JP2004530660A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004530660A5 JP2004530660A5 JP2002569838A JP2002569838A JP2004530660A5 JP 2004530660 A5 JP2004530660 A5 JP 2004530660A5 JP 2002569838 A JP2002569838 A JP 2002569838A JP 2002569838 A JP2002569838 A JP 2002569838A JP 2004530660 A5 JP2004530660 A5 JP 2004530660A5
- Authority
- JP
- Japan
- Prior art keywords
- ftc
- cis
- hydrate
- amorphous
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 238000000634 powder X-ray diffraction Methods 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 6
- 238000001816 cooling Methods 0.000 claims 5
- 239000013078 crystal Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 238000002844 melting Methods 0.000 claims 3
- 230000008018 melting Effects 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000000155 melt Substances 0.000 claims 1
- 238000010791 quenching Methods 0.000 claims 1
- 230000000171 quenching effect Effects 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27256001P | 2001-03-01 | 2001-03-01 | |
| US60/272,560 | 2001-03-01 | ||
| US30960501P | 2001-08-02 | 2001-08-02 | |
| US60/309,605 | 2001-08-02 | ||
| PCT/US2002/006184 WO2002070518A1 (en) | 2001-03-01 | 2002-03-01 | Polymorphic and other crystalline forms of cis-ftc |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009097656A Division JP2009197005A (ja) | 2001-03-01 | 2009-04-14 | 多形型および他の結晶型のシス−ｆｔｃ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004530660A JP2004530660A (ja) | 2004-10-07 |
| JP2004530660A5 true JP2004530660A5 (enExample) | 2005-12-22 |
| JP5105689B2 JP5105689B2 (ja) | 2012-12-26 |
Family
ID=26955597
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569838A Expired - Fee Related JP5105689B2 (ja) | 2001-03-01 | 2002-03-01 | 多形型および他の結晶型のシス−ｆｔｃ |
| JP2009097656A Pending JP2009197005A (ja) | 2001-03-01 | 2009-04-14 | 多形型および他の結晶型のシス−ｆｔｃ |
| JP2012229555A Pending JP2013040192A (ja) | 2001-03-01 | 2012-10-17 | 多形型および他の結晶型のシス−ｆｔｃ |
| JP2014184339A Pending JP2015028045A (ja) | 2001-03-01 | 2014-09-10 | 多形型および他の結晶型のシス−ｆｔｃ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009097656A Pending JP2009197005A (ja) | 2001-03-01 | 2009-04-14 | 多形型および他の結晶型のシス−ｆｔｃ |
| JP2012229555A Pending JP2013040192A (ja) | 2001-03-01 | 2012-10-17 | 多形型および他の結晶型のシス−ｆｔｃ |
| JP2014184339A Pending JP2015028045A (ja) | 2001-03-01 | 2014-09-10 | 多形型および他の結晶型のシス−ｆｔｃ |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6723728B2 (enExample) |
| EP (3) | EP1574512B1 (enExample) |
| JP (4) | JP5105689B2 (enExample) |
| KR (4) | KR20040002871A (enExample) |
| CN (4) | CN102911165B (enExample) |
| AT (2) | ATE383355T1 (enExample) |
| AU (1) | AU2002335489B2 (enExample) |
| CA (4) | CA2788498C (enExample) |
| CY (2) | CY1107983T1 (enExample) |
| DE (2) | DE60207850T2 (enExample) |
| DK (2) | DK1574512T3 (enExample) |
| ES (3) | ES2253544T3 (enExample) |
| PT (2) | PT1903041E (enExample) |
| WO (1) | WO2002070518A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1574512T3 (da) | 2001-03-01 | 2008-03-03 | Abbott Lab | Polymorfe og andre krystallinske former af cis-FTC |
| TWI244393B (en) * | 2002-08-06 | 2005-12-01 | Idenix Pharmaceuticals Inc | Crystalline and amorphous forms of beta-L-2'-deoxythymidine |
| JP4996241B2 (ja) | 2003-01-14 | 2012-08-08 | ギリアード サイエンシーズ， インコーポレイテッド | 組み合わせ抗ウイルス治療のための組成物および方法 |
| US6943249B2 (en) * | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| US6887855B2 (en) | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| US20060014949A1 (en) * | 2004-07-13 | 2006-01-19 | Supergen Inc. | Compositions and formulations of decitabine polymorphs and methods of use thereof |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
| WO2009005338A2 (en) * | 2007-07-05 | 2009-01-08 | Ultimorphix Technologies B.V. | Solid forms ult-i, ult-2 and ult-3 of emtricitabine |
| WO2010055526A1 (en) | 2008-11-12 | 2010-05-20 | Lupin Limited | A novel polymorph of emtricitabine and a process for preparing of the same |
| WO2011007367A1 (en) | 2009-07-15 | 2011-01-20 | Lupin Limited | An improved process for preparation of efavirenz |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4476248A (en) | 1983-02-28 | 1984-10-09 | The Upjohn Company | Crystallization of ibuprofen |
| EP0141927B1 (en) | 1983-08-18 | 1991-10-30 | Beecham Group Plc | Antiviral guanine derivatives |
| US5684153A (en) | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| CS264222B1 (en) | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
| WO1989002733A1 (en) | 1987-09-22 | 1989-04-06 | The Regents Of The University Of California | Liposomal nucleoside analogues for treating aids |
| NZ228645A (en) | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
| US5047407A (en) | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
| US5041449A (en) | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
| US6175008B1 (en) | 1988-04-11 | 2001-01-16 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
| US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
| US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
| US5463092A (en) | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
| US5700937A (en) | 1990-02-01 | 1997-12-23 | Emory University | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
| US6642245B1 (en) | 1990-02-01 | 2003-11-04 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
| US5827727A (en) * | 1990-02-01 | 1998-10-27 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
| US6703396B1 (en) | 1990-02-01 | 2004-03-09 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers |
| US5204466A (en) | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
| WO1991016920A1 (en) | 1990-05-07 | 1991-11-14 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
| JPH05507279A (ja) | 1990-05-29 | 1993-10-21 | ネクススター・ファーマシューティカルズ・インコーポレイテッド | グリセロールジ―およびトリホスフェート誘導体の合成 |
| JP3347723B2 (ja) | 1990-06-13 | 2002-11-20 | グラツィエル，アーノルド | 含リンプロドラッグ |
| US5674849A (en) | 1990-10-24 | 1997-10-07 | Allelix Biopharmaceuticals Inc. | Anti-viral compositions |
| US5256641A (en) | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
| US5149794A (en) | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5543389A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
| US6228860B1 (en) * | 1990-11-13 | 2001-05-08 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes with antiviral properties |
| US5444063A (en) | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
| US5925643A (en) | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
| US5179104A (en) | 1990-12-05 | 1993-01-12 | University Of Georgia Research Foundation, Inc. | Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides |
| IL100502A (en) | 1991-01-03 | 1995-12-08 | Iaf Biochem Int | PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (- |
| IL100965A (en) * | 1991-02-22 | 1999-12-31 | Univ Emory | 2-Hydroxymethyl-5-(5-fluorocytosin-l-yl)-1,3-oxathiolane its resolution and pharmaceutical compositions containing it |
| GB9104740D0 (en) | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
| IT1244501B (it) | 1991-03-22 | 1994-07-15 | Sigma Tau Ind Farmaceuti | Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono |
| WO1992018517A1 (en) | 1991-04-17 | 1992-10-29 | Yale University | Method of treating or preventing hepatitis b virus |
| GB9110874D0 (en) | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
| ZA923641B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| GB9111902D0 (en) | 1991-06-03 | 1991-07-24 | Glaxo Group Ltd | Chemical compounds |
| EP0594677A4 (en) | 1991-07-12 | 1997-09-17 | Vical Inc | Antiviral liponucleosides: treatment of hepatitis b |
| US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
| GB9116601D0 (en) * | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
| US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
| JPH08510236A (ja) | 1993-05-12 | 1996-10-29 | カール ワイ． ホステトラー | 局所使用のためのアシクロビル誘導体 |
| GB9311709D0 (en) | 1993-06-07 | 1993-07-21 | Iaf Biochem Int | Stereoselective synthesis of nucleoside analogues using bicycle intermediate |
| US5587362A (en) | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| IL113432A (en) * | 1994-04-23 | 2000-11-21 | Glaxo Group Ltd | Process for the diastereoselective synthesis of nucleoside analogues |
| US5808040A (en) | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
| SE9500872L (sv) * | 1995-03-10 | 1996-04-01 | Tony Wiseby | Anordning vid sikte för pilbåge |
| US5869461A (en) | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
| DE19543707A1 (de) * | 1995-11-23 | 1997-05-28 | Inst Neue Mat Gemein Gmbh | Verfahren zum Konservieren von Papier |
| GB9525606D0 (en) | 1995-12-14 | 1996-02-14 | Iaf Biochem Int | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
| AU5127098A (en) | 1996-11-29 | 1998-06-22 | Smithkline Beecham Plc | Use of a combination of penciclovir and alpha-interferon in the manufacture of a medicament for the treatment of hepatitis |
| TW318283B (en) | 1996-12-09 | 1997-10-21 | United Microelectronics Corp | Multi-level read only memory structure and manufacturing method thereof |
| EA005097B1 (ru) | 1997-03-19 | 2004-10-28 | Эмори Юниверсити | Синтез 1,3-оксаселеноланнуклеозидов, обладающих активностью против вируса иммунодефицита человека и против вируса гепатита-b |
| RU2244712C2 (ru) * | 1998-08-12 | 2005-01-20 | Гайлид Сайенсиз, Инк. | Способ получения 1,3-оксатиоланового нуклеозида, способ получения производного 1,3-оксатиоланил-5-она |
| CN101186937A (zh) | 1998-10-09 | 2008-05-28 | 爱尔特斯制药公司 | 用于拆分对映体混合物的非均相体系 |
| DK1574512T3 (da) | 2001-03-01 | 2008-03-03 | Abbott Lab | Polymorfe og andre krystallinske former af cis-FTC |
| CA2351049C (en) * | 2001-06-18 | 2007-03-13 | Brantford Chemicals Inc. | Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers |
-
2002
- 2002-03-01 DK DK05076347T patent/DK1574512T3/da active
- 2002-03-01 CN CN201210146874.9A patent/CN102911165B/zh not_active Expired - Fee Related
- 2002-03-01 AT AT05076347T patent/ATE383355T1/de active
- 2002-03-01 CA CA2788498A patent/CA2788498C/en not_active Expired - Fee Related
- 2002-03-01 US US10/086,830 patent/US6723728B2/en not_active Expired - Lifetime
- 2002-03-01 AT AT02748367T patent/ATE312097T1/de active
- 2002-03-01 KR KR10-2003-7011355A patent/KR20040002871A/ko not_active Ceased
- 2002-03-01 JP JP2002569838A patent/JP5105689B2/ja not_active Expired - Fee Related
- 2002-03-01 AU AU2002335489A patent/AU2002335489B2/en not_active Ceased
- 2002-03-01 ES ES02748367T patent/ES2253544T3/es not_active Expired - Lifetime
- 2002-03-01 KR KR1020087016002A patent/KR101015510B1/ko not_active Expired - Fee Related
- 2002-03-01 CA CA002439831A patent/CA2439831C/en not_active Expired - Fee Related
- 2002-03-01 KR KR1020107016624A patent/KR101150250B1/ko not_active Expired - Fee Related
- 2002-03-01 CA CA2690137A patent/CA2690137C/en not_active Expired - Fee Related
- 2002-03-01 CN CN028082850A patent/CN1503796B/zh not_active Expired - Fee Related
- 2002-03-01 EP EP05076347A patent/EP1574512B1/en not_active Expired - Lifetime
- 2002-03-01 DK DK02748367T patent/DK1389207T3/da active
- 2002-03-01 KR KR1020087016003A patent/KR100927024B1/ko not_active Expired - Fee Related
- 2002-03-01 ES ES05076347T patent/ES2299950T3/es not_active Expired - Lifetime
- 2002-03-01 DE DE60207850T patent/DE60207850T2/de not_active Expired - Lifetime
- 2002-03-01 PT PT80002645T patent/PT1903041E/pt unknown
- 2002-03-01 WO PCT/US2002/006184 patent/WO2002070518A1/en not_active Ceased
- 2002-03-01 EP EP02748367A patent/EP1389207B1/en not_active Expired - Lifetime
- 2002-03-01 CA CA2867970A patent/CA2867970A1/en not_active Abandoned
- 2002-03-01 CN CN2012101468804A patent/CN102942563A/zh active Pending
- 2002-03-01 CN CN201210146877.2A patent/CN102911166B/zh not_active Expired - Fee Related
- 2002-03-01 ES ES08000264.5T patent/ES2537007T3/es not_active Expired - Lifetime
- 2002-03-01 PT PT05076347T patent/PT1574512E/pt unknown
- 2002-03-01 DE DE60224592T patent/DE60224592T2/de not_active Expired - Lifetime
- 2002-03-01 EP EP08000264.5A patent/EP1903041B1/en not_active Expired - Lifetime
-
2004
- 2004-04-19 US US10/827,615 patent/US7544692B2/en not_active Expired - Lifetime
-
2006
- 2006-02-10 CY CY20061100192T patent/CY1107983T1/el unknown
-
2008
- 2008-03-31 CY CY20081100369T patent/CY1107913T1/el unknown
-
2009
- 2009-04-14 JP JP2009097656A patent/JP2009197005A/ja active Pending
- 2009-06-09 US US12/481,003 patent/US8637535B2/en not_active Expired - Fee Related
-
2012
- 2012-10-17 JP JP2012229555A patent/JP2013040192A/ja active Pending
-
2014
- 2014-09-10 JP JP2014184339A patent/JP2015028045A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004530660A5 (enExample) | ||
| ES2351958T3 (es) | 5-cloro-3-(4-metanosulfonilfenil)-6'-metil-[2,3'] bipiridinil en forma cristalina pura y procedimiento de síntesis. | |
| CA2572147A1 (en) | Crystalline forms of (-)-(1r,2r)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride | |
| JP2010519247A (ja) | 結晶性ミノサイクリン塩基及びその製造方法 | |
| JP2006241155A (ja) | イバブラジン塩酸塩のβｄ−結晶形態、その製造方法およびそれを含む医薬組成物 | |
| AU2001264804A1 (en) | 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- [2,3']bipyridinyl in pure crystalline form and process for synthesis | |
| CA2439831A1 (en) | Polymorphic and other crystalline forms of cis-ftc | |
| JP2010514725A5 (enExample) | ||
| JP2016510767A5 (enExample) | ||
| Chaplin et al. | Dynamic diastereomeric salt resolution of narwedine and its transformation to (−)-galanthamine | |
| US20080076825A1 (en) | Novel Crystalline Forms of Entacapone and Production Thereof | |
| JP2004504390A (ja) | （ｒ）−ｎ−［５−メチル−８−（４−メチルピペラジン−１−イル）−１，２，３，４−テトラヒドロ−２−ナフチル］−４−モルホリノベンズアミドの新規な形態 | |
| US20030153600A1 (en) | 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl in pure crystalline form and process for synthesis | |
| RU2007143025A (ru) | Полиморфизм додекагидроклопента[а]фенантренилового эфира тиофенкарбоновой кислоты | |
| KR860001228B1 (ko) | d-및 l-2-(6-메톡시-2-나프틸)-프로피온산 혼합물의 광학적 분할방법 | |
| JP2010540440A5 (enExample) | ||
| KR20060127892A (ko) | 온단세트론의 신규한 다형 형태, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 항구토제로서의 이의 용도 | |
| CA3232656A1 (en) | Crystal form of imidazolinone derivative | |
| WO2003037903A1 (en) | Olanzapine dihydrate-ii a process for its preparation and use thereof | |
| EP2356121A1 (en) | Process for resolving zopiclone | |
| JP2005501857A5 (enExample) | ||
| Petit et al. | Resolution of Pasteur salts by auto-seeded preferential crystallization | |
| JP2008506682A5 (enExample) | ||
| CN113214321B (zh) | 一种米诺膦酸e晶型的制备方法 | |
| RU2003113536A (ru) | Кристаллические формы гидрохлорида 1-[6-хлор-5-(трифторметил)-2-пиридинил]пиперазина |