JP2005520803A5 - - Google Patents
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- Publication number
- JP2005520803A5 JP2005520803A5 JP2003557970A JP2003557970A JP2005520803A5 JP 2005520803 A5 JP2005520803 A5 JP 2005520803A5 JP 2003557970 A JP2003557970 A JP 2003557970A JP 2003557970 A JP2003557970 A JP 2003557970A JP 2005520803 A5 JP2005520803 A5 JP 2005520803A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- chloro
- sodium
- hydroxybenzoyl
- butanoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UQFYDAAKCZKDHS-UHFFFAOYSA-M sodium;4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate Chemical compound [Na+].OC1=CC(Cl)=CC=C1C(=O)NCCCC([O-])=O UQFYDAAKCZKDHS-UHFFFAOYSA-M 0.000 claims 18
- 229910052708 sodium Inorganic materials 0.000 claims 9
- 239000011734 sodium Substances 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 6
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 5
- 238000002844 melting Methods 0.000 claims 4
- 230000008018 melting Effects 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- GCVGCXMTCJMBHY-UHFFFAOYSA-N 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoic acid Chemical compound OC(=O)CCCNC(=O)C1=CC=C(Cl)C=C1O GCVGCXMTCJMBHY-UHFFFAOYSA-N 0.000 claims 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- 238000000113 differential scanning calorimetry Methods 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- -1 4-chloro-2-hydroxybenzoyl Chemical group 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical group CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34761002P | 2002-01-09 | 2002-01-09 | |
| PCT/US2003/000878 WO2003057650A2 (en) | 2002-01-09 | 2003-01-09 | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005520803A JP2005520803A (ja) | 2005-07-14 |
| JP2005520803A5 true JP2005520803A5 (enExample) | 2008-03-13 |
| JP4508646B2 JP4508646B2 (ja) | 2010-07-21 |
Family
ID=23364463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003557970A Expired - Fee Related JP4508646B2 (ja) | 2002-01-09 | 2003-01-09 | ４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7227033B2 (enExample) |
| EP (2) | EP2272501B1 (enExample) |
| JP (1) | JP4508646B2 (enExample) |
| AU (1) | AU2003223158B2 (enExample) |
| CA (1) | CA2471144C (enExample) |
| ES (2) | ES2664189T3 (enExample) |
| WO (1) | WO2003057650A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997036480A1 (en) | 1996-03-29 | 1997-10-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| UA80248C2 (en) | 2000-06-29 | 2007-09-10 | Compounds and compositions for delivering active agents | |
| CA2471144C (en) * | 2002-01-09 | 2011-06-07 | Emisphere Technologies, Inc. | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate |
| AU2004204727B8 (en) * | 2003-01-06 | 2006-11-09 | Emisphere Technologies, Inc. | Night-time oral insulin therapy |
| US20050203001A1 (en) * | 2004-03-05 | 2005-09-15 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
| US20050192298A1 (en) * | 2004-02-27 | 2005-09-01 | Pfizer Inc | Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide |
| US8273794B2 (en) * | 2004-05-14 | 2012-09-25 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US9498487B2 (en) | 2004-05-19 | 2016-11-22 | Emisphere Technologies, Inc. | Topical cromolyn formulations |
| MXPA06013295A (es) | 2004-05-19 | 2007-02-22 | Emisphere Tech Inc | Formulaciones de aciclovir. |
| JP2008509145A (ja) * | 2004-08-03 | 2008-03-27 | エミスフィアー テクノロジーズ インコーポレイテッド | 抗糖尿病性経口インスリン−ビグアニドの組み合わせ |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| GB0427600D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| GB0427603D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| WO2006072070A2 (en) | 2004-12-29 | 2006-07-06 | Emisphere Technologies, Inc. | Pharmaceutical formulations of gallium salts |
| WO2006076692A1 (en) | 2005-01-12 | 2006-07-20 | Emisphere Technologies, Inc. | Compositions for buccal delivery of parathyroid hormone |
| WO2007005995A2 (en) | 2005-07-05 | 2007-01-11 | Emisphere Technologies, Inc. | Compositions for buccal delivery of human growth hormone |
| WO2008003050A2 (en) * | 2006-06-28 | 2008-01-03 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
| WO2011017346A2 (en) | 2009-08-03 | 2011-02-10 | Emisphere Technologies, Inc. | Fast-acting naproxen composition with reduced gastrointestinal effects |
| JP6374388B2 (ja) | 2012-09-21 | 2018-08-15 | インテンシティ セラピューティクス, インク.Intensity Therapeutics, Inc. | 癌の治療方法 |
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| FR3020947B1 (fr) | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
| FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
| WO2020111139A1 (ja) * | 2018-11-29 | 2020-06-04 | Ｎｅｃソリューションイノベータ株式会社 | 座標算出装置、座標算出方法、及びコンピュータ読み取り可能な記録媒体 |
| CN111925298B (zh) * | 2020-09-02 | 2023-05-30 | 无锡紫杉药业有限公司 | 一种4-cnab及其制备方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5811856B2 (ja) * | 1975-07-14 | 1983-03-04 | 中外製薬株式会社 | ２ ４− ビス （２’ − アセトキシベンズアミド ） アンソクコウサンノ イケイケツシヨウノ セイゾウホウ |
| JPS5312417A (en) * | 1976-07-20 | 1978-02-03 | Sumitomo Chem Co Ltd | Preparation of amorphous d rugs |
| US4421685A (en) | 1980-03-27 | 1983-12-20 | Eli Lilly And Company | Process for producing an insulin |
| CA1214170A (fr) * | 1981-06-16 | 1986-11-18 | Patrick Choay | Procedes de preparation de nouveaux composes du type arylbenzenesulfonamide |
| USRE35862E (en) | 1986-08-18 | 1998-07-28 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| US5443841A (en) | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
| US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5583020A (en) * | 1992-11-24 | 1996-12-10 | Ribozyme Pharmaceuticals, Inc. | Permeability enhancers for negatively charged polynucleotides |
| US5401516A (en) | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
| US5766633A (en) | 1993-04-22 | 1998-06-16 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5534488A (en) | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| JP3462895B2 (ja) * | 1993-11-05 | 2003-11-05 | 三井化学株式会社 | 安息香酸誘導体の多価金属塩の製造方法 |
| US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| TW487582B (en) | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
| ATE324907T1 (de) * | 1997-02-07 | 2006-06-15 | Emisphere Tech Inc | Verbindung und arzneizusammensetzung zur verabreichung von wirkstoffen |
| US5776888A (en) | 1997-02-07 | 1998-07-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| GB9808896D0 (en) * | 1998-04-25 | 1998-06-24 | Smithkline Beecham Plc | Novel compound |
| HU230799B1 (hu) * | 1998-06-19 | 2018-06-28 | Teijin Pharma Limited | 2-(3-Ciano-4-izobutiloxifenil)-4-metil-5-tiazolkarbonsav polimorf módosulatai és eljárás ezek előállítására |
| KR100659753B1 (ko) | 1998-08-07 | 2006-12-20 | 에미스페어 테크놀로지스, 인코포레이티드 | 활성제 전달용 화합물 및 조성물 |
| CN1338924A (zh) | 1999-01-08 | 2002-03-06 | 艾米斯菲尔技术有限公司 | 聚合物输送剂和输送剂化合物 |
| DE19903275A1 (de) * | 1999-01-28 | 2000-08-03 | Merck Patent Gmbh | Lyophilisate mit verbesserter Rekonstituierbarkeit |
| ATE309197T1 (de) * | 1999-02-05 | 2005-11-15 | Emisphere Tech Inc | Verfahren zur herstellung alkylierter salicylamide |
| CA2364849A1 (en) | 1999-02-26 | 2000-08-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| EP1175390B1 (en) * | 1999-04-05 | 2005-02-02 | Emisphere Technologies, Inc. | Disodium salts, monohydrates, and ethanol solvates |
| GB9923933D0 (en) * | 1999-10-08 | 1999-12-08 | Smithkline Beecham Lab | Novel pharmaceutical |
| GB9923934D0 (en) * | 1999-10-08 | 1999-12-08 | Smithkline Beecham Plc | Novel pharmaceutical |
| ATE427925T1 (de) | 1999-11-05 | 2009-04-15 | Emisphere Tech Inc | Phenoxycarbonsaureverbindungen und zusammensetzungen zur verabreichung aktiver wirkstoffe |
| JP2001240581A (ja) * | 2000-02-29 | 2001-09-04 | Senju Pharmaceut Co Ltd | アミノベンズアミド誘導体およびその用途 |
| EP1284724B1 (en) | 2000-03-21 | 2012-04-18 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides via a dicarboxylate intermediate |
| UA80248C2 (en) | 2000-06-29 | 2007-09-10 | Compounds and compositions for delivering active agents | |
| US6482847B2 (en) * | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| CA2471144C (en) | 2002-01-09 | 2011-06-07 | Emisphere Technologies, Inc. | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate |
-
2003
- 2003-01-09 CA CA2471144A patent/CA2471144C/en not_active Expired - Lifetime
- 2003-01-09 EP EP10012220A patent/EP2272501B1/en not_active Expired - Lifetime
- 2003-01-09 EP EP03719286.1A patent/EP1469827B1/en not_active Expired - Lifetime
- 2003-01-09 AU AU2003223158A patent/AU2003223158B2/en not_active Ceased
- 2003-01-09 ES ES03719286.1T patent/ES2664189T3/es not_active Expired - Lifetime
- 2003-01-09 WO PCT/US2003/000878 patent/WO2003057650A2/en not_active Ceased
- 2003-01-09 US US10/501,205 patent/US7227033B2/en not_active Expired - Lifetime
- 2003-01-09 ES ES10012220T patent/ES2412306T3/es not_active Expired - Lifetime
- 2003-01-09 JP JP2003557970A patent/JP4508646B2/ja not_active Expired - Fee Related
-
2005
- 2005-07-14 US US11/183,039 patent/US7208178B2/en not_active Expired - Lifetime
-
2007
- 2007-03-14 US US11/686,341 patent/US7462368B2/en not_active Expired - Lifetime
- 2007-04-12 US US11/734,591 patent/US7420085B2/en not_active Expired - Lifetime
-
2008
- 2008-07-02 US US12/167,126 patent/US7893297B2/en not_active Expired - Fee Related
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