CN100379709C - 制备亚磷酸酯化(phosphitylated)化合物的方法 - Google Patents

制备亚磷酸酯化(phosphitylated)化合物的方法 Download PDF

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Publication number
CN100379709C
CN100379709C CNB038087634A CN03808763A CN100379709C CN 100379709 C CN100379709 C CN 100379709C CN B038087634 A CNB038087634 A CN B038087634A CN 03808763 A CN03808763 A CN 03808763A CN 100379709 C CN100379709 C CN 100379709C
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CN
China
Prior art keywords
phosphitylated
acid
phosphoramidite
compounds
dimethoxytrityl
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Expired - Fee Related
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CNB038087634A
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English (en)
Chinese (zh)
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CN1646452A (zh
Inventor
C·维尔纳
F·内伦茨
A·坎施克-康拉德森
K.瑞迪
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Honeywell International Inc
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Honeywell International Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNB038087634A 2002-02-22 2003-02-24 制备亚磷酸酯化(phosphitylated)化合物的方法 Expired - Fee Related CN100379709C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35912402P 2002-02-22 2002-02-22
US60/359,124 2002-02-22
US36232002P 2002-03-07 2002-03-07
US60/362,320 2002-03-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 200610110601 Division CN1919852A (zh) 2002-02-22 2003-02-24 纯化亚磷酸酯化化合物的方法

Publications (2)

Publication Number Publication Date
CN1646452A CN1646452A (zh) 2005-07-27
CN100379709C true CN100379709C (zh) 2008-04-09

Family

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Family Applications (1)

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CNB038087634A Expired - Fee Related CN100379709C (zh) 2002-02-22 2003-02-24 制备亚磷酸酯化(phosphitylated)化合物的方法

Country Status (8)

Country Link
US (2) US6894158B2 (https=)
EP (1) EP1476407A2 (https=)
JP (1) JP2005518451A (https=)
KR (1) KR20040088520A (https=)
CN (1) CN100379709C (https=)
AU (1) AU2003217706A1 (https=)
CA (1) CA2477039A1 (https=)
WO (1) WO2003072586A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100379709C (zh) * 2002-02-22 2008-04-09 霍尼韦尔国际公司 制备亚磷酸酯化(phosphitylated)化合物的方法
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
CN104211741B (zh) * 2014-09-05 2017-05-31 河南师范大学 一种氘代核苷亚磷酰胺单体的合成方法
CN117233281B (zh) * 2023-09-14 2024-11-05 上海奥锐特生物科技有限公司 2-氰乙基-n,n,n’,n’-四异丙基亚磷酰二胺的检测方法
CN117417401A (zh) * 2023-10-19 2024-01-19 康羽生命科学技术(苏州)有限公司 一种2-tbs尿苷单体合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725677A (en) * 1983-08-18 1988-02-16 Biosyntech Gmbh Process for the preparation of oligonucleotides
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1196365A1 (ru) * 1984-06-01 1985-12-07 Научно-исследовательский институт физико-химических проблем Белорусского государственного университета им.В.И.Ленина Способ очистки алкилгалогенидов от примесей спиртов и алкилфосфитов
US4783263A (en) * 1986-06-17 1988-11-08 Trost Paul B Detoxification process
DE3788914T2 (de) * 1986-09-08 1994-08-25 Ajinomoto Kk Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
US6340749B1 (en) * 1995-10-06 2002-01-22 Avecia Biotechnology Inc. Preparation of nucleoside phosphoramidites and oligonucleotide synthesis
AU4800197A (en) 1996-10-15 1998-05-11 Nexstar Pharmaceuticals, Inc. Improved coupling activators for oligonucleotide synthesis
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
CN100379709C (zh) * 2002-02-22 2008-04-09 霍尼韦尔国际公司 制备亚磷酸酯化(phosphitylated)化合物的方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725677A (en) * 1983-08-18 1988-02-16 Biosyntech Gmbh Process for the preparation of oligonucleotides
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
nucleotides pyridinium salts-an effective class of catalysts foroligonucleotide synthesis. MARKUS BEIER.HELVETICA CHIMICA ACTA,Vol.82 . 1999 *

Also Published As

Publication number Publication date
AU2003217706A8 (en) 2003-09-09
JP2005518451A (ja) 2005-06-23
WO2003072586B1 (en) 2004-05-13
KR20040088520A (ko) 2004-10-16
US7217814B2 (en) 2007-05-15
CN1646452A (zh) 2005-07-27
EP1476407A2 (en) 2004-11-17
WO2003072586A3 (en) 2004-04-08
US6894158B2 (en) 2005-05-17
US20050124804A1 (en) 2005-06-09
CA2477039A1 (en) 2003-09-04
WO2003072586A2 (en) 2003-09-04
US20030232980A1 (en) 2003-12-18
AU2003217706A1 (en) 2003-09-09

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Granted publication date: 20080409

Termination date: 20100224