JP2005519117A5 - - Google Patents
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- Publication number
- JP2005519117A5 JP2005519117A5 JP2003572979A JP2003572979A JP2005519117A5 JP 2005519117 A5 JP2005519117 A5 JP 2005519117A5 JP 2003572979 A JP2003572979 A JP 2003572979A JP 2003572979 A JP2003572979 A JP 2003572979A JP 2005519117 A5 JP2005519117 A5 JP 2005519117A5
- Authority
- JP
- Japan
- Prior art keywords
- methanol
- ethanol
- solvent
- methylene chloride
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- ILAHWRKJUDSMFH-UHFFFAOYSA-N boron tribromide Chemical compound BrB(Br)Br ILAHWRKJUDSMFH-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02005117 | 2002-03-07 | ||
| EP02005115 | 2002-03-07 | ||
| PCT/EP2003/002321 WO2003074511A1 (en) | 2002-03-07 | 2003-03-06 | Quinoline derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010022863A Division JP2010095550A (ja) | 2002-03-07 | 2010-02-04 | キノリン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005519117A JP2005519117A (ja) | 2005-06-30 |
| JP2005519117A5 true JP2005519117A5 (https=) | 2006-04-20 |
Family
ID=27790094
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003572979A Pending JP2005519117A (ja) | 2002-03-07 | 2003-03-06 | キノリン誘導体 |
| JP2010022863A Pending JP2010095550A (ja) | 2002-03-07 | 2010-02-04 | キノリン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010022863A Pending JP2010095550A (ja) | 2002-03-07 | 2010-02-04 | キノリン誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US7399768B2 (https=) |
| EP (1) | EP1480970B1 (https=) |
| JP (2) | JP2005519117A (https=) |
| KR (1) | KR101027977B1 (https=) |
| CN (2) | CN1939915A (https=) |
| AR (1) | AR038730A1 (https=) |
| AU (1) | AU2003219023B2 (https=) |
| BR (1) | BR0308201A (https=) |
| CA (2) | CA2477720C (https=) |
| CO (1) | CO5611196A2 (https=) |
| CY (1) | CY1106409T1 (https=) |
| DE (1) | DE60311233T2 (https=) |
| DK (1) | DK1480970T3 (https=) |
| EC (1) | ECSP045271A (https=) |
| EG (1) | EG24415A (https=) |
| ES (1) | ES2279100T3 (https=) |
| IL (1) | IL163769A0 (https=) |
| MX (1) | MXPA04008666A (https=) |
| MY (1) | MY134325A (https=) |
| NO (1) | NO20044117L (https=) |
| NZ (1) | NZ534732A (https=) |
| PE (1) | PE20030927A1 (https=) |
| PL (2) | PL210336B1 (https=) |
| PT (1) | PT1480970E (https=) |
| RU (1) | RU2345991C2 (https=) |
| SI (1) | SI1480970T1 (https=) |
| TW (1) | TW200406401A (https=) |
| WO (1) | WO2003074511A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1757601E (pt) * | 2002-03-07 | 2009-10-23 | Novartis Ag | Derivados de quinolina e sua utilização em glaucoma e miopia |
| CR20200225A (es) | 2017-11-24 | 2020-07-25 | H Lundbeck As | Nuevos fármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| EP3972971A1 (en) | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's diseases |
| WO2020234277A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease |
| JP7641234B2 (ja) | 2019-05-21 | 2025-03-06 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
| WO2020234276A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL100555A (en) * | 1991-02-07 | 2000-08-31 | Hoechst Marion Roussel Inc | N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them |
| GB9326010D0 (en) * | 1993-12-21 | 1994-02-23 | Sandoz Ltd | Improvements in or relating to organic compounds |
| TW378209B (en) * | 1996-07-08 | 2000-01-01 | Novartis Ag | Benzo[g]quinoline derivatives, their preparation and the pharmaceutical composition containing them |
| PE20030240A1 (es) * | 2001-07-09 | 2003-04-16 | Novartis Ag | DERIVADOS DE BENZO [g] QUINOLINA |
-
2003
- 2003-03-03 EG EG2003030215A patent/EG24415A/xx active
- 2003-03-05 TW TW092104671A patent/TW200406401A/zh unknown
- 2003-03-05 PE PE2003000212A patent/PE20030927A1/es not_active Application Discontinuation
- 2003-03-05 AR ARP030100740A patent/AR038730A1/es unknown
- 2003-03-06 PL PL370915A patent/PL210336B1/pl unknown
- 2003-03-06 EP EP03714784A patent/EP1480970B1/en not_active Expired - Lifetime
- 2003-03-06 CN CNA2006101357990A patent/CN1939915A/zh active Pending
- 2003-03-06 PL PL394208A patent/PL215012B1/pl unknown
- 2003-03-06 ES ES03714784T patent/ES2279100T3/es not_active Expired - Lifetime
- 2003-03-06 AU AU2003219023A patent/AU2003219023B2/en not_active Ceased
- 2003-03-06 WO PCT/EP2003/002321 patent/WO2003074511A1/en not_active Ceased
- 2003-03-06 NZ NZ534732A patent/NZ534732A/en unknown
- 2003-03-06 PT PT03714784T patent/PT1480970E/pt unknown
- 2003-03-06 IL IL16376903A patent/IL163769A0/xx unknown
- 2003-03-06 JP JP2003572979A patent/JP2005519117A/ja active Pending
- 2003-03-06 DK DK03714784T patent/DK1480970T3/da active
- 2003-03-06 BR BR0308201-6A patent/BR0308201A/pt not_active Application Discontinuation
- 2003-03-06 KR KR1020047012409A patent/KR101027977B1/ko not_active Expired - Fee Related
- 2003-03-06 CA CA2477720A patent/CA2477720C/en not_active Expired - Fee Related
- 2003-03-06 CA CA2706618A patent/CA2706618A1/en not_active Abandoned
- 2003-03-06 US US10/506,232 patent/US7399768B2/en not_active Expired - Fee Related
- 2003-03-06 RU RU2004129767/04A patent/RU2345991C2/ru not_active IP Right Cessation
- 2003-03-06 CN CNB038053608A patent/CN1293070C/zh not_active Expired - Fee Related
- 2003-03-06 DE DE60311233T patent/DE60311233T2/de not_active Expired - Lifetime
- 2003-03-06 MX MXPA04008666A patent/MXPA04008666A/es active IP Right Grant
- 2003-03-06 SI SI200330755T patent/SI1480970T1/sl unknown
- 2003-03-07 MY MYPI20030808A patent/MY134325A/en unknown
-
2004
- 2004-09-02 EC EC2004005271A patent/ECSP045271A/es unknown
- 2004-09-15 CO CO04091781A patent/CO5611196A2/es not_active Application Discontinuation
- 2004-09-28 NO NO20044117A patent/NO20044117L/no not_active Application Discontinuation
-
2007
- 2007-03-22 CY CY20071100405T patent/CY1106409T1/el unknown
-
2008
- 2008-06-12 US US12/137,819 patent/US20080255176A1/en not_active Abandoned
-
2010
- 2010-02-04 JP JP2010022863A patent/JP2010095550A/ja active Pending
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