JP2005518451A5 - - Google Patents

Download PDF

Info

Publication number
JP2005518451A5
JP2005518451A5 JP2003571292A JP2003571292A JP2005518451A5 JP 2005518451 A5 JP2005518451 A5 JP 2005518451A5 JP 2003571292 A JP2003571292 A JP 2003571292A JP 2003571292 A JP2003571292 A JP 2003571292A JP 2005518451 A5 JP2005518451 A5 JP 2005518451A5
Authority
JP
Japan
Prior art keywords
acid
compound
group
base
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003571292A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005518451A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/005682 external-priority patent/WO2003072586A2/en
Publication of JP2005518451A publication Critical patent/JP2005518451A/ja
Publication of JP2005518451A5 publication Critical patent/JP2005518451A5/ja
Pending legal-status Critical Current

Links

JP2003571292A 2002-02-22 2003-02-24 ホスフィチル化化合物を製造する方法 Pending JP2005518451A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35912402P 2002-02-22 2002-02-22
US36232002P 2002-03-07 2002-03-07
PCT/US2003/005682 WO2003072586A2 (en) 2002-02-22 2003-02-24 Methods of producing phosphitylated compounds

Publications (2)

Publication Number Publication Date
JP2005518451A JP2005518451A (ja) 2005-06-23
JP2005518451A5 true JP2005518451A5 (https=) 2006-01-05

Family

ID=27767563

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003571292A Pending JP2005518451A (ja) 2002-02-22 2003-02-24 ホスフィチル化化合物を製造する方法

Country Status (8)

Country Link
US (2) US6894158B2 (https=)
EP (1) EP1476407A2 (https=)
JP (1) JP2005518451A (https=)
KR (1) KR20040088520A (https=)
CN (1) CN100379709C (https=)
AU (1) AU2003217706A1 (https=)
CA (1) CA2477039A1 (https=)
WO (1) WO2003072586A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8994076B2 (en) 2009-05-29 2015-03-31 Life Technologies Corporation Chemically-sensitive field effect transistor based pixel array with protection diodes

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100379709C (zh) * 2002-02-22 2008-04-09 霍尼韦尔国际公司 制备亚磷酸酯化(phosphitylated)化合物的方法
CN104211741B (zh) * 2014-09-05 2017-05-31 河南师范大学 一种氘代核苷亚磷酰胺单体的合成方法
CN117233281B (zh) * 2023-09-14 2024-11-05 上海奥锐特生物科技有限公司 2-氰乙基-n,n,n’,n’-四异丙基亚磷酰二胺的检测方法
CN117417401A (zh) * 2023-10-19 2024-01-19 康羽生命科学技术(苏州)有限公司 一种2-tbs尿苷单体合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
SU1196365A1 (ru) * 1984-06-01 1985-12-07 Научно-исследовательский институт физико-химических проблем Белорусского государственного университета им.В.И.Ленина Способ очистки алкилгалогенидов от примесей спиртов и алкилфосфитов
US4783263A (en) * 1986-06-17 1988-11-08 Trost Paul B Detoxification process
DE3788914T2 (de) * 1986-09-08 1994-08-25 Ajinomoto Kk Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
US6340749B1 (en) * 1995-10-06 2002-01-22 Avecia Biotechnology Inc. Preparation of nucleoside phosphoramidites and oligonucleotide synthesis
AU4800197A (en) 1996-10-15 1998-05-11 Nexstar Pharmaceuticals, Inc. Improved coupling activators for oligonucleotide synthesis
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
CN100379709C (zh) * 2002-02-22 2008-04-09 霍尼韦尔国际公司 制备亚磷酸酯化(phosphitylated)化合物的方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8994076B2 (en) 2009-05-29 2015-03-31 Life Technologies Corporation Chemically-sensitive field effect transistor based pixel array with protection diodes

Similar Documents

Publication Publication Date Title
JP7484951B2 (ja) オリゴヌクレオチドの製造方法
US4980460A (en) Protected nucleosides which permit more efficient oligonucleotide syntheses
JP7803520B2 (ja) オリゴヌクレオチド合成用セグメントおよびその製造方法、ならびにそれを用いたオリゴヌクレオチドの合成方法
AU739468B2 (en) Activators for oligonucleotide synthesis
JP4945129B2 (ja) フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
JP5143872B2 (ja) ホスホネートヌクレオシド誘導体
JP2898750B2 (ja) 有機リン化合物をイオウ化するための方法およびそのための試薬
JP4580870B2 (ja) リボヌクレオチド又はリボヌクレオチド誘導体の製造方法
JP2005518451A5 (https=)
CN116209668A (zh) 核酸寡聚物的制造方法
JP2004508379A (ja) オリゴヌクレオチド合成用のシントン
US5204456A (en) Derivatives of nucleosides and their use for the synthesis of oligonucleotides
JP7075681B2 (ja) 立体制御オリゴヌクレオチド合成用光学活性セグメントおよびその製造方法、ならびにそれを用いた立体制御オリゴヌクレオチドの合成方法
CN119585232A (zh) 硫化溶液
US6894158B2 (en) Methods of producing phosphitylated compounds
WO2020166705A1 (ja) オリゴヌクレオチドの製造方法
JPH01128996A (ja) ヌクレオシド誘導体、特に２′−デオキシシチジン及びオリゴヌクレオチド合成へのそれらの使用
KR20250042734A (ko) 올리고뉴클레오티드의 제조 방법
WO2000004062A1 (en) Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
JP3983691B2 (ja) オリゴヌクレオチドの化学的合成法
JPH069682A (ja) レトロウイルス感染用治療薬としてのポリヌクレオチドホスホロジチオエート
CN116981676A (zh) 用于减少由最终脱保护期间烷基胺暴露造成的脱嘧啶化的氢化肉桂酰基保护的核糖鸟苷亚磷酰胺
CN1919852A (zh) 纯化亚磷酸酯化化合物的方法
WO2024143276A1 (ja) オリゴヌクレオチドの製造方法
JPH1129591A (ja) 人工ヌクレアーゼ機能を有するオリゴデオキシリボヌクレオチド、ならびに、その製造用の中間体、その製造方法および使用方法