JP2005519904A5 - - Google Patents
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- JP2005519904A5 JP2005519904A5 JP2003561571A JP2003561571A JP2005519904A5 JP 2005519904 A5 JP2005519904 A5 JP 2005519904A5 JP 2003561571 A JP2003561571 A JP 2003561571A JP 2003561571 A JP2003561571 A JP 2003561571A JP 2005519904 A5 JP2005519904 A5 JP 2005519904A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- contained
- weight
- morphine
- diclofenac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 4
- 229960005181 morphine Drugs 0.000 claims description 4
- 229930014694 morphine Natural products 0.000 claims description 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N Morphine Chemical group O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 3
- 229960001259 diclofenac Drugs 0.000 claims description 3
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical group OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000008188 pellet Substances 0.000 claims 4
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims 2
- 210000000845 Cartilage Anatomy 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 239000007894 caplet Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 229940035676 ANALGESICS Drugs 0.000 description 6
- 230000000202 analgesic Effects 0.000 description 6
- 239000000730 antalgic agent Substances 0.000 description 6
- -1 benzodiazepam Chemical compound 0.000 description 5
- 239000000470 constituent Substances 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- GHASVSINZRGABV-UHFFFAOYSA-N 5-flurouricil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N Codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- IAKHMKGGTNLKSZ-INIZCTEOSA-N Colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
- LNNWVNGFPYWNQE-UHFFFAOYSA-N Desomorphine Chemical compound C1C2=CC=C(O)C3=C2C24CCN(C)C1C2CCCC4O3 LNNWVNGFPYWNQE-UHFFFAOYSA-N 0.000 description 2
- 229960002949 Fluorouracil Drugs 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N Indometacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 229960004380 Tramadol Drugs 0.000 description 2
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N Tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 description 2
- 210000003932 Urinary Bladder Anatomy 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Xylocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- WREGKURFCTUGRC-POYBYMJQSA-N ddC Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 description 2
- BXZVVICBKDXVGW-NKWVEPMBSA-N ddIno Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 125000005647 linker group Chemical group 0.000 description 2
- 210000000056 organs Anatomy 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- DUEBHXGFCXXGHK-CVEARBPZSA-N (1S,2R)-2-amino-1,2-bis(4-methoxyphenyl)ethanol Chemical compound C1=CC(OC)=CC=C1[C@@H](N)[C@@H](O)C1=CC=C(OC)C=C1 DUEBHXGFCXXGHK-CVEARBPZSA-N 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 1
- 229940116904 ANTIINFLAMMATORY THERAPEUTIC RADIOPHARMACEUTICALS Drugs 0.000 description 1
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- 229940023040 Acyclovir Drugs 0.000 description 1
- 229940009456 Adriamycin Drugs 0.000 description 1
- XJKJWTWGDGIQRH-BFIDDRIFSA-N Alginic acid Chemical compound O1[C@@H](C(O)=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](C)[C@@H](O)[C@H]1O XJKJWTWGDGIQRH-BFIDDRIFSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K Aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 1
- UIQMVEYFGZJHCZ-SSTWWWIQSA-N Antorphin Chemical compound C([C@@H](N(CC1)CC=C)[C@@H]2C=C[C@@H]3O)C4=CC=C(O)C5=C4[C@@]21[C@H]3O5 UIQMVEYFGZJHCZ-SSTWWWIQSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 210000000988 Bone and Bones Anatomy 0.000 description 1
- 210000004556 Brain Anatomy 0.000 description 1
- 240000000772 Brassica cretica Species 0.000 description 1
- 235000003351 Brassica cretica Nutrition 0.000 description 1
- 235000003343 Brassica rupestris Nutrition 0.000 description 1
- 229960001113 Butorphanol Drugs 0.000 description 1
- IFKLAQQSCNILHL-QHAWAJNXSA-N Butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 description 1
- 229920002301 Cellulose acetate Polymers 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229940064701 Corticosteroid nasal preparations for topical use Drugs 0.000 description 1
- 229960001334 Corticosteroids Drugs 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- XLMALTXPSGQGBX-GCJKJVERSA-N Dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 description 1
- IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 description 1
- 229960004679 Doxorubicin Drugs 0.000 description 1
- ZOWQTJXNFTWSCS-IAQYHMDHSA-N Eptazocine Chemical compound C1N(C)CC[C@@]2(C)C3=CC(O)=CC=C3C[C@@H]1C2 ZOWQTJXNFTWSCS-IAQYHMDHSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- OGDVEMNWJVYAJL-LEPYJNQMSA-N Ethyl morphine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OCC OGDVEMNWJVYAJL-LEPYJNQMSA-N 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N Ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229960004578 Ethylmorphine Drugs 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N Fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229960002428 Fentanyl Drugs 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N Fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N Flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N Ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 1
- 229960002963 Ganciclovir Drugs 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- GWOFUCIGLDBNKM-UHFFFAOYSA-N Glafenine Chemical compound OCC(O)COC(=O)C1=CC=CC=C1NC1=CC=NC2=CC(Cl)=CC=C12 GWOFUCIGLDBNKM-UHFFFAOYSA-N 0.000 description 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 description 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N Hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 description 1
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- OZWKMVRBQXNZKK-UHFFFAOYSA-N Ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 1
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
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- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 description 1
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- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 description 1
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Description
「薬」及び「医薬」は、ここでは同意であり、当分野で使用される意味である。
ここで使用される「医薬的に許容できるキャリア」とは、液体フィラー、希釈剤、賦形剤、溶媒又は封入材料等の医薬的に許容できる材料、組成物又は媒体(vehicle)を言い、体の1つの器官又は一部から体の別の器官又は一部へ目的の調整物質を運び輸送するものに使用される。それぞれのキャリアは配合物の他の成分と共存でき、患者に有害でない意味で「適合性」がある必要がある。医薬的に許容できるキャリアに使用できる材料の例として、(1)乳糖、ブドウ糖及びショ糖等の糖類;(2)コーンスターチ及び馬鈴薯澱粉等の澱粉;(3)カルボキシメチルセルロース、エチルセルロース及びセルロースアセテートのナトリウム塩等のセルロース及びその誘導体;(4)粉末化トラガカント;(5)モルト;(6)ゼラチン;(7)タルク;(8)ココアバター及び座薬ワックス等の賦形剤;(9)落花生油、綿実油、紅花油、ゴマ油、オリーブ油、コーン油及び大豆油等の油;(10)プロピレングリコール等のグリコール;(11)グリセリン、ソルビトール、マンニトール及びポリエチレングリコール等のポリオール;(12)オレイン酸エチルエステル及びラウリン酸エチルエステル等のエステル;(13)寒天;(14)水酸化マグネシウム及び水酸化アルミニウム等の緩衝剤;(15)アルギン酸;(16)パイロジェンフリー水;(17)等張食塩水;(18)エチルアルコール;(19)リン酸塩緩衝溶液;並びに(20)医薬配合物で使用される他の非毒性かつ共存性の物質、が挙げられる。
ここで使用される「医薬的に許容できるキャリア」とは、液体フィラー、希釈剤、賦形剤、溶媒又は封入材料等の医薬的に許容できる材料、組成物又は媒体(vehicle)を言い、体の1つの器官又は一部から体の別の器官又は一部へ目的の調整物質を運び輸送するものに使用される。それぞれのキャリアは配合物の他の成分と共存でき、患者に有害でない意味で「適合性」がある必要がある。医薬的に許容できるキャリアに使用できる材料の例として、(1)乳糖、ブドウ糖及びショ糖等の糖類;(2)コーンスターチ及び馬鈴薯澱粉等の澱粉;(3)カルボキシメチルセルロース、エチルセルロース及びセルロースアセテートのナトリウム塩等のセルロース及びその誘導体;(4)粉末化トラガカント;(5)モルト;(6)ゼラチン;(7)タルク;(8)ココアバター及び座薬ワックス等の賦形剤;(9)落花生油、綿実油、紅花油、ゴマ油、オリーブ油、コーン油及び大豆油等の油;(10)プロピレングリコール等のグリコール;(11)グリセリン、ソルビトール、マンニトール及びポリエチレングリコール等のポリオール;(12)オレイン酸エチルエステル及びラウリン酸エチルエステル等のエステル;(13)寒天;(14)水酸化マグネシウム及び水酸化アルミニウム等の緩衝剤;(15)アルギン酸;(16)パイロジェンフリー水;(17)等張食塩水;(18)エチルアルコール;(19)リン酸塩緩衝溶液;並びに(20)医薬配合物で使用される他の非毒性かつ共存性の物質、が挙げられる。
III.構成成分の例示
構成成分は、1以上の官能基を有する生物学的活性成分であり、その官能基はそれら構成成分(二量体、三量体等となる)、他の生物学的活性成分又は(結合基が使用された場合には)結合基と加水分解可能な結合を形成する。構成成分として例えば、モルヒネ、リドカイン、ベンゾジアゼパム、トラマドール及び関連する化合物等の鎮痛剤;抗炎症性ステロイド剤(コルチコステロイド);ジクロフェナク、ナプロキセン、ケトロラク、フルルビプロフェン及びインドメタシン等の非ステロイド性抗炎症剤(NSAID);抗生物質;フルコナゾール及び関連化合物等の抗真菌剤;フォスカルネットナトリウム、トリフルオロチミジン、アシクロビル、ガンシクロビル、ジデオキシイノシン(ddI)、ジデオキシシチジン(ddC)等の抗ウィルス剤;5−フルオロウラシル(5FU)、アドリアマイシン及びその関連化合物等の抗増殖剤;ムラミールジペプチド及び関連化合物等の免疫調節剤;コルヒチン、ビンクリスチン、サイトカラシンB及び関連化合物等の細胞輸送/移動阻害剤;シクロスポリン、インシュリン、成長因子又は成長ホルモン等のサイトカイン及びペプチド/蛋白質等が挙げられる。
構成成分は、1以上の官能基を有する生物学的活性成分であり、その官能基はそれら構成成分(二量体、三量体等となる)、他の生物学的活性成分又は(結合基が使用された場合には)結合基と加水分解可能な結合を形成する。構成成分として例えば、モルヒネ、リドカイン、ベンゾジアゼパム、トラマドール及び関連する化合物等の鎮痛剤;抗炎症性ステロイド剤(コルチコステロイド);ジクロフェナク、ナプロキセン、ケトロラク、フルルビプロフェン及びインドメタシン等の非ステロイド性抗炎症剤(NSAID);抗生物質;フルコナゾール及び関連化合物等の抗真菌剤;フォスカルネットナトリウム、トリフルオロチミジン、アシクロビル、ガンシクロビル、ジデオキシイノシン(ddI)、ジデオキシシチジン(ddC)等の抗ウィルス剤;5−フルオロウラシル(5FU)、アドリアマイシン及びその関連化合物等の抗増殖剤;ムラミールジペプチド及び関連化合物等の免疫調節剤;コルヒチン、ビンクリスチン、サイトカラシンB及び関連化合物等の細胞輸送/移動阻害剤;シクロスポリン、インシュリン、成長因子又は成長ホルモン等のサイトカイン及びペプチド/蛋白質等が挙げられる。
本発明の1以上の構成成分に適切な鎮痛剤として:ベンゾジアゼパム、ブプレノルフィン、ブトルファノール、コデイン、デスモルヒネ(desmorphine)、デゾシン、ジヒドロモルヒネ、ジメフェプタノール、エプタゾシン、エチルモルヒネ、フェンタニル、グラフェニン、ヒドロモルホン、isoladol、ケトベニドン(ketobenidone)、p−lactophetide、レボルファノール、リドカイン、メプタジノール、メタゾシン、メペリジン、メタドン、メトポン、モルヒネ、ナルブフィン、ナルメフェン、ナロルフィン、ナロキソン、ノルレボルファノール、ノルモルヒネ、オキシコドン、オキシモルホン、ペンタゾシン、フェンペリジン(phenperidine)、フェニルラミドール(phenylramidol)、プロポキシフェン、トラマドール及びviminol並びに及び/又はそのアナログ、誘導体又はそれらの塩が挙げられる。上記鎮痛剤はそれぞれ1以上の上記記載の官能基を有し、それら全ては、1以上の同一の鎮痛剤、異なる鎮痛剤又は異なる医薬的活性成分に結合されることが出来る鎮痛剤である。
本発明のコドラッグは;懸濁液又はゲル中に懸濁された粒子の形状で注入され、挿入され、又はインプラントされ;ポリマーマトリックス中に溶解されて注入され、挿入され、又はインプラントされ;ローション、クリーム又はスプレー等で表皮的に適用され;膀胱(bladder)、前立腺、骨転移、脳、若しくは他の腫瘍部位又は腫瘍切除された部位の中又は周囲に注入され;人工補装具(即ち、可撓性膝若しくは股関節部)又はステント中に組み込まれ;人工補装具、骨ねじ、金属板等上に被覆され;耳内に適用され;局所性疼痛症状又は痛みを伴う症状に適用され;ガーゼ、包装用品、包帯又は手当用品中に含浸させて使用できる。
Claims (8)
- 医薬組成物は5重量%〜90重量%のコドラッグを含有する請求項1〜6いずれか1項の医薬組成物。
- 上記ペレットは、直径0.1mm〜5.0mmである請求項23の医薬組成物。
- 上記ペレットは、長さ0.3mm〜3.0mmである請求項23の医薬組成物。
- 上記ペレットは、重さ0.5g〜5gである請求項23の医薬組成物。
- 5〜40個のペレットの、錠剤、商標カプレット、又はカプセルが滑膜性連結、線維性連結、若しくは軟骨性連結、又は上記連結(関節)の周囲の組織へ適用される請求項43、45又は46の方法。
- コドラッグは医薬組成物中に5重量%〜90重量%で含有され、ヒドロゲル形成化合物は医薬組成物中に10重量%〜90重量%で含有され、生体適合性ポリマーは医薬組成物中に0重量%〜50重量%で含有される請求項61の医薬組成物。
- ポリ(エチレングリコール)、ヒアルロン酸、及びモルヒネへ共有結合したジクロフェナクのコドラッグ、を含有する請求項62の医薬組成物。
- ジクロフェナク−モルヒネコドラッグは医薬組成物中に5重量%〜90重量%で含有され、ヒアルロン酸又はその誘導体は医薬組成物中に10重量%〜90重量%で含有され、ポリ(エチレングリコール)は医薬組成物中に0重量%〜50重量%で含有される請求項65の医薬組成物。
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JP2012145841A Withdrawn JP2012180383A (ja) | 2002-01-18 | 2012-06-28 | コドラッグのコントロールデリバリ用ポリマー性ゲルシステム |
Family Applications After (1)
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JP2012145841A Withdrawn JP2012180383A (ja) | 2002-01-18 | 2012-06-28 | コドラッグのコントロールデリバリ用ポリマー性ゲルシステム |
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US (3) | US20030203030A1 (ja) |
EP (1) | EP1465596A1 (ja) |
JP (2) | JP5105697B2 (ja) |
AU (1) | AU2003205278B2 (ja) |
CA (1) | CA2472188C (ja) |
MX (1) | MXPA04006875A (ja) |
WO (1) | WO2003061626A1 (ja) |
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-
2003
- 2003-01-21 AU AU2003205278A patent/AU2003205278B2/en not_active Ceased
- 2003-01-21 EP EP03703953A patent/EP1465596A1/en not_active Withdrawn
- 2003-01-21 MX MXPA04006875A patent/MXPA04006875A/es not_active Application Discontinuation
- 2003-01-21 CA CA2472188A patent/CA2472188C/en not_active Expired - Fee Related
- 2003-01-21 WO PCT/US2003/001906 patent/WO2003061626A1/en active Application Filing
- 2003-01-21 JP JP2003561571A patent/JP5105697B2/ja not_active Expired - Fee Related
- 2003-01-21 US US10/349,202 patent/US20030203030A1/en not_active Abandoned
-
2008
- 2008-08-28 US US12/229,943 patent/US20090010986A1/en not_active Abandoned
-
2012
- 2012-02-09 US US13/370,106 patent/US20120195934A1/en not_active Abandoned
- 2012-06-28 JP JP2012145841A patent/JP2012180383A/ja not_active Withdrawn
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