JP2005513103A5 - - Google Patents
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- Publication number
- JP2005513103A5 JP2005513103A5 JP2003554193A JP2003554193A JP2005513103A5 JP 2005513103 A5 JP2005513103 A5 JP 2005513103A5 JP 2003554193 A JP2003554193 A JP 2003554193A JP 2003554193 A JP2003554193 A JP 2003554193A JP 2005513103 A5 JP2005513103 A5 JP 2005513103A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- alkyl
- compound
- agent
- ophthalmically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- UFQDKRWQSFLPQY-UHFFFAOYSA-N 4,5-dihydro-1h-imidazol-3-ium;chloride Chemical compound Cl.C1CN=CN1 UFQDKRWQSFLPQY-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 239000003604 miotic agent Substances 0.000 claims 1
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 229940054534 ophthalmic solution Drugs 0.000 claims 1
- 229940100654 ophthalmic suspension Drugs 0.000 claims 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34337801P | 2001-12-20 | 2001-12-20 | |
| PCT/US2002/039316 WO2003053436A1 (en) | 2001-12-20 | 2002-12-09 | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005513103A JP2005513103A (ja) | 2005-05-12 |
| JP2005513103A5 true JP2005513103A5 (enExample) | 2006-01-12 |
Family
ID=23345873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003554193A Pending JP2005513103A (ja) | 2001-12-20 | 2002-12-09 | 緑内障の処置のための新規ベンゾジフランイミダゾリンおよびベンゾフランイミダゾリン誘導体ならびにそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7208512B2 (enExample) |
| EP (1) | EP1455780A4 (enExample) |
| JP (1) | JP2005513103A (enExample) |
| KR (1) | KR20040068315A (enExample) |
| CN (1) | CN1268334C (enExample) |
| AR (1) | AR037880A1 (enExample) |
| AU (1) | AU2002353088B2 (enExample) |
| BR (1) | BR0215172A (enExample) |
| CA (1) | CA2469904A1 (enExample) |
| MX (1) | MXPA04006029A (enExample) |
| TW (1) | TW593302B (enExample) |
| WO (1) | WO2003053436A1 (enExample) |
| ZA (1) | ZA200404473B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| WO2004054572A2 (en) | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
| US7476687B2 (en) * | 2003-11-26 | 2009-01-13 | Alcon, Inc. | Substituted furo[2,3-g]indazoles for the treatment of glaucoma |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| US6989445B2 (en) | 2003-12-15 | 2006-01-24 | Alcon, Inc. | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| WO2006062839A1 (en) | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| TW200744567A (en) * | 2005-09-23 | 2007-12-16 | Alcon Inc | Phenylethylamine analogs and their use for treating glaucoma |
| WO2007149728A2 (en) * | 2006-06-20 | 2007-12-27 | Alcon Research, Ltd. | Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES323985A1 (es) | 1966-02-26 | 1966-12-16 | Blade Pique Juan | Procedimiento para la obtenciën de derivados del imidazol |
| US5011846A (en) | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
| EP0445073A1 (de) | 1990-02-27 | 1991-09-04 | Ciba-Geigy Ag | Benzofurane |
| JP3321593B2 (ja) | 1990-06-26 | 2002-09-03 | エイオールテック バイオマテリアルズ ピーティーワイ リミテッド | ポリウレタンエラストマー |
| US5578612A (en) | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| PT100603A (pt) | 1991-06-21 | 1993-08-31 | Smithkline Beecham Plc | Uso de analogos de triptamina, analogos de triptamina, sua preparacao e composicoes farmaceuticas que os contem |
| GB9216380D0 (en) | 1992-07-31 | 1992-09-16 | Glaxo Group Ltd | Medicaments |
| US5290781A (en) | 1993-01-05 | 1994-03-01 | Iolab Corporation | Ketaneserinol as an agent to reduce intraocular pressure |
| US5891131A (en) | 1993-02-01 | 1999-04-06 | Arizona Board Of Regents | Method and apparatus for automated simulation and design of corneal refractive procedures |
| TW334423B (en) | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| TW270114B (enExample) | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| US5538974A (en) | 1994-01-27 | 1996-07-23 | Senju Pharamceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| DE69502539T2 (de) | 1994-03-18 | 1998-10-01 | Senju Pharma Co | Sarpogrelat enthaltende opthalmologische Zubereitungen zur Senkung des intraokularen Druckes |
| TW403738B (en) | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
| US5874477A (en) | 1994-08-12 | 1999-02-23 | The University Of Hawaii | Method of treatment for malaria utilizing serotonin receptor ligands |
| US5998467A (en) | 1995-10-25 | 1999-12-07 | Mitsubishi Chemical Corporation | Medicine for oculopathy |
| AU2340997A (en) | 1996-03-27 | 1997-10-17 | Merck & Co., Inc. | A method for inhibiting clot formation |
| US5902815A (en) | 1996-09-03 | 1999-05-11 | Washington University | Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction |
| WO1998018458A1 (en) | 1996-10-31 | 1998-05-07 | Alcon Laboratories, Inc. | Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma |
| GB9700899D0 (en) | 1997-01-17 | 1997-03-05 | Smithkline Beecham Plc | Novel treatment |
| US6107324A (en) | 1998-04-14 | 2000-08-22 | Arena Pharmaceuticals Inc. | 5-HT2A receptor inverse agonists |
| WO1999059499A2 (en) | 1998-05-19 | 1999-11-25 | Alcon Laboratories, Inc. | Serotonergic 5ht7 receptor compounds for treating ocular and cns disorders |
| GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| GB9819033D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
| EP1112106B1 (en) | 1998-09-18 | 2005-11-23 | Alcon Manufacturing Ltd. | Serotonergic 5ht2 agonists for treating glaucoma |
| SK8192001A3 (en) | 1998-12-17 | 2001-12-03 | American Home Prod | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivatives being 5ht2c agonists |
| GB9902047D0 (en) | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| AU2042301A (en) | 1999-12-03 | 2001-06-12 | Alcon Universal Limited | 1-aminoalkyl-1H-indoles for treating glaucoma |
| US6660870B1 (en) | 2000-03-17 | 2003-12-09 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
| PL358481A1 (en) | 2000-03-17 | 2004-08-09 | Alcon Inc. | 6-hydroxy-indazole derivatives for treating glaucoma |
| US6806285B1 (en) | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
| DK1267847T3 (da) | 2000-03-17 | 2004-03-08 | Alcon Inc | 5HT2-antagonist til regulering af IOP og behandling af glaucom |
| WO2001070701A1 (en) | 2000-03-17 | 2001-09-27 | Alcon, Inc. | 5-hydroxy indazole derivatives for treating glaucoma |
| DK1268482T3 (da) | 2000-03-17 | 2003-12-22 | Alcon Inc | Pyranoindoler til behandling af glaukom |
| JP2003527423A (ja) | 2000-03-17 | 2003-09-16 | アルコン、インコーポレイテッド | 緑内障処置用の５−ｈｔ２および５−ｈｔ１ａアゴニスト活性を有する化合物 |
| WO2002098860A1 (en) | 2001-06-01 | 2002-12-12 | Alcon, Inc. | Novel fused indazoles and indoles and their use for the treatment of glaucoma |
| DK1392292T3 (da) | 2001-06-01 | 2006-05-29 | Alcon Inc | Pyranoindazoler og deres anvendelse til behandling af glaukom |
| MXPA03010806A (es) | 2001-06-01 | 2004-11-22 | Alcon Inc | Nuevos analogos de arilaminopropano y su uso para el tratamiento de glaucoma. |
| US6884816B2 (en) | 2001-08-31 | 2005-04-26 | Alcon, Inc. | Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma |
| JP2005511764A (ja) | 2001-12-14 | 2005-04-28 | アルコン，インコーポレイテッド | 緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物 |
| WO2003051291A2 (en) | 2001-12-14 | 2003-06-26 | Alcon, Inc. | Substituted 5-hydroxy-indole compounds for the treatment of glaucoma |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| PL375564A1 (en) | 2002-08-30 | 2005-11-28 | Alcon, Inc. | Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma |
| CA2492468A1 (en) | 2002-09-24 | 2004-04-08 | Virginia Commonwealth University | .beta.-hydroxyphenylalkylamines and their use for treating glaucoma |
| WO2004054572A2 (en) | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
| PL376084A1 (en) | 2002-12-23 | 2005-12-12 | Alcon, Inc. | 1-alkyl-3-aminoindazoles |
-
2002
- 2002-11-29 TW TW091134883A patent/TW593302B/zh not_active IP Right Cessation
- 2002-12-09 US US10/525,410 patent/US7208512B2/en not_active Expired - Fee Related
- 2002-12-09 MX MXPA04006029A patent/MXPA04006029A/es active IP Right Grant
- 2002-12-09 EP EP02790063A patent/EP1455780A4/en not_active Withdrawn
- 2002-12-09 AU AU2002353088A patent/AU2002353088B2/en not_active Ceased
- 2002-12-09 JP JP2003554193A patent/JP2005513103A/ja active Pending
- 2002-12-09 KR KR10-2004-7009781A patent/KR20040068315A/ko not_active Withdrawn
- 2002-12-09 CN CNB028254643A patent/CN1268334C/zh not_active Expired - Fee Related
- 2002-12-09 BR BR0215172-3A patent/BR0215172A/pt not_active IP Right Cessation
- 2002-12-09 CA CA002469904A patent/CA2469904A1/en not_active Abandoned
- 2002-12-09 WO PCT/US2002/039316 patent/WO2003053436A1/en not_active Ceased
- 2002-12-17 AR ARP020104911A patent/AR037880A1/es unknown
-
2004
- 2004-06-07 ZA ZA200404473A patent/ZA200404473B/en unknown
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