JP2005518405A5 - - Google Patents
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- Publication number
- JP2005518405A5 JP2005518405A5 JP2003559491A JP2003559491A JP2005518405A5 JP 2005518405 A5 JP2005518405 A5 JP 2005518405A5 JP 2003559491 A JP2003559491 A JP 2003559491A JP 2003559491 A JP2003559491 A JP 2003559491A JP 2005518405 A5 JP2005518405 A5 JP 2005518405A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- composition according
- polyol
- composition
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 51
- 238000009472 formulation Methods 0.000 claims 26
- 229920005862 polyol Polymers 0.000 claims 15
- 150000003077 polyols Chemical class 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000008187 granular material Substances 0.000 claims 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 3
- 229940112822 chewing gum Drugs 0.000 claims 3
- 235000015218 chewing gum Nutrition 0.000 claims 3
- 239000008101 lactose Substances 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 238000005056 compaction Methods 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims 1
- YCKSFFKKEWTLIZ-UHFFFAOYSA-N 2-(4-benzhydrylpiperazin-1-ium-1-yl)acetate Chemical compound C1CN(CC(=O)O)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 YCKSFFKKEWTLIZ-UHFFFAOYSA-N 0.000 claims 1
- PGLIUCLTXOYQMV-GHVWMZMZSA-N 2-[2-[4-[(r)-(4-chlorophenyl)-phenylmethyl]piperazine-1,4-diium-1-yl]ethoxy]acetic acid;dichloride Chemical compound Cl.Cl.C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 PGLIUCLTXOYQMV-GHVWMZMZSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims 1
- 108010011485 Aspartame Proteins 0.000 claims 1
- PGLIUCLTXOYQMV-UHFFFAOYSA-N Cetirizine hydrochloride Chemical compound Cl.Cl.C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 PGLIUCLTXOYQMV-UHFFFAOYSA-N 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 239000000619 acesulfame-K Substances 0.000 claims 1
- 230000003113 alkalizing effect Effects 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000000605 aspartame Substances 0.000 claims 1
- 235000010357 aspartame Nutrition 0.000 claims 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims 1
- 229960003438 aspartame Drugs 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229960001803 cetirizine Drugs 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 229940109275 cyclamate Drugs 0.000 claims 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229960003308 levocetirizine dihydrochloride Drugs 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 229940081974 saccharin Drugs 0.000 claims 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 1
- 235000019204 saccharin Nutrition 0.000 claims 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims 1
- 229940085605 saccharin sodium Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02000871.0 | 2002-01-15 | ||
| EP02000871 | 2002-01-15 | ||
| PCT/EP2003/000260 WO2003059328A1 (en) | 2002-01-15 | 2003-01-14 | Formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010035633A Division JP5467685B2 (ja) | 2002-01-15 | 2010-02-22 | 処方 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005518405A JP2005518405A (ja) | 2005-06-23 |
| JP2005518405A5 true JP2005518405A5 (enExample) | 2006-01-05 |
| JP4724367B2 JP4724367B2 (ja) | 2011-07-13 |
Family
ID=8185261
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003559491A Expired - Lifetime JP4724367B2 (ja) | 2002-01-15 | 2003-01-14 | 処方 |
| JP2010035633A Expired - Lifetime JP5467685B2 (ja) | 2002-01-15 | 2010-02-22 | 処方 |
| JP2012051259A Expired - Lifetime JP5623447B2 (ja) | 2002-01-15 | 2012-03-08 | 処方 |
| JP2013228128A Abandoned JP2014024866A (ja) | 2002-01-15 | 2013-11-01 | 処方 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010035633A Expired - Lifetime JP5467685B2 (ja) | 2002-01-15 | 2010-02-22 | 処方 |
| JP2012051259A Expired - Lifetime JP5623447B2 (ja) | 2002-01-15 | 2012-03-08 | 処方 |
| JP2013228128A Abandoned JP2014024866A (ja) | 2002-01-15 | 2013-11-01 | 処方 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20050038039A1 (enExample) |
| EP (1) | EP1467715B1 (enExample) |
| JP (4) | JP4724367B2 (enExample) |
| KR (1) | KR101005648B1 (enExample) |
| CN (2) | CN100455287C (enExample) |
| AT (1) | ATE486587T1 (enExample) |
| AU (3) | AU2003201161B2 (enExample) |
| BR (1) | BR0306870A (enExample) |
| CA (1) | CA2472396A1 (enExample) |
| CO (1) | CO5590918A2 (enExample) |
| DE (1) | DE60334773D1 (enExample) |
| ES (1) | ES2354688T3 (enExample) |
| MX (1) | MXPA04006775A (enExample) |
| NO (1) | NO333936B1 (enExample) |
| NZ (1) | NZ534039A (enExample) |
| PL (1) | PL212123B1 (enExample) |
| RU (1) | RU2004123612A (enExample) |
| WO (1) | WO2003059328A1 (enExample) |
| ZA (1) | ZA200404796B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE388693T1 (de) * | 2002-04-04 | 2008-03-15 | Pfizer Prod Inc | Wohlschmeckende kautablette |
| EP2260871B1 (fr) * | 2004-04-01 | 2013-05-15 | Pierre Fabre Medicament | Complexes d'inclusions comprenant du piroxicam, une cyclodextrine et l'arginine |
| US7318935B2 (en) * | 2004-05-21 | 2008-01-15 | Accu-Break Technologies, Inc. | Pharmaceutical tablets with active and inactive segments |
| US7838031B2 (en) | 2004-05-21 | 2010-11-23 | Lawrence Solomon | Method of administering a partial dose using a segmented pharmaceutical tablet |
| US7622137B2 (en) * | 2004-05-21 | 2009-11-24 | Accu-Break Technologies, Inc. | Dosage forms contained within a capsule or sachet |
| US8158148B2 (en) * | 2004-05-21 | 2012-04-17 | Accu-Break Technologies, Inc. | Pharmaceutical tablets comprising two or more unitary segments |
| US7713547B2 (en) | 2004-05-21 | 2010-05-11 | Accu-Break Pharmaceuticals, Inc. | Method of administering a partial dose of a segmented pharmaceutical tablet |
| US7329418B2 (en) * | 2004-05-21 | 2008-02-12 | Accu Break Technologies, Inc. | Pharmaceutical tablets having height greater than width |
| US7780985B2 (en) * | 2005-07-12 | 2010-08-24 | Accu-Break Technologies, Inc. | Tablets having a printed separation mark to guide breaking |
| BRPI0513455A (pt) * | 2004-07-22 | 2008-05-06 | Pfizer Prod Inc | formulação para mascaramento de sabor compreendendo o fármaco em uma forma de dissolução retardada e/ou ciclodextrina em uma forma de dissolução melhorada |
| US20060083786A1 (en) * | 2004-07-29 | 2006-04-20 | Glenmark Pharmaceuticals Limited | Taste masking pharmaceutical composition containing levocetirizine |
| KR100714616B1 (ko) * | 2005-06-23 | 2007-05-07 | 삼성전기주식회사 | 지수 함수 발생기 및 이를 이용한 가변 이득 증폭기 |
| US20070086974A1 (en) * | 2005-10-06 | 2007-04-19 | Gawande Rahul S | Cetirizine compositions |
| WO2007058660A1 (en) * | 2005-11-18 | 2007-05-24 | Accu-Break Technologies, Inc. | Segmented pharmaceutical dosage forms |
| US20070237815A1 (en) * | 2006-04-06 | 2007-10-11 | Lawrence Solomon | Dosage forms and methods comprising amlodipine and chlorthalidone |
| WO2007144902A1 (en) * | 2006-06-12 | 2007-12-21 | Jubliant Organosys Limited | Chewable bilayer tablet formulation |
| US20110086092A1 (en) * | 2006-08-08 | 2011-04-14 | Accu-Break Technologies, Inc. | Pharmacuetical tablets containing a plurality of active ingredients |
| EP2083801A1 (en) * | 2006-11-30 | 2009-08-05 | Accu-Break Technologies, Inc. | Divisible osmotic dosage forms and methods of use |
| US20090004231A1 (en) | 2007-06-30 | 2009-01-01 | Popp Shane M | Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring |
| EP2550967A1 (en) * | 2007-07-11 | 2013-01-30 | Fertin Pharma A/S | Compressed chewing gum tablet comprising taste-masking agent |
| US20100260818A1 (en) * | 2007-07-11 | 2010-10-14 | Fertin Pharma A/S | Stable medicated chewing gum comprising cyclodextrin inclusion complex |
| EP2296486B1 (en) * | 2008-05-26 | 2015-04-29 | Fertin Pharma A/S | Film-coated compressed chewing gum |
| CA2734691C (en) | 2008-09-05 | 2017-05-16 | Mcneil-Ppc, Inc. | Method for making cetirizine tablets |
| WO2010107404A1 (en) | 2009-03-16 | 2010-09-23 | Mahmut Bilgic | Stable pharmaceutical combinations |
| WO2011110939A2 (en) | 2010-03-11 | 2011-09-15 | Rubicon Research Private Limited | Pharmaceutical compositions of substituted benzhydrylpiperazines |
| WO2011146032A2 (en) * | 2010-05-18 | 2011-11-24 | Mahmut Bilgic | Effervescent formulations |
| US20170105988A1 (en) * | 2014-03-27 | 2017-04-20 | Ucb Biopharma Sprl | Pharmaceutical Compositions Comprising Levocetirizine |
| JP2016094364A (ja) * | 2014-11-14 | 2016-05-26 | ニプロ株式会社 | 安定化および苦味抑制された口腔内崩壊製剤 |
| JP7049610B2 (ja) * | 2018-05-21 | 2022-04-07 | 高田製薬株式会社 | レボセチリジン固形製剤 |
| KR20220137065A (ko) | 2020-02-03 | 2022-10-11 | 존슨 앤드 존슨 컨수머 인코포레이티드 | 세티리진을 포함하는 단일층 츄어블 정제 |
| US20230366038A1 (en) * | 2022-05-16 | 2023-11-16 | Bioo Scientific Corporation | Compositions and methods relating to loop mediated isothermal amplification (lamp) |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4238510A (en) * | 1979-02-21 | 1980-12-09 | Life Savers, Inc. | Sugarless coating for chewing gum and confections and method |
| US4260596A (en) * | 1979-08-13 | 1981-04-07 | Bristol-Myers Company | Edible unit dosage form consisting of outer mannitol shell and inner liquid or gel center and method for manufacturing the same |
| FR2647343B1 (fr) | 1989-05-24 | 1994-05-06 | Rhone Poulenc Sante | Nouvelle forme pharmaceutique poreuse et sa preparation |
| US5460825A (en) * | 1990-05-23 | 1995-10-24 | Mcneil-Ppc, Inc. | Taste mask coatings for preparing chewable pharmaceutical tablets |
| NZ243667A (en) * | 1991-08-02 | 1995-02-24 | Kurihara Yoshie | Chewing gum containing coated curculin derivative or fruit containing curculin |
| TW401300B (en) * | 1992-12-25 | 2000-08-11 | Senju Pharma Co | Antiallergic composition for ophthalmic or nasal use |
| US5380530A (en) * | 1992-12-29 | 1995-01-10 | Whitehill Oral Technologies | Oral care composition coated gum |
| CA2128820A1 (en) | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
| HU213407B (en) | 1993-12-09 | 1997-06-30 | Egyt Gyogyszervegyeszeti Gyar | Process for producing tablet with diffusive-osmotic release |
| IT1274034B (it) * | 1994-07-26 | 1997-07-14 | Applied Pharma Res | Composizioni farmaceutiche a base di gomma da masticare e procedimento per la loro preparazione |
| US5866179A (en) * | 1996-05-03 | 1999-02-02 | Avant-Garde Technologies & Products S.A. | Medicated chewing gum and a process for preparation thereof |
| EP0811374A1 (en) | 1996-05-29 | 1997-12-10 | Pfizer Inc. | Combination dosage form comprising cetirizine and pseudoephedrine |
| US6172095B1 (en) * | 1996-11-25 | 2001-01-09 | The Procter & Gamble Company | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| BE1011251A3 (fr) * | 1997-07-03 | 1999-06-01 | Ucb Sa | Compositions pharmaceutiques administrables par voie orale, comprenant une substance active et une cyclodextrine. |
| ATE288742T1 (de) * | 1997-07-10 | 2005-02-15 | Gergely Dr & Co | Lösliche, gummihaltige, dragierte kautablette |
| DE19814256A1 (de) * | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Feste, schnellzerfallende Cetirizin-Formulierungen |
| US6319513B1 (en) * | 1998-08-24 | 2001-11-20 | The Procter & Gamble Company | Oral liquid mucoadhesive compounds |
| US6627234B1 (en) * | 1998-12-15 | 2003-09-30 | Wm. Wrigley Jr. Company | Method of producing active agent coated chewing gum products |
| EP1311240A1 (en) * | 2000-08-14 | 2003-05-21 | Fertin Pharma A/S | Method for preparation of chewing gum with customer acceptable taste |
| WO2002049607A2 (en) * | 2000-12-20 | 2002-06-27 | Firmenich Sa | Flavoured oral drug delivery system |
| US20030035839A1 (en) * | 2001-05-15 | 2003-02-20 | Peirce Management, Llc | Pharmaceutical composition for both intraoral and oral administration |
| US7014867B2 (en) * | 2001-06-28 | 2006-03-21 | Ucb Farchim Sa | Tablet comprising cetirizine and pseudoephedrine |
| ATE388693T1 (de) * | 2002-04-04 | 2008-03-15 | Pfizer Prod Inc | Wohlschmeckende kautablette |
-
2003
- 2003-01-14 RU RU2004123612/15A patent/RU2004123612A/ru unknown
- 2003-01-14 CN CNB038022869A patent/CN100455287C/zh not_active Expired - Lifetime
- 2003-01-14 KR KR1020047010865A patent/KR101005648B1/ko not_active Expired - Lifetime
- 2003-01-14 ES ES03729449T patent/ES2354688T3/es not_active Expired - Lifetime
- 2003-01-14 AU AU2003201161A patent/AU2003201161B2/en not_active Ceased
- 2003-01-14 NZ NZ534039A patent/NZ534039A/en not_active IP Right Cessation
- 2003-01-14 JP JP2003559491A patent/JP4724367B2/ja not_active Expired - Lifetime
- 2003-01-14 AT AT03729449T patent/ATE486587T1/de not_active IP Right Cessation
- 2003-01-14 PL PL370292A patent/PL212123B1/pl unknown
- 2003-01-14 BR BR0306870-6A patent/BR0306870A/pt not_active Application Discontinuation
- 2003-01-14 DE DE60334773T patent/DE60334773D1/de not_active Expired - Lifetime
- 2003-01-14 WO PCT/EP2003/000260 patent/WO2003059328A1/en not_active Ceased
- 2003-01-14 EP EP03729449A patent/EP1467715B1/en not_active Expired - Lifetime
- 2003-01-14 CA CA002472396A patent/CA2472396A1/en not_active Abandoned
- 2003-01-14 US US10/501,359 patent/US20050038039A1/en not_active Abandoned
- 2003-01-14 CN CN200910005882XA patent/CN101632642B/zh not_active Expired - Lifetime
- 2003-01-14 MX MXPA04006775A patent/MXPA04006775A/es active IP Right Grant
-
2004
- 2004-06-17 ZA ZA200404796A patent/ZA200404796B/en unknown
- 2004-07-14 CO CO04067032A patent/CO5590918A2/es not_active Application Discontinuation
- 2004-08-13 NO NO20043367A patent/NO333936B1/no not_active IP Right Cessation
-
2008
- 2008-05-23 AU AU2008202280A patent/AU2008202280B2/en not_active Ceased
- 2008-08-28 US US12/230,420 patent/US8946229B2/en active Active
-
2009
- 2009-07-27 AU AU2009203044A patent/AU2009203044B2/en not_active Ceased
-
2010
- 2010-02-22 JP JP2010035633A patent/JP5467685B2/ja not_active Expired - Lifetime
-
2011
- 2011-09-23 US US13/242,378 patent/US20120010218A1/en not_active Abandoned
-
2012
- 2012-03-08 JP JP2012051259A patent/JP5623447B2/ja not_active Expired - Lifetime
-
2013
- 2013-11-01 JP JP2013228128A patent/JP2014024866A/ja not_active Abandoned
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