US US11/543,922 patent/US20070072291A1/en not_active Abandoned
-
2007
- 2007-12-07 JP JP2007317758A patent/JP2008119002A/ja active Pending
-
2009
- 2009-05-28 US US12/474,191 patent/US20090239295A1/en not_active Abandoned
- 2009-05-28 US US12/474,183 patent/US20090233363A1/en not_active Abandoned
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