JP2005518451A - ホスフィチル化化合物を製造する方法 - Google Patents

ホスフィチル化化合物を製造する方法 Download PDF

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Publication number
JP2005518451A
JP2005518451A JP2003571292A JP2003571292A JP2005518451A JP 2005518451 A JP2005518451 A JP 2005518451A JP 2003571292 A JP2003571292 A JP 2003571292A JP 2003571292 A JP2003571292 A JP 2003571292A JP 2005518451 A JP2005518451 A JP 2005518451A
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JP
Japan
Prior art keywords
acid
compound
base
phosphitylated
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003571292A
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English (en)
Japanese (ja)
Other versions
JP2005518451A5 (https=
Inventor
ヴェルナー，クリスティアン
ネレンツ，フランク
カンシック−コンラッドセン，アンドレアス
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Honeywell International Inc
Original Assignee
Honeywell International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Honeywell International Inc filed Critical Honeywell International Inc
Publication of JP2005518451A publication Critical patent/JP2005518451A/ja
Publication of JP2005518451A5 publication Critical patent/JP2005518451A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2003571292A 2002-02-22 2003-02-24 ホスフィチル化化合物を製造する方法 Pending JP2005518451A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35912402P 2002-02-22 2002-02-22
US36232002P 2002-03-07 2002-03-07
PCT/US2003/005682 WO2003072586A2 (en) 2002-02-22 2003-02-24 Methods of producing phosphitylated compounds

Publications (2)

Publication Number Publication Date
JP2005518451A true JP2005518451A (ja) 2005-06-23
JP2005518451A5 JP2005518451A5 (https=) 2006-01-05

Family

ID=27767563

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003571292A Pending JP2005518451A (ja) 2002-02-22 2003-02-24 ホスフィチル化化合物を製造する方法

Country Status (8)

Country Link
US (2) US6894158B2 (https=)
EP (1) EP1476407A2 (https=)
JP (1) JP2005518451A (https=)
KR (1) KR20040088520A (https=)
CN (1) CN100379709C (https=)
AU (1) AU2003217706A1 (https=)
CA (1) CA2477039A1 (https=)
WO (1) WO2003072586A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100379709C (zh) * 2002-02-22 2008-04-09 霍尼韦尔国际公司 制备亚磷酸酯化(phosphitylated)化合物的方法
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
CN104211741B (zh) * 2014-09-05 2017-05-31 河南师范大学 一种氘代核苷亚磷酰胺单体的合成方法
CN117233281B (zh) * 2023-09-14 2024-11-05 上海奥锐特生物科技有限公司 2-氰乙基-n,n,n’,n’-四异丙基亚磷酰二胺的检测方法
CN117417401A (zh) * 2023-10-19 2024-01-19 康羽生命科学技术(苏州)有限公司 一种2-tbs尿苷单体合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
SU1196365A1 (ru) * 1984-06-01 1985-12-07 Научно-исследовательский институт физико-химических проблем Белорусского государственного университета им.В.И.Ленина Способ очистки алкилгалогенидов от примесей спиртов и алкилфосфитов
US4783263A (en) * 1986-06-17 1988-11-08 Trost Paul B Detoxification process
DE3788914T2 (de) * 1986-09-08 1994-08-25 Ajinomoto Kk Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
US6340749B1 (en) * 1995-10-06 2002-01-22 Avecia Biotechnology Inc. Preparation of nucleoside phosphoramidites and oligonucleotide synthesis
AU4800197A (en) 1996-10-15 1998-05-11 Nexstar Pharmaceuticals, Inc. Improved coupling activators for oligonucleotide synthesis
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
CN100379709C (zh) * 2002-02-22 2008-04-09 霍尼韦尔国际公司 制备亚磷酸酯化(phosphitylated)化合物的方法

Also Published As

Publication number Publication date
AU2003217706A8 (en) 2003-09-09
WO2003072586B1 (en) 2004-05-13
KR20040088520A (ko) 2004-10-16
US7217814B2 (en) 2007-05-15
CN1646452A (zh) 2005-07-27
EP1476407A2 (en) 2004-11-17
WO2003072586A3 (en) 2004-04-08
US6894158B2 (en) 2005-05-17
US20050124804A1 (en) 2005-06-09
CN100379709C (zh) 2008-04-09
CA2477039A1 (en) 2003-09-04
WO2003072586A2 (en) 2003-09-04
US20030232980A1 (en) 2003-12-18
AU2003217706A1 (en) 2003-09-09

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