JP2005520803A5 - - Google Patents
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- Publication number
- JP2005520803A5 JP2005520803A5 JP2003557970A JP2003557970A JP2005520803A5 JP 2005520803 A5 JP2005520803 A5 JP 2005520803A5 JP 2003557970 A JP2003557970 A JP 2003557970A JP 2003557970 A JP2003557970 A JP 2003557970A JP 2005520803 A5 JP2005520803 A5 JP 2005520803A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- chloro
- sodium
- hydroxybenzoyl
- butanoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UQFYDAAKCZKDHS-UHFFFAOYSA-M sodium;4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate Chemical compound [Na+].OC1=CC(Cl)=CC=C1C(=O)NCCCC([O-])=O UQFYDAAKCZKDHS-UHFFFAOYSA-M 0.000 claims 18
- 229910052708 sodium Inorganic materials 0.000 claims 9
- 239000011734 sodium Substances 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 6
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 5
- 238000002844 melting Methods 0.000 claims 4
- 230000008018 melting Effects 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- GCVGCXMTCJMBHY-UHFFFAOYSA-N 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoic acid Chemical compound OC(=O)CCCNC(=O)C1=CC=C(Cl)C=C1O GCVGCXMTCJMBHY-UHFFFAOYSA-N 0.000 claims 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- 238000000113 differential scanning calorimetry Methods 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- -1 4-chloro-2-hydroxybenzoyl Chemical group 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical group CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34761002P | 2002-01-09 | 2002-01-09 | |
| PCT/US2003/000878 WO2003057650A2 (en) | 2002-01-09 | 2003-01-09 | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005520803A JP2005520803A (ja) | 2005-07-14 |
| JP2005520803A5 true JP2005520803A5 (enExample) | 2008-03-13 |
| JP4508646B2 JP4508646B2 (ja) | 2010-07-21 |
Family
ID=23364463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003557970A Expired - Fee Related JP4508646B2 (ja) | 2002-01-09 | 2003-01-09 | ４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7227033B2 (enExample) |
| EP (2) | EP2272501B1 (enExample) |
| JP (1) | JP4508646B2 (enExample) |
| AU (1) | AU2003223158B2 (enExample) |
| CA (1) | CA2471144C (enExample) |
| ES (2) | ES2664189T3 (enExample) |
| WO (1) | WO2003057650A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2595697A (en) | 1996-03-29 | 1997-10-22 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| WO2003057650A2 (en) * | 2002-01-09 | 2003-07-17 | Emisphere Technologies, Inc. | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate |
| NZ523017A (en) | 2000-06-29 | 2004-10-29 | Emisphere Tech Inc | Compounds and compositions for delivering active agents and preparation method thereof |
| US7384914B2 (en) * | 2003-01-06 | 2008-06-10 | Emisphere Technologies, Inc. | Night-time oral insulin therapy |
| US20050203001A1 (en) * | 2004-03-05 | 2005-09-15 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
| US20050192298A1 (en) * | 2004-02-27 | 2005-09-01 | Pfizer Inc | Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide |
| ES2393324T3 (es) * | 2004-05-14 | 2012-12-20 | Emisphere Technologies, Inc. | Compuestos y composiciones para administrar principios activos |
| BRPI0510906A (pt) | 2004-05-19 | 2007-11-06 | Emisphere Tech Inc | composição farmacêutica tópica, composição para administração tópica e seu uso |
| BRPI0510820A (pt) | 2004-05-19 | 2007-11-27 | Emisphere Tech Inc | composição farmacêutica, forma unitária de dosagem e seus usos |
| AU2005271526B2 (en) * | 2004-08-03 | 2011-12-08 | Emisphere Technologies, Inc. | Antidiabetic oral insulin-biguanide combination |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| GB0427600D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| GB0427603D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| MX2007008082A (es) | 2004-12-29 | 2007-09-05 | Emisphere Tech Inc | Formulaciones farmaceuticas de sales de galio. |
| US8110547B2 (en) | 2005-01-12 | 2012-02-07 | Emisphere Technologies, Inc. | Compositions for buccal delivery of parathyroid hormone |
| WO2007005995A2 (en) | 2005-07-05 | 2007-01-11 | Emisphere Technologies, Inc. | Compositions for buccal delivery of human growth hormone |
| WO2008003050A2 (en) * | 2006-06-28 | 2008-01-03 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
| US20110039930A1 (en) | 2009-08-03 | 2011-02-17 | Emisphere Technologies, Inc. | Fast-acting naproxen composition with reduced gastrointestinal effects |
| MX375442B (es) | 2012-09-21 | 2025-03-06 | Intensity Therapeutics Inc | Un agente terapéutico y un agente mejorador de la permeación intracelular para usarse en el tratamiento de cáncer. |
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| FR3020947B1 (fr) * | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
| JP7188798B2 (ja) * | 2018-11-29 | 2022-12-13 | Ｎｅｃソリューションイノベータ株式会社 | 座標算出装置、座標算出方法、及びプログラム |
| CN111925298B (zh) * | 2020-09-02 | 2023-05-30 | 无锡紫杉药业有限公司 | 一种4-cnab及其制备方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5811856B2 (ja) * | 1975-07-14 | 1983-03-04 | 中外製薬株式会社 | ２ ４− ビス （２’ − アセトキシベンズアミド ） アンソクコウサンノ イケイケツシヨウノ セイゾウホウ |
| JPS5312417A (en) * | 1976-07-20 | 1978-02-03 | Sumitomo Chem Co Ltd | Preparation of amorphous d rugs |
| US4421685A (en) | 1980-03-27 | 1983-12-20 | Eli Lilly And Company | Process for producing an insulin |
| DE3266360D1 (en) | 1981-06-16 | 1985-10-24 | Choay Sa | Medicines containing as active ingredients compounds of the arylbenzenesulfonamide-type, and processes for their preparation |
| USRE35862E (en) | 1986-08-18 | 1998-07-28 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| US5443841A (en) | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
| US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5583020A (en) | 1992-11-24 | 1996-12-10 | Ribozyme Pharmaceuticals, Inc. | Permeability enhancers for negatively charged polynucleotides |
| US5401516A (en) | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
| IL109403A0 (en) | 1993-04-22 | 1994-07-31 | Emisphere Tech Inc | Oral drug delivery compositions and methods |
| US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5534488A (en) | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| JP3462895B2 (ja) * | 1993-11-05 | 2003-11-05 | 三井化学株式会社 | 安息香酸誘導体の多価金属塩の製造方法 |
| US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| TW487582B (en) * | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
| ATE383169T1 (de) | 1997-02-07 | 2008-01-15 | Emisphere Tech Inc | Komponente und zusammensetzungen zur verabreichung von wirkstoffen |
| US5776888A (en) | 1997-02-07 | 1998-07-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| GB9808896D0 (en) * | 1998-04-25 | 1998-06-24 | Smithkline Beecham Plc | Novel compound |
| PL200710B1 (pl) * | 1998-06-19 | 2009-01-30 | Teijin Pharma Ltd | Polimorfy kwasu 2-(3-cyjano-4-izobutyloksyfenylo)-4-metylo-5-tiazolokarboksylowego i sposób ich wytwarzania |
| IL140930A0 (en) | 1998-08-07 | 2002-02-10 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| JP2002534363A (ja) | 1999-01-08 | 2002-10-15 | エミスフェアー・テクノロジーズ・インク | ポリマー性デリバリー剤及びデリバリー剤化合物 |
| DE19903275A1 (de) | 1999-01-28 | 2000-08-03 | Merck Patent Gmbh | Lyophilisate mit verbesserter Rekonstituierbarkeit |
| AU3357800A (en) * | 1999-02-05 | 2000-08-25 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides |
| EP1163209A4 (en) | 1999-02-26 | 2004-12-29 | Emisphere Tech Inc | COMPOUNDS AND COMPOSITIONS FOR ADMINISTRATION OF ACTIVE INGREDIENTS |
| NZ534409A (en) * | 1999-04-05 | 2006-03-31 | Emisphere Tech Inc | Disodium salts, monohydrates, and ethanol solvates for delivering active agents |
| GB9923934D0 (en) * | 1999-10-08 | 1999-12-08 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB9923933D0 (en) * | 1999-10-08 | 1999-12-08 | Smithkline Beecham Lab | Novel pharmaceutical |
| MXPA02004092A (es) | 1999-11-05 | 2003-02-12 | Emisphere Tech Inc | Compuestos y composiciones de acido fenilaminocarboxilico para administrar agentes activos. |
| JP2001240581A (ja) * | 2000-02-29 | 2001-09-04 | Senju Pharmaceut Co Ltd | アミノベンズアミド誘導体およびその用途 |
| JP4799794B2 (ja) | 2000-03-21 | 2011-10-26 | エミスフェアー・テクノロジーズ・インク | ジカルボキシル化中間体を介してアルキル化サリチルアミドを調製する方法。 |
| NZ523017A (en) * | 2000-06-29 | 2004-10-29 | Emisphere Tech Inc | Compounds and compositions for delivering active agents and preparation method thereof |
| WO2003057650A2 (en) * | 2002-01-09 | 2003-07-17 | Emisphere Technologies, Inc. | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate |
| US6482847B2 (en) * | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
-
2003
- 2003-01-09 WO PCT/US2003/000878 patent/WO2003057650A2/en not_active Ceased
- 2003-01-09 US US10/501,205 patent/US7227033B2/en not_active Expired - Lifetime
- 2003-01-09 CA CA2471144A patent/CA2471144C/en not_active Expired - Lifetime
- 2003-01-09 ES ES03719286.1T patent/ES2664189T3/es not_active Expired - Lifetime
- 2003-01-09 EP EP10012220A patent/EP2272501B1/en not_active Expired - Lifetime
- 2003-01-09 AU AU2003223158A patent/AU2003223158B2/en not_active Ceased
- 2003-01-09 JP JP2003557970A patent/JP4508646B2/ja not_active Expired - Fee Related
- 2003-01-09 EP EP03719286.1A patent/EP1469827B1/en not_active Expired - Lifetime
- 2003-01-09 ES ES10012220T patent/ES2412306T3/es not_active Expired - Lifetime
-
2005
- 2005-07-14 US US11/183,039 patent/US7208178B2/en not_active Expired - Lifetime
-
2007
- 2007-03-14 US US11/686,341 patent/US7462368B2/en not_active Expired - Lifetime
- 2007-04-12 US US11/734,591 patent/US7420085B2/en not_active Expired - Lifetime
-
2008
- 2008-07-02 US US12/167,126 patent/US7893297B2/en not_active Expired - Fee Related
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