JP4508646B2 - ４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体 - Google Patents

４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体 Download PDF

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Publication number
JP4508646B2
JP4508646B2 JP2003557970A JP2003557970A JP4508646B2 JP 4508646 B2 JP4508646 B2 JP 4508646B2 JP 2003557970 A JP2003557970 A JP 2003557970A JP 2003557970 A JP2003557970 A JP 2003557970A JP 4508646 B2 JP4508646 B2 JP 4508646B2
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Japan
Prior art keywords
sodium
chloro
amino
hydroxybenzoyl
crystalline polymorph
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Expired - Fee Related
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JP2003557970A
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Japanese (ja)
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JP2005520803A5 (enExample
JP2005520803A (ja
Inventor
サテジ・バンダーカー
シンガイ・マジュル
ハリナ・レウチク
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エミスフェアー・テクノロジーズ・インク
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Publication of JP2005520803A5 publication Critical patent/JP2005520803A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2003557970A 2002-01-09 2003-01-09 ４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体 Expired - Fee Related JP4508646B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34761002P 2002-01-09 2002-01-09
PCT/US2003/000878 WO2003057650A2 (en) 2002-01-09 2003-01-09 Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate

Publications (3)

Publication Number Publication Date
JP2005520803A JP2005520803A (ja) 2005-07-14
JP2005520803A5 JP2005520803A5 (enExample) 2008-03-13
JP4508646B2 true JP4508646B2 (ja) 2010-07-21

Family

ID=23364463

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003557970A Expired - Fee Related JP4508646B2 (ja) 2002-01-09 2003-01-09 ４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体

Country Status (7)

Country Link
US (5) US7227033B2 (enExample)
EP (2) EP1469827B1 (enExample)
JP (1) JP4508646B2 (enExample)
AU (1) AU2003223158B2 (enExample)
CA (1) CA2471144C (enExample)
ES (2) ES2412306T3 (enExample)
WO (1) WO2003057650A2 (enExample)

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CZ303736B6 (cs) 2000-06-29 2013-04-17 Emisphere Technologies, Inc. Slouceniny a prostredky pro zavádení aktivních cinidel
US7227033B2 (en) 2002-01-09 2007-06-05 Emisphere Technologies, Inc. Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl) amino] butanoate
US7384914B2 (en) * 2003-01-06 2008-06-10 Emisphere Technologies, Inc. Night-time oral insulin therapy
US20050203001A1 (en) * 2004-03-05 2005-09-15 Emisphere Technologies, Inc. Oral insulin therapies and protocol
US20050192298A1 (en) * 2004-02-27 2005-09-01 Pfizer Inc Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide
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GB0427603D0 (en) * 2004-12-16 2005-01-19 Novartis Ag Organic compounds
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WO2006076692A1 (en) 2005-01-12 2006-07-20 Emisphere Technologies, Inc. Compositions for buccal delivery of parathyroid hormone
US8030271B2 (en) 2005-07-05 2011-10-04 Emisphere Technologies, Inc. Compositions and methods for buccal delivery of human growth hormone
US9364502B2 (en) * 2006-06-28 2016-06-14 Emisphere Technologies, Inc. Gallium nitrate formulations
WO2011017346A2 (en) 2009-08-03 2011-02-10 Emisphere Technologies, Inc. Fast-acting naproxen composition with reduced gastrointestinal effects
CN104884065B (zh) 2012-09-21 2019-01-01 强烈治疗剂公司 治疗癌症的方法
EP2919804B1 (fr) 2012-11-13 2018-01-31 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
WO2020111139A1 (ja) * 2018-11-29 2020-06-04 Ｎｅｃソリューションイノベータ株式会社 座標算出装置、座標算出方法、及びコンピュータ読み取り可能な記録媒体
CN111925298B (zh) * 2020-09-02 2023-05-30 无锡紫杉药业有限公司 一种4-cnab及其制备方法

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Also Published As

Publication number Publication date
WO2003057650A3 (en) 2003-10-16
AU2003223158A1 (en) 2003-07-24
EP1469827A4 (en) 2006-08-16
ES2664189T3 (es) 2018-04-18
CA2471144A1 (en) 2003-07-17
AU2003223158B2 (en) 2008-01-17
CA2471144C (en) 2011-06-07
EP1469827A2 (en) 2004-10-27
WO2003057650A2 (en) 2003-07-17
US20070161708A1 (en) 2007-07-12
US20090010882A1 (en) 2009-01-08
HK1153136A1 (en) 2012-03-23
US7208178B2 (en) 2007-04-24
US7227033B2 (en) 2007-06-05
EP1469827B1 (en) 2017-12-27
US7420085B2 (en) 2008-09-02
US20050272639A1 (en) 2005-12-08
US20080033204A1 (en) 2008-02-07
EP2272501B1 (en) 2013-03-20
US20050250852A1 (en) 2005-11-10
JP2005520803A (ja) 2005-07-14
US7893297B2 (en) 2011-02-22
US7462368B2 (en) 2008-12-09
EP2272501A1 (en) 2011-01-12
ES2412306T3 (es) 2013-07-11

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